Role of nerve growth factor (NGF) in muscular pain
| Project/Area Number |
20390063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya University |
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Principal Investigator |
MIZUMURA Kazue Nagoya University, 環境医学研究所, 教授 (00109349)
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| Co-Investigator(Renkei-kenkyūsha) |
KATANOSAKA Kimiaki 名古屋大学, 環境医学研究所, 助教 (50335006)
KOZAKI Yasuko 金城学院大学, 薬学部, 准教授 (20126882)
TAGUCHI Toru 名古屋大学, 環境医学研究所, 助教 (90464156)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 筋性疼痛 / 神経成長因子 / 遅発性筋痛 / ブラジキニン / 神経障害性疼痛 / 機械痛覚過敏 / 繰り返し寒冷ストレス / グリア由来神経栄養因子 / ラット / 神経因性疼痛 / 細径線維受容器 / ストレス / 後根神経節細胞 / 侵害受容器 / 単一神経記録 |
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| Research Abstract |
To clarify the peripheral mechanism of muscular mechanical hyperalgesia, we analyzed roles of nerve growth factor (NGF) produced in the muscle in a few muscular pain models. We demonstrated that delayed onset muscle soreness was a result of sensitization of thin-fiber receptors by NGF that was up-regulated in the muscle after activation of B2 bradykinin receptors during exercise. We also demonstrated that NGF was not involved in muscular mechanical hyperalgesia in the repeated cold stress model, whereas it was involved in the spinal nerve ligation/cut model.
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Report
(4 results)
Research Products
(85 results)
