Research of transporter-adaptor network as target of drug effect and toxicity
| Project/Area Number |
20390047
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
KATO Yukio Kanazawa University, 薬学系, 教授 (30251440)
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| Co-Investigator(Renkei-kenkyūsha) |
WAKAYAMA Tomohiko 金沢大学, 医学系, 准教授 (70305100)
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| Research Collaborator |
NAKAMICHI Noritaka 金沢大学, 薬学系, 准教授 (10401895)
SUGIURA Tomoko 金沢大学, 薬学系, 助教 (70542190)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | トランスポーター / アダプター / 薬物動態 / 生体膜透過 / タンパク質間相互作用 / 薬物代謝 / PDZドメイン / PDZK1 / Rab8 / タンパ質間相互作用 |
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| Research Abstract |
Transporters are the membrane proteins involved in permeation of drug molecules across plasma membranes. Although they are assumed to play fundamental roles in drug absorption and disposition, little information is available on their direct association with drug efficacy and toxicity. Therefore, the aim of the present study was to clarify pharmacokinetic, pharmacodynamic and toxicodynamic roles of transporters by focusing on their adaptor proteins which have already been clarified by our previous studies. As the final results of this grant, we have clarified (i) the roles of carnitine/organic cation transporters (OCTNs) in drug disposition and efficacy in small intestine, liver, kidney and heart, (ii) the roles of influx and efflux transporters in gastrointestinal drug absorption, and (iii) direct interaction and regulation of three intestinal influx transporters by an adaptor protein PDZK1.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine.2010
Author(s)
Sugiura T, Otake T, Shimizu T, Wakayama T, Silver DL, Utsumi R, Nishimura T, Iseki S, Nakamichi N, Kubo Y, Tsuji A, Kato Y.
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Journal Title
Drug Metab Pharmacokinet 25(5)
Pages: 588-598
Related Report
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[Journal Article] Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver.2010
Author(s)
Sugiura T, Kato S, Shimizu T, Wakayama T, Nakamichi N, Kubo Y, Iwata D, Suzuki K, Soga T, Asano M, Iseki S, Tamai I, Tsuji A, Kato Y.
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Journal Title
Drug Metab Dispos 38(10)
Pages: 1665-1672
Related Report
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[Journal Article] Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.2010
Author(s)
Kato Y, Kubo Y, Iwata D, Kato S, Sudo T, Sugiura T, Kagaya T, Wakayama T, Hirayama A, Sugimoto M, Sugihara K, Kaneko S, Soga T, Asano M, Tomita M, Matsui T, Wada M, Tsuji A.
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Journal Title
Pharm Res 27(5)
Pages: 832-840
NAID
Related Report
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[Journal Article] Funetional expression of carnitine/organic cation transporter OCTNI/SLC22A4 in mouse small intestine and liver.2010
Author(s)
Sugiura T, Kato S, Shimizu T, Wakayama T, Nakamichi N, Kuho Y, Iwata D, Suzuki K, Soga T, Asano M, Iseki S, Tamai I, Tsuji A, Kato Y
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Journal Title
Drug Metab Dispos
Volume: 38(10)
Pages: 1665-1672
Related Report
Peer Reviewed
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[Journal Article] Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.2010
Author(s)
Kato Y, Kubo Y, Iwata D, Kato S, Sudo T, Sugiura T, Kagaya T, Wakayama T, Hirayama A, Sugimoto M, Sugihara K, Kaneko S, Soga T, Asano M, Tomita M, Matsui T, Wada M, Tsuji A.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Cancer detection using a PET tracer, ^<11>C-glycylsarcosine, targeted to H^+/peptide transporter.2008
Author(s)
Mitsuoka K, Miyoshi S, Kato Y, Murakami Y, Utsumi R, Kubo Y, Hiraiwa M, Noda A, Nakamura Y, Nishimura S, Tsuji A.
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Journal Title
J Nucl Med 49(4)
Pages: 615-622
Related Report
Peer Reviewed
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[Presentation] 11C-Glycylsarcocine Targeting the Peptide Transporter as a Novel PET Imaging Tracer for Cancer Detection.2008
Author(s)
Mitsuoka K, Miyoshi S, Murakami Y, Hiraiwa M, Noda A, Kubo Y, Kato Y, Nakamura Y, Nishimura S, Tsuji A.
Organizer
55th SNM Annual Meeting 2008
Place of Presentation
New Orleans, USA
Related Report
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