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Development of quantitative evaluation method of the drug transport systems at the blood brain barrier which influences the CNS effect.

Research Project

Project/Area Number 20390046
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

KUSUHARA Hiroyuki  The University of Tokyo, 大学院・薬学系研究科, 准教授 (00302612)

Co-Investigator(Kenkyū-buntansha) MAEDA Kazuya  東京大学, 大学院・薬学系研究科, 助教 (00345258)
Co-Investigator(Renkei-kenkyūsha) WATANABE Yasuyosi  理化学研究所, 分子イメージング科学研究センター, センター長 (40144399)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords薬学 / 薬剤反応性 / 脳・神経 / 血液脳関門 / トランスポーター / 分子イメージング
Research Abstract

This study focused on the drug transporters expressed in the blood-brain barrier, and aimed at developing quantitative evaluation method of the impact of such drug transporters. In vivo studies using knockout mice elucidated that drugs that are actively extruded by ABC transporters, Mrp4, P-gp and Bcrp at the blood-brain barrier, and thereby, showing limited penetration into the central nervous system. This study also elucidated drugs that are removed by Oat3 from the central nervous system. In conjunction with Mrp4, Oat3 forms efficient directional transport across the blood-brain barrier. This study also found some transporter substrates applicable to PET study.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (83 results)

All 2011 2010 2009 2008 Other

All Journal Article (19 results) (of which Peer Reviewed: 18 results) Presentation (58 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Organic anion transporter 3 mediates the efflux transport of an amphipathic organic anion, dehydroepi-androsterone sulfate, across the blood-brain barrier in mice.2011

    • Author(s)
      Miyajima M, Kusuhara H, Fujishima M, Adachi Y, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos. 39

      Pages: 814-819

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1.2011

    • Author(s)
      Sugiyama T, Shuto T, Suzuki S, Sato T, Koga T, Suico MA, Kusuhara H, Sugiyama Y, Cyr DM, Kai H.
    • Journal Title

      Biochem Biophys Res Commun. 404

      Pages: 853-858

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organic anion transporter 3 mediates the efflux transport of an amphip athic organic anion, dehydroepiandrosterone sulfate, across the blood-brain harrier in mice.2011

    • Author(s)
      Miyajima M, et al
    • Journal Title

      Drug Metab Dispos

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.2010

    • Author(s)
      Ose A, Kusuhara H, Endo C, Tohyama K, Miyajima M, Kitamura S, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos 38

      Pages: 168-176

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.2010

    • Author(s)
      Kodaira H, Kusuhara H, Ushiki J, Fuse E, Sugiyama Y.
    • Journal Title

      J Pharmacol Exp Ther 333

      Pages: 788-796

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Positron emission tomography studies using (15R)-16-m-[11C]tolyl-17, 18, 19, 20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010

    • Author(s)
      Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
    • Journal Title

      J Pharmacol Exp Ther. 335

      Pages: 314-323

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.2010

    • Author(s)
      Higashikuni Y, Sainz J, Nakamura K, Takaoka M, Enomoto S, Iwata H, Sahara M, Tanaka K, Koibuchi N, Ito S, Kusuhara H, Sugiyama Y, Hirata Y, Nagai R, Sata M.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30

      Pages: 2128-2135

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans.2010

    • Author(s)
      Watanabe T, Kusuhara H, Sugiyama Y.
    • Journal Title

      J Pharmacokinet Pharmacodyn. 37

      Pages: 575-590

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans.2010

    • Author(s)
      Watanabe T, et al
    • Journal Title

      J Pharmacokinet Pharmacodyn

      Volume: 137 Pages: 575-590

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positron emission tomography studies using (15R)-16-m-[11C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.2010

    • Author(s)
      Takashima T, et al
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 335 Pages: 314-323

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function.2010

    • Author(s)
      Higashikuni Y, et al
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 30 Pages: 2128-2135

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1.2010

    • Author(s)
      Sugiyama T, et al
    • Journal Title

      Biochem Biophys Res Common

      Volume: 404 Pages: 853-858

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.2010

    • Author(s)
      Ose A, et al
    • Journal Title

      Drug Metab Dispos 38

      Pages: 168-176

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limited brain distribution of [3R, 4R, 5S]-4-acetamido -5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4).2009

    • Author(s)
      Ose A, Ito M, Kusuhara H, Yamatsugu K, Kanai M, Shibasaki M, Hosokawa M, Schuetz JD, Sugiyama Y.
    • Journal Title

      Drug Metab Dispos 37

      Pages: 315-321

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro-in vivo extrapolation of transporter- mediated clearance in the liver and kidney.2009

    • Author(s)
      Kusuhara H, Sugiyama Y.
    • Journal Title

      Drug Metab Pharmacokinet. 24

      Pages: 37-52

    • NAID

      10025722604

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-l-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3(Oat3/S1c22a8) and multidrug resistance-associated protein 4(Mrp4/Abcc4).2009

    • Author(s)
      Ose A他
    • Journal Title

      Drug Metab Dispos. 37

      Pages: 315-321

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney2009

    • Author(s)
      Kusuhara H, Sugiyama Y
    • Journal Title

      Drug Metab Pharmacokinet 24

      Pages: 37-52

    • NAID

      10025722604

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血液脳関門・腎尿細管分泌における薬物トランスポーターの役割2009

    • Author(s)
      楠原洋之
    • Journal Title

      遺伝子医学Mook12最新トランスポーター研究2009 12

      Pages: 128-139

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Kinetic Analysis of the Cooperation of P-glycoprotein(P-gp/Abcb1)and Breast Cancer Resistance Protein(Bcrp/Abcg2)in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone.

    • Author(s)
      Kodaira H, et al
    • Journal Title

      J Pharmacol Exp Ther (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Prediction of CNS effect of histamine H1 antagonist based on the systemic exposure and in vitro experiments2010

    • Author(s)
      Kanamitsu K, 他
    • Organizer
      日本薬物動態学会、第25回年会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Prediction of cationic drug disposition in the human brain2010

    • Author(s)
      Wu C, 他
    • Organizer
      日本薬物動態学会 第25回年会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Prediction of differences between drug concentrations in the extracellular fluid in the brain and cerebrospinal fluid2010

    • Author(s)
      小平浩史, 他
    • Organizer
      日本薬物動態学会 第25回年会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Prediction of CNS effect of histamine H1 antagonist based on the systemic exposure and in vitro experiments2010

    • Author(s)
      Kanamitsu K, et al
    • Organizer
      日本薬物動態学会 第25回年会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterizing organic anion transport at the blood-brain barrier2010

    • Author(s)
      宮島真理, 他
    • Organizer
      FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] IVIVE for hepatic and renal transporters2010

    • Author(s)
      楠原洋之
    • Organizer
      FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, USA(招待講演)
    • Year and Date
      2010-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] IVIVE for hepatic and renal transporters2010

    • Author(s)
      Hiroyuki Kusuhara
    • Organizer
      FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] CHARACTERIZING ORGANIC ANION TRANSPORT AT THE BLOOD-BRAIN BARRIER2010

    • Author(s)
      Mari Miyajima, et al
    • Organizer
      FIP Pharmaceutical Sciences 2010 World Congress/AAPS Annual Meeting and Exposition
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Modulation of Drug Response by Transporter .Mediated Membrane Transport2010

    • Author(s)
      楠原洋之
    • Organizer
      GPEN2010
    • Place of Presentation
      North Carolina, USA(招待講演)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Transport mechanisms of organic anions at the blood-brain barrier2010

    • Author(s)
      宮島真理, 他
    • Organizer
      GPEN2010
    • Place of Presentation
      NorthCarolina, USA
    • Year and Date
      2010-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Modulation of Drug Response by Transporter-Mediated Membrane Transport2010

    • Author(s)
      Hiroyuki Kusuhara
    • Organizer
      GPEN2010
    • Place of Presentation
      North Carolina, USA
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] TRANSPORT MECHANISMS OF ORGANIC ANIONS AT THE BLOOD-BRATN BARRIER2010

    • Author(s)
      Mari Miyajima, et al
    • Organizer
      GPEN2010
    • Place of Presentation
      North Carolina, USA
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 医薬品体内動態における薬物トランスポーターの役割:機能変動が薬剤応答性に与える影響2010

    • Author(s)
      楠原洋之
    • Organizer
      日本毒性病理学会 第11会教育セミナー(招待講演)
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 医薬品体内動態における薬物トランスポーターの役割:機能変動が薬剤応答性に与える影響2010

    • Author(s)
      楠原洋之
    • Organizer
      日本毒性病理学会第11会教育セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Drug Transporters in Modulation of Drug Response by Transporter-Mediated Membrane Transport2010

    • Author(s)
      楠原洋之
    • Organizer
      New Horizons in Toxicity Prediction The 2nd International Lhasa Symposium(招待講演)
    • Place of Presentation
      Leeds, UK
    • Year and Date
      2010-09-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Modulation of Drug Response by Transporter-Mediated Membrane Transport2010

    • Author(s)
      Hiroyuki Kusuhara
    • Organizer
      New Horizons in Toxicity Prediction The 2^<nd> Inter national Lhasa Symposium
    • Place of Presentation
      Leeds, UK
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血液脳関門・血液脳脊髄液関門の能動的関門機構としてのABCトランスポーターMRP4の重要性2010

    • Author(s)
      楠原洋之, 他
    • Organizer
      第4回トランスポーター研究会九州部会
    • Place of Presentation
      長崎
    • Year and Date
      2010-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 血液脳関門・血液脳脊髄液関門の能動的関門機構としての有機アニオントランスポーターOAT3の重要性2010

    • Author(s)
      楠原洋之, 他
    • Organizer
      第4回トランスポーター研究会九州部会
    • Place of Presentation
      長崎
    • Year and Date
      2010-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 血液脳関門・血液脳脊髄液関門の能動的関門機構としてのABCトランスボーターMRP4の重要性2010

    • Author(s)
      楠原洋之, 他
    • Organizer
      第4回トランスポーター研究会九州部会
    • Place of Presentation
      長崎
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血液脳関門・血液脳脊髄液関門の能動的関門機構としての有機アニオントランスポーターOAT3の重要性2010

    • Author(s)
      楠原洋之、小平浩史、宮島真理、杉山雄一
    • Organizer
      第4回トランスボーター研究会九州部会
    • Place of Presentation
      長崎
    • Year and Date
      2010-09-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] マイクロドーズ臨床試験による医薬品体内動態特性評価2010

    • Author(s)
      楠原洋之
    • Organizer
      第35回医用マススペクトル学会年会(招待講演)
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-10
    • Related Report
      2010 Final Research Report
  • [Presentation] マイクロドーズ臨床試験による医薬品体内動態特性評2010

    • Author(s)
      楠原洋之
    • Organizer
      第35回医用マススペクトル学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] トランスポーターを介した薬物間相互作用の予測2010

    • Author(s)
      楠原洋之
    • Organizer
      医療薬学フォーラム2010(招待講演)
    • Place of Presentation
      広島
    • Year and Date
      2010-07-11
    • Related Report
      2010 Final Research Report
  • [Presentation] トランスポーターを介した薬物間相互作用の予測2010

    • Author(s)
      楠原洋之
    • Organizer
      医療薬学フォーラム2010
    • Place of Presentation
      広島
    • Year and Date
      2010-07-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Drug Transporters in the Blood-Brain Barrier2010

    • Author(s)
      楠原洋之
    • Organizer
      4th International Symposium Rational Integration of Transport Metabolism and Drug Delivery(招待講演)
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2010-05-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of Drug Transporters in the Blood-Brain Barrier2010

    • Author(s)
      Hiroyuki Kusuhara
    • Organizer
      4th International Symposium Rational Integration of Transport Metabolism and Drug Delivery
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Multiplicity in the efflux transport system for organic anions at the blood-brain barrier2009

    • Author(s)
      楠原洋之, 他
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-01
    • Related Report
      2010 Final Research Report
  • [Presentation] MULTIPLICITY IN THE EFFLUX TRANSPORT SYSTEM FOR ORGANIC ANIONS AT THE BLOOD-BRAIN BARRIER2009

    • Author(s)
      Kusuhara H, et al
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Quantitative investigation of the synergistic role of p-glycoprotein (p-gp/abcb1) and breast cancer resistance protein (bcrp/abcg2) in limiting the brain and testis penetration of erlotinib and mitoxantrone2009

    • Author(s)
      小平浩史, 他
    • Organizer
      第24回日本薬物動態学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] QUANTITATIVE INVESTIGATION OF THE SYNERGISTIC ROLE OF P-GLYCOPROTEIN(P-GP/ABCB1)AND BREAST CANCER RESISTANCE PROTEIN(BCRP/ABCG2)IN LIMITING THE BRAIN AND TESTIS PENETRATION OF ERLOTINIB AND MITOXANTRONE2009

    • Author(s)
      Kodaira H, et al
    • Organizer
      第24回日本薬物動態学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Importance of multidrug resistance-associated protein 4 (mrp4) in blood-brain barrier2009

    • Author(s)
      Kanamitsu K, 他
    • Organizer
      第24回日本薬物動態学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Multiple organic anion transporters involved in blood-brain barrier transport2009

    • Author(s)
      宮島真理, 他
    • Organizer
      第24回日本薬物動態学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] IMPORTANCE OF MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 4(MRP4)IN BLOOD-BRAIN BARRIER2009

    • Author(s)
      Kanamitsu K, et al
    • Organizer
      第24回日本薬物動態学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] MULTIPLE ORGANIC ANION TRANSPORTERS INVOLVED INBLOOD-BRAIN BARRIER TRANSPORT2009

    • Author(s)
      Miyajima M, et al
    • Organizer
      第24回日本薬物動態学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Involvement of multiple organic anion transporters in the brain-to-blood efflux of dehydro epiandrosterone sulfate (DHEAS)2009

    • Author(s)
      宮島真理, 他
    • Organizer
      Biomedical Transporters 2009
    • Place of Presentation
      トゥーン(スイス) (ベストポスター賞に採択された)
    • Year and Date
      2009-08-09
    • Related Report
      2010 Final Research Report
  • [Presentation] INVOLVEMENT OF MULTIPLE ORGANIC ANION TRANSPORTERS IN THE BRAIN-TO-BLOOD EFFLUX OF DEHYDROEPIANDROSTERONE SULFATE(DHEAS)2009

    • Author(s)
      Miyajima M, et al
    • Organizer
      Biomedical Transporters 2009
    • Place of Presentation
      トゥーン(スイス)
    • Year and Date
      2009-08-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗インフルエンザ薬OSELTAMIVIRおよびその活性体RO64-0802の脳内濃度の個体間変動の解析2009

    • Author(s)
      楠原洋之, 他
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-03
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Investigation of the efflux mechanisms of oseltamivir and its active form RO64-0802 across the blood-brain barrier2009

    • Author(s)
      楠原洋之
    • Organizer
      8th Cerebral Vascular Biology International Conference(招待講演)
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Active efflux across the blood-brain barrier causes differences between the drug concentrations in the extracellular fluid in the brain and csf2009

    • Author(s)
      小平浩史, 他
    • Organizer
      8th Cerebral Vascular Biology International Conference
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Dehydroepi- androsterone sulfate (DHEAS) is effluxed by organic anion transporter 3 across the blood-brain barrier2009

    • Author(s)
      宮島真理, 他
    • Organizer
      8th Cerebral Vascular Biology International Conference
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-28
    • Related Report
      2010 Final Research Report
  • [Presentation] INVESTIGATION OF THE EFFLUX MECHANISMS OF OSELTAMIVIR AND ITS ACTIVE FORM RO64-0802 ACROSS THE BLOOD-BRAIN BARRIER2009

    • Author(s)
      Kusuhara H
    • Organizer
      8th Cerebral Vascular Biology International Conference
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ACTIVE EFFLUX ACROSS THE BLOOD-BRAIN BARRIER CAUSES DIFFERENCES BETWEEN THE DRUG CONCENTRATIONS IN THE EXTRACELLULAR FLUID IN THE BRAIN AND CSF2009

    • Author(s)
      Kodaira H, et al
    • Organizer
      8th Cerebral Vascular Biology International Conference
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] DEHYDROEPIANDROSTERONE SULFATE(DHEAS)IS EFFLUXED BY ORGANIC ANION TRANSPORTER 3 ACROSS THE BLOOD-BRAIN BARRIER2009

    • Author(s)
      Miyajima M, et al
    • Organizer
      8th Cerebral Vascular Biology International Conference
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] トランスポーターノックアウトマウス、in vitro系を用いた医薬品体内動態の解析:腎臓、脳に焦点をあてて2009

    • Author(s)
      楠原洋之
    • Organizer
      第2回Biomonthly Symposiumトランスポーターシンポジウム:トランスポーター研究の新たな展開(招待講演)
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-02
    • Related Report
      2010 Final Research Report
  • [Presentation] トランスポーターノックアウトマウス、in vitro系を用いた医薬品体内動態の解析:腎臓、脳に焦点をあてて2009

    • Author(s)
      楠原洋之
    • Organizer
      第2回Biomonthly Symposiumトランスポーターシンポジウム:トランスポーター研究の新たな展開
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳脊髄液中薬物濃度が脳中遊離型薬物濃度の指標となるための条件解析2009

    • Author(s)
      小平浩史, 他
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] デヒドロエピアンドロステロン硫酸抱合体(DHEAS)の血液脳関門排出輸送機構の解析2009

    • Author(s)
      宮島真理, 他
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 医薬品の中枢応答性と血液脳関門における異物排泄2009

    • Author(s)
      楠原洋之、杉山雄一
    • Organizer
      日本薬学会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 血液脳関門におけるデヒドロエピアンドロステロン硫酸抱合体(DHEAS)の輸送機構の解明2008

    • Author(s)
      宮島真理, 他
    • Organizer
      第2回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-12-20
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 抗インフルエンザ薬oseltamivirおよびその活性代謝物Ro64-0802の血液脳関門を介した排出メカニズムの解析2008

    • Author(s)
      楠原洋之, 他
    • Organizer
      第29回日本臨床薬理学会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 抗インフルエンザ薬oseltamivirおよびその活性代謝物Ro64-0802の血液脳関門を介Lた排出メカニズムの解析2008

    • Author(s)
      楠原洋之 他
    • Organizer
      第29回日本臨床薬理学会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Carrier-mediated efflux of DHEAS across the blood-brain barrier2008

    • Author(s)
      宮島真理, 他
    • Organizer
      第23回日本薬物動態学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Can drug concentration in the cerebrospinal fluid be a surrogate for the unbound concentration of cns drugs in the brain?2008

    • Author(s)
      小平浩史, 他
    • Organizer
      第23回日本薬物動態学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Active efflux of ro 64-0802, the active form of oseltamivir, across the blood-brain barrier2008

    • Author(s)
      Ose A, 他
    • Organizer
      第23回日本薬物動態学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] CARRIER-MEDIATED EFFLUX OF DHEAS ACROSS THE BLOOD-BRAIN BARRIER2008

    • Author(s)
      Miyajima M 他
    • Organizer
      第23回日本薬物動態学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] CAN DRUG CONCENTRATION IN THE CEREBROSPINAL FLUID BE A SURROGATE FOR THE UNBOUND CONCENTRATION OF CNS DRUGS IN THE BRAIN?2008

    • Author(s)
      Kodaira H 他
    • Organizer
      第23回日本薬物動態学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ACTIVE EFFLUX OF RO 64-0802, THE ACTIVE FORM OF OSELTAMIVIR,ACROSS THE BLOOD-BRAIN BARRIER2008

    • Author(s)
      Ose A 他
    • Organizer
      第23回日本薬物動態学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] トランスポーターを利用した医薬品の中枢へのデリバリー2008

    • Author(s)
      楠原洋之
    • Organizer
      第24回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-29
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Book] トランスポートソーム生体膜輸送機構の全体像に迫る(編集金井好克)(トランスポーターノックアウトマウスを用いた医薬品体内動態の解析)2011

    • Author(s)
      楠原洋之
    • Total Pages
      10
    • Publisher
      メディカルドゥ
    • Related Report
      2010 Final Research Report
  • [Book] トランスホーターノックアウトマウスを用いた医薬品体内動態の解析"トランスボートソーム 生体膜輸送機構の全体像に迫る"(編集 金井好克)2011

    • Author(s)
      楠原洋之
    • Total Pages
      10
    • Publisher
      メディカルドゥ
    • Related Report
      2010 Annual Research Report
  • [Book] 創薬技術の革新 マイクロドーズからPET分子イメージングへの新展開(編集杉山雄一、山下伸二、栗原千絵子)(薬物動態関連遺伝子多型による薬物動態の変動予測法の開発)2010

    • Author(s)
      楠原洋之、前田和哉、杉山雄一
    • Total Pages
      10
    • Publisher
      メディカルドゥ
    • Related Report
      2010 Final Research Report
  • [Book] 薬物動態関連遺伝子多型による薬物動態の変動予測法の開発"創薬技術の革新マイクロドーズからPET分子イメージングへの新展開"(編集 杉山雄一、山下伸二、栗原千絵子)2010

    • Author(s)
      楠原洋之、前田和哉、杉山雄一
    • Total Pages
      10
    • Publisher
      メディカルドゥ
    • Related Report
      2010 Annual Research Report
  • [Book] 遺伝子医学Mook12 最新トランスポーター研究2009(血液脳関門・腎尿細管分泌における薬物トランスポーターの役割)2009

    • Author(s)
      楠原洋之
    • Total Pages
      12
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.f.u-tokyo.ac.jp/~sugiyama/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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