Organic synthesis using cationic species under non-acidic conditions
Project/Area Number |
20390004
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Osaka University |
Principal Investigator |
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
Keywords | 合成化学 / アセタール / カチオン性塩 / エーテル化合物 / TMSOTf / 2-halo-pyridine / 求核置換反応 / 混合アセタール / 選択的還元反応 / カチオン性の塩 / MEM-エーテル / 脱保護 / アセトナイド / シクロアルケン混合アセタール / 2,5-ジ置換テトラヒドラフラン / 有機亜鉛試薬 / MOM-エーテル / メチレンジオキシ / 2-デオキシ糖 / ジサッカライド |
Research Abstract |
Efficient deprotection of acetal-type protective groups(MOM-, MEM-, SEM-, and BOM-ether) of hydroxyl function and one-pot transformation of MOM-ethers to other acetal-type protective groups have been developed. Introduction of some nucleophiles to the anomeric position of 2-deoxysugars via cationic salt intermediates has been succeeded. Nucleophilic substitution of carbon nucleopohiles to cationic salt intermediate has been developed by studying the kind of pyridine-type base for forming salt. Efficient preparation method of crowded ethers, which are hard to be synthesized by previous methods, has been developed by the reaction of the salts, from MOM-ethers, and organocuprate reagents.
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Report
(4 results)
Research Products
(130 results)