| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
Prrt3-Long is a member of family C metabotropic receptors whose ligand has not been identified yet. From the same Prrt3 gene, a secretion protein Prrt3-Short, which consists of only the N-terminal extracellular region of Prrt3-Long, is transcribed by splice variation. To obtain clues of their function, we raised specific antibodies and analyzed their expression pattern in the mouse. Prrt3-Long protein was observed to be expressed in the pars tuberalis where melatonin receptor is also known to be expressed. Prrt3-Short protein was observed to be expressed in the choroid plexus in the brain ventricles. From these expression patterns, it was suggested that Prrt3-Long possibly plays a role in the photoperiodism and that Prrt3-Short might be a humoral factor which regulates the brain function.
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