| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
We applied proteomic approach to elucidate individual differences in chemotherapeutic response of human colorectal cancer cells and to develop protein biomarkers for predicting chemosensitivity. We have identified the protein S100A10 whose expression well correlated with sensitivity to oxaliplatin, and our findings suggested this protein a potential biomarker in clinical setting. Furthermore, we have also found several proteins as potential biomarkers to predict sensitivity to anticancer drugs such as 5-fluorouracil and active metabolite of irinotecan.
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