| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
In this project, we found that LOX-1 clustering is essential to exert its specific binding to oxidized LDL (OxLDL). We also revealed that each LOX-1 molecule in the cluster is required to maintain the proper homo-dimeric form, otherwise the clustered LOX-1 do not bind to OxLDL. On the cell surface, LOX-1 clustering was found to be mediated by its preferential localization on the lipid-raft, which localization is regulated by the palmitoylation to two cystein residues in the trans-membrane region. We also devised non-toxic MRI imaging reagent which will be applied to see the location of LOX-1 in vein, which should be the marker for the early-stage atherosclerosis.
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