| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Research Abstract |
The difference in the functions and regulatory mechanisms of heparan sulfate (HS) and chondroitin sulfate/dermatan sulfate (CS/DS) is still obscure. In the present study we analyzed molecular interactions between signaling molecules and the glycosaminoglycan (GAG) chains, especially CS/DS chains, to investigate the differences in the roles of HS and CS/DS in the signaling processes. Our results revealed that not only the sequences of disaccharide units but also the conformation of oligosaccharide domains and electrostatic distribution along the chains are important.
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