Analyses of an orphan metabotropic receptor and a secretion protein encoded by the same gene
Project/Area Number |
20390062
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General physiology
|
Research Institution | National Institute for Physiological Sciences |
Principal Investigator |
KUBO Yoshihiro National Institute for Physiological Sciences, 分子生理研究系, 教授 (80211887)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
Keywords | 生理学 / 神経科学 / 生体分子 / 蛋白質 / シグナル伝達 |
Research Abstract |
Prrt3-Long is a member of family C metabotropic receptors whose ligand has not been identified yet. From the same Prrt3 gene, a secretion protein Prrt3-Short, which consists of only the N-terminal extracellular region of Prrt3-Long, is transcribed by splice variation. To obtain clues of their function, we raised specific antibodies and analyzed their expression pattern in the mouse. Prrt3-Long protein was observed to be expressed in the pars tuberalis where melatonin receptor is also known to be expressed. Prrt3-Short protein was observed to be expressed in the choroid plexus in the brain ventricles. From these expression patterns, it was suggested that Prrt3-Long possibly plays a role in the photoperiodism and that Prrt3-Short might be a humoral factor which regulates the brain function.
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Report
(4 results)
Research Products
(23 results)