Budget Amount *help |
¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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Research Abstract |
We have previously demonstrated that the neurotransmitter acetylcholine is synthesized by two enzymes, cChAT and pChAT. The pChAT occurs not only in peripheral cholinergic neurons but also in neuronal crest derived neurons (primary sensory, postganglionic sympathetic and intramural enteric neurons) of experimental animals. The present study aims at examining whether pChAT is also present in humans. Using protein purification and antibody production methods, we have firstly succeeded to visualize neurons containing human pChAT.
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