| Project/Area Number |
20390007
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
KUNISHIMA Munetaka Kanazawa University, 薬学系, 教授 (10214975)
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| Co-Investigator(Kenkyū-buntansha) |
HIOKI Kazuhito 神戸学院大学, 薬学部, 助教 (70268522)
HOJO Keiko 神戸学院大学, 薬学部, 助教 (20289028)
TANAKA Hiroyuki 金沢大学, 薬学系, 助教 (40378873)
MORISAKI Daiki 金沢大学, 薬学系, 助教 (30462740)
YAMADA Kohei 金沢大学, 薬学系, 助教 (40583232)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | トリアジン / アミド / 脱水縮合 / 標識化 / ホスト化合物 / タンパク質 / 脂質 / オキサゾリン / トリアジノン / カルボン酸 / カリクサジン |
|---|
| Research Abstract |
Dehydrocondensing reagents composed of 1,3,5-triazine are superior to other related reagents because they allow synthesizing amides in aqueous solvents or in alcohols, in addition, a diversity of functional groups can be readily introduced into the chlorotriazine ring. In this research project, we examined reactions using such useful triazine reagents in various reaction fields including aqueous or non-aqueous homogeneous solvents, polymers, interfaces, and proteins. As a result, we succeeded in developing several new chemical transformation methods, and new technologies available for functional analysis of biomolecules such as membranes or proteins.
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