Activation and regulation of the disease-related IL-6/STAT3 signaling
| Project/Area Number |
20390017
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
MATSUDA Tadashi Hokkaido University, 大学院・薬学研究院, 教授 (20212219)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MUROMOTO Ryuta 北海道大学, 大学院・薬学研究院, 助教 (30455597)
SEKINE Yuichi 北海道大学, 大学院・薬学研究院, 助教 (20396295)
OHBAYASHI Norihiko 北海道大学, 大学院・薬学研究院, 助教 (40421979)
NANBO Asuka 北海道大学, 大学院・薬学研究院, 講師 (60359487)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
|---|
| Keywords | 免疫 / がん / シグナル伝達 / サイトカイン / IL-6 / STAT3 / 自己免疫疾患 / 癌 / 炎症 |
|---|
| Research Abstract |
Since we cloned interleukin-6 (IL-6) as B cell stimulatory factor 2 in 1986, IL-6 has been reported to influence cell proliferation, differentiation, and survival as well as mature cell functions. Signal transducer and activator of transcription 3 (STAT3) is a key molecule to mediate IL-6-induced cellular events. Indeed, STAT3 is activated in many tumor tissues, and the dimmer of STAT3 promotes cellular transformation, indicating that STAT3 itself can act as a proto-oncogene. In addition to oncogenesis, IL-6/STAT3 axis influences host immune systems. For example, IL-6/STAT3 axis is involved in the Toll-like receptor signaling pathways, the development and maturation of dendritic cells, and the differentiation of Th17 T-cell subset. These facts are likely to suggest that manipulation of IL-6/STAT3 signals could be suitable target for a variety of disease such as cancer and autoimmune diseases. We have energetically examined regulatory mechanisms of IL-6/STAT3-mediated signal transduction for the development of novel therapeutic strategies.
|
Report
(4 results)
Research Products
(74 results)
-
-
[Journal Article] Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.2010
Author(s)
Ikeda O., Y. Sekine, A. Mizushima, M. Nakasuji, Y. Miyasaka, C. Yamamoto, R. Muromoto, A. Nanbo, K. Oritani, A. Yoshimura, T. Matsuda
-
Journal Title
J. Biol. Chem. 285
Pages: 38093-38103
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.2009
Author(s)
Muromoto R., N. Taira, O. Ikeda, K. Shiga, S. Kamitani, S. Togi, S. Kawakami, Y. Sekine, A. Nanbo, K. Oritani, T. Matsuda
-
Journal Title
Biochem. Biophys. Res. Commun. 382
Pages: 63-68
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Development of Et, primary myelofibrosis and PV in mice expressing JAK2 V617F2008
Author(s)
Shide K., Shimoda K. S., Kumano T., Karube K., Kameda T., Takenaka K., Oku S., Abe H., Katayose K. S., Kubiki Y., Kusumo K., Hasuike S., Tahara Y., Nagata K., Matsuda T., Ohshima K., Harada M., Shimoda K.
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Physical and functional interactions between ZIP kinase and UbcH52008
Author(s)
Ohbayashi N., K. Okada, S. Kawakami, S. Togi, N. Sato, O. Ikeda, S. Kamitani, R. Muromoto, Y. Sekine, T. Kawai, S. Akira, T. Matsuda
-
Journal Title
Biochem. Biophys. Res. Commun. 372
Pages: 708-712
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
