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Construction and analysis of model organisms for human liver diseases

Research Project

Project/Area Number 20390022
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NISHINA Hiroshi  Tokyo Medical and Dental University, 難治疾患研究所, 教授 (60212122)

Co-Investigator(Kenkyū-buntansha) ASAOKA Yoichi  東京医科歯科大学, 難治疾患研究所, 助教 (10436644)
中村 貴  東京医科歯科大学, 難治疾患研究所, 助教 (80431948)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsノックアウトマウス / メダカ / 肝形成 / 肝再生 / 脂肪肝 / 肝機能 / シグナル伝達 / モデル生物
Research Abstract

We previously performed a screen in medaka to isolate mutants with impaired liver development. The medaka hio mutants exhibit a profound (but transient) defect in liver specification that resembles the liver formation defect found in the zebrafish prometheus (prt) mutants, whose mutation occurs in the wnt2bb gene. Positional cloning revealed that the hio mutation affects the raldh2 gene encoding retinaldehyde dehydrogenase type2 (RALDH2), the enzyme principally responsible for retinoic acid (RA) biosynthesis. Our data reveal the unexpected finding that RA signaling positively regulates the wnt2bb gene expression required for liver specification in medaka. Furthermore, we have succeeded in isolating ken mutation that models human disease non-alcoholic steatohepatitis (NASH). NASH are serious human diseases in the modern world, so ken mutation may shed a new light on the molecular mechanisms of these diseases and the preventive medicine.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (87 results)

All 2010 2009 2008 Other

All Journal Article (40 results) (of which Peer Reviewed: 11 results) Presentation (38 results) Book (5 results) Remarks (4 results)

  • [Journal Article] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka.2010

    • Author(s)
      Takahiro Negishi, Yoko Nagai, Yoichi Asaoka, Mami Ohno, Misako Namae, Hiroshi Mitani, Takashi Sasaki, Nobuyoshi Shimizu, Shuji Terai, Isao Sakaida, Hisato Kondoh, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina
    • Journal Title

      Hepatology 51

      Pages: 1037-1045

    • Related Report
      2010 Final Research Report
  • [Journal Article] Filamin Associates with Stress Signaling Kinases MKK7 and MKK4 and Regulates JNK Activation.2010

    • Author(s)
      Kentaro Nakagawa, Misato Sugahara, Tokiwa Yamasaki, Hiroaki Kajiho, Shinya Takahashi, 平山順, Yasuhiro Minami, Yasutaka Ohta, Toshio Watanabe, Yutaka Hata, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Biochem.J. 427

      Pages: 237-245

    • Related Report
      2010 Final Research Report
  • [Journal Article] p38 Mitogen-Activated Protein Kinase Controls a Switch between Cardiomyocyte and Neuronal Commitment of Murine Embryonic Stem Cells by Activating Myocyte Enhancer Factor 2C-Dependent Bone Morphogenetic Protein 2 Transcription.2010

    • Author(s)
      Jinzhan Wu, Junko Kubota, Jun Hirayama, Yoko Nagai, Sachiko Nishina, Tadashi Yokoi, Yoichi Asaoka, Jungwon Seo, Nao Shimizu, Hiroaki Kajiho, Takashi Watanabe, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Stem Cells and Development 19

      Pages: 1723-1734

    • Related Report
      2010 Final Research Report
  • [Journal Article] Negative regulation of wnt11 by JNK signaling is required for convergent extension during vertebrate gastrulation.2010

    • Author(s)
      Jungwon Seo, Yoichi Asaoka, Yoko Nagai, Jun Hirayama, Tokiwa Yamasaki, Misako Namae, Shinya Ohata, Nao Shimizu, Takahiro Negishi, Daiju Kitagawa, Hisato Kondoh, Makoto Furutani-Seiki, Josef M.Penninger, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      J.Cell.Biochem. 110

      Pages: 1022-1037

    • Related Report
      2010 Final Research Report
  • [Journal Article] The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka.2010

    • Author(s)
      Yoko Nagai, Yoichi Asaoka, Misako Namae, Kota Saito, Haruka Momose, Hiroshi Mitani, Makoto Furutani-Seiki, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Biochem.Biophys.Res.Commun. 396

      Pages: 887-893

    • Related Report
      2010 Final Research Report
  • [Journal Article] A Global In VivoDrosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function.2010

    • Author(s)
      G.Gregory Neely, Keiji Kuba, Anthony Cammarato, Kazuya Isobe, Sabine Amann, Liyong Zhang, Mitsushige Murata, Lisa Elmen, Vaijayanti Gupta, Suchir Arora, Rinku Sarangi, Debasis Dan, Susumu Fujisawa, Takako Usami, Cui-ping Xia, Alex C.Keene, Nakissa N.Alayari, Hiroyuki Yamakawa, Ulrich Elling, Christian Berger, Maria Novatchkova, Rubina Koglgruber, Keiichi Fukuda, Hiroshi Nishina, Mitsuaki Isobe, J.Andrew Pospisilik, Yumiko Imai, Arne Pfeufer, Andrew A.Hicks, Peter P.Pramstaller, Sai Subramaniam, Akinori Kimura, Karen Ocorr, Rolf Bodmer, Josef M.Penninger
    • Journal Title

      Cell 141

      Pages: 142-153

    • Related Report
      2010 Final Research Report
  • [Journal Article] Involvement of JNK in the regulation of autophagic cell death.2010

    • Author(s)
      Shigeomi Shimizu, Akimitsu Konishi, Yuya Nishida, Takeshi Mizuta, Hiroshi Nishina, Akitsugu Yamamoto, Yoshihide Tsujimoto
    • Journal Title

      Oncogene 29

      Pages: 2070-2082

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.2010

    • Author(s)
      Ryuichi Mashima, Kazuho Honda, Yi Yang, Yohei Morita, Akane Inoue, Sumimasa Arimura, Hiroshi Nishina, Hideo Ema, Hiromitsu Nakauchi, Brian Seed, Hideaki Oda, Yuji Yamanashi
    • Journal Title

      Laboratory Investigation 90

      Pages: 1357-1364

    • Related Report
      2010 Final Research Report
  • [Journal Article] Medaka as a Novel and Accurate Model for Human Nonalcoholic Steatohepatitis.2010

    • Author(s)
      Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida
    • Journal Title

      Disease Models & Mechanisms 3

      Pages: 431-440

    • Related Report
      2010 Final Research Report
  • [Journal Article] An improved method for cell-to-cell transmission of infectious prion.2010

    • Author(s)
      Masahiko Tanaka, Hideyuki Hara, Hiroshi Nishina, Kentaro Hanada, Kenichi Hagiwara, Tomohiko Maehama
    • Journal Title

      Biochem.Biophys.Res.Commun. 397

      Pages: 505-508

    • Related Report
      2010 Final Research Report
  • [Journal Article] [review] Diverse Physiological Functions of MKK4 and MKK7 during Early Embryogenesis.2010

    • Author(s)
      Yoichi Asaoka, Hiroshi Nishina
    • Journal Title

      J.Biochem. 148

      Pages: 393-401

    • Related Report
      2010 Final Research Report
  • [Journal Article] [review] A common origin : signaling similarities in the regulation of the circadian clock and DNA damage responses.2010

    • Author(s)
      内田好海, 平山順, 仁科博史
    • Journal Title

      Biol.Pharm.Bull. 33

      Pages: 535-544

    • Related Report
      2010 Final Research Report
  • [Journal Article] [review] Utility and limitations of SP600125, an inhibitor of stress- responsive c-Jun N-terminal kinase.2010

    • Author(s)
      Shuhei Tanemura, Tokiwa Yamasaki, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Curr.Enzym.Inhib. 6

      Pages: 26-33

    • Related Report
      2010 Final Research Report
  • [Journal Article] 小型魚類メダカを用いた肝形成および肝疾患研究:肝細胞研究会ホームページ2010

    • Author(s)
      仁科博史
    • Journal Title

      研究交流

    • Related Report
      2010 Final Research Report
  • [Journal Article] 概日リズムによる生理機能の制御機構2010

    • Author(s)
      平山順、内田好海、宮村憲央、沢登健治、仁科博史
    • Journal Title

      自律神経 47

      Pages: 297-300

    • NAID

      10026905906

    • Related Report
      2010 Final Research Report
  • [Journal Article] 「メタボロームの分布可視化法について」メタボロミクス:その解析技術と臨床・創薬応用研究の最前線、メディカルドゥ2010

    • Author(s)
      中村貴、早坂孝宏、井上菜穂子、仁科博史、瀬藤光利
    • Journal Title

      遺伝子医学MOOK 16

      Pages: 131-135

    • Related Report
      2010 Final Research Report
  • [Journal Article] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka.2010

    • Author(s)
      Takahiro Negishi, et al.
    • Journal Title

      Hepa tology

      Volume: 51 Pages: 1037-1045

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Filamin Associates with Stress Signaling Kinases MKK7 and MKK4 and Regulates JNK Activation.2010

    • Author(s)
      Kentaro Nakagawa, et al.
    • Journal Title

      Biochem.J.

      Volume: 427 Pages: 237-245

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p38 Mitogen-Activated Protein Kinase Controls a Switch between Cardiomyocyte and Neuronal Commitment of Murine Embryonic Stem Cells by Activating Myocyte Enhancer Factor 2C-Dependent Bone Morphogenetic Protein 2 Transcription.2010

    • Author(s)
      Jinzhan Wu, et al.
    • Journal Title

      J.Cell.Biochem.

      Volume: 110 Pages: 1022-1037

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common light signaling pathways controlling DNA repair and circadian clock entrainment.2009

    • Author(s)
      Jun Hirayama, Norio Miyamura, Yoshimi Uchida, Yoichi Asaoka, Reiko Honda, Kenji Sawanobori, Takeshi Todo, Takuro Yamamoto, Paolo Sassone-Corsi, Hiroshi Nishina
    • Journal Title

      Cell Cycle 8

      Pages: 2794-2801

    • Related Report
      2010 Final Research Report
  • [Journal Article] Blockage by SP600125 of Fce Receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signaling pathway. 平成22年度JB論文賞受賞2009

    • Author(s)
      Shuhei Tanemura, Haruka Momose, Nao Shimizu, Daiju Kitagawa, Jungwon Seo, Tokiwa Yamasaki, Kentaro Nakagawa, Hiroaki Kajiho, Josef M.Penninger, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      J.Biochem. 145

      Pages: 345-354

    • Related Report
      2010 Final Research Report
  • [Journal Article] CrxOS Maintains Self-Renewal Capacity of Murine Embryonic Stem Cells.2009

    • Author(s)
      Ryota Saito, Tokiwa Yamasaki, Yoko Nagai, Jinzhan Wu, Hiroaki Kajiho, Tadashi Yokoi, Eiichiro Noda, Sachiko Nishina, Hitoshi Niwa, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Biochem.Biophys.Res.Commun. 390

      Pages: 1129-1135

    • Related Report
      2010 Final Research Report
  • [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells.2009

    • Author(s)
      Shinya Ohata, Makiko Nawa, Takeshi Kasama, Tokiwa Yamasaki, Kenji Sawanobori, Shoji Hata, Takashi Nakamura, Yoichi Asaoka, Toshio Watanabe, Hitoshi Okamoto, Takahiko Hara, Shuji Terai, Isao Sakaida, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Biochem.Biophys.Res.Commun. 379

      Pages: 817-823

    • Related Report
      2010 Final Research Report
  • [Journal Article] CLOCK : BMAL-independent circadian oscillation of zebrafish Cryptochrome1a gene.2009

    • Author(s)
      Norio Miyamura, Jun Hirayama, Kenji Sawanobori, Teruya Tamaru, Yoichi Asaoka, Reiko Honda, Takuro Yamamoto, Hatsume Uno, Ken Takamatsu, Hiroshi Nishina
    • Journal Title

      Biol.Pharm.Bull 32

      Pages: 1183-1187

    • Related Report
      2010 Final Research Report
  • [Journal Article] Pax6-5a Promotes Neuronal Differentiation of Murine Embryonic Stem Cells.2009

    • Author(s)
      Nao Shimizu, Hajime Watanabe, Junko Kubota, Jinzhan Wu, Ryota Saito, Tadashi Yokoi, Takumi Era, Takeshi Iwatsubo, Takashi Watanabe, Sachiko Nishina, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages: 999-1003

    • NAID

      130000117177

    • Related Report
      2010 Final Research Report
  • [Journal Article] Medaka : a promising model animal for comparative population genomics.2009

    • Author(s)
      Yoshifumi Matsumoto, Hiroki Oota, Yoichi Asaoka, Hiroshi Nishina, Koji Watanabe, Janusz M Bujnicki, Shoji Oda, Shoji Kawamura, Hiroshi Mitani
    • Journal Title

      BMC Research Notes 2

      Pages: 88-88

    • Related Report
      2010 Final Research Report
  • [Journal Article] [review] Liver development : lessons from knockout mice and mutant fish.2009

    • Author(s)
      中村貴, 仁科博史
    • Journal Title

      Hepatol.Res. 39

      Pages: 633-644

    • Related Report
      2010 Final Research Report
  • [Journal Article] Medaka : a promising model animal for comparative population genomics.2009

    • Author(s)
      Matsumoto, Y, et al.
    • Journal Title

      BMC Research Notes 2

      Pages: 88-88

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common light signaling pathways controlling DNA repair and circadian clock entrainment2009

    • Author(s)
      Hirayama, J, et al.
    • Journal Title

      Cell Cycle 8

      Pages: 2794-27801

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells.2009

    • Author(s)
      Ohata, S, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 379

      Pages: 817-823

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast.2008

    • Author(s)
      Shinya Takahashi, Yasuhiro Araki, Yuriko Ohya, Takeshi Sakuno, Shin-ichi Hoshino, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada
    • Journal Title

      RNA 14

      Pages: 1950-1958

    • Related Report
      2010 Final Research Report
  • [Journal Article] RalA functions as an indispensable signal mediator for nutrient sensing system.2008

    • Author(s)
      Tomohiko Maehama, Masahiko Tanaka, Hiroshi Nishina, Makoto Murakami, Yasunori Kanaho, Kentaro Hanada
    • Journal Title

      J.Biol.Chem. 283

      Pages: 35053-35059

    • Related Report
      2010 Final Research Report
  • [Journal Article] Antagonistic control of cell fates by JNK and p38-MAPK signaling.2008

    • Author(s)
      Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM.
    • Journal Title

      Cell Death Differ. 15

      Pages: 89-93

    • Related Report
      2010 Final Research Report
  • [Journal Article] Novel antibody to human BASP1 labels apoptotic cells post-caspase activation.2008

    • Author(s)
      Shizue Ohsawa, Tomomi Watanabe, Toshiaki Katada, Hiroshi Nishina, Masayuki Miura
    • Journal Title

      Biochem.Biophys.Res.Commun. 371

      Pages: 639-643

    • Related Report
      2010 Final Research Report
  • [Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver.2008

    • Author(s)
      Yoshio Marumoto, Shuji Terai, Yohei Urata, Toshihiko Matsumoto, Yuko Mizunaga, Naoki Yamamoto, Haiyan Jin, Koichi Fujisawa, Tomoaki Murata, Koh Shinoda, Hiroshi Nishina, Isao Sakaida
    • Journal Title

      Biochem.Biophys.Res.Commun. 367

      Pages: 546-552

    • Related Report
      2010 Final Research Report
  • [Journal Article] Antagonistic control of cell fates by JNK and p38-MAPK signaling.2008

    • Author(s)
      Wada T, et al.
    • Journal Title

      Cell Death Differ. 15

      Pages: 89-93

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CC14 -treated cirrhotic liver.2008

    • Author(s)
      Yoshio Marumoto, et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 367 367

      Pages: 546-552

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel antibody to human BASP1 labels apoptotic cells post -caspase activation.2008

    • Author(s)
      Shizue Ohsawa, et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 371

      Pages: 639-643

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upf1 potentially serves as a RING -related E3 ubiquitin ligasevia its association with Upf3 in yeast.2008

    • Author(s)
      Shinya Takahashi, et al.
    • Journal Title

      RNA 14

      Pages: 1950-1958

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RalA functions as an indispensable signal mediator for nutrient sensing system.2008

    • Author(s)
      Tomohiko Maehama, et al.
    • Journal Title

      J. Biol. Chem. 371

      Pages: 35053-35059

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Negative Regulation of Wnt11 Expression by Jnk Signaling during Convergent Extension2010

    • Author(s)
      浅岡洋一, 仁科博史
    • Organizer
      9 th International meeting on ZEBRAFISH DEVELOPMENT AND GENETICS
    • Place of Presentation
      Wisconsin, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Liver biology and disease: lessons from mutant fish2010

    • Author(s)
      浅岡洋一, 仁科博史
    • Organizer
      The Joint Symposium of the 5^<th> International Symposium of Institute Network and the International Symposium Commemorating Inauguration of Kanazawa University Cancer Research Institute
    • Place of Presentation
      Kanazawa
    • Related Report
      2010 Final Research Report
  • [Presentation] The LIM protein Ajuba is required for ciliogenesis andleft-right axis determination in medaka2010

    • Author(s)
      仁科博史
    • Organizer
      FASEB Summer Research Conferences 2010
    • Place of Presentation
      Aspen, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulation of ES cell differentiation2010

    • Author(s)
      仁科博史
    • Organizer
      Lectures on Organogenesis and Regeneration in Fayoum University
    • Place of Presentation
      Fayoum, Egypt
    • Related Report
      2010 Final Research Report
  • [Presentation] Generation and Regeneration of liver2010

    • Author(s)
      仁科博史
    • Organizer
      Fayoum University International Symposium on Stem Cells
    • Place of Presentation
      Fayoum, Egypt
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 細胞死調節因子Daxxによる分子時計制御2010

    • Author(s)
      仁科博史
    • Organizer
      細胞死研究会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類を用いたトランスポートソーム下流シグナル伝達系の解析2010

    • Author(s)
      仁科博史
    • Organizer
      膜輸送公開シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 肝細胞の増殖を制御するシグナル伝達の解析2010

    • Author(s)
      仁科博史
    • Organizer
      第12回日本肝臓医生物学研究会
    • Place of Presentation
      静岡
    • Related Report
      2010 Final Research Report
  • [Presentation] マウスやメダカを用いたMAPキナーゼシグナル伝達系の生理機能の解析2010

    • Author(s)
      仁科博史
    • Organizer
      東京女子医大セミナー
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類メダカを用いた肝臓研究2010

    • Author(s)
      仁科博史
    • Organizer
      第7回日本胎盤臨床研究会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類メダカを用いた肝臓左右性決定機構の解明2010

    • Author(s)
      仁科博史
    • Organizer
      第17回肝細胞研究会
    • Place of Presentation
      秋田
    • Related Report
      2010 Final Research Report
  • [Presentation] ストレス応答性キナーゼMKK7欠損マウスにおける脳形成異常2010

    • Author(s)
      山崎世和、仁科博史
    • Organizer
      第9回生命科学研究会
    • Place of Presentation
      筑波
    • Related Report
      2010 Final Research Report
  • [Presentation] ストレス応答性JNKシグナル伝達系のゼブラフィッシュ初期胚における役割2010

    • Author(s)
      浅岡洋一、仁科博史
    • Organizer
      第16回小型魚類研究会
    • Place of Presentation
      埼玉
    • Related Report
      2010 Final Research Report
  • [Presentation] マウスやメダカを用いた肝形成機構の解明2010

    • Author(s)
      仁科博史
    • Organizer
      北里大学セミナー
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類メダカを用いた肝形研究2010

    • Author(s)
      仁科博史
    • Organizer
      第22回分子糖尿病研究会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 高橋良輔世話人ワークショップ;小型魚類メダカやゼブラフィッシュを用いた疾患研究2010

    • Author(s)
      仁科博史
    • Organizer
      BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類ゼブラフィッシュおよびメダカを用いた器官形成機構の解明2010

    • Author(s)
      仁科博史
    • Organizer
      徳島大学大学院ヘルスバイオサイエンス研究部セミナー
    • Place of Presentation
      徳島
    • Related Report
      2010 Final Research Report
  • [Presentation] 扁平胚の表現型を示すYAPメダカ変異体の単離と解析2009

    • Author(s)
      仁科博史
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Physiological roles of Hippo signaling pathway using Medaka, Oryzias Latipes.2009

    • Author(s)
      仁科博史
    • Organizer
      RASSF First International Symposium
    • Place of Presentation
      Banff, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] モデル生物を用いた「細胞の生と死」を制御するシグナル伝達系の解析2009

    • Author(s)
      仁科博史
    • Organizer
      埼玉大学セミナー
    • Place of Presentation
      浦和
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類を用いたSAPK/JNKシグナル系の解析2009

    • Author(s)
      仁科博史
    • Organizer
      生理学研究所セミナー
    • Place of Presentation
      岡崎
    • Related Report
      2010 Final Research Report
  • [Presentation] 顕微質量分析装置を用いた再生肝の解析2009

    • Author(s)
      中村貴、仁科博史
    • Organizer
      第16回肝細胞研究会
    • Place of Presentation
      山形
    • Related Report
      2010 Final Research Report
  • [Presentation] NMD制御因子Upf1はユビキチンリガーゼとして機能する2009

    • Author(s)
      高橋真也, 堅田利明, 仁科博史
    • Organizer
      RNA学会
    • Place of Presentation
      新潟
    • Related Report
      2010 Final Research Report
  • [Presentation] 共培養系を用いた高効率な異常型プリオンタンパク質伝播実験系の確立2009

    • Author(s)
      田中正彦、前濱朝彦、仁科博史
    • Organizer
      平成21年度文部科学省科学研究費補助金特定領域「G蛋白質シグナル」研究班会議
    • Place of Presentation
      千葉
    • Related Report
      2010 Final Research Report
  • [Presentation] メダカ扁平胚hirame変異体の単離と解析2009

    • Author(s)
      仁科博史
    • Organizer
      理化学研究所CDB
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 畑裕世話人シンポジウム;細胞死・細胞増殖制御を司る新しいシグナル伝達系Hippo pathway2009

    • Author(s)
      仁科博史
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類を用いた器官形成シグナルの解析2009

    • Author(s)
      仁科博史
    • Organizer
      東京大学薬学セミナー
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression.2008

    • Author(s)
      Takahiro Negishi, Hiroshi Nishina
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass, USA
    • Year and Date
      2008-08-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly2008

    • Author(s)
      高橋真也, 堅田利明, 仁科博史
    • Organizer
      RNA 2008 Thirteenth Annual Meeting of the RNA Society
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2010 Final Research Report
  • [Presentation]2008

    • Author(s)
      仁科博史主催
    • Organizer
      第7回日本肝臓医生物学研究会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞の生死および組織・器官の形成を制御するHippoシグナル伝達系2008

    • Author(s)
      仁科博史
    • Organizer
      山口肝臓シンポジウム
    • Place of Presentation
      宇部
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類を用いた肝疾患モデルスクリーニング2008

    • Author(s)
      仁科博史
    • Organizer
      日本製薬工業協会・創薬部会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] マウスやメダカを用いた器官形成の研究2008

    • Author(s)
      仁科博史
    • Organizer
      東京工業大学
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類を用いた組織や器官形成に関わるシグナル伝達系の解析2008

    • Author(s)
      仁科博
    • Organizer
      千葉大学医学部発生生物学セミナー
    • Place of Presentation
      千葉
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト疾患を模倣するメダカ変異体の単離と薬剤スクリーニング系の開発2008

    • Author(s)
      仁科博史
    • Organizer
      JAXA宇宙生物学研究室セミナー
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 小型魚類を用いたシグナル伝達系の解析2008

    • Author(s)
      仁科博史
    • Organizer
      Metabolic Research : Cutting Edge
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 肝臓学の動向2008

    • Author(s)
      仁科博史
    • Organizer
      早稲田大学先進理工学部
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 脊椎動物の初期胚形成制御におけるSAPK/JNKシグナル伝達系の役割2008

    • Author(s)
      仁科博史
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Book] 分子細胞生物学第6版(Lodish et al.)(翻訳分担)2010

    • Author(s)
      仁科博史
    • Publisher
      東京化学同人
    • Related Report
      2010 Final Research Report
  • [Book] 生物学事典(執筆分担)2010

    • Author(s)
      仁科博史
    • Publisher
      東京化学同人
    • Related Report
      2010 Final Research Report
  • [Book] 分子細胞生物学(Lodish, et al.)(第6版)2010

    • Author(s)
      仁科博史, ら翻訳分担
    • Total Pages
      1096
    • Publisher
      東京化学同人
    • Related Report
      2010 Annual Research Report
  • [Book] ベーシックマスター生化学(シグナル伝達の分子機構)(執筆分担)2008

    • Author(s)
      仁科博史
    • Publisher
      オーム社
    • Related Report
      2010 Final Research Report
  • [Book] ベーシックマスター生化学2008

    • Author(s)
      仁科博
    • Total Pages
      414
    • Publisher
      オーム社
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.tmd.ac.jp/mri/dbio/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/dbio/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/dbio/index.html#

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/dbio/index.html#

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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