Development of drug candidates that epigenetically regulate gene expression

• Project/Area Number: 20390034
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Nagoya City University
• Principal Investigator: MIYATA Naoki 名古屋市立大学, 大学院・薬学研究科, 教授 (50114674)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Takayoshi 名古屋市立大学, 大学院・薬学研究科, 講師 (90372838) ; NAKAGAWA Hidehiko 名古屋市立大学, 大学院・薬学研究科, 准教授 (80281674)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000); Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2008: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: エピジェネティクス / 遺伝子発現制御 / 創薬分子設計 / ヒストン脱メチル化酵素阻害剤 / ヒストン脱アセチル化酵素阻害薬 / ヒストン脱アセチル化酵素阻害剤 / 制がん剤 / チューブリン

Research Abstract

Chromatin remodeling, caused by histone modifications, plays a crucial role in the regulation of epigenetic gene expression. Histone deacetylase(HDAC) and histone demethylase(HDME) were selected as target enzymes. Isozyme selective and highly active inhibitors against these enzymes were designed and synthesized. HDAC8, SIRT and HDAC3 selective and JMJD2, PHF8, LSD1 selective inhibitors were developed.

Research Products

• [Journal Article] Loss of deacetylation activity of hdac6 affects emotional behavior in mice (2012)
  • Author(s): Masahide Fukada
  • Journal Title: PLoS One Volume: 7 Issue: 2 Pages: e30924-e30924
  • DOI: 10.1371/journal.pone.0030924
  • Peer Reviewed
• [Journal Article] Lysine demethylases inhibitors (2011)
  • Author(s): Takayoshi Suzuki, Naoki Miyata
  • Journal Title: J. Med. Chem. Volume: 54 Pages: 8236-8250
• [Journal Article] Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor (2011)
  • Author(s): Daisuke Ogasawara
  • Journal Title: Bioorg.Med.Chem. Volume: 19 Issue: 12 Pages: 3702-3708
  • DOI: 10.1016/j.bmc.2010.12.024
  • Peer Reviewed
• [Journal Article] Lysine demethylases inhibitors (2011)
  • Author(s): Takayoshi Suzuki
  • Journal Title: J.Med.Chem. Volume: 54 Issue: 24 Pages: 8236-8250
  • DOI: 10.1021/jm201048w
  • Peer Reviewed
• [Journal Article] Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events (2011)
  • Author(s): Shusaku Uchida
  • Journal Title: Neuron Volume: 69 Issue: 2 Pages: 359-372
  • DOI: 10.1016/j.neuron.2010.12.023
  • Peer Reviewed
• [Journal Article] Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression (2011)
  • Author(s): Ann Florence B
  • Journal Title: Fed.Eur.Biochem.Soc.Lett Volume: 585 Issue: 7 Pages: 1103-1111
  • DOI: 10.1016/j.febslet.2011.03.017
  • Peer Reviewed
• [Journal Article] Design, Synthesis, Enzyme-inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors (2010)
  • Author(s): Shohei Hamada, Takayoshi Suzuki, Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme, Hiroki Ozasa, Yukihiro Itoh, Daisuke Ogasawara, Haruka Komaarashi, Aiko Katoh, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki
  • Journal Title: J. Med. Chem. Volume: 53 Pages: 5629-5638
• [Journal Article] An Unexpected Example of Copper-Mediated In Situ Click Chemistry (2010)
  • Author(s): Takayoshi Suzuki, Yosuke Ota, Yuki Kasuya, Motoh Mutsuga, Yoko Kawamura, Hiroki Tsumoto, Hidehiko Nakagawa, M. G. Finn, Naoki Miyata
  • Journal Title: Angew. Chem. Int. Ed. Engl. Volume: 49 Pages: 6817-6820
• [Journal Article] Design, Synthesis, Enzyme-inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors (2010)
  • Author(s): Shohei Hamada, Takayoshi Suzuki, Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme, Hiroki Ozasa, Yukihiro Itoh, Daisuke Ogasawara, Haruka Komaarashi, Aiko Katoh, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata
  • Journal Title: J.Med.Chem. 53 Pages: 5629-5638
  • Peer Reviewed
• [Journal Article] An Unexpected Example of Copper-Mediated In Situ Click Chemistry (2010)
  • Author(s): Takayoshi Suzuki, Yosuke Ota, Yuki Kasuya, Motoh Mutsuga, Yoko Kawamura, Hiroki Tsumoto, Hidehiko Nakagawa, M.G.Finn, Naoki Miyata
  • Journal Title: Angew.Chem.Int.Ed.Engl. 49 Pages: 6817-6820
  • Peer Reviewed
• [Journal Article] Design, Synthesis, Enzyme-inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors (2010)
  • Author(s): Shohei Hamada
  • Journal Title: J.Med.Chem. Volume: 53 Pages: 5629-5638
  • Peer Reviewed
• [Journal Article] An Unexpected Example of Copper-Mediated In Situ Click Chemistry (2010)
  • Author(s): Takayoshi Suzuki
  • Journal Title: Angew.Chem.Int.Ed.Engl. Volume: 49 Pages: 6817-6820
  • Peer Reviewed
• [Journal Article] Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors (2010)
  • Author(s): Takayoshi Suzuki
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 20 Pages: 1124-1127
  • Peer Reviewed
• [Journal Article] Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors (2009)
  • Author(s): Rie Ueda, Takayoshi Suzuki, Koshiki Mino, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata
  • Journal Title: J. Am. Chem. Soc. Volume: 131 Pages: 17536-17537
• [Journal Article] Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate (2009)
  • Author(s): Tomomi Asaba, Takayoshi Suzuki, Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
  • Journal Title: J. Am. Chem. Soc. Volume: 31 Pages: 6989-6996
• [Journal Article] Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors (2009)
  • Author(s): Nobuaki Suzuki, Takayoshi Suzuki, Yosuke Ota, Tatsuya Nakano, Masaaki Kurihara, Haruhiro Okuda, Takao Yamori, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
  • Journal Title: J. Med. Chem. Volume: 52 Pages: 2909-2922
• [Journal Article] Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors (2009)
  • Author(s): Rie Ueda, Takayoshi Suzuki, Koshiki Mino, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 17536-17537
  • Peer Reviewed
• [Journal Article] Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate (2009)
  • Author(s): Tomomi Asaba, Takayoshi Suzuki, Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 6989-6996
  • Peer Reviewed
• [Journal Article] Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors (2009)
  • Author(s): Nobuaki Suzuki, Takayoshi Suzuki, Yosuke Ota, Tatsuya Nakano, Masaaki Kurihara, Haruhiro Okuda, Takao Yamori, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyata
  • Journal Title: J.Med.Chem. 52 Pages: 2909-2922
  • Peer Reviewed
• [Journal Article] Identification of Cell-Active Lysine Specific Demethylase 1-Selective Inhibitors (2009)
  • Author(s): Rie Ueda
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 17536-17537
  • Peer Reviewed
• [Journal Article] Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine (2009)
  • Author(s): Takayoshi Suzuki
  • Journal Title: Bioorg.Med.Chem.Lett. 19 Pages: 5670-5672
  • Peer Reviewed
• [Journal Article] Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors (2009)
  • Author(s): Takayoshi Suzuki
  • Journal Title: Bioorg.Med.Chem. 17 Pages: 5900-5905
  • Peer Reviewed
• [Journal Article] Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate (2009)
  • Author(s): Tomomi Asaba
  • Journal Title: J.Am.Chem.Soc. 131 Pages: 6989-6996
  • Peer Reviewed
• [Journal Article] Design, Synthesis, and Biological Activity of Boronic acid-Based Histone Deacetylase Inhibitors (2009)
  • Author(s): Nobuaki Suzuki
  • Journal Title: J.Med.Chem. 52 Pages: 2909-2922
  • Peer Reviewed
• [Journal Article] Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors (2009)
  • Author(s): Shohei Hamada
  • Journal Title: Bioorg.Med.Chem.Lett. 19 Pages: 2852-2855
  • Peer Reviewed
• [Journal Article] Non-Hydroxamate Histone Deacetylase Inhibitors (2009)
  • Author(s): Takayoshi Suzuki
  • Journal Title: Frontiers in Medicinal Chemistry 4 Pages: 619-641
  • Peer Reviewed
• [Journal Article] Inhibition of Human Sirtuins by In Situ Generation of an Acetylated Lysine-ADP-ribose Conjugate (2009)
  • Author(s): Tomomi Asaba
  • Journal Title: J. Am. Chem. Soc. 129(in press)
  • Peer Reviewed
• [Journal Article] Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors (2009)
  • Author(s): Shohei Hamada
  • Journal Title: Bioorg. Med. Chem. Lett. 19(in press)
  • Peer Reviewed
• [Journal Article] Microtuble Acetylation Through HDAC6 Inhibition Results in Increased Transfection Efficiency (2008)
  • Author(s): Erin E. Vaughan
  • Journal Title: Mol. Ther. 16 Pages: 1841-1847
  • Peer Reviewed
• [Journal Article] HDAC6選択的阻害薬 (2008)
  • Author(s): 伊藤幸裕
  • Journal Title: 医学のあゆみ 224 Pages: 71-74
• [Journal Article] Isoform-selective histone deacetylase inhibitors (2008)
  • Author(s): Yukihiro Itoh
  • Journal Title: Current Pharmaceutical Design 14 Pages: 529-544
  • Peer Reviewed
• [Presentation] Discovery of isozyme-selective histone deacetylase inhibitors by click chemistry (2012)
  • Author(s): Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata, et. al.
  • Organizer: ACS National Meetng, Sprong 2012
  • Place of Presentation: San Diego
  • Year and Date: 2012-03-25
• [Presentation] Design, synthesis, and biological evaluation of cyclopropylamine-based LSD1 inhibitors (2012)
  • Author(s): Daisuke Ogasawara
  • Organizer: ACS National Meetng, Sprong 2012
  • Place of Presentation: San Diego
  • Year and Date: 2012-03-25
• [Presentation] Design, synthesis, and biological activity of JMJD2 histone demethylase inhibitors (2012)
  • Author(s): Hiroki Ozasa
  • Organizer: ACS National Meetng, Sprong 2012
  • Place of Presentation: San Diego
  • Year and Date: 2012-03-25
• [Presentation] Discovery of SIRT2-selective inhibitors (2012)
  • Author(s): Hideyuki Sawada
  • Organizer: ACS National Meetng, Sprong 2012
  • Place of Presentation: San Diego
  • Year and Date: 2012-03-25
• [Presentation] Click chemistryを用いたHDAC3選択的阻害薬の探索 (2012)
  • Author(s): 粕谷侑輝
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
• [Presentation] ヒストン脱メチル化酵素の阻害薬認識におけるCH…O水素結合の重要性 (2011)
  • Author(s): 小笹弘貴
  • Organizer: 第57回日本薬学会東海支部総会・本会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-09
• [Presentation] Synthesis and biological activity of N-alkylated analogues of NCL-1, a lysine-specific demethylase 1 selective inhibitor (2011)
  • Author(s): Mohammed Naseer Ahmed Khan
  • Organizer: 第57回日本薬学会東海支部総会・本会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-09
• [Presentation] Design, Synthesis, and Biological Activity of cyclopropylamine-based LSD1 inhibitor (2011)
  • Author(s): Daisuke Ogasawara, Takayoshi Suzuki, Hidehiko Nakagawa, Naoki Miyata, et. al.
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: 東京
• [Presentation] 創薬化学のすすめ:タンパク質の翻訳後修飾を阻害する化合物の創生を例にして (2011)
  • Author(s): 宮田直樹
  • Organizer: 創薬懇話会2011
  • Place of Presentation: 岡山
• [Presentation] HDAC8選択的阻害剤の創製とその応用 (2011)
  • Author(s): 鈴木孝禎
  • Organizer: 日本ケミカルバイオロジー学会第6年会
  • Place of Presentation: 東京
• [Presentation] 創薬化学のすすめ:タンパク質の翻訳後修飾酵素を阻害する化合物の創製を例にして (2011)
  • Author(s): 宮田直樹
  • Organizer: 創薬懇話会2011 in岡山
  • Place of Presentation: 岡山(招待講演)
• [Presentation] ヒストン脱メチル化酵素JMJD2の阻害薬認識におけるCH…O水素結合の重要性 (2011)
  • Author(s): 小笹弘貴
  • Organizer: 創薬懇話会2011 in岡山
  • Place of Presentation: 岡山
• [Presentation] 銅触媒in situクリックケミストリー (2011)
  • Author(s): 粕谷侑輝
  • Organizer: 創薬懇話会2011 in岡山
  • Place of Presentation: 岡山
• [Presentation] Protein-Templated Copper-Catalyzed Azide-Alkyne Cycloaddition (2011)
  • Author(s): Takayoshi Suzuki
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: 東京
• [Presentation] Discovery of Isozyme-Selective Histone Deacetylase Inhibitor by Click Chemistry (2011)
  • Author(s): Yuki Kasuya
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: 東京
• [Presentation] The Importance of CH…O Hydrogen Bond in Protein-Ligand Binding (2011)
  • Author(s): Hiroki Ozasa
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: 東京
• [Presentation] LSD1選択的阻害薬NCL1の光学活性体の合成,構造決定および生物活性評価 (2010)
  • Author(s): 小笠原大介
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2010
  • Place of Presentation: 静岡県立大学(静岡)
  • Year and Date: 2010-11-28
• [Presentation] エピジェネティックに遺伝子発現を制御する低分子化合物の設計と合成 (2010)
  • Author(s): 宮田直樹
  • Organizer: 第38回構造活性相関シンポジウム
  • Place of Presentation: 徳島
  • Year and Date: 2010-10-31
• [Presentation] エピジェネティックに遺伝子発現を制御する低分子化合物の設計と合成 (2010)
  • Author(s): 宮田直樹
  • Organizer: 第38回構造活性相関シンポジウム
  • Place of Presentation: 徳島大学(徳島)招待講演
  • Year and Date: 2010-10-31
• [Presentation] エピジェネティックに遺伝子発現を制御する低分子化合物の設計と合成 (2010)
  • Author(s): 宮田直樹
  • Organizer: 第38回構造活性相関シンポジウム
  • Place of Presentation: 徳島大学(徳島)(招待講演)
  • Year and Date: 2010-10-31
• [Presentation] azide-alkyne環化付加反応を触媒するCu-蛋白質複合体の発見 (2010)
  • Author(s): 粕谷侑輝
  • Organizer: 第56回日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜薬科大学(岐阜)
  • Year and Date: 2010-07-03
• [Presentation] 低分子型LSD1選択的阻害薬の創製 (2010)
  • Author(s): 上田理恵
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] Click Chemistry を用いたHDAC8選択的阻害薬の創製 (2010)
  • Author(s): 太田庸介
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] Jumonji Cドメインを含むヒストン脱メチル化酵素阻害薬の創製 (2010)
  • Author(s): 浜田翔平
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] Discovery of selective inhibitors of lysine specific demethylase-1 (2010)
  • Author(s): T. Suzuki, H. Nakagawa, N. Miyata, et. al.
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu, USA
• [Presentation] Identification of isozyme-selective histone deacetylase inhibitors by click chemistry (2010)
  • Author(s): Y. Kasuya, N. Miyata, et. al.
  • Organizer: Pacifichem2010
  • Place of Presentation: Honolulu, USA
• [Presentation] Discovery of selective inhibitors of lysine specific demethylase-1 (2010)
  • Author(s): T.Suzuki, 宮田直樹, et.al.
  • Organizer: Pacifichem2010
  • Place of Presentation: Honolulu, USA.
• [Presentation] Identification of isozyme-selective histone deacetylase inhibitors by click chemistry (2010)
  • Author(s): Y. Kasuya, 宮田直樹, et.al.
  • Organizer: Pacifichem2010
  • Place of Presentation: Honolulu, USA.
• [Presentation] Discovery of selective inhibitors of lysine specific demethylase-1 (2010)
  • Author(s): T.Suzuki
  • Organizer: Pacifichem2010
  • Place of Presentation: Honolulu, USA
• [Presentation] シクロプロピルアミン構造を基にしたLSD1選択的阻害薬の設計・合成と生物活性評価 (2009)
  • Author(s): 上田理恵
  • Organizer: 創薬懇話会2009 in 岐阜
  • Place of Presentation: 岐阜
  • Year and Date: 2009-12-10
• [Presentation] in situ click chemistry を用いたHDAC阻害薬の創製 (2009)
  • Author(s): 太田庸介
  • Organizer: 創薬懇話会2009 in 岐阜
  • Place of Presentation: 岐阜
  • Year and Date: 2009-12-10
• [Presentation] N-oxalylglycine をリード化合物としたヒストン脱メチル化酵素JHDM阻害薬の設計, 合成と活性評価 (2009)
  • Author(s): 浜田翔平
  • Organizer: 創薬懇話会2009 in 岐阜
  • Place of Presentation: 岐阜
  • Year and Date: 2009-12-10
• [Presentation] LSD1選択的阻害薬の設計・合成と生物活性評価 (2009)
  • Author(s): 上田理恵
  • Organizer: 第28回メディシナルケミストリーシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-11-25
• [Presentation] Click Chemistry を用いたHDAC8阻害薬の創製 (2009)
  • Author(s): 太田庸介
  • Organizer: 第28回メディシナルケミストリーシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-11-25
• [Presentation] N-oxalylglycine 誘導体の合成及びヒストン脱メチル化酵素JMJD2阻害活性評価 (2009)
  • Author(s): 浜田翔平
  • Organizer: 第28回メディシナルケミストリーシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-11-25
• [Presentation] ヒストン脱メチル化酵素LSD1選択的阻害薬の創製 (2009)
  • Author(s): 上田理恵
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2009
  • Place of Presentation: 四日市
  • Year and Date: 2009-11-23
• [Presentation] Click Chemistry を用いたHDAC8阻害薬の探索 (2009)
  • Author(s): 太田庸介
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2009
  • Place of Presentation: 四日市
  • Year and Date: 2009-11-23
• [Presentation] エエピジェネティックに遺伝子発現を制御する化合物:新たな制がん剤の開発をめざして (2009)
  • Author(s): 宮田直樹
  • Organizer: 第2回Cancer Research Seminar
  • Place of Presentation: 愛知
  • Year and Date: 2009-11-18
• [Presentation] エエピジェネティックに遺伝子発現を制御する化合物:新たな制がん剤の開発をめざして (2009)
  • Author(s): 宮田直樹
  • Organizer: 第2回Cancer Research Seminar
  • Place of Presentation: 名古屋市立大学(愛知)
  • Year and Date: 2009-11-18
• [Presentation] エピジェネティックに遺伝子発現を制御する化合物:新たな制がん剤の開発をめざして (2009)
  • Author(s): 宮田直樹
  • Organizer: 第2回 Cancer Research Seminar
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-18
• [Presentation] 触媒メカニズムに基づいたSIRT阻害薬の創製 (2009)
  • Author(s): 鈴木孝禎
  • Organizer: 第7回次世代を担う有機化学シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-24
• [Presentation] Jumonji Cドメインを持つヒストン脱メチル化酵素阻害薬の設計, 合成と生物活性評価 (2009)
  • Author(s): 浜田翔平
  • Organizer: 第55回日本薬学会東海支部総会・大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-11
• [Presentation] HDAC6非感受性阻害薬の創製とその多発性骨髄腫細胞増殖抑制機構の解明 (2009)
  • Author(s): 宮田直樹、他
  • Organizer: 日本ケミカルバイオロジー学会第4回年会
  • Place of Presentation: 兵庫
  • Year and Date: 2009-05-19
• [Presentation] HDAC6非感受性阻害薬の創製とその多発性骨髄腫細胞増殖抑制機構の解明 (2009)
  • Author(s): 宮田直樹, 他
  • Organizer: 日本ケミカルバイオロジー学会第4回年会
  • Place of Presentation: 神戸(兵庫)
  • Year and Date: 2009-05-19
• [Presentation] HDAC6非感受性障害薬の創製とその多発性骨髄腫細胞増殖抑制機構の解明 (2009)
  • Author(s): 宮田直樹
  • Organizer: 日本ケミカルバイオロジー学会 第4回年会
  • Place of Presentation: 神戸
  • Year and Date: 2009-05-19
• [Presentation] HDAC6選択的阻害薬の創製とその応用 (2009)
  • Author(s): 鈴木孝禎
  • Organizer: 日本ケミカルバイオロジー学会 第4回年会
  • Place of Presentation: 神戸
  • Year and Date: 2009-05-18
• [Presentation] 触媒メカニズムを基にした新規SIRT阻害薬の創製と阻害メカニズム解析 (2009)
  • Author(s): 浅場智美
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] 触媒メカニズムを基に設計したボロン酸を有するHDAC阻害薬の創製 (2009)
  • Author(s): 鈴木信明
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] アイソフォーム選択的ヒストン脱アセチル化酵素阻害薬の創製研究 (2009)
  • Author(s): 鈴木孝禎
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] JMJD2阻害薬の設計, 合成と生物活性評価 (2009)
  • Author(s): 浜田翔平
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] ボロン酸を有する新規HDAC阻害薬の創製 (2008)
  • Author(s): 鈴木信明
  • Organizer: 第27回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-26
• [Presentation] 新規SIRT阻害薬の創製と酵素阻害メカニズムの解析 (2008)
  • Author(s): 浅場智美
  • Organizer: 第27回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-26
• [Presentation] ボロン酸を有する新規HDAC阻害薬の設計、合成と活性評価 (2008)
  • Author(s): 鈴木信明
  • Organizer: 第54回日本薬学会東海支部大会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-07-05
• [Remarks] 新聞/WEB報道朝日新聞、読売新聞、平成24年2月16日。共同通信、平成24年2月16日。
  • URL: http://www.47news.jp/CN/201202/CN2012021601001686.html
• [Remarks] 専門学術紹介記事SciBX, 46, p. 3,(2009).
• [Remarks]
  • URL: http://www.phar.nagoya-cu.ac.jp/hp/ykg/Yakka/index.html
• [Remarks]
  • URL: http://www.phar.nagoya-cu.ac.jp/hp/ykg/Yakka/index.html
• [Remarks]
  • URL: http://www.phar.nagoya-cu.ac.jp/research_course/res_course01.html
• [Remarks]
  • URL: http://www.phar.nagoya-cu.ac.jp/research_course/res_course01.html
• [Remarks]
  • URL: http://www.phar.nagoya-cu.ac.jp/hp/ykg/Yakka/index.html
• [Patent(Industrial Property Rights)] 新規ヒドロキサム酸誘導体及びその用途 (2012)
  • Inventor(s): 宮田直樹、他
  • Industrial Property Rights Holder: 名古屋市立大学、他
  • Filing Date: 2012-02-24
• [Patent(Industrial Property Rights)] 新規アミド化合物及びその用途 (2012)
  • Inventor(s): 宮田直樹、他
  • Industrial Property Rights Holder: 名古屋市立大学
  • Filing Date: 2012-02-23
• [Patent(Industrial Property Rights)] 新規アミド化合物及びその用途 (2012)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 公立大学法人名古屋市立大学
  • Industrial Property Number: 2012-037082
  • Filing Date: 2012-02-23
• [Patent(Industrial Property Rights)] 新規ヒドロキサム酸誘導体及びその用途 (2012)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 公立大学法人名古屋市立大学, 他
  • Industrial Property Number: 2012-038977
  • Filing Date: 2012-02-24
• [Patent(Industrial Property Rights)] 抗うつ薬及びその用途 (2010)
  • Inventor(s): 宮田直樹、他
  • Industrial Property Rights Holder: 名古屋市立大学、他
  • Filing Date: 2010-09-02
• [Patent(Industrial Property Rights)] HIV複製阻害剤 (2010)
  • Inventor(s): 宮田直樹、他
  • Industrial Property Rights Holder: 名古屋市立大学、他
  • Filing Date: 2010-08-06
• [Patent(Industrial Property Rights)] ヒドロキサム酸誘導体及びそれを用いたHDAC8阻害剤 (2010)
  • Inventor(s): 宮田直樹、他
  • Industrial Property Rights Holder: 名古屋市立大学、他
  • Filing Date: 2010-01-21
• [Patent(Industrial Property Rights)] ヒドロキサム酸誘導体及びJHDM阻害剤 (2010)
  • Inventor(s): 宮田直樹、他
  • Industrial Property Rights Holder: 名古屋市立大学、他
  • Filing Date: 2010-01-20
• [Patent(Industrial Property Rights)] 抗うつ薬及びその用途 (2010)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Filing Date: 2010-09-02
• [Patent(Industrial Property Rights)] HIV複製阻害剤 (2010)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Filing Date: 2010-08-06
• [Patent(Industrial Property Rights)] ヒドロキサム酸誘導体及びそれを用いたHDAC8阻害剤 (2010)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Filing Date: 2010-01-21
• [Patent(Industrial Property Rights)] ヒドロキサム酸誘導体及びJHDM阻害剤 (2010)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Filing Date: 2010-01-20
• [Patent(Industrial Property Rights)] LSD阻害剤 (2010)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Filing Date: 2010-06-11
• [Patent(Industrial Property Rights)] HIV複製阻害剤 (2010)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Filing Date: 2010-08-06
• [Patent(Industrial Property Rights)] 抗うつ薬及びその用途 (2010)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Filing Date: 2010-09-02
• [Patent(Industrial Property Rights)] ヒドロキサム酸誘導体及びJHDM阻害剤 (2010)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Industrial Property Number: 2010-009834
  • Filing Date: 2010-01-20
• [Patent(Industrial Property Rights)] ヒドロキサム酸誘導体及びそれを用いたHDAC8阻害剤 (2010)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Industrial Property Number: 2010-011431
  • Filing Date: 2010-01-21
• [Patent(Industrial Property Rights)] LSD阻害剤 (2009)
  • Inventor(s): 宮田直樹、他
  • Industrial Property Rights Holder: 名古屋市立大学、他
  • Filing Date: 2009-06-11
• [Patent(Industrial Property Rights)] LSD阻害剤 (2009)
  • Inventor(s): 宮田直樹, 他
  • Industrial Property Rights Holder: 名古屋市立大学, 他
  • Industrial Property Number: 2009-140553
  • Filing Date: 2009-06-11