| Project/Area Number |
20380162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KISO Yasuo Yamaguchi University, 農学部, 教授 (10142374)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Hiroyuki 山口大学, 農学部, 教授 (40193750)
KATO Hirotomo 山口大学, 農学部, 准教授 (00346579)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 胎盤 / 子宮NK細胞 / アレルギー / IgE / 血管内皮成長因子 / 胎盤成長因子 / 胎盤迷路部 / 間膜腺 / 糖尿病 / 栄養膜細胞層 / ラセン動脈 |
|---|
| Research Abstract |
Under the condition of diabetes or allergy, differentiation of uterine natural killer (uNK) cells was delayed, their apoptosis was inhibited, and placental growth factor (PlGF) was decreased in production. However, the number of mature uNK cells was significantly increased, suggesting that deficiency of PlGF was compensated with PlGF secreted by uNK cells. Under such conditions, expression of vascular endothelial growth factor had no changes, but decidualization was promoted, suggesting that differentiation of uNK cells was induced by insulin-like growth factor and interleukin-15 derived from decidual cells.
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