Comprehensive analysis to determine chemical structures in supercoolingpromoting substances from xylem parenchyma cells of trees and considerations to obtain much volume of supercooling-promoting substances for their applications

• Project/Area Number: 20380099
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Wood science
• Research Institution: Hokkaido University
• Principal Investigator: FUJIKAWA Seizo Hokkaido University, 名誉教授 (50091492)
• Co-Investigator(Kenkyū-buntansha): FUKUSHI Yukiharu 北海道大学, 大学院・農学研究院, 講師 (60218906) ; ARAKAWA Keita 北海道大学, 大学院・農学研究院, 准教授 (00241381)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000); Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
• Keywords: 抽出成分 / 微量成分 / 木部柔細胞 / 樹木柔細胞 / 過冷却促進物質 / 氷核形成物質 / フラボノール配糖体 / 加水分角型タンニン / 有機合成 / 新規産業素材 / 樹木木部柔細胞 / 氷核形成阻害物質 / タンニン酸 / 抽出物 / ケンフェロール

Research Abstract

From xylem parenchyma cells in trees that can supercool to -40C during winter, we identified a several kinds of flavonol glycosides and hydrolysable tannins. Based on such results, we could also identified more than 50 kinds of flavonol and tannin-related compounds that promoted supercooling of water. We also tried to use these supercooling-promoting substances as novel materials that inhibit freezing of water.

Research Products

• [Journal Article] Successful introduction of novel supercoolant, kaempferol-7-0-beta-D- glucopyranoside (KF7G), to sub-zero non-freezing rat heart preservation (2010)
  • Author(s): Shimada S, Motomura N, Kinoshita O, saito A, Kasuga J, Matsusaka Y, Kawabata J, Kuwabara C, Fujikawa S, Ono M
  • Journal Title: Low Temperature Medicine 36 Pages: 20-24
  • Peer Reviewed
• [Journal Article] Analysis of supercooling-facilitating (anti-ice nucleation) activity of flavonol glycosides (2010)
  • Author(s): Kasuga J, Fukushi Y, Kuwabara C, Wang D, Nishioka A, Fujikawa E, Arakawa K, Fujikawa S
  • Journal Title: Cryobiology 60 Pages: 240-243
  • NAID: 120002036092
  • Peer Reviewed
• [Journal Article] Endoplasmic localized-small heat shock protein that accumulates in mulberry tree (Morus bombycis koids.) during seasonal cold acclimation is responsive to abscisic acid (2010)
  • Author(s): Ukaji N, Kuwabara C, Kanno Y, Seo M, Takezawa D, Arakawa K, Fujikawa S
  • Journal Title: Tree Physiology 30 Pages: 502-513
  • Peer Reviewed
• [Journal Article] Endoplasmic localized-small heat shock protein that accumulates in mulberry tree (Morus bombycis koids.) duringseasonal cold acclimation is responsive to abscisic acid. (2010)
  • Author(s): Ukaji N
  • Journal Title: Tree Physiology Volume: 30 Pages: 502-513
  • Peer Reviewed
• [Journal Article] Response to dehydration and irrigation in invasive native sapling : osmotic adjustment versus leaf shedding. (2010)
  • Author(s): Yazaki K
  • Journal Title: Tree Physiology Volume: 30 Pages: 597-607
  • Peer Reviewed
• [Journal Article] Successful introduction of novel supercoolant, kaempferol-7-O-beta-D-glucopyranoside (KF7G), to sub-zero non-freezing rat heart preservation. (2010)
  • Author(s): Shimada S
  • Journal Title: Low Temperature Medicine Volume: 36 Pages: 20-24
  • Peer Reviewed
• [Journal Article] Endoplasmic reticulum-localized small heat shock protein that accumulates in mulberry tree(Morus bombycis Koids.)during seasonal cold acclimation is responsive to abscisic acid. (2010)
  • Author(s): Ukaji N
  • Journal Title: Tree Physiology 25(In press)
  • Peer Reviewed
• [Journal Article] Analysis of supercooling-facilitating(anti-ice nucleation)activity of flavonol glycosides. (2010)
  • Author(s): Kasuga J
  • Journal Title: Cryobiology 60 Pages: 240-243
  • Peer Reviewed
• [Journal Article] Cryo-scanning electron microscopic study on freezing behaviors of tissue cells in dormant buds of larch (Larix kaempferi) (2009)
  • Author(s): Endoh K, Kasuga J, Arakawa K, Fujikawa S
  • Journal Title: Cryobiology 59 Pages: 214-222
  • Peer Reviewed
• [Journal Article] Factors related to change of deep supercooling capability in xylem parenchyma cells of trees (2009)
  • Author(s): Fujikawa S, Kasuga J, Takata N, Arakawa K
  • Journal Title: Plant Cold Hardiness ; From the Laboratory to the Field(Gusta LV, Wisniewski ME, Tanino K (eds), CABI Press) Pages: 29-42
  • Peer Reviewed
• [Journal Article] 樹木の凍結抵抗性-凍らない水- (2009)
  • Author(s): 藤川清三、春日純、荒川圭太
  • Journal Title: 低温生物工学会誌 55 Pages: 37-41
  • Peer Reviewed
• [Journal Article] Factors related to change of deep supercooling capability in xylem parenchyma cells of trees. (2009)
  • Author(s): Fujikawa S
  • Journal Title: Plant Cold Hardiness ; From the Laboratory to the Field. (Gusta LV et al, Eds.)CABI Press Pages: 29-42
  • Peer Reviewed
• [Journal Article] Impact of simulated acid snow stress on leaves of cold-acclimated winter wheat. (2009)
  • Author(s): Arakawa K
  • Journal Title: Plant Cold Hardiness ; From the Laboratory to the Field. (Gusta LV et al, Eds.)CABI Press Pages: 173-182
  • Peer Reviewed
• [Journal Article] 樹木の凍結抵抗性-凍らない水- (2009)
  • Author(s): 藤川清三
  • Journal Title: 低温生物工学会誌 55 Pages: 37-41
  • Peer Reviewed
• [Journal Article] Cryo-scanning electron microscopic study on freezing behaviors of tissue cells in dormant buds of larch(Larix kaempferi) (2009)
  • Author(s): Endoh K
  • Journal Title: Cryobiology 59 Pages: 214-222
  • Peer Reviewed
• [Journal Article] Improved cryopreservation by diluted vitrification solution with supercooling-facilitating flavonol glycoside (2008)
  • Author(s): Kami D, Kasuga J, Arakawa K, Fujikawa S
  • Journal Title: Cryobiology 57 Pages: 242-245
  • Peer Reviewed
• [Journal Article] Deep supercooling xylem parenchyma cells of katsura tree (Cercidiphyllum japonicum) contain flavonol glycosides exhibiting high anti-ice nucleation activity (2008)
  • Author(s): Kasuga J, Hashidoko Y, Nishioka A, Yoshiba M, Arakawa K, Fujikawa S
  • Journal Title: Plant, Cell and Environment 31 Pages: 1335-1348
  • Peer Reviewed
• [Journal Article] 過冷却促進物質 (2008)
  • Author(s): 藤川清三、春日純
  • Journal Title: 検査と技術 36 Pages: 546-549
• [Journal Article] Long- and short-term freezing induce different types of injury in Arabidopsis thaliana leaf cells (2008)
  • Author(s): Nagao M
  • Journal Title: Planta 227 Pages: 477-489
  • Peer Reviewed
• [Journal Article] 過冷却促進物質 (2008)
  • Author(s): 藤川清三
  • Journal Title: 検査と技術 36 Pages: 546-549
• [Journal Article] 凍結過程に存在する酸性物質が植物細胞の生存に及ぼす影響 (2008)
  • Author(s): 稲田秀俊
  • Journal Title: 日本冷凍空調学会論文集 25 Pages: 233-238
  • Peer Reviewed
• [Journal Article] Deep supercooling xylem parenchyma cells of katsura tree (Cercidiphyllum japonicum) contain flavonol glycosides exhibiting high anti-ice nucleation activity (2008)
  • Author(s): Kasuga J
  • Journal Title: Plant, Cell and Environment 31 Pages: 1335-1348
  • Peer Reviewed
• [Journal Article] Effects of light condition after simulated acid snow stress on leaves of winter wheat (2008)
  • Author(s): Inada H
  • Journal Title: Environmental Science 14 Pages: 53-71
  • Peer Reviewed
• [Journal Article] Improved cryopreservation by diluted vitrification solution with supercooling-facilitating flavonol glycoside (2008)
  • Author(s): Kami D
  • Journal Title: Cryobiology 57 Pages: 242-245
  • Peer Reviewed
• [Journal Article] Conducting pathways in north temperate deciduous broadleaves trees (2008)
  • Author(s): Umebayashi T
  • Journal Title: IAWA Journal 29 Pages: 247-263
  • Peer Reviewed
• [Presentation] 器官外凍結によって氷点下温度に適応するカラマツ冬芽の凍結適応機構 (2011)
  • Author(s): 遠藤圭太
  • Organizer: 第61回日本木材学会大会
  • Place of Presentation: 京都大学農学部・京都市
  • Year and Date: 2011-03-18
• [Presentation] 針葉樹師部柔細胞の冬季構造特性について (2011)
  • Author(s): 山本絢平
  • Organizer: 第61回日本木材学会大会
  • Place of Presentation: 京都大学農学部・京都市
  • Year and Date: 2011-03-18
• [Presentation] 深過冷却するカラマツ木部由来の冬季誘導性タンパク質(LkDRP1、LkDRP2)に関する研究 (2011)
  • Author(s): 能美彩香
  • Organizer: 第61回日本木材学会大会
  • Place of Presentation: 京都大学農学部・京都市
  • Year and Date: 2011-03-18
• [Presentation] 低温走査型電子顕微鏡(Cryo-SEM)による冬芽の凍結挙動観察 (2010)
  • Author(s): 遠藤圭太
  • Organizer: 日本顕微鏡学会北海道支部学術講演会
  • Place of Presentation: 酪農学園大学・江別市
  • Year and Date: 2010-12-11
• [Presentation] 水を凍らせづらくする物質-過冷却促進(氷核形成阻害)物質- (2010)
  • Author(s): 藤川清三
  • Organizer: 伝熱学会北海道支部会
  • Place of Presentation: 北海道大学工学部・札幌
  • Year and Date: 2010-12-10
• [Presentation] 水を凍らせづらくする物質-過冷却促進(氷核形成阻害)物質- (2010)
  • Author(s): 藤川清三
  • Organizer: 伝熱学会北海道支部会
  • Place of Presentation: 北海道大学工学部・札幌市 招待講演
  • Year and Date: 2010-12-10
• [Presentation] 生物凍結適応論-過冷却- (2010)
  • Author(s): 藤川清三
  • Organizer: 九工大セミナー
  • Place of Presentation: 九州工業大学・北九州市 招待講演
  • Year and Date: 2010-11-30
• [Presentation] 樹木の寒冷環境適応機構とその産業的応用の可能性 (2010)
  • Author(s): 藤川清三
  • Organizer: 岩手大学CRCセミナー
  • Place of Presentation: 岩手大学・盛岡
  • Year and Date: 2010-11-17
• [Presentation] 樹木の寒冷環境適応機構とその産業的応用の可能性 (2010)
  • Author(s): 藤川清三
  • Organizer: CRCセミナー
  • Place of Presentation: 岩手大学・盛岡市 招待講演
  • Year and Date: 2010-11-17
• [Presentation] カラマツ(Larix kaempferi)木部柔細胞の過冷却能に関与する冬季誘導性タンパク質(LkDRP 1及びLkDRP2)に関する研究 (2010)
  • Author(s): 能美彩香
  • Organizer: 第42回日本木材学会北海道支部研究発表会
  • Place of Presentation: 札幌コンベンションセンター・札幌市
  • Year and Date: 2010-11-09
• [Presentation] ハイブリッドアスペンの凍結抵抗性に関する研究 (2010)
  • Author(s): 板羽貴史
  • Organizer: 第42回日本木材学会北海道支部研究発表会
  • Place of Presentation: 札幌コンベンションセンター・札幌市
  • Year and Date: 2010-11-09
• [Presentation] 異なる凍結挙動を示すカツラおよびシラカンバ冬芽の組織細胞 (2010)
  • Author(s): 遠藤圭太
  • Organizer: 42回日本木材学会北海道支部講演会
  • Place of Presentation: 札幌コンベンションセンター・札幌市
  • Year and Date: 2010-11-09
• [Presentation] 樹木の凍結適応機構について (2010)
  • Author(s): 荒川圭太
  • Organizer: 森林バイオ研究センター・セミナー
  • Place of Presentation: 森林バイオ研究センター・日立市 招待講演
  • Year and Date: 2010-08-27
• [Presentation] Identification of supercooling-facilitating (anti-ice nucleating) hydrolyzable tannins from xylem parenchyma cells in katsura tree (Cercidiphyllum japonicum) (2010)
  • Author(s): Wang., D.
  • Organizer: Cryo-2010
  • Place of Presentation: マリオットローヤルホテ・、ブリストル・英国
  • Year and Date: 2010-07-18
• [Presentation] Supercooling-facilitating (anti-ice nucleation) activity of phenolic compounds in solutions containing different types of ice nucleation substances (2010)
  • Author(s): Kuwabara, C.
  • Organizer: Cryo-2010
  • Place of Presentation: マリオットローヤルホテル・ブリストル・英国
  • Year and Date: 2010-07-18
• [Presentation] Comparison of freezing behaviors between extracellular freezing and extraogan freezing in dormant buds in trees (2010)
  • Author(s): Endoh, K.
  • Organizer: Cryo-2010
  • Place of Presentation: マリオットローヤルホテル・ブリストル・英国
  • Year and Date: 2010-07-18
• [Presentation] 過冷却促進(氷核形成阻害)物質の応用についての検討 (2010)
  • Author(s): 桑原慎子
  • Organizer: 第55回低温生物工学会大会
  • Place of Presentation: 東京工業大学・大岡山キャンパス
  • Year and Date: 2010-06-26
• [Presentation] Unfrozen water in trees (2010)
  • Author(s): 藤川清三
  • Organizer: Special Seminar at School of Life Science in Lanzhou University
  • Place of Presentation: 中国・蘭州大学
  • Year and Date: 2010-05-21
• [Presentation] Unfrozen water in trees (2010)
  • Author(s): Fujikawa, S
  • Organizer: Special Seminar at School of Life Science in Lanzhou University
  • Place of Presentation: 蘭州大学・中国 招待講演
  • Year and Date: 2010-05-21
• [Presentation] Cold adaptation mechanisms of trees (2010)
  • Author(s): Fujikawa, S
  • Organizer: Special Seminar at School of Life Science in Lanzhou University
  • Place of Presentation: 蘭州大学・中国 招待講演
  • Year and Date: 2010-05-20
• [Presentation] Diversity of freezing adaptation mechanisms in tissue cells of Japanese white birch (2010)
  • Author(s): Endoh, K.
  • Organizer: 第4回国際樹液サミット
  • Place of Presentation: 美深町民センター・美深町 招待講演
  • Year and Date: 2010-04-17
• [Presentation] トドマツ針葉の凍結挙動 (2010)
  • Author(s): 遠藤圭太
  • Organizer: 第60回日本木材学会大会
  • Place of Presentation: 宮崎観光ホテル、宮崎市
  • Year and Date: 2010-03-18
• [Presentation] カラマツ木部柔細胞の深過冷却能に関与する冬期誘導性タンパク質 (2010)
  • Author(s): 能美彩香
  • Organizer: 第60回日本木材学会大会
  • Place of Presentation: 宮崎観光ホテル、宮崎市
  • Year and Date: 2010-03-18
• [Presentation] Identification of new supercooling(anti-ice nucleation)substances from deep supercooling xylem parenchyma parenchyma cells in katsura tree(Cercidiphyllum japonicum) (2010)
  • Author(s): Wang Donghui
  • Organizer: 第60回日本木材学会大会
  • Place of Presentation: 宮崎観光ホテル、宮崎市
  • Year and Date: 2010-03-18
• [Presentation] 深過冷却する木部柔細胞由来のフラボノール配糖体と類似化合物の過冷却活性 (2010)
  • Author(s): 宇梶愼子
  • Organizer: 第60回日本木材学会大会
  • Place of Presentation: 宮崎観光ホテル、宮崎市
  • Year and Date: 2010-03-17
• [Presentation] Influence of acidification of snow (simulated acid snow Stress) on wheat seedlines (2010)
  • Author(s): Arakawa, K
  • Organizer: Special Seminar at School of Life Science in Lanzhou University
  • Place of Presentation: 蘭州大学・中国 招待講演
• [Presentation] 電子顕微鏡による生物の凍結に関する研究 (2009)
  • Author(s): 藤川清三
  • Organizer: 日本顕微鏡学会北海道支部
  • Place of Presentation: 酪農学園大学、江別市。
  • Year and Date: 2009-12-12
• [Presentation] 樹の中の凍らない水 (2009)
  • Author(s): 藤川清三
  • Organizer: 市民公開・農学特別講演会
  • Place of Presentation: 北海道大学農学部、札幌市
  • Year and Date: 2009-11-27
• [Presentation] 樹木の寒冷適応-基礎研究から応用へ- (2009)
  • Author(s): 藤川清三
  • Organizer: 日本木材学会・北海道支部、平成21年度研究発表会
  • Place of Presentation: 道北地域旭川地場産業振興センター、旭川市
  • Year and Date: 2009-11-09
• [Presentation] トドマツ針葉の耐凍性および凍結挙動 (2009)
  • Author(s): 遠藤圭太
  • Organizer: 日本木材学会・北海道支部、平成21年度研究発表会
  • Place of Presentation: 道北地域旭川地場産業振興センター、旭川市
  • Year and Date: 2009-11-09
• [Presentation] 樹の中の凍らない水。何故? (2009)
  • Author(s): 藤川清三
  • Organizer: 九大・北大合同フロンティア・セミナー
  • Place of Presentation: 東京ステーションコンファレンス、東京都
  • Year and Date: 2009-10-20
• [Presentation] CRYO-SEMによる凍結試料の観察-植物の凍結適応機構の研究においてCRYO-SEMが果たした役割 (2009)
  • Author(s): 藤川清三
  • Organizer: SEMユーザーズミーティング
  • Place of Presentation: 東京大学、東京都
  • Year and Date: 2009-09-18
• [Presentation] Why do isolated tissues from dormant buds result in poorer freezing resistances than those in whole buds under extraorgan freezing? (2009)
  • Author(s): Endoh K
  • Organizer: 46^<th> Annual Meeting of Cryobiology
  • Place of Presentation: 北海道大学学術交流会館、札幌
  • Year and Date: 2009-07-20
• [Presentation] Difference in supercooling-facilitating(anti-ice nucleation)activity among diverse kinds of flavonol glycosides. (2009)
  • Author(s): Kasuga J
  • Organizer: 46^<th> Annual Meeting of Cryobiology
  • Place of Presentation: 北海道大学学術交流会館、札幌
  • Year and Date: 2009-07-19
• [Presentation] Study on winter-induced proteins involved in freezing resistance of xylem tissue of larch. (2009)
  • Author(s): Arakawa K
  • Organizer: 46^<th> Annual Meeting of Cryobiology
  • Place of Presentation: 北海道大学学術交流会館、札幌
  • Year and Date: 2009-07-19
• [Presentation] Application of anti-ice nucleation substances from deep supercooling xylem parenchyma cells in trees in order to regulate freezing condition for cryopreservation (2009)
  • Author(s): 藤川清三
  • Organizer: 1^<st> International Symposium on Cryopreservation in Horticultural Speciess
  • Place of Presentation: アレンベルグ城・ベルギー
  • Year and Date: 2009-04-07
• [Presentation] Application of anti-ice nucleation substances from deep supercooling xylem parenchyma cells in trees in order to regulate freezing condition for cryopreservation (2009)
  • Author(s): Fujikawa S
  • Organizer: 1^<st> International Symposium on Cryopreservation in Horticultural Species
  • Place of Presentation: アレンベルグ城、ベルギー
  • Year and Date: 2009-04-07
• [Presentation] カラマツ木部柔細胞の深過冷却能に関与する可溶性蛋白質の解析 (2009)
  • Author(s): 荒川圭太
  • Organizer: 第50回日本植物生理学会年会
  • Place of Presentation: 名古屋大学、名古屋
  • Year and Date: 2009-03-24
• [Presentation] 可溶性糖の添加によるブナ木部柔細胞の過冷却能力の変化 (2009)
  • Author(s): 春日純
  • Organizer: 第59回日本木材学会大会
  • Place of Presentation: 松本大学、松本市
  • Year and Date: 2009-03-15
• [Presentation] カラマツ冬芽(長枝芽)の凍結挙動 (2009)
  • Author(s): 遠藤圭太
  • Organizer: 第59回日本木材学会大会
  • Place of Presentation: 松本大学、松本市
  • Year and Date: 2009-03-15
• [Presentation] カラマツ木部柔細胞の深過冷却能に関与する低温誘導性蛋白質の解析 (2009)
  • Author(s): 荒川圭太
  • Organizer: 第59回日本木材学会大会
  • Place of Presentation: 松本大学、松本市
  • Year and Date: 2009-03-15
• [Presentation] 深過冷却する樹木細胞中の過冷却促進(氷核形成阻害)物質 (2009)
  • Author(s): 藤川清三
  • Organizer: 日本冷凍空調学会セミナー
  • Place of Presentation: きゅりあん・品川区
  • Year and Date: 2009-01-16
• [Presentation] 深過冷却する樹木細胞中の過冷却促進(氷核形成阻害)物質 (2009)
  • Author(s): 藤川清三
  • Organizer: 日本冷凍空調学会セミナー
  • Place of Presentation: 大井町きゅりあん、東京
  • Year and Date: 2009-01-16
• [Presentation] 過冷却により越冬する樹木木部柔細胞の研究による「凍らない水」の作成 (2008)
  • Author(s): 藤川清三
  • Organizer: 積水化学「自然に学ぶものづくり」研究助成プログラム発表会
  • Place of Presentation: 積水化学本社、京都
  • Year and Date: 2008-10-21
• [Presentation] 樹の中の凍らない水-氷核形成阻害物質の存在- (2008)
  • Author(s): 藤川清三
  • Organizer: NEDO第10回先端燃料電池技術研究会
  • Place of Presentation: 白金台NEDO会館、東京
  • Year and Date: 2008-08-27
• [Presentation] Application of anti-ice nucleation flavonol glycosides to supercooling preservation and cryo-preservation of biological specimens (2008)
  • Author(s): Fujikawa S
  • Organizer: 45^<th> Annual Meeting of Society for Cryobiology
  • Place of Presentation: シャーロットホテル、シャーロット、USA
  • Year and Date: 2008-07-20
• [Presentation] Purification and identification of anti-ice nucleation substances in deep supercooling xylem parenchyma cells of katsura tree (Cercidiphyllum japonicum) (2008)
  • Author(s): Kasuga J
  • Organizer: Plant Biology 2008
  • Place of Presentation: Chichen Itza Exhibit Hall. Merida, Mexico
  • Year and Date: 2008-06-29
• [Presentation] 樹木の凍結抵抗性-凍らない水- (2008)
  • Author(s): 藤川清三
  • Organizer: 低温生物工学会セミナー
  • Place of Presentation: 石川県立大学・石川県
  • Year and Date: 2008-06-13
• [Presentation] 樹木の凍結抵抗性-凍らない水- (2008)
  • Author(s): 藤川清三
  • Organizer: 低温生物工学会セミナー
  • Place of Presentation: 石川県立大学、石川県石川郡
  • Year and Date: 2008-06-13
• [Book] 森を取り戻すために-2;林木の育種(林隆久・編) (2010)
  • Author(s): 藤川清三
  • Total Pages: 171
  • Publisher: 海青社
• [Remarks] アウトリーチ活動 (1)藤川清三:樹木の中の凍らない水、市民公開農学特別講座2009年11月27日、北海道大学農学部・札幌 (2)藤川清三:樹の中の凍らない水。何故?、九大・北大フロンティアセミナー、2009年10月20日、東京コンファレンスステーション・東京 ホームページ等
• [Patent(Industrial Property Rights)] 過冷却促進剤 (2011)
  • Inventor(s): 藤川清三・福士幸治・荒川圭太
  • Industrial Property Rights Holder: 北海道大学・アミノアップ化学
  • Filing Date: 2011-03-03
• [Patent(Industrial Property Rights)] 過冷却促進剤 (2010)
  • Inventor(s): 藤川清三, 福士幸治, 荒川圭太, 西岡浩
  • Industrial Property Rights Holder: 国立大学法人北海道大学 株式会社アミノアップ化学
  • Filing Date: 2010-03-04
• [Patent(Industrial Property Rights)] Supercooling-promoting agent (2009)
  • Inventor(s): 藤川清三・春日純・橋床泰之・福士幸治・荒川圭太
  • Industrial Property Rights Holder: 北海道大学・オリンパス
  • Filing Date: 2009-08-01
• [Patent(Industrial Property Rights)] Supercoolig promoting agent (2009)
  • Inventor(s): 藤川清三, 春日純, 橋床泰之, 荒川圭太, 福士幸治
  • Industrial Property Rights Holder: 北海道大学オリンパス光学
  • Filing Date: 2009-02-15
  • Overseas