Study of molecular mechanism of the ER quality control in plants
| Project/Area Number |
20380188
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KOIZUMI Nozomu Osaka Prefecture University, 生命環境科学研究科, 教授 (20252835)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 小胞体ストレス / シロイヌナズナ / 転写因子 / スプライシング / シャペロン / 小胞体 / タンパク質の品質管理 |
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| Research Abstract |
If proteins with abnormal structures accumulate in the intracellular compartment called the endoplasmic reticulum (ER), such condition is transmitted to the nucleus causing activation of genes for chaperones that assist the correct folding of proteins. We found that a sensor protein IRE1 localizing on the ER membrane is involved in cytoplasmic splicing as the first report of cytoplasmic splicing in plants. It was considered that a membrane bound transcription factor bZIP60 was converted to active form losing its transmembrane domain by the splicing and translocated to the nucleus activating target genes.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] NtbZIP60, an endoplasmic reticulum-localized transcription factor, plays a role in the defense response against bacterial pathogens in tobacco.2008
Author(s)
Tateda, C., Ozaki, R., Onodera, Y., Takahashi, Y., Yamaguchi, K., Berberich, T., Koizumi N., Kusano T.
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Journal Title
Journal of Plant Research 121
Pages: 603-611
Related Report
Peer Reviewed
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