Studies on synthetic antioxidants for prevention of oxidative stress-related diseases

• Project/Area Number: 20390038
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: National Institute of Health Sciences
• Principal Investigator: FUKUHARA Kiyoshi 国立医薬品食品衛生研究所, 有機化学部, 室長 (70189968)
• Co-Investigator(Kenkyū-buntansha): OKUDA Haruhiro 国立医薬品食品衛生研究所, 副所長 (30160807) ; UMEMURA Takashi 国立医薬品食品衛生研究所, 病理部, 室長 (50185071) ; OHNO Akiko 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 (70356236) ; SYODA Takuji 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 (60435708)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 抗酸化剤 / カテキン / 酸化ストレス / アルツハイマー病 / ビタミンE / ポリフェノール / 生活習慣病 / アルツハイマー / アルツハマー / レスベートロール / 活性酸素

Research Abstract

The development of antioxidants with strong radical-scavenging activities has attracted considerable attention in recent years for preventing oxidative stress related diseases. We focused on the chemical modification of natural catechin to improve its pharmacological properties with the aim of developing clinically useful chemopreventive agents. Treatment of catechin with ketone by way of an Oxa-Pictet-Spengler reaction enabled the structure of catechin to be planar. Thus synthesized planar catechin analogues showed strong antioxidative activity. We also synthesized catechin analogues (CN) having nynhidrin structure. These catechin analogues significantly blocked the self-aggregation of s-amyloid and reduced the neuronal viability loss evoked by s-amyloid.

Research Products

• [Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: identification of oxidative stress biomarkers (2013)
  • Author(s): Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., Takikawa, O
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 52 Issue: 2 Pages: 133-138
  • DOI: 10.3164/jcbn.12-118
  • NAID: 130004466706
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Comparison of in vivo and in vitro antioxidative parameters for eleven food factors (2013)
  • Author(s): H. P. Indo
  • Journal Title: RSC Advances Volume: 3 Issue: 14 Pages: 4535-4538
  • DOI: 10.1039/c3ra22686g
  • Peer Reviewed
• [Journal Article] Kinetics and Mechanism for the Scavenging Reaction of the 2,2-Diphenyl-1-picrylhydrazyl Radical by Synthetic Artepillin C Analogues (2012)
  • Author(s): T. Kawashima, S. Manda, Y. Uto, K. Ohkubo, H. Hori, K. Matsumoto, K. Fukuhara, N. Ikota, S. Fukuzumi, T. Ozawa, K. Anzai, I. Nakanishi
  • Journal Title: Bulletin of the Chemical Society of Japan Volume: 85 Issue: 8 Pages: 877-883
  • DOI: 10.1246/bcsj.20120005
  • NAID: 130004153096
  • ISSN: 0009-2673, 1348-0634
  • Peer Reviewed
• [Journal Article] Chlorine atom substitution infuluences radical scavenging activity of 6-chromanol (2012)
  • Author(s): K. Inami, Y. Ishizuka, M. Furukawa, I. Nakanishi, K. Ohkubo, K. Fukuhara, S. Fukuzumi, M. Mochizuki
  • Journal Title: Bioorg. Med. Chem Volume: 20 Issue: 13 Pages: 4049-4055
  • DOI: 10.1016/j.bmc.2012.05.008
  • Peer Reviewed
• [Journal Article] Determination of Lusidin-specific DNA adducts by liquid chromatography with tandem mass spectrometry in the livers and kidneys of rats given Lucidin-3-O-primeveroside (2012)
  • Author(s): Y. Ishii, K. Inoue, S. Takasu, M. Jin, K. Matsushita, K. Kuroda, K. Fukuhara, A. Nishikawa, T. Umemura
  • Journal Title: Chem. Res. Toxicol Volume: 25 Issue: 5 Pages: 1112-1118
  • DOI: 10.1021/tx300084p
  • Peer Reviewed
• [Journal Article] A New Approach to Characterization of Insulin Derived from Different Species Using 1H-NMR Coupled with Multivariate Analysis (2012)
  • Author(s): A. Ohno, T. Kawanishi, H. Okuda, K. Fukuhara, K.
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 60 Issue: 3 Pages: 320-324
  • DOI: 10.1248/cpb.60.320
  • NAID: 130001852416
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy (2012)
  • Author(s): Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
  • Journal Title: Bioorg. Med. Chem. Lett. Volume: 22 Issue: 4 Pages: 1793-1796
  • DOI: 10.1016/j.bmcl.2011.11.086
  • Peer Reviewed
• [Journal Article] Synthesis and enhanced radical scavenging activity of a conformationally constrained epigallocatechin analogue (2011)
  • Author(s): K. Imai, I. Nakanishi, A. Anzai, T. Ozawa, N. Miyata, S. Urano, H. Okuda, A. Nakamura, K. Fukuhara
  • Journal Title: Chem. Lett. Volume: 40 Issue: 12 Pages: 1417-1419
  • DOI: 10.1246/cl.2011.1417
  • NAID: 10030221524
  • Peer Reviewed
• [Journal Article] Peroxynitrite generation from a NO-releasing nitrobenzene derivative in response to photoirradiation (2011)
  • Author(s): N. Ieda, H. Nakagawa, T. Horinouchi, T. Peng, D. Yang, H. Tsumoto, T. Suzuki, K. Fukuhara, N. Miyata
  • Journal Title: Chem. Comm. Volume: 47 Issue: 22 Pages: 6449-6451
  • DOI: 10.1039/c1cc11681a
  • Peer Reviewed
• [Journal Article] A 1H NMR-based Metabolomics Approach for Mechanistic Insight into Acetaminophen-induced Hepatotoxicity (2011)
  • Author(s): K. Fukuhara, A. Ohno, Y. Ando, T. Yamoto, H. Okuda
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 26 Issue: 4 Pages: 399-406
  • DOI: 10.2133/dmpk.DMPK-11-RG-005
  • NAID: 130004463199
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed
• [Journal Article] Photoinduced nitric oxide release from a nitrobenzene derivative in mitchondria (2011)
  • Author(s): T. Horinouchi, H. Nakagawa, T. Suzuki, K. Fukuhara, N. Miyata
  • Journal Title: Chem. Eur. J. Volume: 17 Issue: 17 Pages: 4809-4813
  • DOI: 10.1002/chem.201001967
  • Peer Reviewed
• [Journal Article] Characterization of Tea Cultivated at Four Different Altitudes Using 1H NMR Analysis Coupled with Multivariate Statistics (2011)
  • Author(s): A. Ohno, K. Oka, C. Sakuma, H. Okuda, K. Fukuhara
  • Journal Title: J. Agric. Food Chem Volume: 59 Issue: 10 Pages: 5181-5187
  • DOI: 10.1021/jf200204y
  • Peer Reviewed
• [Journal Article] Detection and quantification of specific-DNA adducts by LC-MS/MS in the livers of rats given estragole at the carcinogenic dose (2011)
  • Author(s): Y. Ishii, Y, Suzuki, D. Hibi, M. Jin, K. Fukuhara, T. Umemura, A. Nishikawa
  • Journal Title: Chem. Res. Toxico Volume: 24 Issue: 4 Pages: 532-541
  • DOI: 10.1021/tx100410y
  • Peer Reviewed
• [Journal Article] Enzyme-assisted synthesis of the glucuronide conjugate of psilocin, a hall ucinogenic component of magic mushroom (2011)
  • Author(s): T.Shoda
  • Journal Title: Drug Test.Analysis Volume: 3 Issue: 9 Pages: 594-596
  • DOI: 10.1002/dta.244
  • Peer Reviewed
• [Journal Article] A novel mitchondria-localizing nitrobenzene derivative as a donor for photouncaging of nitric oxide (2011)
  • Author(s): T.Horinouchi
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 21 Pages: 2000-2002
  • Peer Reviewed
• [Journal Article] Complete NMR analysis of oxytocin in phosphate buffer (2010)
  • Author(s): A. Ohno, N. Kawasaki, K. Fukuahra, H. Okuda, T. Yamaguchi
  • Journal Title: Magn. Reson. Chem Volume: 48 Issue: 2 Pages: 168-172
  • DOI: 10.1002/mrc.2557
  • Peer Reviewed
• [Journal Article] Chemical structure determination of DNA base modfided by active metabolites of lucidin-3-O-primeveroside (2010)
  • Author(s): Y.Ishii
  • Journal Title: Chem.Res.Toxicol. Volume: 23 Pages: 134-141
  • Peer Reviewed
• [Journal Article] Multiple bond-conjugated photoinduced nitric oxide releaser working with two-photon excitation (2010)
  • Author(s): K.Hishikawa
  • Journal Title: Bioorg.Med.Chem.Lett. Volume: 20 Pages: 302-305
  • Peer Reviewed
• [Journal Article] Complete NMR analysis of oxytocin in phosphate buffer (2010)
  • Author(s): A.Ohno
  • Journal Title: Magn.Reson.Chem. 48 Pages: 168-172
  • Peer Reviewed
• [Journal Article] Intramolecular base-accelerated radicalscavenging reaction of a planar catechin derivative having a lysine moiety (2009)
  • Author(s): K. Fukuahra, I. Nakanishi, K. Ohkubo, Y. Obara, A. Tada, K. Imai, A. Ohno, A. Nakamura, T. Ozawa, S. Urano, S. Saito, S. Fukuzumi, K. Anzai, N. Miyata, H. Okuda
  • Journal Title: Chem. Comm. Issue: 41 Pages: 6180-6182
  • DOI: 10.1039/b913714a
  • Peer Reviewed
• [Journal Article] Photoinduced Nitric Oxide Release from a Hindered Nitrobenzene Derivative by Two-Photon Excitation (2009)
  • Author(s): K. Hishikawa, H. Nakagawa, K. Fukuhara, H. Tsumoto, T. Suzuki, N. Miyata
  • Journal Title: J. Am. Chem. Soc. Volume: 131 Issue: 22 Pages: 7488-7489
  • DOI: 10.1021/ja8093668
  • Peer Reviewed
• [Journal Article] Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative having a lysine moiety (2009)
  • Author(s): K.Fukuahra, I.Nakanishi, K.Ohkubo, Y.Obara, A.Tada, K.Imai, A.Ohno, A.Nakamura, T.Ozawa, S.Urano, S.Saito, S.Fukuzumi, K.Anzai, N.Miyata, H.Okuda
  • Journal Title: Chem.Comm. Pages: 6180-6182
  • Peer Reviewed
• [Journal Article] Novel Ninhydrin adduct of catechin with potent antioxidative activity (2009)
  • Author(s): K.Fukuhara, A.Ohno, I.Nakanishi, K.Imai, A.Nakamura, K.Anzai, N.Miyata, H.Okuda
  • Journal Title: Tetrahedron Lett. 50 Pages: 6989-6992
  • Peer Reviewed
• [Journal Article] Photoinduced Nitric Oxide Release from a Hindered Nitrobenzene Derivative by Two-Photon Excitation (2009)
  • Author(s): K.Hishikawa
  • Journal Title: J.Am.Chem.Soc 131 Pages: 7488-7489
  • Peer Reviewed
• [Journal Article] Intramolecular base-accelerated radical-scavenging reaction of a planar catechin derivative having a lysine moiety (2009)
  • Author(s): K.Fukuahra
  • Journal Title: Chem.Comm. Pages: 6180-6182
  • Peer Reviewed
• [Journal Article] Time-dependent changes of oxytocin using 1H NMR coupled with multivariate an alysis : a new approach for quality evaluation of protein/peptide biologic drugs (2009)
  • Author(s): A.Ohno
  • Journal Title: Chem.Pharm.Bull. 57 Pages: 1396-1399
  • Peer Reviewed
• [Journal Article] Novel Ninhydrin adduct of catechin with potent antioxidative activity (2009)
  • Author(s): K.Fukuhara
  • Journal Title: Tetrahedron Lett. 50 Pages: 6989-6992
  • Peer Reviewed
• [Journal Article] The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease (2008)
  • Author(s): H. Kobayashi, K. Fukuhara, S. Tada-Oikawa, Y. Yada, Y. Hiraku, M. Murata, S. Oikawa
  • Journal Title: J. Neurochem Volume: 108 Pages: 397-407
  • Peer Reviewed
• [Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol (2008)
  • Author(s): K. Fukuhara, I. Nakanishi, A. Matsuoka, T. Matsumura, S. Honda, M. Hayashi, T. Ozawa, N. Miyata, S. Saito, N. Ikota, H. Okuda
  • Journal Title: Chem. Res. Toxicol Volume: 21 Issue: 2 Pages: 282-287
  • DOI: 10.1021/tx7003008
  • Peer Reviewed
• [Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol (2008)
  • Author(s): K.Fukuhara, I.Nakanishi, A.Matsuoka, T.Matsumura, S.Honda, M.Hayashi, T.Ozawa, N.Miyata, S.Saito, N.Ikota, H.Okuda
  • Journal Title: Chem.Res.Toxicol. 21 Pages: 282-287
  • Peer Reviewed
• [Journal Article] The mechanisms of oxidative DNA damage and apoptosis induced by norsal solinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease (2008)
  • Author(s): H. Kobayashi, K. Fukuhara, M. Murata, S. Oikawa
  • Journal Title: J. Neurochem. 108 Pages: 397-407
  • Peer Reviewed
• [Journal Article] Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol (2008)
  • Author(s): K. Fukuhara, I. Nakanishi, A. Matsuoka, H Okuda, et. al.
  • Journal Title: Chem. Res. Toxicol. 21 Pages: 282-287
  • Peer Reviewed
• [Journal Article] A pilot study of evaluation of the antioxidative activity of resveratrol and its analogue in a 6-month feeding test in young adult mice (2008)
  • Author(s): A. Matsuoka, K. Kodama, K. Fukuhara, et. al.
  • Journal Title: Food. Chem. Toxicol. 46 Pages: 1125-1130
  • Peer Reviewed
• [Journal Article] Enhanced Radical-Scavenging Activity of Naturally-Oriented Artepillin C Derivatives (2008)
  • Author(s): S. Manda, I. Nakanishi, K. Fukuhara, et. al.
  • Journal Title: Chem. Commun. Pages: 626-628
  • Peer Reviewed
• [Journal Article] Characterization of tea cultivated at four different altitudes using 1H NMR analysis coupled with multivariate statistics
  • Author(s): A.Ohno, K.Oka, C.Sakuma, H.Okuda, K.Fukuhara
  • Journal Title: J.Agri.Food Chem. in press.
  • Peer Reviewed
• [Journal Article] 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen induced hepatotoxicity
  • Author(s): K.Fukuhara, A.Ohno, Y.Ando, T.Yamato, H.Okuda
  • Journal Title: Drug.Metab.Pharm. in press.
  • NAID: 130004463199
  • Peer Reviewed
• [Presentation] NMR メタボロミクスを用いたアセトアミノフェンの細胞毒性機構の解析 (2013)
  • Author(s): 太田庸介
  • Organizer: 日本薬学会第133 年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-27
• [Presentation] カテキンをテンプレートとしたアルツハイマー病予防薬の開発 (2013)
  • Author(s): 大野彰子
  • Organizer: 日本薬学会第133 年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-27
• [Presentation] AD 治療薬の開発を指向した Aβ1-40 およびAβ1-42 のC 末端モチーフ を有するビタミンE 誘導体の合成とAβ 凝集阻害能の解析 (2013)
  • Author(s): 荒井卓也
  • Organizer: 日本薬学会第133 年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-27
• [Presentation] レスべラトロールをテンプレートとした新規抗酸化物質の開発 (2013)
  • Author(s): 長久保貴哉
  • Organizer: 日本薬学会第133 年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-27
• [Presentation] AD 治療薬を指向した Aβ の C末端モチーフを有する Trolox 誘導体の開発 (2013)
  • Author(s): 大野彰子
  • Organizer: 第24回ビタミン E 研究会
  • Place of Presentation: 東京
  • Year and Date: 2013-01-10
• [Presentation] 新たな活性酸素ドナーとして期待されるシアニン誘導体の合成 (2013)
  • Author(s): 今井耕平
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] AD治療薬の開発を指向したAβ1-40およびAβ1-42 のC末端モチーフを有するビタミンE誘導体の合成とAβ凝集阻害能の解析 (2013)
  • Author(s): 荒井卓也
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] カテキンをテンプレートとしたアルツハイマー治療薬の開発 (2013)
  • Author(s): 大野彰子
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] NMRメタボロミクスを用いたアセトアミノフェンの細胞毒性機構の解析 (2013)
  • Author(s): 太田庸介
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] レスベラトロールをテンプレートとした新規抗酸化物質の開発 (2013)
  • Author(s): 長久保貴哉
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
• [Presentation] AD 治療薬を指向した Aβ の C 末端モチーフを有するTrolox 誘導体の開発 (2013)
  • Author(s): 荒井卓也
  • Organizer: 第24回ビタミン E 研究会
  • Place of Presentation: 東京
• [Presentation] メチル基を有するフラボノイド系抗酸化剤の合成と ラジカル消去活性 (2012)
  • Author(s): 福原 潔
  • Organizer: 第30回メディシナルケミストリーシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2012-11-28
• [Presentation] The application of NMR-based metabolomics in drug development (2012)
  • Author(s): Fukuhara, K
  • Organizer: The 3^<rd> Internatilnal Symposium on Drug Discovery and Design by NMR
  • Place of Presentation: 横浜
  • Year and Date: 2012-10-12
• [Presentation] Methyl analogues of quercetin for improved radical-scavenging activities (2012)
  • Author(s): Fukuhara, K
  • Organizer: 244^<th> American Chemical Society National Meeting & Exposition
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2012-08-19
• [Presentation] New approach to quality evaluation for a difference of the high-order structure of peptide/protein drug (2012)
  • Author(s): Ohno, A
  • Organizer: 244^<th> American Chemical Society National Meeting & Exposition
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2012-08-19
• [Presentation] NMR を用いた拡張型心筋症モデルハムスターのメタボローム解析 (2012)
  • Author(s): 大野彰子
  • Organizer: 第65回日本酸化ストレス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2012-06-06
• [Presentation] NMR を用いたアルツハイマー症モデルマウスのメタボローム解析 (2012)
  • Author(s): 福原 潔
  • Organizer: 第65回日本酸化ストレス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2012-06-06
• [Presentation] アルテピリンCおよびその類縁体の密度汎関数計算による熱力学的パラメータとフリーラジカル消去活性との関係 (2012)
  • Author(s): 中西郁夫
  • Organizer: 第65回日本酸化ストレス学会学術集会
  • Year and Date: 2012-06-06
• [Presentation] NMR によるメタボローム情報の創薬への利用:有効性・安全性評価のためのメタボロミクス (2012)
  • Author(s): 福原 潔
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-27
• [Presentation] ^1H NMR を用いたHepG2 細胞のメタホロミクス:APAP の影響 (2012)
  • Author(s): 太田庸介
  • Organizer: 日本薬学会第132 年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-27
• [Presentation] NMR 法による紅茶葉の品質評価 (2012)
  • Author(s): 大野彰子
  • Organizer: 日本薬学会第132 年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-27
• [Presentation] 強力なラジカル消去活性を有するフラボノイド誘導体の合成 (2012)
  • Author(s): 今井耕平
  • Organizer: 日本薬学会第132 年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-27
• [Presentation] アミロイドβを標的としたアルツハイマー予防薬の開発 (2012)
  • Author(s): 福原 潔
  • Organizer: 第23回ビタミンE研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-27
• [Presentation] メチル基を有するフラボノイド系抗酸化剤の合成とラジカル消去活性 (2012)
  • Author(s): 福原 潔
  • Organizer: 第30回メディシナルケミストリーシンポジウム
  • Place of Presentation: 東京
• [Presentation] The Application of NMR-Based Metabolomics in Drug Development (2012)
  • Author(s): Fukuahra, K
  • Organizer: The 3rd International Symposium on Drug Discovery and Design by NMR
  • Place of Presentation: Yokohama
  • Invited
• [Presentation] New approach to quality evaluation for a difference of the high-order structure of peptide/protein drugs (2012)
  • Author(s): Ohno, A.
  • Organizer: 244th American Chemical Society National Meeting & Exposition
  • Place of Presentation: Philadelphia
• [Presentation] Methyl analogues of quercetin for improved radical-scavenging activities (2012)
  • Author(s): Fukuhara, K
  • Organizer: 244th American Chemical Society National Meeting & Exposition
  • Place of Presentation: Philadelphia
• [Presentation] アルテピリン C およびその類縁体の密度汎関数計算による熱力学的パラメータとフリーラジカル消去活性との関係 (2012)
  • Author(s): 中西郁夫
  • Organizer: 第65回日本酸化ストレス学会学術集会
  • Place of Presentation: 徳島
• [Presentation] A new NMR-based quality evaluation of biopolymer drug (2011)
  • Author(s): Ohno, A.
  • Organizer: drug,8^<th> AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: 東京
  • Year and Date: 2011-11-29
• [Presentation] Potential lead for an Alzheimer drug: a peptide that blocks amyloid s induced neurotoxicity (2011)
  • Author(s): Fukuhara,K
  • Organizer: 8^<th> AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: 東京
  • Year and Date: 2011-11-29
• [Presentation] Synthesis and Radical-scavenging Activity of Planar Catechin Derivatives with Various Amino Acids as a Promising Antioxidant (2011)
  • Author(s): Imai, K
  • Organizer: The 8^<th> AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: 東京
  • Year and Date: 2011-11-29
• [Presentation] Potential lead for an Alzheimer Drug : A peptide that blocks amyloid β induced neurotoxicity (2011)
  • Author(s): Fukuhara, K.
  • Organizer: The 8th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: Tokyo
  • Year and Date: 2011-11-29
• [Presentation] ^1H NMR - 多変量解析法による異なる高度で栽培・製造された紅茶葉の成分解析 (2011)
  • Author(s): 大野彰子
  • Organizer: 第4回食品薬学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-10-29
• [Presentation] New approach for quality evaluation for insulins derived from different species using 1H NMR coupled with multivariate analysis (2011)
  • Author(s): Ohno, A
  • Organizer: 242^<th> American Chemical Society National Meeting & Exposition
  • Place of Presentation: Denver,USA
  • Year and Date: 2011-08-28
• [Presentation] Novel Trolox-C-termal motifs of Aβ42 as neuroprotective agents for the treatment of Alzheimer's diseases (2011)
  • Author(s): Fukuhara, K.
  • Organizer: 242^<th> American Chemical Society National Meeting & Exposition
  • Place of Presentation: Denver
  • Year and Date: 2011-08-28
• [Presentation] 抗酸化活性およびアミロイドβ蛋白凝集抑制作用を有する新規アルツハイマー病予防薬の開発 (2011)
  • Author(s): 大野彰子
  • Organizer: 第64回日本酸化ストレス学会学術集会
  • Place of Presentation: 北海道留寿都
  • Year and Date: 2011-07-03
• [Presentation] ラジカル消去活性増強を目的としたアミノ酸を有する平面型カテキン誘導体の合成 (2011)
  • Author(s): 今井耕平
  • Organizer: 第64回日本酸化ストレス学会学術集会
  • Place of Presentation: 北海道留寿都
  • Year and Date: 2011-07-03
• [Presentation] ラジカル消去活性増強を目的としたケルセチン誘導体の合成 (2011)
  • Author(s): 高垣亮平
  • Organizer: 第64回日本酸化ストレス学会学術集会
  • Place of Presentation: 北海道留寿都
  • Year and Date: 2011-07-03
• [Presentation] Novel trolox.C.terminal motifs of As42 as neuroprotective agents for the treatment of Alzheimer's diseases (2011)
  • Author(s): Fukuhara, K
  • Organizer: 242^<th> American Chemical Society National Meeting & Exposition
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-07-02
• [Presentation] ^1H NMR によるアセトアミノフェン誘発肝障害のメタホロミクス (2011)
  • Author(s): 福原 潔
  • Organizer: 第64回日本酸化ストレス学会学術集会
  • Place of Presentation: 北海道留寿都
  • Year and Date: 2011-07-02
• [Presentation] 抗酸化活性およびアミロイドβ 蛋白凝集抑制作用を有する新規アルツハ イマー病予防薬の開発 (2011)
  • Author(s): 大野彰子
  • Organizer: 第64回日本酸化ストレス学会学術集会
  • Place of Presentation: 北海道留寿都
  • Year and Date: 2011-07-02
• [Presentation] NMR 法によるインスリンの種差の解析手法開発 (2011)
  • Author(s): 大野彰子
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-29
• [Presentation] ^1H NMR によるメタボロミクス:薬物代謝酵素阻害によるAPAP 誘発肝障害の軽減 (2011)
  • Author(s): 福原 潔
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-29
• [Presentation] Planar catechin derivatives incorporating basic amino acids for chemoprevention of oxidative stress related diseases (2011)
  • Author(s): Fukuhara, K
  • Organizer: International Symposium on Free Radical Research: Contribution to Medicine (FRCM 2011)
  • Place of Presentation: 京都
  • Year and Date: 2011-01-21
• [Presentation] Planar catechin derivatives incorporating basic amino acids for chemoprevention of oxidative stress related diseases (2011)
  • Author(s): K.Fukuhara
  • Organizer: International Symposium on Free Radical Research : Contribution to Medicine
  • Place of Presentation: Kyoto
  • Year and Date: 2011-01-20
• [Presentation] Planar catechin derivatives incorporating basic amino acids for chemoprevention of oxidative stress related diseases (2011)
  • Author(s): K.Fukuhara
  • Organizer: International Symposium on Free Radical Research : Contribution to Medicine
  • Place of Presentation: 京都
  • Year and Date: 2011-01-20
• [Presentation] Synthesis of β-galactose-conjugated porphyrin analog with high affinity to cancer cell for photodynamic therapy (2010)
  • Author(s): K.Fukuhara
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu
  • Year and Date: 2010-12-19
• [Presentation] Electron-transfer oxidation of the phenolate anion derived from a vitamin E model (2010)
  • Author(s): I Nakanishi
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu
  • Year and Date: 2010-12-19
• [Presentation] Application of a multivariate analysis based on 1H-NMR to new approach for quality evaluation of the protein/peptide biological drugs (2010)
  • Author(s): Ohno, A
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-18
• [Presentation] Electron-transfer oxidation of the phenolate anion derived from a vitamin E model (2010)
  • Author(s): Nakanishi, I
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Year and Date: 2010-12-18
• [Presentation] Synthesis of nitroacridineN-oxide analog as a new type of ROS donor (2010)
  • Author(s): Imai, K
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-18
• [Presentation] ^1H NMR-based metabolomics approach for analysis of APAP hepatotoxicity (2010)
  • Author(s): Fukuhara, K
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-18
• [Presentation] Effects of metal ions on the radical-scavenging reactions by curcumin (2010)
  • Author(s): Kawashima, T
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-18
• [Presentation] Application of a multivariate analysis based on 1H-NMR to new approach for quality evaluation of the protein/peptide biological drugs (2010)
  • Author(s): A.Ohno
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu
  • Year and Date: 2010-12-18
• [Presentation] 1H NMR-based metabolomics approach for analysis of APAP hepatotoxicity (2010)
  • Author(s): K.Fukuhara
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu
  • Year and Date: 2010-12-18
• [Presentation] βアミロイドの凝集阻害を標的とした抗酸化活性を有する新規アルツハイマー治療薬の開発 (2010)
  • Author(s): 大野彰子
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2010-11-18
• [Presentation] 分子内に塩基性アミノ酸を有する平面型カテキン誘導体の抗酸化活性 (2010)
  • Author(s): 福原潔
  • Organizer: 29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2010-11-18
• [Presentation] βアミロイドの凝集阻害を標 的とした抗酸化活性を有する新規アルツ ハイマー治療薬の開発 (2010)
  • Author(s): 大野彰子
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2010-11-17
• [Presentation] 分子内に塩基性アミノ酸を有する平面型カテキン誘導体の抗酸化活性 (2010)
  • Author(s): 福原 潔
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2010-11-17
• [Presentation] Synthesis of Conformationally Constrained Epigallocatechin Analogue as a Promising Antioxidant (2010)
  • Author(s): K.Fukuhara
  • Organizer: SFRBM's 17th Annual Meeting
  • Place of Presentation: Orlando
  • Year and Date: 2010-11-17
• [Presentation] (2010)
  • Author(s): K.Fukuhara
  • Organizer: 240^<th> American Chemical Society National Meeting & Exposition
  • Place of Presentation: Boston
  • Year and Date: 2010-08-23
• [Presentation] Enhanced radical scavenging activities of catechin derivatives incorporating basic amino acids (2010)
  • Author(s): Fukuhara, K
  • Organizer: 240^<th> American Chemical Society National Meeting & Exposition
  • Place of Presentation: Boston, USA
  • Year and Date: 2010-08-22
• [Presentation] ^1H NMR を利用したAPAPによる肝障害のメタボロミクス (2010)
  • Author(s): 福原 潔
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-06-25
• [Presentation] I1H NMRを利用したAPAPによる肝障害のメタボロミクス (2010)
  • Author(s): 福原潔
  • Organizer: 第63回日本酸化ストレス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-06-24
• [Presentation] 2-ニトロイミダゾールの光増感作用の解析, (2010)
  • Author(s): 福原 潔
  • Organizer: 講演ハイライト(タイトル:活性酸素が薬になる～身体にやさしい癌治療を目指して～)日本薬学会第130 年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] NMR/主成分分析法を利用したオキシトシンの品質評価手法の開発 (2010)
  • Author(s): 大野彰子
  • Organizer: 日本薬学会第130 年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] Intramolecular Base-Accelerated Radical- Scavenging Reaction by Vitamin E Derivatives Bearing a Pyridine Moiety (2010)
  • Author(s): 中西郁夫
  • Organizer: Oxygen Club of California 2010 World Congress
  • Place of Presentation: California
  • Year and Date: 2010-03-19
• [Presentation] ビタミンE類縁体アニオンによる電子移動還元反応 (2010)
  • Author(s): 中西郁夫
  • Organizer: 第21回ビタミンE研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-22
• [Presentation] エピガロカテキン誘導体の合成-高い抗酸化能を示すエビ体への期待- (2010)
  • Author(s): 今井耕平
  • Organizer: 第24回日本酸化ストレス学会関東支部会
  • Place of Presentation: つくば
  • Year and Date: 2010-01-09
• [Presentation] Synthesis of nitroacridine-N-oxide analogue for the purpose of photodynamic therapy (2009)
  • Author(s): 今井耕平
  • Organizer: The 5^<th> Joint Meeting of The Societies For Free Radical Research Australasia and Japan
  • Place of Presentation: Sydney
  • Year and Date: 2009-12-03
• [Presentation] ラジオイムノテラピーに有効なニトロイミダゾール-抗体コンジュゲートの作成 (2009)
  • Author(s): 福原潔
  • Organizer: 第28回メディシナルケミストリーシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-11-27
• [Presentation] ラジオイムノテラピーに有効なニトロイミダゾール?抗体コンジュゲートの作成 (2009)
  • Author(s): 福原 潔
  • Organizer: 第28回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2009-11-25
• [Presentation] Radical-Scavenging Activity of Biosynthetic Precursors of Vitamin E and Their D erivatives (2009)
  • Author(s): 中西郁夫
  • Organizer: 16^<th> Annual Meeting of the Society for Free Radical Biology and Medicine(SFRBM)
  • Place of Presentation: San Francisco
  • Year and Date: 2009-11-20
• [Presentation] カテコール骨格固定型カテキン誘導体の合成 (2009)
  • Author(s): 今井耕平
  • Organizer: 第53回日本薬学会関東支部大会
  • Place of Presentation: 埼玉
  • Year and Date: 2009-10-03
• [Presentation] 天然カテキンの生物活性制御を目的とした化学修飾法の開発 (2009)
  • Author(s): 福原 潔
  • Organizer: 第62回日本酸化ストレス学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-06-12
• [Presentation] 新規光線力学療法剤の開発-ニトロアクリジンN-オキシド誘導体の合成- (2009)
  • Author(s): 今井耕平
  • Organizer: 第62回日本酸化ストレス学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-06-12
• [Presentation] 天然カテキンの生物活性制御を目的とした化学修飾法の開発 (2009)
  • Author(s): 福原潔
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-06-11
• [Presentation] 新規光線力学療法剤の開発-ニトロアクリジンN-オキシド誘導体の合成- (2009)
  • Author(s): 今井耕平
  • Organizer: 第62回日本酸化ストレス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-06-11
• [Presentation] ニンヒドリンの反応特性を利用した新規カテキン誘導体の合成 (2009)
  • Author(s): 福原 潔
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] ラジカル消去活性増強を目的とした立体固定化エピカテキンの合成 (2009)
  • Author(s): 今井耕平
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] ビタミンE 類縁体アニオンによる電子移動還元反応 (2009)
  • Author(s): 中西郁夫
  • Organizer: 第21回ビタミンE 研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-05
• [Presentation] レスベラトロールをテンプレートとした新規化学予防物質の開発 (2008)
  • Author(s): 福原 潔
  • Organizer: 第27回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-26
• [Presentation] ラジカル消去活性の増強と遺伝毒性の軽減を目的としたレスベラトロールの誘導化 (2008)
  • Author(s): 福原潔, 中西郁夫, 宮田直樹, 奥田晴宏
  • Organizer: 第61回日本酸化ストレス学会学術集会
  • Place of Presentation: 京都
• [Presentation] 金属イオン存在下におけるヒドロキノン類のラジカル消去反応 (2008)
  • Author(s): 中西郁夫, 大久保敬, 福原潔, 奥田晴宏, 安西和紀
  • Organizer: 第61回日本酸化ストレス学会学術集会
  • Place of Presentation: 京都
• [Presentation] 天然抗酸化物質の生合成前駆体およびその類縁体のラジカル消去活性 (2008)
  • Author(s): 中西郁夫, 宇都義浩, 大久保敬, 福原潔, 奥田晴宏
  • Organizer: 第8回AOB(Antioxidant Biofactor)研究会
  • Place of Presentation: 東京
• [Presentation] ヒドロキノン類によるラジカル消去速度に及ぼす金属イオンの効果 (2008)
  • Author(s): 中西郁夫, 宇都義浩, 福原潔, 奥田晴宏, 安西和紀
  • Organizer: 第18回金属の関与する生体関連反応シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] ブラジル産プロポリスに含まれるフェノール性抗酸化物質およびその誘導体のラジカル消去活性 (2008)
  • Author(s): 中西郁夫, 大久保敬, 奥田晴宏, 福原潔, 安西和紀
  • Organizer: 第41回酸化反応討論会
  • Place of Presentation: 福岡
• [Presentation] エピカテキンの抗酸化作用の増強を目的とした立体構造固定化 (2008)
  • Author(s): 今井耕平, 中西郁夫, 奥田晴宏, 福原潔
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 沖縄
• [Presentation] 放射線防護剤を指向した分子内に塩基性部位を有する新規ビタミンE誘導体の開発 (2008)
  • Author(s): 中西郁夫, 乳井美奈子, 福原潔, 奥田晴宏, 安西和紀
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 沖縄
• [Presentation] ビタミン Cおよびその誘導体の有機溶媒中におけるラジカル消去機構
  • Author(s): 中西郁夫
  • Organizer: 第27回日本酸化ストレス学会関東支部会
  • Place of Presentation: 東京
• [Presentation] がん治療に有用なシアニン骨格を有する新規光線力学療法剤の合成
  • Author(s): 今井耕平
  • Organizer: 第2回CSJ化学フェスタ2012
  • Place of Presentation: 東京
• [Patent(Industrial Property Rights)] フラバノール誘導体‐アセトン誘導体付 加物,その製造方法並びにそれを利用したア ミロイドβ 蛋白凝集阻害剤及びアルツハイマ ー予防又は治療剤 (2011)
  • Inventor(s): 福原潔,大野彰子,奥田晴宏
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興
  • Filing Date: 2011-08-25
• [Patent(Industrial Property Rights)] フラバノール誘導体-アセトン誘導体付加物,その製造方法並びにそれを利用したアミロイドβ蛋白凝集阻害剤及びアルツハイマー予防又は治療剤 (2011)
  • Inventor(s): 福原潔, 大野彰子, 奥田晴宏
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Industrial Property Number: 2011-183246
  • Filing Date: 2011-08-25