| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
We have reported that 1BnTIQ, which is increased in parkinsonian cerebrospinal fluid, binds to β-tubulin and inhibits its ubiquitination. In this study, we examined the effect of MPP^+ on β-tubulin ubiquitination. MPP^+ (10μM) reduced the content ubiquitinated β-tubulin. Consistent with this, β-tubulin in 1% Nonidet P-40-insoluble fraction was accumulated in a time-dependent manner. Thus, the inhibition of tubulin ubiquitination and its accumulation may involved in neuronal cell death in Parkinson's disease.
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