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Study on growth, physiology and toxicology of Dinophysis spp. causing diarrheic shellfish poisoning

Research Project

Project/Area Number 20380116
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General fisheries
Research InstitutionFisheries Research Agency

Principal Investigator

KAMIYAMA Takashi  独立行政法人水産総合研究センター, 東北区水産研究所, 主幹研究員 (60371803)

Co-Investigator(Kenkyū-buntansha) SUZUKI Toshiyuki  独立行政法人水産総合研究センター, 中央水産研究所, グループ長 (70371804)
NAGAI Satoshi  独立行政法人水産総合研究センター, 瀬戸内海区水産研究所, 主任研究員 (80371962)
NISHITANI Go  東北大学, 大学院・農学研究科, 助教 (70450781)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords有毒プランクトン / 下痢性貝毒 / ディノフィシス / Dinophysis acuminata / Dinophysis fortii / 毒生産 / オカダ酸 / ペクテノトキシン / Myrionecta rubra / ペクテノトキシン2
Research Abstract

We examined characteristics of growth, nutritional physiology and lipophilic toxin production of the genus Dinophysis and effects of environmental conditions on them. Characteristics of cellular toxin contents and toxin composition of natural Dinophysis spp. collected in various Japanese coastal waters were clarified. In laboratory experiments growth of Dinophysis spp. depends on specific prey source, the ciliate Myrionecta rubra, feeding on the Cryptophyceae Teleaulax amphioxeia, and was influenced by temperature and light intensity. Toxin production also varied in response to these environmental factors and growth phase. Parts of toxin components were excreted into surrounding seawater with progress of the growth. Cellular toxin contents were occasionally largely different among local strains of Dinophysis species cultivated under the same conditions, suggesting effects of genetic characteristics on the toxin production.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (67 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (23 results) Book (1 results) Remarks (10 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Multiple plastids collected by the dinoflagellate Dinophysis mitra through kleptoplastidy Applied and Environmental Microbiology2012

    • Author(s)
      Nishitani, G., Nagai, S., Hayakawa, S., Kosaka, Y., Sakurada, K., Kamiyama, T., 他1名
    • Volume
      78
    • Pages
      813-821
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple plastids collected by the dinoflagellate Dinophysis mitra through kleptoplastidy2012

    • Author(s)
      西谷豪
    • Journal Title

      Applied and Environmental Microbiology

      Volume: Vol.78 Issue: 3 Pages: 813-821

    • DOI

      10.1128/aem.06544-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 伊勢湾における有毒渦鞭毛藻Dinophysis属の発生とムラサキイガイM ytilus galloprovincialisの毒化との関係2011

    • Author(s)
      畑直亜,鈴木敏之, ほか2名
    • Journal Title

      日本水産学会誌

      Volume: 77 Pages: 1065-1075

    • NAID

      10029654102

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in the production and excretion kinetics of okdaic acid, dinohysistoxin-1, and pectenotoxin-2 between cultures of Dinophysis acuminata and Dinophysis fortii isolated from western Japan2011

    • Author(s)
      Nagai, S., Suzuki, T., Nishikawa, T. and Kamiyama, T.
    • Journal Title

      Journal of Phycology

      Volume: 47 Pages: 1326-1337

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] LC-MS/MS analysis of diarrhetic shellfish poisoning(DSP) toxins, okadaic acid and dinophysistoxin analogues, and other lipophilic toxins2011

    • Author(s)
      Suzuki, T., ほか1名
    • Journal Title

      Analytical Sciences

      Volume: 27 Pages: 571-584

    • NAID

      10028288958

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 伊勢湾における有毒渦鞭毛藻Dinophysis属の発生とムラサキイガイMytilus galloprovincialisの毒化との関係2011

    • Author(s)
      畑直亜
    • Journal Title

      日本水産学会誌

      Volume: Vol.77 Pages: 1065-1075

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in the production and excretion kinetics of okdaic acid, dinohysistoxin-1, and pectenotoxin-2 between cultures of Dinophysis acuminata and Dinophysis fortii isolated from western Japan2011

    • Author(s)
      長井敏
    • Journal Title

      Journal of Phycology

      Volume: Vol.47 Issue: 6 Pages: 1326-1337

    • DOI

      10.1111/j.1529-8817.2011.01076.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LC-MS/MS analysis of diarrhetic shellfish poisoning (DSP) toxins, okadaic acid and dinophysistoxin analogues, and other lipophilic toxins2011

    • Author(s)
      鈴木敏之
    • Journal Title

      Analytical Sciences

      Volume: Vol.27 Pages: 571-584

    • NAID

      10028288958

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shellfish toxin monitoring system in Japan and some Asian countries2011

    • Author(s)
      Suzuki, T.
    • Journal Title

      New Trends in Marin and Freshwaters Toxins Food Safety Concerns

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of temperature on production of okadaic acid, dinophysistoxin-1, and pectenotoxin-2 by Dinophysis acuminata in culture experiments2010

    • Author(s)
      Kamiyama, T., Nagqai, S., Suzuki, T., ほか1名
    • Journal Title

      Aquatic Microbial Ecology

      Volume: 60 Pages: 193-202

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal variability of lipophilic shellfish toxins in bivalves and waters, and abundance of Dinophysis spp2010

    • Author(s)
      Kim, J. H., Lee, K. J., Suzuki, T., ほか4名
    • Journal Title

      Journal of Shellfish Research

      Volume: 29 Pages: 1061-1067

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-level congruence of Myrionecta rubra prey and Dinophysis species plastid identities as revealed by genetic analyses of isolates from Japanese coastal waters2010

    • Author(s)
      Nishitani, G., Nagai, S., Baba, K., Kiyokawa, S., Kousaka, Y., Miyamura, K., Nishikawa, T., Sakurada, K., Shinada, A. and Kamiyama, T.
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 76 Pages: 2791-2798

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of temperature on production of okadaic acid, dinophysistoxin-1, and pectenotoxin-2 by Dinophysis acuminata in culture experiments.2010

    • Author(s)
      Kamiyama, T., Nagqai, S., Suzuki, T., ほか1名
    • Journal Title

      Aquatic Microbial Ecology 60

      Pages: 193-202

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] High-level congruence of Myrionecta rubra prey and Dinophysis species plastid identities as revealed by genetic analyses of isolates from Japanese coastal waters.2010

    • Author(s)
      Nishitani, G., Nagai, S., Baba, K., Kiyokawa, S., Kousaka, Y., Miyamura, K., Nishikawa, T., Sakurada, K., Shinada, A., Kamiyama, T.
    • Journal Title

      Applied and Environmental Microbiology 76

      Pages: 2791-2798

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Effect of temperature on production of okadaic acid, dinophysistoxin-1, and pectenotoxin'2 by Dinophysis acvminata in culture experiments2010

    • Author(s)
      Kamiyama, T.
    • Journal Title

      Aquatic Microbial Ecology

      Volume: 60 Pages: 193-202

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic analysis of the cryptomonad nucleomorph in natural Myrinecta rubra cells reveal a simple lineage of Dinophysis kleptoplastids..2010

    • Author(s)
      Niahitani, G.
    • Journal Title

      Proceedings of XIII International Conference on Harmful algae

      Pages: 175-179

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal Vafiability of Lipophilic Shellfish Tbxins in Bivalves and Waters, and Abundance of Dinophysis spp.in Jinhae Bay, Korea2010

    • Author(s)
      Kim, J.H.
    • Journal Title

      Journal of Shellfish Research

      Volume: 29 Pages: 1061-1067

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本産ホタテガイ(Patinopecten yessoensis)とイガイ(Mytilus coruscus)のジノフィシストキシン1脂肪酸エステル2010

    • Author(s)
      鈴木敏之
    • Journal Title

      食品衛生研究

      Volume: 60 Pages: 13-15

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-level congruence of Myrionecta rubra prey and Dinophysis species plastid identities as revealed by genetic analyses of isolates from Japanese coastal waters2010

    • Author(s)
      Nishitani, G.
    • Journal Title

      Applied and Environmental Microbiology 76

      Pages: 2791-2798

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liquid-chromatographic hybrid triple quadrupole linear-ion-trap MS/MS analysis of fatty-acid esters of dinophysistoxin-1 in bivalves and toxic dinoflagellates in Japan Fisheries Science2009

    • Author(s)
      Suzuki, T., Kamiyama, T., ほか4名
    • Volume
      75
    • Pages
      1039-1048
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Production of Dinophysistoxin-1 and pectenotoxin-2 by a cultured of Dinophysis acuminata(Dinophyceae)2009

    • Author(s)
      Kamiyama, T. and Suzuki, T.
    • Journal Title

      Harmful Algae

      Volume: 8 Pages: 312-317

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liquid-chromatographic hybrid triple-quadrupole linear-ion-trap MS/MS analysis of fatty-acid esters of dinophysistoxin-1 in bivalves and toxic dinoflagellates in Japan Fisheries Science2009

    • Author(s)
      Suzuki, T., Kamiyama, T., ほか4名
    • Journal Title

      75

      Pages: 1039-1048

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Liquid-chromatographic hybrid triple-quadrupole linear-ion-trap MS/MS analysis of fatty-acid esters of dinophysistoxin-1 in bivalves and toxic dinoflagellates in Japan2009

    • Author(s)
      Suzuki, T.
    • Journal Title

      Fisheries Science 75

      Pages: 1039-1048

    • NAID

      10024979778

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of Dinophysistoxin-1 and pectenotoxin-2 by a cultured of Dinophys is acuminata (Dinophyceae)2009

    • Author(s)
      Kamiyama, T., Suzuki, T.
    • Journal Title

      Harmful Algae 8

      Pages: 312-317

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LC-MS/MS analysis of okadaic acid analogues and other lipophilic toxins in single-cell isolates of several Dinophysis species collected in Hokkaido, Japan2009

    • Author(s)
      Suzuki, T., Miyazono, A., Baba, K., Sugawara, R., Kamiyama, T.
    • Journal Title

      Harmful Algae 8

      Pages: 233-238

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predation by the toxic dinoflagellate Dinophysis fortii on the ciliate Myrionecta rubra and observation of sequestration of ciliate chloroplasts.2008

    • Author(s)
      Nagai, S., Nishitani, G., Tomaru, Y., Sakiyama, S., Kamiyama, T.
    • Journal Title

      Journal of Phycology 44

      Pages: 909-922

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Production of Dinophysistoxin-1 and pectenotoxin-2 by a cultured of Dinophysis acuminata (Dinophyceae).2008

    • Author(s)
      Kamiyama, T., Suzuki, T.
    • Journal Title

      Harmful Algae 8

      Pages: 312-317

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Successful cultivation of the toxic dinoflagellate Dinophysis caudata (Dinophyceae)2008

    • Author(s)
      Nishitani, G., Nagai. S., Sakiyama, S., Kamiyama, T.
    • Journal Title

      Plankton & Benthos Research 3

      Pages: 78-85

    • NAID

      10021072763

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predation by the toxic dinoflagellate Dinophysis fortii on the ciliate Myrionect a rubra and observation of sequestration of ciliate chloroplasts2008

    • Author(s)
      Nagai, S., Nishitani, G., Tomaru, Y., Sakiyama, S., Kamiyama, T.
    • Journal Title

      Journal of Phycology 44

      Pages: 909-922

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth characteristics and phylogenetic analysis of the marine dinoflagellate Dinophysis infundibulus (Dinophyceae)2008

    • Author(s)
      Nishitani, G., Nagai, S., Takano, Y., Sakiyama, S., Baba, K., Kamiyama, T.
    • Journal Title

      Aquatic Microbial Ecology 52

      Pages: 209-221

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 国内沿岸で採集したDinophysis属のLC-MS/MSによる毒組成分析2011

    • Author(s)
      鈴木敏之
    • Organizer
      平成23年度日本水産学会秋季大会
    • Place of Presentation
      長崎大学
    • Year and Date
      2011-09-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 国内沿岸で採集したDinophysis属のLC-MS/MSによる毒組成分析2011

    • Author(s)
      鈴木敏之
    • Organizer
      平成23年度日本水産学会秋季大会
    • Place of Presentation
      長崎市
    • Year and Date
      2011-09-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dmophysis属培養株による新規エステル型オカダ酸群の探索2011

    • Author(s)
      内田肇
    • Organizer
      平成23年度日本水産学会春季大会
    • Place of Presentation
      東京都
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] High-performance liquid Chromatographic-fluorometric detection of okadais acid analogues as 9-anthrylmethyl esters with an automatic column switching cleanup method2010

    • Author(s)
      Uchida, H.
    • Organizer
      45th Session of the Joint UJNR Panel on Toxic Microorganisms ; Methodology and Training for Detection of Seafood Toms
    • Place of Presentation
      シアトル市
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 有毒渦鞭毛藻Dinophysis triposの増殖特性と毒生産2010

    • Author(s)
      神山孝史
    • Organizer
      平成22年度日本水産学会秋季大会
    • Place of Presentation
      京都大学
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 有毒渦鞭毛藻Dinophysis triposの増殖特性と毒生産2010

    • Author(s)
      神山孝史
    • Organizer
      平成22年度日本水産学会秋季大会
    • Place of Presentation
      京都市
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 下痢性貝毒原因種 Dinophysis acuminata の毒生産に及ぼす温度の影響2010

    • Author(s)
      神山孝史
    • Organizer
      平成22年度日本水産学会春季大会
    • Place of Presentation
      日本大学藤沢キャンパス(神奈川県藤沢市)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 西日本から単離した下痢性貝毒原因渦鞭毛藻 Dinophysis acuminata および D.fortii の毒生産と排出2010

    • Author(s)
      長井敏
    • Organizer
      平成22年度日本水産学会春季大会
    • Place of Presentation
      日本大学藤沢キャンパス(神奈川県藤沢市)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 西日本から単離した下痢性貝毒原因渦鞭毛藻 Dinophysis fortii の毒生産に及ぼす培養温度の影響2010

    • Author(s)
      長井敏
    • Organizer
      平成22年度日本水産学会春季大会
    • Place of Presentation
      日本大学藤沢キャンパス(神奈川県藤沢市)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Predation on the ciliate Myrionecta rubra by the toxic dinoflagellate Dinophysis acuminata/fortii/infundibulus and observation of sequestration of ciliate chloroplasts2009

    • Author(s)
      Nagai, S
    • Organizer
      6th International Workshop on Targeted HAB species in the East Asia Waters
    • Place of Presentation
      東京大学
    • Year and Date
      2009-11-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Predation on the ciliate Myrionecta rubra by the toxic dinoflagellate Dinophysis acuminata/fortii/infundibulus and observation of sequestration of ciliate chloroplasts2009

    • Author(s)
      Nagai, S.
    • Organizer
      6th International Workshop on Targeted HAB species in the East Asia Waters.
    • Place of Presentation
      東京大学
    • Year and Date
      2009-11-21
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Predation on the ciliate Myrionecta rubra by the toxic dinoflagellate Dinophysis acuminata/fortii/infundibulus and observation of sequestration of ciliate chloroplasts2009

    • Author(s)
      長井敏
    • Organizer
      6^<th> International Workshop on targeted HAB species in the East Asia Waters
    • Place of Presentation
      東京大学
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fatty acid esters of diarrhetic shellfish toxin dinophysistoxin-1 in bivalves and toxic dinoflagellates in Japan2009

    • Author(s)
      鈴木敏之
    • Organizer
      44th Toxic Microorganisms Joint Panel
    • Place of Presentation
      国立医薬品食品衛生研究所
    • Year and Date
      2009-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Fatty acid esters of diarrhetic shellfish toxin dinophysistoxin-1 in bivalves and toxic dinoflagellates in Japan2009

    • Author(s)
      鈴木敏之
    • Organizer
      44th Toxic Microorganisms Joint Panel, UJNR Scientific Session
    • Place of Presentation
      国立医薬品食品衛生研究所
    • Year and Date
      2009-11-10
    • Related Report
      2010 Self-evaluation Report 2009 Annual Research Report
  • [Presentation] 有毒渦鞭毛藻 Dinophysis acuminata の増殖に及ぼす培養温度の影響2009

    • Author(s)
      西谷豪
    • Organizer
      2009年度日本プランクトン学会・日本ベントス学会合同大会
    • Place of Presentation
      北海道函館市
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 渦鞭毛藻 Dinophysis mitra 1細胞から検出した葉緑体遺伝子配列の多様性2009

    • Author(s)
      西谷豪
    • Organizer
      平成21年度日本水産学会秋季大会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 夏季石巻湾における下痢性貝毒原因種 Dinophysis 属と繊毛虫類の出現変動の関係2009

    • Author(s)
      神山孝史
    • Organizer
      平成21年度日本水産学会秋季大会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 下痢性貝毒原因渦鞭毛藻Dinophysis属の葉緑体起源に関する分子生態学的研究2009

    • Author(s)
      西谷豪
    • Organizer
      平成21年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2009-03-28
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 西日本から単離した下痢性貝毒原因渦鞭毛藻Dinophysis fortiiの毒生産に及ぼす培養温度の影響2009

    • Author(s)
      長井敏
    • Organizer
      平成22年度日本水産学会春季大会
    • Place of Presentation
      日本大学藤沢キャンパス
    • Year and Date
      2009-03-27
    • Related Report
      2011 Final Research Report 2010 Self-evaluation Report
  • [Presentation] 西日本から単離した下痢性貝毒原因渦鞭毛藻Dinophysis acuminataおよびD. fortiiの毒生産と排出2009

    • Author(s)
      長井敏
    • Place of Presentation
      日本大学藤沢キャンパス
    • Year and Date
      2009-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 西日本から単離した下痢性貝毒原因渦鞭毛藻Dinophysis acuminataおよびD.fortiiの毒生産と排出2009

    • Author(s)
      長井敏
    • Place of Presentation
      日本大学藤沢キャンパス
    • Year and Date
      2009-03-27
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Genetic analyses of the cryptomonad nucleomorph in natural Myrionecta rubra cells reveal a simple lineage of Dinophysis kleptoplastids2008

    • Author(s)
      Nishitani, G., Nagai, S., Nishikawa, T., Miyamura, K., Sakurada, K., Kamiyama, T.
    • Organizer
      The 13th International Conference on Harmful Algae
    • Place of Presentation
      香港
    • Year and Date
      2008-11-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] LC-MS/MS analysis of okadaic acid analogues and lipophilic toxins in several Dinophysis species isolated in Japan2008

    • Author(s)
      Suzuki, T., Miyazono, A., Okumura, Y., Kamiyama, T.
    • Organizer
      122th AOAC annual meeting and exposition
    • Place of Presentation
      アメリカ合衆国テキサス州
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Book] Chapter 10.Shellfish toxin monitoring system in Japan and some Asian countries2011

    • Author(s)
      Suzuki, T. and Watanabe, R.
    • Publisher
      Nova Science Pub
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/cgi-bin/htmlgen/htmllab.cgi?yudoku

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/HABD/TPS/toppage.htm

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/cgi-bin/htmlgen/htmllab.cgi?yudoku

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/HABD/TPS/top-page.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/cgi-bin/htmlgen/htmllab.cgi?yudoku

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/HABD/TPS/top-page.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/cgi-bin/htmlgen/htmllab.cgi?yudoku

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/HABD/TPS/top-page.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/cgi-bin/htmlgen/htmllab.cgi?yudoku

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://feis.fra.affrc.go.jp/HABD/TPS/top-page.htm

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 下痢性貝毒オカダ酸・ジノフィシストキシン群または脂溶性毒ペクテノトキシン群の製造方法2009

    • Inventor(s)
      鈴木敏之・長井敏・神山孝史
    • Industrial Property Rights Holder
      独立行政法人水産総合研究センター種
    • Industrial Property Number
      2009-275063
    • Filing Date
      2009-12-03
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 下痢性貝毒オカダ酸・ジノフィシストキシン群または脂溶性毒ペクテノトキシン群の製造方法2009

    • Inventor(s)
      鈴木敏之・長井敏・神山孝史
    • Industrial Property Rights Holder
      独立行政法人水産総合研究センター
    • Filing Date
      2009-12-03
    • Related Report
      2010 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 下痢性毒オカダ酸・ジノフィシストキシン群または脂溶性毒ペクテノトキシン群の製造方法2009

    • Inventor(s)
      鈴木敏之, 長井敏, 神山孝史
    • Industrial Property Rights Holder
      独立行政法人水産総合研究センター
    • Industrial Property Number
      2009-275063
    • Filing Date
      2009
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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