Identification of canine hair follicle stem cells, reconstruction Of hair follicle and its application to wound healing
| Project/Area Number |
20380171
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
IWASAKI Toshiroh Tokyo University of Agriculture and Technology, 大学院・農学研究院, 教授 (50262754)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIFUJI Koji 東京農工大学, 大学院・農学研究院, 准教授 (20365422)
OHYAMA Manabu 慶応義塾大学, 医学研究科, 講師 (10255424)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 犬 / 幹細胞 / 皮膚 / 毛包 / 創傷治癒 |
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| Research Abstract |
This research project demonstrated that canine hair follicle stem cells are located in a bulge area of hair follicles and high proliferation potency in the hair follicle stem cells. Stem cell marker proteins, K15, follistatin were stained intensely in the bulge area and related genes such as SOX9, LHX2, TCF4 and NFATC1 were expressed in hair follicle cells of bulge area. In vivo transplant of canine hair follicle stem cells with dermal papilla cells to nude mice successfully reconstituted the hair follicle and its adnexa in nude mouse skin. These results may give a new insight not only to canine hair follicle biology but also to human medicine.
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Report
(4 results)
Research Products
(21 results)
