| Project/Area Number |
20390055
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Fujita Health University |
|---|
Principal Investigator |
SENDA Takao Fujita Health University, 医学部, 教授 (10187875)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NOMURA Ryuji 藤田保健衛生大学, 医学部, 講師 (20325161)
SHIMOMURA Atsushi 藤田保健衛生大学, 医学部, 講師 (50340237)
HASEGAWA Yoshimi 藤田保健衛生大学, 医学部, 講師 (40288494)
KOGO Akiko 藤田保健衛生大学, 医学部, 助教 (20340242)
OHKUMA Mahito 藤田保健衛生大学, 医学部, 講師 (50329710)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MIYAKAWA Tsuyoshi 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
MIYACHI Ei-Ichi 藤田保健衛生大学, 医学部, 教授 (90129685)
|
|---|
| Research Collaborator |
ONOUCHI Takanori 藤田保健衛生大学, 大学院生
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
|
|---|
| Keywords | APC / PSD-95 / 脳形成 / 細胞分化 / 遺伝子改変マウス / 行動解析 / 統合失調様行動異常 / 脳内モノアミン / ノルアドレナリン / ドーパミン / セロトニン / 線条体 / 樹状突起棘 / c-fos / 電気生理学的解析 / PTP / LTP / 甲状腺 / 行動学的解析 / 作業記憶 / 海馬歯状回 / 大脳皮質前頭葉 / MAP2C / 微小管 |
|---|
| Research Abstract |
APC(adenomatous polyposis coli)was originally identified as a tumor suppressor protein. In the present study, we investigated functions of the APC regions except for the βcatenin-binding domain. Systemic behavior tests revealed schizophrenia-like behavior disorders of APC1638T mice which lack the C-terminus of APC. APC1638T mice showed morphological abnormalities of the hippocampal pyramidal neuron spines and conduction defects of the synapses. Also, distributions of monoamines in the APC1638T mouse brain altered. These disorders of APC1638T mice may cause their schizophrenia-like behavior.
|
