Postnatal carcinogenic risks of fetal stage exposure to environmental pollutants and its epigenetic molecular mechanism
| Project/Area Number |
20380168
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHSAKO Seiichiroh The University of Tokyo, 大学院・医学系研究科, 准教授 (00274837)
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| Co-Investigator(Kenkyū-buntansha) |
MIYABARA Yuichi 信州大学, 山岳科学総合研究所, 准教授 (80311330)
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| Research Collaborator |
TAKEDA Makio 残留農薬研究所, 毒性部, 室長
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 有害化学物質 / ゲノム / 発生・分化 / 環境 / 薬剤反応性 / エピジェネティクス |
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| Research Abstract |
Recently much attention is focused to the hypothesis that the fetal stage environments can influence health and disease after birth. Laboratory animals exposed to dioxin in the fetal stage are prone to cancer when they are administered carcinogens such as benzo[a]pyrene in adulthood. In the present study using mice, we demonstrated that the epigenetic memory including DNA methylation of the gene for CYP1A1 enzyme responsible for metabolic activation of carcinogens was altered by perinatal exposure to dioxin and revealed a part of molecular mechanism causing this alteration.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] When does the sex ratio of offspring of the paternal 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decrease : In the spermatozoa stage or at fertilization?2010
Author(s)
Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, Tanida T, Mitsuhashi T, Nanmori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N.
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Journal Title
Reprod Toxicol 29
Pages: 68-73
Related Report
Peer Reviewed
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[Journal Article] When does the sex ratio of offspring of the paternal 2,3,7,8-tetrachlorodibenzo p-dioxin (TCDD) exposure decrease : In the spermatozoa stage or at fertilization?2010
Author(s)
Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, Tanida T, Mitsuhashi T, Namnori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N.
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Journal Title
Reproductive Toxicology
Volume: 29
Pages: 68-73
Related Report
Peer Reviewed
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[Journal Article] Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.2010
Author(s)
Ohsako S., Fukuzawa N., Ishimura R., Kawakami T., Wu Q., Nagano R., Zaha H., Sone H., Yonemoto J., Tohyama C.
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Journal Title
Biol Reprod (in press)(印刷中, 掲載確定)
Related Report
Peer Reviewed
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[Journal Article] When does the sex ratio of offspring of the paternal 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD)exposure decrease : In the spermatozoa stage or at fertilization?2010
Author(s)
Ishihara K, Ohsako S, Tasaka K, Harayama H, Miyake M, Warita K, Tanida T, Mitsuhashi T, Nanmori T, Tabuchi Y, Yokoyama T, Kitagawa H, Hoshi N.
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Journal Title
Reprod Toxicol 29
Pages: 68-73
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
大迫誠一郎
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Journal Title
科学「プログラムされる"病"の新たな仮説-環境化学物質による代謝系遺伝子の次世代エピゲノム変化」(岩波書店)
Pages: 984-988
Related Report
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