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Identifying responsible genes involved in stress sensitivity and social affiliation in cattle.

Research Project

Project/Area Number 20380151
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Zootechnical science/Grassland science
Research InstitutionNational Institute of Agrobiological Sciences

Principal Investigator

YAYOU Kenichi  National Institute of Agrobiological Sciences, 脳神経機能研究ユニット, 主任研究員 (40343967)

Co-Investigator(Kenkyū-buntansha) YAYAMOTO Naoyuki  独立行政法人農業・食品産業技術総合研究機構, 近畿中国四国農業研究センター・畜産草地・鳥獣害研究領域, 上席研究員 (20250011)
ITO Shuichi  東海大学, 農学部・応用動物科学科, 准教授 (60425577)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywordsストレス感受性 / 社会的親和性 / 行動遺伝子 / 遺伝子多型解析 / オキシトシン受容体遺伝子 / オキシトシン / CD38遺伝子 / 一塩基多型 / オキシトシン受容体 / 褐毛和種 / 遺伝子多型 / アルギニンバソプレッシン / 副腎皮質刺激ホルモン放出ホルモン
Research Abstract

In cattle oxytocin might be involved in the regulation of behavioral and physiological stress responses in the brain. We showed that neonatal oxytocin could be involved in the behavioral development in calves. Moreover, our data suggested that oxytocin receptor gene promoter region polymorphisms and CD38 single nucleotide polymorphism might be influenced stress sensitivity, social affiliation, and milk production in cattle. These findings help to develop new breeding strategy focused on adaptability to their environment in cattle.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (43 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (21 results) Remarks (11 results)

  • [Journal Article] Effect of intracerebroventricular injections of prolactin-releasing peptide on prolactin release2011

    • Author(s)
      Kitagawa S, Abe N, Sutoh M, Kasuya E, Sugita S, Aoyama M, Yayou K
    • Journal Title

      stress-related responses in steers Animal Science Journal 82(2)

      Pages: 314-319

    • Related Report
      2010 Final Research Report
  • [Journal Article] Relationships of stress responses with plasma oxytocin and prolactin in heifer calves.2010

    • Author(s)
      Yayou K, Ito S, Yamamoto N, Kitagawa S, Okamura H
    • Journal Title

      Physiology & Behavior 99(3)

      Pages: 362-369

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of intracerebroventricular injections of prolactin-releasing peptide on prolactin release and stress-related responses in steers2010

    • Author(s)
      Kitagawa Sayuki
    • Journal Title

      Animal Science Journal

      Volume: 82(2) Pages: 314-319

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A possible role of central serotonin in L-tryptophan-induced GH secretion in cattle.2010

    • Author(s)
      Kasuya Etsuko
    • Journal Title

      Animal Science Journal

      Volume: 81(3) Pages: 345-351

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships of stress responses with plasma oxytocin and prolactin in heifer calves2010

    • Author(s)
      Yayou Ken-ichi
    • Journal Title

      Physiology & Behavior 99

      Pages: 362-369

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of intracerebroventricular administration of neuromedin U or neuromedin S in steers General2009

    • Author(s)
      Yayou K, Kitagawa S, Ito S, Kasuya E, Sutoh M
    • Journal Title

      Comparative Endocrinology 163(3)

      Pages: 324-328

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of AVP V1a and CRH receptor antagonist on psychological stress responses to frustrating condition in sheep2009

    • Author(s)
      Yayou K, Nakamura M, Ito S
    • Journal Title

      Journal of Veterinary Medical Science 71(4)

      Pages: 431-439

    • NAID

      130000134342

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of AVP V1a and CRH receptor antagonist on psychological stress responses to frustrating condition in sheep2009

    • Author(s)
      Yayou Ken-ichi
    • Journal Title

      Journal of Veterinary Medical Science 71

      Pages: 431-439

    • NAID

      130000134342

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of intracerebroventricular administration of neuromedin U or neuromedin S in steers2009

    • Author(s)
      Yayou Ken-ichi
    • Journal Title

      General and Comparative Endocrinology 163

      Pages: 324-328

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracerebroventricularly administered oxytocin attenuated cortisol secretion, but not behavioral responses, during isolation in Holstein steers2008

    • Author(s)
      Yayou K, Ito S, Kasuya E, Sutoh M, Ohkura S, Okamura HH
    • Journal Title

      Journal of Veterinary Medical Science 70(7)

      Pages: 665-671

    • NAID

      110006839586

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intracerebroventricularly administered oxytocin attenuated cortisol secretion, but not behavioral responses, during isolation in Holstein steers2008

    • Author(s)
      Yayou K
    • Journal Title

      J. Vet. Med. Sci. 70(7)

      Pages: 665-67

    • NAID

      110006839586

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mammary energy consumption and its relation to whole bodyenergy metabolism in lactating cows fed high-concentrate diets.2010

    • Author(s)
      Higuchi K (127) : 231-232
    • Organizer
      Energy and protein metabolism and nutrition (3rd International EAAP Symposium on Energy and Protein Metabolism and Nutrition)
    • Place of Presentation
      Parma, Italy(イタリア、パルマ)
    • Year and Date
      2010-09-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of intracerebroventricular administration of oxytocin or prolactin-releasing peptide on feeding behavior in cattle.2010

    • Author(s)
      Yayou K
    • Organizer
      The 44th Congress of the International Society for Applied Ethology
    • Place of Presentation
      Uppsala, Sweden
    • Year and Date
      2010-08-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of intracerebroventricular administration of oxytocin or prolactin-releasing peptide on feeding behavior in cattle.2010

    • Author(s)
      Yayou Ken-ichi
    • Organizer
      The 44th Congress of the International Society for Applied Ethology
    • Place of Presentation
      Uppsala, Sweden(スウェーデン ウプサラ)
    • Year and Date
      2010-08-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Can broiler chickens run fast?2010

    • Author(s)
      Ito S
    • Organizer
      The 44th Congress of the International Society for Applied Ethology
    • Place of Presentation
      Uppsala, Sweden(スウェーデン ウプサラ)
    • Year and Date
      2010-08-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 夏季放牧における褐毛和種と黒毛和種の行動2010

    • Author(s)
      伊藤秀一
    • Organizer
      日本家畜管理学会・応用動物行動学会2010年度春季合同研究発表会
    • Place of Presentation
      明治大学駿河台キャンパス(東京都)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 熊本種における飼料形状の違いが行動と生産性におよぼす影響2010

    • Author(s)
      萩原慎太郎
    • Organizer
      日本家畜管理学会・応用動物行動学会2010年度春季合同研究発表会
    • Place of Presentation
      明治大学駿河台キャンパス(東京都)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウシにおける中枢性ドーパミンによるプロラクチン分泌調節2010

    • Author(s)
      須藤まどか
    • Organizer
      日本畜産学会第112回大会
    • Place of Presentation
      明治大学駿河台キャンパス(東京都)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウシ消化管におけるlingual antimicrobial peptide(LAP)の免疫組織化学的局在2010

    • Author(s)
      磁部直樹
    • Organizer
      日本畜産学会第112回大会
    • Place of Presentation
      明治大学駿河台キャンパス(東京都)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] カリウムと窒素の同時制御による泌乳牛の尿量低減化2010

    • Author(s)
      大谷文博
    • Organizer
      日本畜産学会第112回大会
    • Place of Presentation
      明治大学駿河台キャンパス(東京都)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウシの採食行動へのオキシトシンおよびプロラクチン放出ペプチド脳室内投与の効果2010

    • Author(s)
      矢用健一
    • Organizer
      日本畜産学会第112回大会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ウシの採食行動へのオキシトシンおよびプロラクチン放出ペプチド脳室内投与の効果2010

    • Author(s)
      矢用健一
    • Organizer
      日本畜産学会第112回大会
    • Place of Presentation
      明治大学駿河台キャンパス(東京都)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 夏季放牧における褐毛和種と黒毛和種の行動2010

    • Author(s)
      伊藤秀一
    • Organizer
      日本家畜管理学会・応用動物行動学会2010年度春期研究発表会
    • Place of Presentation
      東京都千代田区
    • Related Report
      2010 Final Research Report
  • [Presentation] ウシ第3脳室へのニューロメジンUおよびS注入の効果2009

    • Author(s)
      矢用健一
    • Organizer
      日本畜産学会第111回大会
    • Place of Presentation
      沖縄県中頭郡西原町
    • Year and Date
      2009-09-29
    • Related Report
      2010 Final Research Report
  • [Presentation] ウシ第3脳室へのニューロメジンUおよびS注入の効果2009

    • Author(s)
      矢用健一
    • Organizer
      日本畜産学会第111回大会
    • Place of Presentation
      琉球大学千原キャンパス(沖縄県)
    • Year and Date
      2009-09-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 飼料粒度がブロイラーの行動と生産性におよぼす影響2009

    • Author(s)
      萩原慎太郎
    • Organizer
      日本畜産学会第111回大会
    • Place of Presentation
      琉球大学千原キャンパス(沖縄県)
    • Year and Date
      2009-09-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Relationships of acute stress responses with plasma oxytocin in heifer calves2009

    • Author(s)
      Yayou Ken-ichi
    • Organizer
      43rd Congress of the International Society for Applied Ethology
    • Place of Presentation
      Cairns Convention Centre(ケアンズ,オーストラリア)
    • Year and Date
      2009-07-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウシにおける急性ストレス反応と末梢血中オキシトシン濃度との関係2009

    • Author(s)
      矢用健一
    • Organizer
      日本畜産学会第110回大会
    • Place of Presentation
      神奈川県藤沢市
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] ウシにおける急性ストレス反応と末梢血中オキシトシン濃度との関係2009

    • Author(s)
      矢用健一
    • Organizer
      日本畜産学会第110回大会
    • Place of Presentation
      日本大学生物資源科学部
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Relationships of acute stress responses with plasma oxytocin in heifer calves.2009

    • Author(s)
      矢用健一
    • Organizer
      The 43rd Congress of the International Society for Applied Ethology
    • Place of Presentation
      Cairns, Austlaria
    • Related Report
      2010 Final Research Report
  • [Presentation] The relationship between prolactin and reactivity to acute stressor in heifer calves.2008

    • Author(s)
      矢用健一
    • Organizer
      The 42nd International Congress of the International Society for Applied Ethology
    • Place of Presentation
      Dublin, Ireland
    • Related Report
      2010 Final Research Report
  • [Presentation] The relationship between prolactin and reactivity to acute stressor in heifer calves2008

    • Author(s)
      Yayou K
    • Organizer
      The 42nd International Congress of the International Society for Applied Ethology
    • Place of Presentation
      University College, Dublin, Ireland
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] DDBJ/EMBL/GenBank登録(2011年3月31日までデータ非公開)

    • Related Report
      2009 Annual Research Report
  • [Remarks] 1. Accession number AB481089 Bos taurus oxytocin gene, 5' non coding region and exon 1. (Japanese Black) N Yamamoto, K Yayou, S Ito, T Kojima, K Oshima

    • Related Report
      2009 Annual Research Report
  • [Remarks] 2. Accession number AB481090 Bos taurus oxytocin gene, exon 2 and exon 3. (Japanese Black) N Yamamoto, K Yayou, S Ito, T Kojima, K Oshima

    • Related Report
      2009 Annual Research Report
  • [Remarks] 3. Accession number AB481091 Bos taurus oxytocin gene, 5' non coding region 1. (Japanese Brown) N Yamamoto, K Yayou, S Ito, T Kojima, K Oshima

    • Related Report
      2009 Annual Research Report
  • [Remarks] 4. Accession number AB481092 Bos taurus oxytocin gene, 5' non coding region 2. (Japanese Brown) N Yamamoto, K Yayou, S Ito, T Kojima, K Oshima

    • Related Report
      2009 Annual Research Report
  • [Remarks] 5. Accession number AB481093 Bos taurus oxytocin gene, 5' non coding region 3. (Japanese Brown) N Yamamoto, K Yayou, S Ito, T Kojima, K Oshima

    • Related Report
      2009 Annual Research Report
  • [Remarks] 6. Accession number AB481094 Bos taurus oxytocin gene, 5' non coding region 4 and exon 1. (Japanese Brown) N Yamamoto, K Yayou, S Ito, T Kojima, K Oshima

    • Related Report
      2009 Annual Research Report
  • [Remarks] 7. Accession number AB481095 Bos taurus oxytocin gene, exon 2 and exon 3. (Japanese Brown) N Yamamoto, K Yayou, S Ito, T Kojima, K Oshima

    • Related Report
      2009 Annual Research Report
  • [Remarks] 8. Accession number AB481096 Bos taurus oxytocin gene, 5' non coding region and exon 1. (Holstein Friesian) N Yamamoto, K Yayou, S Ito, T Kojima, K Oshima

    • Related Report
      2009 Annual Research Report
  • [Remarks] 9. Accession number AB481097 Bos taurus oxytocin gene, exon 2 and exon 3. (Holstein Friesian) N Yamamoto, K Yayou, S Ito, T Kojima, K Oshima

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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