| Project/Area Number |
20380170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SASAKI NOBUO The University of Tokyo, 大学院・農学生命科学研究科, 教授 (60107414)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMOTO Hajime 東京大学, 大学院・農学生命科学研究科, 教授 (60163804)
NISHIMURA Ryohei 東京大学, 大学院・農学生命科学研究科, 教授 (80172708)
MOCHIZUKI Manabu 東京大学, 大学院・農学生命科学研究科, 准教授 (90261958)
NAKAGAWA Takayuki 東京大学, 大学院・農学生命科学研究科, 助教 (40447363)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Hiroyuki 東京大学, 大学院・農学生命科学研究科, 教授 (40155891)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2008: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Keywords | 犬骨肉腫 / 犬乳癌 / 細胞株 / ヌードマウス / 移植部位 / 増殖 / 肺転移 / 転移経路 / ヌードマウスモデル / NF-kB / VEGF / NF-κB / クローン細胞株 / ezrin / 低酸素因子 |
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| Research Abstract |
Difference in growth and metastasis was investigated using tumor a cell linetransplanted nude mice model receiving orthotopic and ectopic xenograft. In a canine osteosarcoma cell-xenografted model, growth and metastasis were significantly different depending on the xenografted site and ezrin expression was strongly related to metastasis in this mice model. In a canine mammary cancer model, there was no significant difference in the growth and metastasis depending on the xenografted sites, however VEGF (vascular endothelial growth factor) and NF-κB (nuclear factor κB) expressions were related to growth and metastasis in this mice model.
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