| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Research Abstract |
In this project, we tried to identify the DNA damage avoidance pathway in which WRNIP1 is involved and to clarify how to affect RAD18 and WRN this pathway, and obtained the following results.
(1) WRNIP1 localized to the region containing DNA single-strand breaks via its N-terminal UBZ domain.
(2) RAD18-RAD6 complex bound to replication fork like DNA recruited WRNIP1 to the DNA, and recruited WRNIP1 replaced RAD18-RAD6 complex.
(3) WRNIP1 bound to template-primer DNA recruited WRN to the DNA, and recruited WRN replaced WRNIP1.
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