| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
|
|---|
| Research Abstract |
In this study, I investigated possible involvement of calpain. Using gene-engineering techniques, I generated calpain activity-augmented and suppressed model mice, and clarified that calpain activation caused exacerbation of Aβamyloidosis, tau phosphorylation, microgliosis, somato-dendritic dystrophy and mortality. In addition, I found that vesicular GABA transporter (VGAT) is cleaved by calpain after excitotoxic stimulation or a cerebral ischemia model. These observations indicate that calpain activation may underlie Aβ-triggered pathological cascade and thus shall become a relevant pharmacological target in the treatment of AD.
|
