Discovery and drug applications of novel and essential prostanoid actions mediated by a cluster of receptors

• Project/Area Number: 20390024
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: SUGIMOTO Yukihiko Kyoto University, 大学院・生命科学研究部, 教授 (80243038)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2010: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: プロスタグランジン / GPCR / 発生 / 生殖 / 炎症 / 発現プロファイル / ノックアウトマウス / 生殖腺分化 / 多発性硬化症 / Th17 / ケモカイン / 細胞外マトリクス / 膜ラフト / 受容体サブタイプ / Gタンパク質共役型受容体 / 分娩 / 発熱 / 受精 / GABA / 子宮収縮

Research Abstract

Prostanoids are bioactive lipid mediators derived from plasma phospholipids. It is well-known that prostanoids are the target of aspirin-like drugs, but their whole actions and their molecular mechanisms of each known action have not fully addressed. In this study, we investigated whether prostanoid receptors coupling to similar signal transduction pathways work together in a compensatory fashion. As a result, we found that prostanoids are involved not only in physiological processes such as ovulation, fertilization and parturition, but also in pathological processes such as fever and inflammation. We further showed molecular mechanisms underlying prostanoid-induced actions.

Research Products

• [Journal Article] Roles of Prostaglandin E2-EP1 Receptor Signaling in Regulation of Gastric Motor Activity and Emptying. (2010)
  • Author(s): Mizuguchi S, Ohno T, Hattori Y, Ae T, Minamino T, Satoh T, Arai K, Saeki T,Hayashi I, Sugimoto Y, Narumiya S, Saigenji K, Majima M.
  • Journal Title: Am.J.Physiol.Gastrointest. Liver Physiol. 299
  • Peer Reviewed
• [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling. (2010)
  • Author(s): Tamba S, Yodoi R, Morimoto K, Inazumi T, Sukeno M, Segi-Nishida E, Okuno Y,Tsujimoto G, Narumiya S, Sugimoto Y.
  • Journal Title: Biochimie 92 Pages: 665-675
  • Peer Reviewed
• [Journal Article] Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads. (2010)
  • Author(s): Kusaka, M., Katoh-Fukui, Y., Ogawa, H.,Miyabayashi, K., Baba, T., Shima, Y.,Sugiyama, N., Sugimoto, Y., Okuno, Y., Kodama, R., Iizuka-Kogo, A., Senda, T., Sasaoka, T., Kitamura, K., Aizawa, S., Morohashi, K.
  • Journal Title: Endocrinology. 151 Pages: 5893-5904
  • NAID: 120005227384
  • Peer Reviewed
• [Journal Article] COX-2 andprostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. (2010)
  • Author(s): Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M.
  • Journal Title: Am.J.Pathol. 176 Pages: 1469-1483
  • Peer Reviewed
• [Journal Article] Recruited bone marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during chronic inflammation. (2010)
  • Author(s): Ueno, T., Suzuki, T., Oikawa, A., Hosono, K., Kosaka, Y., Amano, H., Kitasato, H., Toda, M., Hayashi, I., Kato, T., Ito, Y., Sugimoto, Y., Narumiya, S., Okamoto, H., Majima, M.
  • Journal Title: Biomed.Pharmacother. 64 Pages: 93-100
  • Peer Reviewed
• [Journal Article] Host prostaglandin EP3 receptor signaling relevant totumor-associated lymphangiogenesis. (2010)
  • Author(s): Kubo, H., Hosono, K., Suzuki, T., Ogawa, Y., Kato, H., Kamata, H., Ito, Y., Amano, H., Kato, T., Sakagami, H., Hayashi, I., Sugimoto, Y., Narumiya, S., Watanabe, M., Majima, M.
  • Journal Title: Biomed.Pharmacother. 64 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Molecular biology of histidine decarboxylase and prostaglandin receptors. (2010)
  • Author(s): Ichikawa A, Sugimoto Y, Tanaka S.
  • Journal Title: Proc.Jpn.Acad. 86 Pages: 848-866
  • NAID: 130000442356
  • Peer Reviewed
• [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling. (2010)
  • Author(s): Tamba, S., Yodoi, R., Morimoto, K., Sugimoto, Y., et al.
  • Journal Title: Biochimie Volume: 92 Pages: 665-675
  • Peer Reviewed
• [Journal Article] Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads. (2010)
  • Author(s): Kusaka, M., Katoh-Fukui, Y., Ogawa, H., Miyabayashi, K., Baba, T., Shima, Y., Sugimoto, Y., Morohashi, K, et al.
  • Journal Title: Endocrinology Volume: 151 Pages: 5893-5904
  • NAID: 120005227384
  • Peer Reviewed
• [Journal Article] COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. (2010)
  • Author(s): Katoh, H., Hosono, K., Ito, Y., Suzuki, T. Ogawa, Y., Kubo, H., Sugimoto, Y., Narumiya, S., Majima, M., et al.
  • Journal Title: Am.J.Pathol. Volume: 176 Pages: 1469-1483
  • Peer Reviewed
• [Journal Article] Roles of Prostaglandin E2-EP1 Receptor Signaling in Regulation of Gastric Motor Activity and Emptying. (2010)
  • Author(s): Mizuguchi, S., Ohno, T., Hattori, Y., Ae, T., Minamino, T., Satoh, T., Arai, K., Saeki, T., Hayashi, I., Sugimoto, Y., et al.
  • Journal Title: Am.J.Physiol.Gastrointest.Liver Physiol. Volume: 299
  • Peer Reviewed
• [Journal Article] Recruited bone marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during chronic inflammation. (2010)
  • Author(s): Ueno, T., Suzuki, T., Oikawa, A., Hosono, K., Kosaka, Y., Amano, H., Kitasato, H., Ito, Y., Sugimoto, Y., Narumiya, S., et al.
  • Journal Title: Biomed.Pharmacother. Volume: 64 Pages: 93-100
  • Peer Reviewed
• [Journal Article] Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis. (2010)
  • Author(s): Kubo, H., Hosono, K., Suzuki, T., Ogawa, Y., Kato, H., Kamata, H., Ito, Y., Amano, H., Sugimoto.Y., Narumiya, S., et al.
  • Journal Title: Biomed.Pharmacother. Volume: 64 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Molecular biology of histidine decarboxylase and prostaglandin receptors. (2010)
  • Author(s): Ichikawa, A., Sugimoto, Y., Tanaka, S.
  • Journal Title: Proc.Jpn.Acad. Volume: 86 Pages: 848-866
  • NAID: 130000442356
  • Peer Reviewed
• [Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca^<2+> pathway in a lipid raft-dependent manner. (2009)
  • Author(s): Yamaoka K, Yano A, Kuroiwa K, Morimoto K, Inazumi T, Hatae N, Tabata H, Segi-Nishida E, Tanaka S, Ichikawa A, Sugimoto Y.
  • Journal Title: Biochem Biophys Res Commun. 389 Pages: 678-682
  • Peer Reviewed
• [Journal Article] Prostaglandin E 2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion. (2009)
  • Author(s): Yao C, Sakata D, Esaki Y, Li Y, Matsuoka T, Kuroiwa K, Sugimoto Y, Narumiya S.
  • Journal Title: Nat.Med. 15 Pages: 633-640
  • Peer Reviewed
• [Journal Article] RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly. (2009)
  • Author(s): Yodoi R, Tamba S, Morimoto K, Segi-Nishida E, Nishihara M, Ichikawa A, Narumiya S, Sugimoto Y.
  • Journal Title: Endocrinology. 150 Pages: 3345-3352
  • Peer Reviewed
• [Journal Article] Prostaglandin E 2 stimulates the production of amyloid beta peptides through internalization of the EP4 receptor. (2009)
  • Author(s): Hoshino T, Namba T, Takehara M, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T.
  • Journal Title: J.Biol.Chem. 284 Pages: 18493-18502
  • Peer Reviewed
• [Journal Article] Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. (2009)
  • Author(s): Amano, H., Ito, Y., Suzuki, T., Kato, S., Matsui, Y., Ogawa, F., Murata, T., Sugimoto, Y., Senior, R., Kitasato, H., Hayashi, I., Satoh, Y., Narumiya, S., Majima, M.
  • Journal Title: Cancer Sci. 100 Pages: 2318-2324
  • NAID: 10027198074
  • Peer Reviewed
• [Journal Article] Involvement of prostaglandin F 2. receptor in ATP-induced mechanical allodynia. (2009)
  • Author(s): Kunori S, Matsumura S, Mabuchi T, Tatsumi S, Sugimoto Y, Minami T, Ito S.
  • Journal Title: Neuroscience. 163 Pages: 362-371
  • Peer Reviewed
• [Journal Article] Prostaglandin E receptor subtype EP4 agonist protects cochleae against noise-induced trauma. (2009)
  • Author(s): Hori R, Nakagawa T, Sugimoto Y, Sakamoto T, Yamamoto N, Hamaguchi K, Ito J.
  • Journal Title: Neuroscience. 160 Pages: 813-819
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of a radioiodinated Lumiracoxib derivative for the imaging of cyclooxygenase-2 expression. (2009)
  • Author(s): Kuge, Y., Obokata, N., Kimura, H., Katada, Y., Temma, T., Sugimoto, Y., Aita, K., Seki, K., Tamaki, N., Saji, H.
  • Journal Title: Nuc.Med.Biol. 36 Pages: 869-876
  • Peer Reviewed
• [Journal Article] Colocalization of prostaglandin F receptor FP and prostaglandin F synthase-I in the spinal cord. (2009)
  • Author(s): Suzuki-Yamamoto, T., Toida, K., Sugimoto, Y., Ishimura, K.
  • Journal Title: J.Lipid Res. 50 Pages: 1996-2003
  • Peer Reviewed
• [Journal Article] Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth. (2009)
  • Author(s): Ogawa, Y., Suzuki, T., Oikawa, A., Hosono, K., Kubo, H., Amano, H., Kitasato, H., Hayashi, I., Kato, T., Sugimoto, Y., Narumiya, S., Watanabe, M., Majima, M.
  • Journal Title: Biochem Biophys Res Commun. 382 Pages: 720-725
  • Peer Reviewed
• [Journal Article] Involvement of CD44 in mast cell proliferation during terminal differentiation. (2009)
  • Author(s): Takano, H., Nakazawa, S., Shirata, N., Tamba, S., Furuta, K., Tsuchiya, S., Morimoto, K, Itano, N., Irie, A., Ichikawa, A., Kimata, K., Nakayama, K., Sugimoto, Y., Tanaka, S.
  • Journal Title: Lab.Invest. 89 Pages: 446-455
  • Peer Reviewed
• [Journal Article] Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method. (2009)
  • Author(s): Tsuchiya, S., Tachida, Y., Segi-Nishida, E., Okuno, Y., Tamba, S., Tsujimoto, G., Tanaka, S., Sugimoto, Y.
  • Journal Title: BMC Genomics 10 Pages: 35-35
  • Peer Reviewed
• [Journal Article] プロスタノイドの作用発現とシグナル・クロストーク (2009)
  • Author(s): 杉本幸彦
  • Journal Title: 実験医学 27(13) Pages: 2047-2052
• [Journal Article] Prostaglandin E2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion (2009)
  • Author(s): Yao, C., Sakata, D., Esaki, Y., Li, Y., Matsuoka, T., Kuroiwa, K., Sugimoto, Y., Narumiya, S.
  • Journal Title: Nature Medicine 15 Pages: 633-640
  • Peer Reviewed
• [Journal Article] RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly (2009)
  • Author(s): Yodoi, R., Tamba, S., Morimoto, K., Segi-Nishida, E., Nishihara, M., Ichikawa, A., Narumiya, S., Sugimoto, Y.
  • Journal Title: Endocrinology 150 Pages: 3345-3352
  • Peer Reviewed
• [Journal Article] Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in alipid raft-dependent manner (2009)
  • Author(s): Yamaoka, K., Yano, A., Kuroiwa, K., Morimoto, K., Inazumi, T., Hatae, N., Tabata, H., Segi-Nishida, E., Tanaka, S., Ichikawa, A., Sugimoto Y.
  • Journal Title: Biochem Biophys Res Commun 389 Pages: 678-682
  • Peer Reviewed
• [Journal Article] Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization. (2008)
  • Author(s): Tamba S, Yodoi R, Segi-Nishida E, Ichikawa A, Narumiya S, Sugimoto Y.
  • Journal Title: Proc.Natl.Acad.Sci.USA 105 Pages: 14539-14544
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors. (2008)
  • Author(s): Tsuchiya H, Oka T, Nakamura K, Ichikawa A, Saper CB, Sugimoto Y.
  • Journal Title: J.Biol.Chem. 283 Pages: 11064-11071
  • Peer Reviewed
• [Journal Article] Essential role of EP3 subtype in prostaglandin E 2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix. (2008)
  • Author(s): Sakanaka, M., Tanaka, S., Sugimoto, Y., Ichikawa, A.
  • Journal Title: Am.J.Physiol.Cell Physiol. 295
  • Peer Reviewed
• [Journal Article] Coiled-coiltag-robe system for quick labeling of membrane receptors in living cells. (2008)
  • Author(s): Yano, Y., Yano, A., Oishi, S., Fujii, N., Sugimoto, Y., Matsuzaki, K.
  • Journal Title: ACS Chem.Biol. 3 Pages: 341-345
  • Peer Reviewed
• [Journal Article] Intracellular third loop-C-terminal tail interaction in prostaglandin EP3?receptor. (2008)
  • Author(s): Yano, Y., Shimbo, T., Sugimoto, Y., Matsuzaki, K.
  • Journal Title: Biochem.Biophys.Res.Commun. 371 Pages: 846-849
  • Peer Reviewed
• [Journal Article] Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells. (2008)
  • Author(s): Takano, H., Nakazawa, S., Okuno, Y., Shirata, N., Tsuchiya, S., Kainoh, T., Takamatsu, S., Furuta, K., Taketomi, Y., Naito, Y., Takematsu, H., Kozutsumi, Y., Tsujimoto, G., Murakami, M., Kudo, I., Ichikawa, A., Nakayama, K., Sugimoto, Y., Tanaka, A.
  • Journal Title: FEBS Lett 582 Pages: 1444-1450
  • Peer Reviewed
• [Journal Article] Prostaglandin I 2 plays a key role in zymosan-induced mouse pleurisy. (2008)
  • Author(s): Yuhki, K.I., Ushikubi, F., Naraba, H., Ueno, A., Kato, H., Kojima, F., Narumiya, S., Sugimoto, Y., Matsushita, M., Oh-Ishi, S.
  • Journal Title: J.Pharmacol.Exp.Ther. 325 Pages: 601-609
  • Peer Reviewed
• [Journal Article] Method for single-cell microarray analysis and application to gene-expression profiling of GABAergic neuron progenitors. (2008)
  • Author(s): Esumi, S., Wu, S-X., Yanagawa, Y., Obata, K., Sugimoto, Y., Tamamaki, N.
  • Journal Title: Neurosci.Res. 60 Pages: 439-451
  • Peer Reviewed
• [Journal Article] Parturition and recruitment of macrophages in cervix of mice lacking the prostaglandin F receptor. (2008)
  • Author(s): Yellon, S. M., Ebner, C. A., Sugimoto, Y.
  • Journal Title: Biol.Reprod. 78 Pages: 438-444
  • Peer Reviewed
• [Journal Article] Infusion of oxytocin induces successful delivery in prostanoid FP receptor- deficient mice. (2008)
  • Author(s): Kawamata, M., Yoshida, M. Sugimoto, Y., Kimura, T., Tonomura, Y., Takayanagi, Y., Yanagisawa, T., Nishimori, K.
  • Journal Title: Mol.Cell.Endocrinol. 283 Pages: 32-37
  • Peer Reviewed
• [Journal Article] Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization. (2008)
  • Author(s): Tamba, S., Yodoi, R., Segi-Nishida, E., Ichikawa, A., Narumiya, S., Sugimoto, Y.
  • Journal Title: Proc. Natl. Acad. Sci. USA 105 Pages: 14539-14544
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors. (2008)
  • Author(s): Tsuchiya, H., Oka, T., Nakamura, K., Ichikawa, A., Saper, C. B., Sugimoto, Y.
  • Journal Title: J. Biol. Chem. 283 Pages: 11064-11071
  • Peer Reviewed
• [Journal Article] Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix. (2008)
  • Author(s): Sakanaka, M., Tanaka, S., Sugimoto, Y., Ichikawa, A.
  • Journal Title: Am. J. Physiol. Cell Physiol. 295 Pages: 1427-1433
  • Peer Reviewed
• [Journal Article] Intracellular third loop-C-terminal tail interaction in prostaglandin EP3β receptor. (2008)
  • Author(s): Yano, Y., Shimbo, T., Sugimoto, Y., Matsuzaki, K.
  • Journal Title: Biochem. Biophys. Res. Commun. 371 Pages: 846-849
  • Peer Reviewed
• [Journal Article] Prostaglandin 12 plays a key role in zymosan-induced mouse pleurisy. (2008)
  • Author(s): Yuhki, K. I., Ushikubi, F., Naraba, H, Ueno, A., Kato, H., Kojima, F., Narumiya, S., Sugimotoo, Y., Matsushita, M., Oh-Ishi, S.
  • Journal Title: J. Pharmacol. Exp. Ther. 325 Pages: 601-609
  • Peer Reviewed
• [Journal Article] Parturition and recruitment of macrophages in cerix of mice lacking the prostaglandin F receptor. (2008)
  • Author(s): Yellon, S. M., Ebner, C. A., Sugimoto, Y.
  • Journal Title: Biol. Reprod. 78 Pages: 438-444
  • Peer Reviewed
• [Journal Article] Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficieent mice. (2008)
  • Author(s): Kawamata, M., Yoshidaa, M. Sugimoto, Y., Kimuraa, T., Tonomura, Y., Takayanagi, Y., Yanagisavva, T., Nishimorii, K.
  • Journal Title: Mol. Cell. Endocrinol. 283 Pages: 32-37
  • Peer Reviewed
• [Presentation] プロスタグランジンE2による視索前野ニューロン突起伸長の促進機構 (2010)
  • Author(s): 杉本幸彦、吉岡美樹、北條寛典、川原浩一、瀬木-西田恵里、成宮周
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場(神戸)(招待講演)
  • Year and Date: 2010-12-10
• [Presentation] sPLA2-III, a mast cell-derived anaphylactic sPLA2, regulates mast cell-dependent anaphylactic response. (2010)
  • Author(s): Yoshitaka Taketomi、Hiroyasu Sato、SatoshiTanaka、Masanori Nakamura、Noriko Ueno、Yasumasa Nishito、Kei Yamamoto、Yukihiko Sugimoto、Shuntaro Hara、Makoto Murakami
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2010-12-10
• [Presentation] プロスタグランジンE2はマスト細胞のEP3受容体を活性化することで炎症を惹起する (2010)
  • Author(s): 森本和志、白田成俊、森大介、高野裕嗣、田中智之、瀬木-西田恵里、杉本幸彦
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2010-12-09
• [Presentation] PGE2 stimulation accelerated the neurite growth in mouse hypothalamic cell line. (2010)
  • Author(s): Hiroyasu Tsuchiya、Yukihiko Sugimoto、Yoko Hujiwara、Akio Fujimura、Taka-aki Koshimizu
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸国際会議場(神戸)
  • Year and Date: 2010-12-08
• [Presentation] 脂肪細胞の分化・成熟における内因性プロスタグランジンの役割 (2010)
  • Author(s): 稲住知明、白田成俊、瀬木-西田恵里、成宮周、杉本幸彦
  • Organizer: 第9回次世代を担う若手ファーマ・バイオフォーラム2010
  • Place of Presentation: 京都大学薬学研究科(京都)
  • Year and Date: 2010-10-02
• [Presentation] Cumulus matrix capacitation for successful sperm penetration: roles of prostaglandin and chemokine (2010)
  • Author(s): 杉本幸彦
  • Organizer: 11th International Symposium on Spermatology【Invited】
  • Place of Presentation: Okinawa Convention Center(Okinawa)
  • Year and Date: 2010-06-27
• [Presentation] Cumulus Matrix Capacitation for Successful Sperm Penetration : Roles of Prostaglandin and Chemokine (2010)
  • Author(s): Sugimoto, Y.
  • Organizer: 11^<th> International Symposium on Spermatology
  • Place of Presentation: Okinawa Convention Center(Okinawa)(invited)
  • Year and Date: 2010-06-27
• [Presentation] プロスタグランジン-ケモカインによる受精促進機構(シンポジウム「プロスタグランジンの生理機能と病態への関わり」) (2010)
  • Author(s): 杉本幸彦
  • Organizer: 日本薬学会第130年会【招待講演】
  • Place of Presentation: 就実大学(岡山)
  • Year and Date: 2010-03-28
• [Presentation] プロスタグランジンE2による視索前野ニューロン突起伸長の促進機構(ワークショップ・生命応答を制御する脂質マシナリー) (2010)
  • Author(s): 杉本幸彦、吉岡美樹、北條寛典、川原浩一、瀬木-西田恵里、成宮周
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会【招待講演】
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] PGE 2 stimulation accelerated the neurite growth in mouse hypothalamic cell line (2010)
  • Author(s): Hiroyoshi Tsuchiya, Yukihiko Sugimoto, Yoko Hujiwara, Akio Fujimura, Taka-aki Koshimizu
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] 脂肪細胞の分化o成熟における内因性プロスタグランジンの役割 (2010)
  • Author(s): 稲住知明、白田成俊、瀬木-西田恵里、成宮周、杉本幸彦
  • Organizer: 第9回次世代を担う若手ファーマ・バイオフォーラム2010
  • Place of Presentation: 京都大学(京都)
• [Presentation] 急性炎症反応におけるPGE2-EP3受容体とPGI2-IP受容体シグナルの役割(優秀発表者賞受賞) (2009)
  • Author(s): 森本和志、白田成俊、森大介、高野裕嗣、田中智之、瀬木-西田恵里、杉本幸彦
  • Organizer: 第8回次世代を担う若手ファーマ・バイオフォーラム2009【優秀発表賞】
  • Place of Presentation: 名古屋市立大学(名古屋)
  • Year and Date: 2009-11-15
• [Presentation] 炎症性疾患におけるプロスタグランジンの新たな役割 (2009)
  • Author(s): 杉本幸彦
  • Organizer: 第3回薬学研究フォーラムin東京【招待講演】
  • Place of Presentation: 薬学会長井記念ホール(東京)
  • Year and Date: 2009-11-13
• [Presentation] アスピリンの標的:プロスタグランジンの作用発現機構 (2009)
  • Author(s): 杉本幸彦
  • Organizer: 第34回西日本薬剤学研修会【招待講演】
  • Place of Presentation: 九州大学九重研修所大分
  • Year and Date: 2009-09-04
• [Presentation] Roles of Prostaglandin E 2 and Its Receptors in the Acute Inflammation (2009)
  • Author(s): 杉本幸彦
  • Organizer: 4th International Conference on Phospholipases A2 and Lipid Mediators.【Invited】
  • Place of Presentation: National Center of Sciences(Tokyo)
  • Year and Date: 2009-05-26
• [Presentation] Roles of Prostaglandin E2 and Its Receptors in the Acute Inflammation (2009)
  • Author(s): Yukihiko Sugimoto
  • Organizer: 4th International Conference on Phospholipases A2 and Lipid Mediators
  • Place of Presentation: 学術総合センター、東京
  • Year and Date: 2009-05-26
• [Presentation] 脂肪細胞の分化と成熟におけるプロスタノイドの役割(シンポジウム「脂肪酸の代謝と機能制御」) (2009)
  • Author(s): 杉本幸彦
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-03-28
• [Presentation] プロスタグランジンーケモカインによる卵丘マトリクスの制御機構 (2009)
  • Author(s): 杉本幸彦
  • Organizer: 第40回精子研究会【招待講演】
  • Place of Presentation: 大阪大学(大阪)
  • Year and Date: 2009-01-10
• [Presentation] マウス胎児線維芽細胞の脂肪細胞への分化における内因性プロスタグランジンの役割 (2009)
  • Author(s): 稲住知明、白田成俊、瀬木-西田恵里、成宮周、杉本幸彦
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] プロスタノイド受容体を介した生殖生理作用の分子機構 (2008)
  • Author(s): 杉本幸彦
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] 複数の受容体を介したプロスタグランジンの子宮収縮は分娩に必須である (2008)
  • Author(s): 川崎友紀子, 藤原拓司, 安藤博之, 笈田浩次, 阿瀬善也, 瀬木(西田恵里), 成宮周, 杉本幸彦
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] プロスタグランジンEP4受容体による視索前野ニューロンの細胞骨格制御 (2008)
  • Author(s): 吉岡美樹, 瀬木(西田恵里), 杉本幸彦
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] 急性炎症反応におけるPGE2-EP3受容体とPGI2-IP受容体シグナルの役割 (2008)
  • Author(s): 森本和志, 白田成俊, 森大介, 高野裕嗣, 田中智之, 瀬木(西田恵里), 杉本幸彦
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] プロスタグランジンE 2(PGE 2)による神経ネットワーク制御 (2008)
  • Author(s): 吉岡美樹、瀬木-西田恵里、杉本幸彦
  • Organizer: ファーマ・バイオフォーラム2008
  • Place of Presentation: 日本薬学会長井記念ホール(東京)
• [Presentation] プロスタノイド受容体を介した生殖生理作用の分子機構(シンポジウム「脂質の新機能」) (2008)
  • Author(s): 杉本幸彦
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Presentation] 複数の受容体を介したプロスタグランジンの子宮収縮は分娩に必須である (2008)
  • Author(s): 川崎友紀子、藤原拓司、安藤博之、笈田浩次、阿瀬善也、瀬木-西田恵里、成宮周、杉本幸彦
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
• [Remarks] 研究室ホームページ
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• [Remarks]
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• [Patent(Industrial Property Rights)] ヒトプロスタグランジンE2受容体EP4に対する抗体 (2010)
  • Inventor(s): 高山喜好、清水朋子、漆畑祐司、杉本幸彦
  • Industrial Property Rights Holder: エヌビィー健康研究所・熊本大学
  • Industrial Property Number: 2010-218158
  • Filing Date: 2010-09-29
• [Patent(Industrial Property Rights)] 不妊治療剤、体外受精促進剤及び不妊治療剤のスクリーニング方法 (2010)
  • Inventor(s): 杉本幸彦、丹波茂郎、市川厚
  • Industrial Property Rights Holder: 杉本幸彦
  • Acquisition Date: 2010-07-23
• [Patent(Industrial Property Rights)] ヒトプロスタグランジンE_2受容体EP4に対する抗体 (2010)
  • Inventor(s): 高山喜好、清水朋子、漆畑祐司、杉本幸彦
  • Industrial Property Rights Holder: エヌビィー健康研究所・熊本大学
  • Industrial Property Number: 2010-218158
  • Filing Date: 2010-09-29