| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Research Abstract |
Pathogenic mechanisms of intracerebral hemorrhage, a neurological disorder for which no effective drug therapies are available, were investigated in experimental animal models. Potential therapeutic effects of drugs that regulate functions of microglia, brain-resident immune cell population were also investigated. Obtained results have revealed that excessively activated microglia contribute to brain tissue damage following intracerebral hemorrhage, and that several low-molecular-weight compounds such as synthetic retinoids can produce therapeutic effects.
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