Research on pathology and protection of intracerebral hemorrhage with special reference to microglial functions
| Project/Area Number |
20390026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
KATSUKI Hiroshi Kumamoto University, 大学院・生命科学研究部, 教授 (40240733)
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| Co-Investigator(Renkei-kenkyūsha) |
ISOHAMA Yoichiro 熊本大学, 大学院・生命科学研究部, 准教授 (10240920)
HISATSUNE Akinori 熊本大学, 大学院・生命科学研究部, 助教 (50347001)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 脳卒中 / トロンビン / ニコチン / レチノイド / ヘムオキシゲナーゼ / アポトーシス / 神経保護 / ミクログリア / 好中球 / 線条体 / 腫瘍壞死因子 / 脳内出血 / 神経細胞死 / ポリアミン / 大脳皮質 |
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| Research Abstract |
Pathogenic mechanisms of intracerebral hemorrhage, a neurological disorder for which no effective drug therapies are available, were investigated in experimental animal models. Potential therapeutic effects of drugs that regulate functions of microglia, brain-resident immune cell population were also investigated. Obtained results have revealed that excessively activated microglia contribute to brain tissue damage following intracerebral hemorrhage, and that several low-molecular-weight compounds such as synthetic retinoids can produce therapeutic effects.
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Report
(4 results)
Research Products
(102 results)
