Functional non-coding RNA expression in activated hepatic stellate cells
| Project/Area Number |
20390053
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Nagoya City University |
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Principal Investigator |
IKEDA Kazuo Nagoya City University, 大学院・医学研究科, 教授 (80275247)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 細胞分化・組織形成 / 肝星細胞 / マイクロRNA / 肝線維化 / コラーゲン / 細胞・組織 |
|---|
| Research Abstract |
MicroRNA, which are endogenous small non-coding RNA, have recently become a focus of interest as post-transcriptional regulators of gene expression. Using a microRNA array and Applied Biosystem's Taq Man micro-RNA assay, we profiled microRNA expression in activated stellate cells and fibrotic liver. More than 20 microRNAs changed their expression levels in activated stellate cells and in fibrotic liver. Among them, miR-17-92 were closely related to cell's proliferation and the liver injury. miR-200b had an association with epithelial-mesenchymal transition.
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Report
(4 results)
Research Products
(32 results)
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[Presentation] 肝星細胞活性化におけるマイクロPNAの関与についての検討2009
Author(s)
陳輝, 小川智之, 飯塚昌司, 関谷由美子, 諏訪友紀子, 上田優希子, 庄秋栄, 葛岩, 後藤公寿, 河田則文, 池田一雄
Organizer
第23回肝類洞壁細胞研究会
Place of Presentation
大阪
Year and Date
2009-12-12
Related Report
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