Elucidation of long-term influence to a central nervous system by an organic arsenic compound
| Project/Area Number |
20390039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ISHII Kazuhiro University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (70323293)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAOKA Akira 筑波大学, 大学院・人間総合科学研究科, 教授 (50192183)
SHIBATA Yasuyuki 国立環境研究所, 化学環境研究領域, 領域長 (80154251)
SETO Yasuo 科学警察研究所, 法科第三部, 部付主任研究官 (10154668)
HIRANO Seisirou 国立環境研究所, 環境リスク研究センター, 室長 (20150162)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 中毒学 / 脳・神経 / 薬理学 / 有害化学物質 |
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| Research Abstract |
This research makes it clear that in the peroral administration of diphenylarsinic acid (DPAA) to Macaca fascicularis (crab-eating macaques), DPAA accumulates in the central nervous system over a long period of time. Using brain PET to study the effects of DPAA on cerebral blood flow and brain glucose metabolism, we found that it had affected the cerebellum, brainstem, and occipital lobes. No pathological changes were seen, however, in the central nerve tissue. In people exposed to DPAA, symptoms present themselves in the brainstem, the cerebellum, and the tempero-occipital lobes, and decreased blood flow and brain glucose metabolism to these areas is also seen. We believe that we were able to reproduce this influence of DPAA on the central nervous system in Macaca fascicularis, as well.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article]2010
Author(s)
平野靖史郎, 小林弥生.
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Journal Title
ヒ素(In"日本臨床-増刊-")68巻1号(日本臨床社)
Pages: 567-511
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[Journal Article]2009
Author(s)
Y.Seto(共著)
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Journal Title
Handbook of the Toxicology of Chemical Warfare Agents' ed.by R.C.Gupta(Elsevier, Amsterdam)
Pages: 813-825
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[Presentation] DPAAの生体影響、ラット・サル・ヒト2009
Author(s)
石井一弘, 岩崎信明, 武田徹, 柴田康行, 平野靖史郎, 石井賢二, 中馬越清隆, 玉岡晃
Organizer
ジフェニルアルシン酸等の健康リスク評価に係るワーキンググループ
Place of Presentation
つくば
Year and Date
2009-02-23
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