Elucidation of bacterial pathogenesis system based on a silkworm infection model

• Project/Area Number: 20390021
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: SEKIMIZU Kazuhisa The University of Tokyo, 大学院・薬学系研究科, 教授 (90126095)
• Co-Investigator(Kenkyū-buntansha): KAITO Chikara 東京大学, 大学院・薬学系研究科, 准教授 (60420238)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: カイコ / 病原性 / 病原性因子 / コロニースプレッデング / 病院分離型MRSA / 市中感染型MRSA / psm-mec遺伝子 / 可動遺伝要素 / SCCmec / バイオフィルム / 黄色ブドウ球菌 / 自然免疫 / 脂質輸送

Research Abstract

In this study, we performed to solve molecular function of CvfB (conserved virulence factor B), which was identified as a virulence regulatory factor using silkworm infection model. CvfB has three S1 RNA binding domain and a Winged-Helix domain revealed by crystal structure at 1.4Å resolution. Moreover, we uncovered the RNA binding activity of CvfB is required for hemolysin production in Staphylococcus aureus.

Research Products

• [Journal Article] Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence. (2011)
  • Author(s): Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, Sekimizu K.
  • Journal Title: PLoS Pathog. 7(2)
  • Peer Reviewed
• [Journal Article] Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay. (2011)
  • Author(s): Dhital S, Hamamoto H, Urai M, Ishii K, Sekimizu K
  • Journal Title: Drug Discoveries & Therapeutics. Volume: 5 Pages: 18-25
  • NAID: 130005054690
  • Peer Reviewed
• [Journal Article] Transcription and Translation Products of the Cytolysin Gene psm-mec on the Mobile Genetic Element SCCmec Regulate Staphylococcus a ureus Virulence. (2011)
  • Author(s): Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiram atsu K, Sekimizu K.
  • Journal Title: PLoS Pathog. Volume: 3;7(2)
  • Peer Reviewed
• [Journal Article] Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae. (2010)
  • Author(s): Ishii K, Hamamoto H, Imamura K, Adachi T, Shoji M, Nakayama K, Sekimizu K.
  • Journal Title: J Biol Chem. 285(43) Pages: 33338-33347
  • Peer Reviewed
• [Journal Article] Insect cytokine paralytic peptide (PP) induces cellular and humoral immune responses in the silkworm Bombyx mori. (2010)
  • Author(s): Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K.
  • Journal Title: J Biol Chem. 285(37) Pages: 28635-28642
  • Peer Reviewed
• [Journal Article] Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module. (2010)
  • Author(s): Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, Wilson IA.
  • Journal Title: Structure. 18(4) Pages: 537-547
  • Peer Reviewed
• [Journal Article] The cvfC operon of Staphylococcus aureus contributes to virulence via expression of the thyA gene. (2010)
  • Author(s): Ikuo M, Kaito C, Sekimizu K.
  • Journal Title: Microb Pathog. 49(1-2)(Epub 2010 Mar 27) Pages: 1-7
  • Peer Reviewed
• [Journal Article] An Invertebrate Hyperglycemic Model for the Identification of Anti-D iabetic Drugs. (2010)
  • Author(s): Matsumoto Y, Sumiya E, Sugita T, Sekimizu K.
  • Journal Title: PLoS one Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae. (2010)
  • Author(s): Ishii K, Hamamoto H, Imamura K,Adachi T, Shoji M, Nakayama K, Sekimizu K.
  • Journal Title: J Biol Chem. Volume: 285(43) Pages: 33338-33347
  • Peer Reviewed
• [Journal Article] Cell-permeable carboxy-terminal p27Kipl peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase (2010)
  • Author(s): Morishita D, Takami M, Yoshikawa S, Katayama Ryohei, Sato S, Kukimoto-Niino M, Umeh ara T, Shirouzu M, Sekimizu K, Yokoyama S, Fujita N
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 2681-2688
  • Peer Reviewed
• [Journal Article] Evaluation of therapeutic effects and pharmacokinetics of antibacterial chromogenic agents in silkworm model of Staphylococcus aureus infection (2010)
  • Author(s): Fujiyuki T, Imamura K, Harnamoto H, Sekimizu K.
  • Journal Title: Drug Dicoveries and Therapeutics Volume: 14(5) Pages: 349-354
  • Peer Reviewed
• [Journal Article] The insect cytokine, paralytic peptide(PP) induces cellular and humora 1 immune responses in the silkworm Bombyx mori. (2010)
  • Author(s): Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K.
  • Journal Title: J Biol Chem. Volume: 285(37) Pages: 28635-28642
  • Peer Reviewed
• [Journal Article] Use of silkworms for identification of drug candidates having appropriate Pharmacokinetics from plant sources (2010)
  • Author(s): Asami Y, Horie R, Hamamoto H, Sekimizu K
  • Journal Title: BMC Pharmacology Volume: 10 Pages: 7-7
  • Peer Reviewed
• [Journal Article] The cvfC operon of Staphylococcus aureus contributes to virulence via the expression of the thvA gene (2010)
  • Author(s): Ikuo M, Kaito C, Sekimizu K
  • Journal Title: Microbial Pathogenesis Volume: 49(1-2) Pages: 1-7
  • Peer Reviewed
• [Journal Article] Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus. (2010)
  • Author(s): Tabuchi Y, Shiratsuchi A, Kurokawa K, Gong JH, Sekimizu K, Lee BL, Nakanishi Y.
  • Journal Title: J Immunol. Volume: 15;185(4) Pages: 2424-2431
  • Peer Reviewed
• [Journal Article] Structure of a virulence regulatory factor CvfB reveals a novel winge d-helix RNA binding module (2010)
  • Author(s): Matsumoto Y, Xu Q, Kaito C, Fan C L, Axelrod H L, Chiu H-J, Klock H E, Knuth M W, Miller M D, Elsliger M-A, Deacon A M, Godzik A, Lesley S A, Sekimizu K, Wilson I A
  • Journal Title: Structure Volume: 18(4) Pages: 537-547
  • Peer Reviewed
• [Journal Article] Shuttle vectors derived from pN315 for study of essential genes in Staphylococcus aureus (2010)
  • Author(s): Matsuo M, Kurokawa K, Lee BL, Sekimizu K.
  • Journal Title: Biol.Pharm. Bull. Volume: 33(2) Pages: 198-203
  • NAID: 130000156624
  • Peer Reviewed
• [Journal Article] The cvfC operon of Staphylococcus aureus contributes to virulence via expression of the thyA gene (2010)
  • Author(s): Ikuo M, Kaito C, Sekimizu K
  • Journal Title: Microb Pathog (in press)
  • Peer Reviewed
• [Journal Article] Structure of a virulence regulatory factor CvfB reveals a novel winged-helix RNA binding module (2010)
  • Author(s): Matsumoto Y, Xu Q, Kaito C, Farr C L, Axelrod H L, Chiu H-J, Klock H E, Knuth M W, Miller M D, Elsliger M-A, Deacon A M, Godzik A, Lesly S A, Sekimizu K, Wilsom I A
  • Journal Title: Structur (in press)
  • Peer Reviewed
• [Journal Article] Shuttle vectors derived from pN315 for study of essential genes in Staphylococcus aureus (2010)
  • Author(s): Matsuo M, Kurokawa K, Lee B L, Sekimizu K
  • Journal Title: Biol Pharm Bull 33 Pages: 198-203
  • NAID: 130000156624
  • Peer Reviewed
• [Journal Article] Novel RNA polymerase II mutation suppresses transcriptional fidelity and oxidative stress sensitivity in rpb9Delta yeast (2010)
  • Author(s): Koyama H, Ueda T, Ito T, Sekimizu K
  • Journal Title: Genes Cells 15 Pages: 151-159
  • Peer Reviewed
• [Journal Article] Rapid exchange of bound ADP on the Staphylococcus aureus replication initiation protein DnaA. (2009)
  • Author(s): Kurokawa K, Mizumura H, Takaki T, Ishii Y, Ichihashi N, Lee BL, Sekimizu K.
  • Journal Title: J Biol Chem. 284(49) Pages: 34201-34210
  • Peer Reviewed
• [Journal Article] Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model. (2009)
  • Author(s): Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee BL, Murakami K, Maki H, Sekimizu K.
  • Journal Title: Antimicrob Agents Chemother. 53(9) Pages: 4025-4027
  • Peer Reviewed
• [Journal Article] Purification of a soil bacteria exotoxin using silkworm toxicity to measure specific activity. (2009)
  • Author(s): Usui K, Miyazaki S, Kaito C, Sekimizu K.
  • Journal Title: Microb Pathog. 46(2) Pages: 59-62
  • Peer Reviewed
• [Journal Article] Pleiotropic roles of polyglycerolphosphate synthase of lipoteichoic acid in growth of Staphylococcus aureus cells. (2009)
  • Author(s): Oku Y, Kurokawa K, Matsuo M, Yamada S, Lee BL, Sekimizu K.
  • Journal Title: J Bacteriol. 191(1) Pages: 141-151
  • Peer Reviewed
• [Journal Article] Distribution of Kakugo virus and its effects on the gene expression profile in the brain of the worker honeybee Apis mellifera L (2009)
  • Author(s): Fujiyuki T, Matsuzaka E, Nakaoka T, Takeuchi H, Wakamo to A, Ohka S, Sekimizu K, Nomoto A, Kubo T
  • Journal Title: J Virol 83 Pages: 11560-11568
  • Peer Reviewed
• [Journal Article] Identification of lipoteichoic acid as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes (2009)
  • Author(s): Hashimoto Y, Tabuchi Y, Sakurai K, Kutsuna M, Kurokawa K, Awasaki T, Sekimizu K, Nakanishi Y, Shiratsuchi A
  • Journal Title: J Immunol 183 Pages: 7451-7460
  • Peer Reviewed
• [Journal Article] Evaluation of target specificity of antibacterial agents using Staphylococcus aureus dd1A mutants and D-cycloserine in a silkworm infection model (2009)
  • Author(s): Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee B L, Murakami K, Maki H, Sekimizu K
  • Journal Title: Antimicrob Agents Chemother 53 Pages: 4025-4027
  • Peer Reviewed
• [Journal Article] Rapid exchange of bound ADP on the Staphylococcus aureus replication initiation protein DnaA (2009)
  • Author(s): Kurokawa K, Mizumura H, Takaki T, Ishii Y, Ichihashi N, Lee B L, Sekimizu K
  • Journal Title: J Blol Chem 284 Pages: 34201-34210
  • Peer Reviewed
• [Journal Article] Prevention of death in bacterium-infected mice by a synthetic antimicrobial peptide, L5, through activation of host immunity (2009)
  • Author(s): Okuyama-Nishida Y, Akiyama N, Sugimori G, Nomura K, Ogawa K, Homma K J, Sekimizu K, Tsujimoto M, Natori S
  • Journal Title: Antimicrob Agents Chemother 53 Pages: 2510-2516
  • Peer Reviewed
• [Journal Article] Auxiliary role for d-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages (2009)
  • Author(s): Shiratsuchi A, Shimizu K, Watanabe I, Hashimoto Y, Kurokawa K, Razanajatovo I M, Park K H, Park H K, Lee B L, Sekimizu K, Nakanishi Y
  • Journal Title: Immunology (in press)
  • NAID: 120001828365
  • Peer Reviewed
• [Journal Article] Silkworm as a model animal to evaluate drug candidate toxicity and metabolism (2009)
  • Author(s): Hamamoto H, Tonoike A, Narushima K, Horie R, Sekimizu K
  • Journal Title: Comp Biochem Physiol C Toxicol Pharmacol 149 Pages: 334-339
  • Peer Reviewed
• [Journal Article] Purification of a soil bacteria exotoxin using silkworm toxicity to measure specific activity. (2009)
  • Author(s): Usui K, Miyazaki S, Kait o C, Sekimizu K.
  • Journal Title: Microbial Pathogenesis 46 Pages: 59-62
  • Peer Reviewed
• [Journal Article] A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus. (2008)
  • Author(s): Kaito C, Omae Y, Matsumoto Y, Nagata M, Yamaguchi H, Aoto T, Ito T, Hiramatsu K, Sekimizu K.
  • Journal Title: PLoS One. 3(12)
  • Peer Reviewed
• [Journal Article] A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus. (2008)
  • Author(s): Kaito C, Omae Y, Matsumo to Y, Nagata M, Yamaguchi H, Aoto T, Ito T, Hira matsu K. Sekimizu K.
  • Journal Title: PLoS ONE 3 Pages: 3921-3921
  • Peer Reviewed
• [Journal Article] Pleiotropic roles of polyglycerolphosphate synthase of lipoteichoic acid in growth of Staphylococcus aureus cells. (2008)
  • Author(s): Oku Y, Kurokawa K, Matsuo M, Yamada S, Lee BL, S ekimizu K.
  • Journal Title: J. Bacteriol. 191 Pages: 141-151
  • Peer Reviewed
• [Presentation] 毒素遺伝子の転写産物と翻訳産物によるメチシリン耐性黄色ブドウ球菌の病原性制御 (2011)
  • Author(s): 垣内力
  • Organizer: 第32回生体膜と薬学の相互作用シンボジウム
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2011-11-29
• [Presentation] カイコ幼虫感染症モデルを用いた、バイオアッセイによる感染症治療薬シーズの開発 (2011)
  • Author(s): 関水和久
  • Organizer: 彩都産学官連携シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2011-01-27
• [Presentation] カイコ幼虫感染症モデルを用いた、バイオアツセイによる感染症治療薬シーズの開発 (2011)
  • Author(s): 関水和久
  • Organizer: 彩都産学官連携シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2011-01-27
• [Presentation] 新規病原性遺伝子群を基盤とする病原性発現システムの把握 (2011)
  • Author(s): 関水和久
  • Organizer: 「特定領域」感染現象のマトリックス第7回全体班会議
  • Place of Presentation: 東京
  • Year and Date: 2011-01-13
• [Presentation] 新規病原性遺伝子群を基盤とする病原性発現システムの把握 (2011)
  • Author(s): 関水和久
  • Organizer: 特定領域感染現象のマトリックス第7回全体班会議
  • Place of Presentation: 東京
  • Year and Date: 2011-01-13
• [Presentation] 招待講演「Slikworm infection models for evaluation of bacterial pathogenecity and the rapeutic effects of antibiotics」 (2010)
  • Author(s): 関水和久
  • Organizer: 拠点大学交流事業 The 9th NRCT-JSPS Joint Seminar
  • Place of Presentation: バンコク
  • Year and Date: 2010-12-09
• [Presentation] USE OF SILKWORMS FOR EVALUATION OF THERAPEUTIC EFFECTS OF AN TIBIOTICS (2010)
  • Author(s): Kazuhisa Sekimizu
  • Organizer: 9th NRCT-JSPSタイジョイントセミナー
  • Place of Presentation: バンコク,タイ
  • Year and Date: 2010-12-09
• [Presentation] 毒素遺伝子の転写産物と翻訳産物によるメチシリン耐性黄色ブドウ球菌の病原性制御 (2010)
  • Author(s): 垣内力
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山県
  • Year and Date: 2010-11-29
• [Presentation] カイコ創薬のすすめ (2010)
  • Author(s): 関水和久
  • Organizer: 2010年度日本農芸化学会西日本支部若手シンポジウム 招待講演
  • Place of Presentation: 九州大学
  • Year and Date: 2010-10-23
• [Presentation] カイコ創薬のすすめ (2010)
  • Author(s): 関水和久
  • Organizer: 日本農芸化学会西日本支部 若手シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-23
• [Presentation] Use of silkworm for evaluation bacterial pathogenisity and the therapeutic effects of antibiosics (2010)
  • Author(s): 関水和久
  • Organizer: 第10回あわじしま感染症・免疫フォーラム 招待講演
  • Place of Presentation: 兵庫県
  • Year and Date: 2010-09-08
• [Presentation] カイコを利用した医薬品開発 (2010)
  • Author(s): 関水和久
  • Organizer: (社)日本薬剤学会第35回製剤セミナー 招待講演
  • Place of Presentation: 浜松市
  • Year and Date: 2010-07-22
• [Presentation] カイコ病態モデルを利用した医薬品開発 (2010)
  • Author(s): 関水和久
  • Organizer: 第35回製剤セミナー
  • Place of Presentation: 静岡
  • Year and Date: 2010-07-22
• [Presentation] カイコモデルDMにおける観察研究 (2010)
  • Author(s): 関水和久
  • Organizer: 中頭病院講演会
  • Place of Presentation: ちばなホール(沖縄)
  • Year and Date: 2010-01-14
• [Presentation] Use of Silkworms for Evaluating Bacterial Pathogenicity and the Therapeutic Effects of Antibiotics (2010)
  • Author(s): Kazuhisa Sekimizu
  • Organizer: The 10^<th> Awaji International Forum on Infe ction and Immunity
  • Place of Presentation: 淡路
• [Presentation] Discovery of novel, therapeutically effective antibiotics by using the silkworm infection model (2010)
  • Author(s): 関水和久
  • Organizer: The 5th Japan-Korea Chemical Biology Symposium
  • Place of Presentation: 韓国釜山
• [Presentation] ヒト病態モデルとしてのカイコ研究の現状と展望 (2009)
  • Author(s): 関水和久
  • Organizer: 公開シンポジウム「カイコ産業の未来～新産業を創出する遺伝子組換えカイコ～」農業生物資源研究所
  • Place of Presentation: 群馬県庁ビジターセンター
  • Year and Date: 2009-09-10
• [Presentation] カイコをモデル動物とした試験方法 (2009)
  • Author(s): 関水和久
  • Organizer: 日本動物実験代替法学会2009年技術講習会
  • Place of Presentation: 臨床研究情報センター(神戸)
  • Year and Date: 2009-08-21
• [Presentation] A Novel Gene fudoh in SCCmec Region Regulates the Colony Spreading Ability and Virulence in Staphylococcus aureus (2008)
  • Author(s): Kaito C
  • Organizer: 13th International Symposium on Staphylococci and Staphylococcal Infections
  • Place of Presentation: オーストラリア
• [Book] 創薬化学の魅力-東京大学大学院薬学系研究科からの発信- (2010)
  • Author(s): 関水和久、垣内力、浜本洋、松本靖彦
  • Publisher: 廣川書店
• [Book] カイコを感染症モデル動物に利用した抗生物質の開拓 (2010)
  • Author(s): 内田龍児、浜本洋、関水和久、供田洋
  • Publisher: バイオサイエンスとインダストリー
• [Remarks] ホームページ
  • URL: http://www.f.u-tokyo.ac.jp/~bisei/
• [Remarks]
  • URL: http://www.f.u-tokyo.ac.jp/~bisei/index.html
• [Patent(Industrial Property Rights)] 獲得免疫機構を有する生物に感染するウイルスに対し抗ウイルス活性を有する試料を自然免疫機構のみを有する生物個体またはその培養細胞を利用してスクリーニングする方法、および該抗ウイルス活性を自然免疫機構のみを有する生物個体またはその培養細胞を利用して評価する方法 (2011)
  • Inventor(s): 関水和久
  • Industrial Property Rights Holder: (株)ゲノム創薬研究所
  • Filing Date: 2011-01-21
• [Patent(Industrial Property Rights)] 新規環状ペプチド化合物とその製造方法及び感染症治療薬 (2010)
  • Inventor(s): 関水和久, 浜本洋, 村上和久
  • Industrial Property Rights Holder: (株)ゲノム創薬研究所・東京大学
  • Industrial Property Number: 2010-119138
  • Filing Date: 2010-05-25
• [Patent(Industrial Property Rights)] 抗生物質産生微生物及びそれが産生した抗生物質 (2010)
  • Inventor(s): 関水和久, 浜本洋, 村上和久
  • Industrial Property Rights Holder: (株)ゲノム創薬研究所・東京大学
  • Industrial Property Number: 2010-119139
  • Filing Date: 2010-05-25
• [Patent(Industrial Property Rights)] 抗生物質含有画分、その抗生物質及びその1抗生物質の製造方法 (2010)
  • Inventor(s): 関水和久, 浜本洋, 村上和久
  • Industrial Property Rights Holder: (株)ゲノム創薬研究所・東京大学
  • Filing Date: 2010-05-25
• [Patent(Industrial Property Rights)] 血糖値降下物質 (2010)
  • Inventor(s): 関水和久, 松本靖彦
  • Industrial Property Rights Holder: (株)ゲノム創薬研究所・東京大学
  • Industrial Property Number: 2010-128203
  • Filing Date: 2010-06-03
• [Patent(Industrial Property Rights)] 糖尿病予防・改善剤のスクリーニング方法及び糖尿病予防・改善剤のスクリーニング用キット (2010)
  • Inventor(s): 関水和久, 松本靖彦
  • Industrial Property Rights Holder: ゲノム創薬研究所、東京大学
  • Industrial Property Number: 2010-034286
  • Filing Date: 2010-02-19
• [Patent(Industrial Property Rights)] 血糖低下剤及びそれを添加してなる糖尿病の予防又は病状改善のための飲食品 (2009)
  • Inventor(s): 関水和久, 小方康至, 松本靖彦
  • Industrial Property Rights Holder: ゲノム創薬研究所、東京大学
  • Filing Date: 2009-06-30
  • Overseas
• [Patent(Industrial Property Rights)] 植物体由来の自然免疫活性化作用が増強された自然免疫活性化組成物 (2009)
  • Inventor(s): 関水和久, 浜本洋
  • Industrial Property Rights Holder: ゲノム創薬研究所、東京大学、イマジングローバルケア
  • Filing Date: 2009-06-22
  • Overseas
• [Patent(Industrial Property Rights)] 自然免疫機能活性化組成物の製造方法及び自然免疫機能活性化組成物 (2009)
  • Inventor(s): 関水和久, 浜本洋
  • Industrial Property Rights Holder: ゲノム創薬研究所、東京大学、イマージングローバルケア
  • Industrial Property Number: 2009-148108
  • Filing Date: 2009-06-22
• [Patent(Industrial Property Rights)] 薬剤の評価方法及び薬剤スクリーニング方法 (2009)
  • Inventor(s): 関水和久, 松本靖彦, 小方康至
  • Industrial Property Rights Holder: ゲノム創薬研究所、東京大学
  • Industrial Property Number: 2009-251567
  • Filing Date: 2009-11-01