Clarification of dietary zinc signal transduction through the intestine to the appetite control region of brain.
| Project/Area Number |
20380072
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
KOMAI Michio Tohoku University, 大学院・農学研究科, 教授 (80143022)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAKAWA Hitoshi 東北大学, 大学院・農学研究科, 准教授 (40206280)
後藤 知子 東北大学, 大学院・農学研究科, 助教 (00342783)
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Tomoko 東北大学, 大学院・農学研究科, 助教 (00342783)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 食欲調節 / 食餌亜鉛 / 食欲調節ペプチド / 亜鉛シグナル / 亜鉛トランスポーター / マイクロダイアリシス / ラット / 摂食調節 / 食餌亜鉛シグナル / Neuronentide Y (NPY) / 消化管迷走神経 / オレキシン(orexin) / 中枢制御機構 / Neuropeptide Y / 消化管迷走神経切除 |
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| Research Abstract |
Food intake control is a very important factor to keep us healthy condition. We investigated the role of dietary zinc in food intake regulation using rats during early-stage zinc deficiency without decreasing zinc concentrations in plasma and tissues. We found that zinc stimulated food intake after oral but not intraperitoneal administration in Sprague-Dawley rats fed zinc-deficient diet for 3 days. The mRNA expression of neuropeptide Y (NPY) and orexin in the hypothalamus significantly increased 3 hrs after oral but not intraperitoneal administration of zinc. Orally administered zinc may stimulate food intake via orexigenic peptides coupled to the afferent vagus nerve in rats after short-term treatment with a zinc-deficient diet.
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Report
(4 results)
Research Products
(34 results)
