A novel targeting DDS for the treatment of autoimmune diseases and allergy

• Project/Area Number: 20390014
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: OKU Naoto University of Shizuoka, 薬学部, 教授 (10167322)
• Co-Investigator(Kenkyū-buntansha): ASAI Tomohiro 静岡県立大学, 薬学部, 講師 (00381731) ; SHIMIZU Kosuke 静岡県立大学, 薬学部, 助教 (30423841)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: ドラッグデリバリー / DDS / 逆標的化 / リポソーム / アレルギー / 花粉症 / 免疫疾患 / ABC現象 / Cryj1 / Cryj 1 / Cryjl

Research Abstract

Specific antigen-sensitized body has the antigen-specific immune cells, which recognize the antigen. The antigen-coupled carrier is recognized by the immune cells. When the carrier encapsulate certain drugs, these drugs are specifically delivered to the immune cells. This strategy would be useful for suppressing the activity of specific immune cells related allergy and other immune diseases.

Research Products

• [Journal Article] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes. (2010)
  • Author(s): Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Shuji Akai, Takayuki Ishii, Eriya Kenjo, Tatsuhiro Ishida, Hiroshi Kiwada, Hideo Tsukada, Naoto Oku
  • Journal Title: Int.J. of Pharmaceutics 392 Pages: 218-223
  • Peer Reviewed
• [Journal Article] A novel DDS strategy, "dual-targeting", and it's application for antineovscular therapy (2010)
  • Author(s): Yuki Murase
  • Journal Title: Cancer Lett. Volume: 287 Pages: 165-171
  • Peer Reviewed
• [Journal Article] Cancer antineovascular therapy with liposome drug delivery systems targeted to Bip/GRP78 (2010)
  • Author(s): Yasufumi Katanasaka
  • Journal Title: Int.J Cancer Volume: 127 Pages: 2685-2698
  • Peer Reviewed
• [Journal Article] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes (2010)
  • Author(s): Hiroyuki Koide
  • Journal Title: Int.J.Pharm. Volume: 392 Pages: 218-223
  • Peer Reviewed
• [Journal Article] PEG化ナノキャリア頻回投与によるaccelerated blood clearance現象の機構解明 (2009)
  • Author(s): 小出裕之、浅井知浩、畑中剣太朗、清水広介、横山昌幸、石田竜弘、際田弘志、奥直人
  • Journal Title: YAKUGAKU ZASSHI 129 Pages: 1445-1451
  • NAID: 130000136135
  • Peer Reviewed
• [Journal Article] In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography (2009)
  • Author(s): Takeo Urakami
  • Journal Title: Artif.Organs 33 Pages: 164-168
  • Peer Reviewed
• [Journal Article] Induction of Apoptosis by Rhinacanthone Isolated from Rhinacanthus Nasutus Roots in Human Cervical Carcinoma Cells (2009)
  • Author(s): Pongpun Siripong
  • Journal Title: Biol.Pharm.Bull 32 Pages: 1251-1260
  • Peer Reviewed
• [Journal Article] Design of Synthetic Polymer Nanoparticles that Capture and Neutralize a Toxic Peptide (2009)
  • Author(s): Yu Hoshino
  • Journal Title: Small 5 Pages: 1562-1568
  • Peer Reviewed
• [Journal Article] Particle size-dependent triggering of accelerated blood clearance phenomenon. (2008)
  • Author(s): Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Takeo Urakami, Takayuki Ishii, Eriya Kenjo, Masamichi Nishihara, Masayuki Yokoyama, Tatsuhiro Ishida, Hiroshi Kiwada, Naoto Oku
  • Journal Title: Int.J.Pharm 362 Pages: 197-200
  • Peer Reviewed
• [Journal Article] Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes. (2008)
  • Author(s): Katanasaka, Y.
  • Journal Title: Int. J. Pharm. 360 Pages: 219-224
  • Peer Reviewed
• [Journal Article] Particle size-dependent triggering of accelerated blood clearancephenomenon. (2008)
  • Author(s): Koide H.
  • Journal Title: Int. J. Pharm. 362 Pages: 197-200
  • Peer Reviewed
• [Journal Article] Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown. (2008)
  • Author(s): Asai, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 368 Pages: 243-248
  • Peer Reviewed
• [Presentation] RT-DDSを応用した新規スギ花粉治療法の開発 (2010)
  • Author(s): 横山智紀
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2010-11-29
• [Presentation] Elucidation of ABC phenomenon caused by repeat injection of PEGylated nanocarrier. (2009)
  • Author(s): 小出裕之
  • Organizer: 4th International Liposome Society Conference
  • Place of Presentation: London, UK.
  • Year and Date: 2009-12-14
• [Presentation] PEG修飾ナノキャリアー頻回投与によるABC現象の機構解明 (2009)
  • Author(s): 小出裕之
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] Efficient cancer therapy by use of neo vascular-targeted liposomes (2008)
  • Author(s): Oku, N.
  • Organizer: EHRLICH-2^<nd> World Conference on Magic Bullets
  • Place of Presentation: Numbers, Germany
  • Year and Date: 2008-10-05
• [Presentation] ナノキャリア頻回投与時におけるABC現象の機構解明 (2008)
  • Author(s): 小出裕之
  • Organizer: 第24回日本DDS学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-30
• [Book] 機能性DDSキャリアの製剤設計(岡田弘晃監修) (2008)
  • Author(s): 清水広介
  • Publisher: シーェムシー出版
• [Remarks] ホームページ等
  • URL: http://w3pharm.u-shizuoka-ken.ac.jp/~radiobio/gyouseki_MBC.html
• [Remarks]
  • URL: http://w3pharm.u-shizuoka-ken.ac.jp/-radiobio/gyouseki_MBC.html
• [Patent(Industrial Property Rights)] Reverse Targeting Lipid Vesicles (2009)
  • Inventor(s): Oku. N, etal.
  • Industrial Property Rights Holder: Oku. N, etal.
  • Filing Date: 2009-02-18
  • Overseas