| Budget Amount *help |
¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Research Abstract |
MicroRNA, which are endogenous small non-coding RNA, have recently become a focus of interest as post-transcriptional regulators of gene expression. Using a microRNA array and Applied Biosystem's Taq Man micro-RNA assay, we profiled microRNA expression in activated stellate cells and fibrotic liver. More than 20 microRNAs changed their expression levels in activated stellate cells and in fibrotic liver. Among them, miR-17-92 were closely related to cell's proliferation and the liver injury. miR-200b had an association with epithelial-mesenchymal transition.
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