Photoaffinity capture for the identification of functional site within proteins of nano-mol amount
| Project/Area Number |
20390032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | University of Toyama |
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Principal Investigator |
HATANAKA Yasumaru University of Toyama, 大学院・医学薬学研究部, 教授 (30111181)
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| Co-Investigator(Kenkyū-buntansha) |
TOMOHIRO Takenori 富山大学, 大学院・医学薬学研究部(薬学), 准教授 (70357581)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 創薬基礎技術 / 薬物結合部位 / 質量分析 / 光アフィニティー / 光プローブ / 膜タンパク質 / 機能部位 / 構造解析 / ペルオキシソーム / β-酸化酵素 / ATP / 固相技術 |
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| Research Abstract |
Recent progress in the drug developments enables the computer aided design of new medicines which are often called as "molecular target drugs." The present research developed several novel photo-activatable probes that are effective for the analysis trace amount proteins. The application of this purobe was successful for solving important binding-site within a metabolic enzyme.
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Report
(4 results)
Research Products
(31 results)
