| Project/Area Number |
20390064
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kochi University |
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Principal Investigator |
KABA HIDETO Kochi University, 教育研究部・医療学系, 教授 (50136371)
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| Co-Investigator(Kenkyū-buntansha) |
OKUTANI Fumino 高知大学, 教育研究部・医療学系, 准教授 (10194490)
TANIGUCHI Mutuo 高知大学, 教育研究部・医療学系, 助教 (10304677)
MURATA Yoshihiro 高知大学, 教育研究部・医療学系, 助教 (40377031)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAMOTO Kazuyo 明海大学, 歯学部, 准教授 (10301798)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 匂い / 記憶 / 学習 / 副嗅球 / 嗅球 / ノルアドレナリン / アセチルコリン / オキシトシン / 僧帽細胞 / 顆粒細胞 / シナプス可塑性 / LTP / フェロモン / カルバコール / カルシウムチャネル / ムスカリン受容体 / KCNQチャネル / 長期増強 |
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| Research Abstract |
In this study we demonstrate that (1) cholinergic inputs from the basal forebrain modulate GABAergic transmission from granule cells to mitral cells in the accessory olfactory bulb (AOB), where neural changes underlying pheromonal learning in female mice occur, (2) noradrenaline-induced long-term potentiation (LTP) at mitral to granule cell synapses in the olfactory bulb (OB) underlies aversive olfactory learning in neonatal rats, (3) oxytocin released at parturition facilitates the induction of LTP at mitral to granule cell synapses in the OB, thereby inducing maternal behavior.
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