| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
|
|---|
| Research Abstract |
Huge numbers of commensal bacteria colonize the gastrointestinal tract of mammals. These organisms play a key role in inducing the development and maintaining the homeostasis of the intestinal immune system. In this study, we have revealed that Bacteroides promote the development of the germinal center in the cecum, and induce total IgA production in the large intestine by increasing IgA^+B cells. Furthermore, we have demonstrated that intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate serum antibody responses induced by dietary antigens through modulation of the intestinal and systemic T cell phenotype by using germ-free mice.
|
