|Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
We have shown that vinexin, a focal adhesion protein, inhibits tumor cell migration but promotes cutaneous wound healing by controlling the localization of growth factor receptors. We have also shown that WAVE2, an actin-nucleating factor that binds to vinexin, recruits cAMP-dependent kinase to the membrane protrusion and promotes the protrusion. Furthermore, another vinexin-binding protein Dlg5 can regulate the secretion of fibronectin, a extracellular matrix. Together, these results indicate the function of focal adhesion proteins as sensors and regulators for cellular microenvironment.