Neurobiological mechanisms underlying olfactory bonds

• Project/Area Number: 20390064
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Kochi University
• Principal Investigator: KABA HIDETO Kochi University, 教育研究部・医療学系, 教授 (50136371)
• Co-Investigator(Kenkyū-buntansha): OKUTANI Fumino 高知大学, 教育研究部・医療学系, 准教授 (10194490) ; TANIGUCHI Mutuo 高知大学, 教育研究部・医療学系, 助教 (10304677) ; MURATA Yoshihiro 高知大学, 教育研究部・医療学系, 助教 (40377031)
• Co-Investigator(Renkei-kenkyūsha): MURAMOTO Kazuyo 明海大学, 歯学部, 准教授 (10301798)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: 匂い / 記憶 / 学習 / 副嗅球 / 嗅球 / ノルアドレナリン / アセチルコリン / オキシトシン / 僧帽細胞 / 顆粒細胞 / シナプス可塑性 / LTP / フェロモン / カルバコール / カルシウムチャネル / ムスカリン受容体 / KCNQチャネル / 長期増強

Research Abstract

In this study we demonstrate that (1) cholinergic inputs from the basal forebrain modulate GABAergic transmission from granule cells to mitral cells in the accessory olfactory bulb (AOB), where neural changes underlying pheromonal learning in female mice occur, (2) noradrenaline-induced long-term potentiation (LTP) at mitral to granule cell synapses in the olfactory bulb (OB) underlies aversive olfactory learning in neonatal rats, (3) oxytocin released at parturition facilitates the induction of LTP at mitral to granule cell synapses in the OB, thereby inducing maternal behavior.

Research Products

• [Journal Article] Ameliorative effects of Eriobotrya japonica seed extract on cellular aging in cultured rat fibroblasts (2011)
  • Author(s): Muramoto K, Quan R-D, Namba T, Kyotani S, Miyamura M, Nishioka Y, Tonosaki K, Doi YL, Kaba H
  • Journal Title: Journal of Natural Medicines 65 Pages: 254-261
  • NAID: 10029461080
  • Peer Reviewed
• [Journal Article] Neurobiology of mammalian olfactory learning that occurs during sensitive periods (2010)
  • Author(s): Kaba H
  • Journal Title: Current Zoology 56 Pages: 819-833
  • Peer Reviewed
• [Journal Article] Common properties between synaptic plasticity in the main olfactory bulb and olfactory learning in young rats (2010)
  • Author(s): Zhang J-J, Okutani F, Huang G-Z, Taniguchi M, Murata Y, Kaba H
  • Journal Title: Neuroscience 170 Pages: 259-267
  • Peer Reviewed
• [Journal Article] Muscarinic receptor type 1 (M1) stimulation, probably through KCNQ/Kv7 channel closure, increases spontaneous GABA release at the dendrodendritic synapse in the mouse accessory olfactory bulb (2010)
  • Author(s): Takahashi Y, Kaba H
  • Journal Title: Brain Research 1339 Pages: 26-40
  • NAID: 120002220975
  • Peer Reviewed
• [Journal Article] The effect of vapor of propylene glycol on rats (2010)
  • Author(s): Inagaki H, Taniguchi M, Muramoto K, Kaba H, Takeuchi Y, Mori Y
  • Journal Title: Chemical Senses 35 Pages: 221-228
  • Peer Reviewed
• [Journal Article] Common properties between synaptic plasticity in the main olfactory bulb and olfactory learning in young rats. (2010)
  • Author(s): Zhang, J.J.
  • Journal Title: Neuroscience Volume: 170 Pages: 259-267
  • Peer Reviewed
• [Journal Article] Muscarinic receptor type 1 (M1) stimulation, probably through KCNQ/Kv7 channel closure, increases spontaneous GABA release at the dendrodendritic synapse in the mouse accessory olfactory bulb (2010)
  • Author(s): Takahashi, Y.
  • Journal Title: Brain Research Volume: 65 Pages: 26-40
  • Peer Reviewed
• [Journal Article] Neurobiology of mammalian olfactory learning that occurs during sensitive periods (2010)
  • Author(s): Kaba, H.
  • Journal Title: Current Zoology Volume: 56 Pages: 819-833
  • Peer Reviewed
• [Journal Article] The effect of vapor of propylene glycol on rats (2010)
  • Author(s): Inagaki, H.
  • Journal Title: Chemical Senses 35 Pages: 221-228
  • Peer Reviewed
• [Journal Article] Oxytocin facilitates the induction of long-term potentiation in the accessory olfactory bulb (2008)
  • Author(s): Fang L-Y, Quan R-D, Kaba H
  • Journal Title: Neuroscience Letters 438 Pages: 133-137
  • NAID: 120001893675
  • Peer Reviewed
• [Journal Article] Oxytocin facilitates the induction of long-term potentiation in the accessory olfactory bulb (2008)
  • Author(s): Fang, L. -Y.
  • Journal Title: Neuroscience Letters 438 Pages: 133-137
  • Peer Reviewed
• [Journal Article] Muscarinic receptor type 1(M1)stimulation, probably through KCNQ/Kv7 channel closure, increases spontaneous GABA release at the dendrodendritic synapse in the mouse accessory olfactory bulb
  • Author(s): Takahashi, Y.
  • Journal Title: Brain Research (印刷中)
  • Peer Reviewed
• [Journal Article] Common propertiel, between synaptic plasticity in the main olfactory bulb and olfactory learning in young rats
  • Author(s): Zhang, J.-J.
  • Journal Title: Neuroscience (印刷中)
  • Peer Reviewed
• [Journal Article] Neurobiology of mammalian olfactory learning that occurs during sensitive periods
  • Author(s): Kaba, H.
  • Journal Title: Current Zoology (印刷中)
  • Peer Reviewed
• [Presentation] Suppression of the recurrent inhibition in the mouse accessory olfactory bulb by the metabotropic glutamate receptor mGluR2 through inhibition of high-voltage-activated Ca currents (2010)
  • Author(s): Taniguchi, M.
  • Organizer: The 8th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Impairment of accessory bulb long-term potentiation and pheromonal learning in mG1uR2-deficient mice (2009)
  • Author(s): Kaba, H.
  • Organizer: Beijing International Meeting on Research in Taste and Smell
  • Place of Presentation: Beijing Marriott Hotel City Wall(Beijing, China)
  • Year and Date: 2009-11-17
• [Presentation] Impairment of accessory bulb long-term potentiation and pheromonal learning in mGluR2-deficient mice (2009)
  • Author(s): Kaba H, Huang G-Z
  • Organizer: Beijing International Meeting on Research in Taste and Smell
  • Place of Presentation: Beijing, China
• [Presentation] Intrabulbar Infusion of Trichostatin A, a HDAC Inhibitor Facilitates Olfactory Learning in Young Rats. (2009)
  • Author(s): 奥谷文乃, 王宇杰, 椛秀人
  • Organizer: Beijing International Meeting on Research in Taste and Smell
  • Place of Presentation: Beijing, China
• [Presentation] Modulation of the synaptic transmission between mitral cells and granule cells in the mouse accessory olfactory bulb by group II metabotropic glutamate receptors (mGLuR2/mGluR3) (2009)
  • Author(s): 谷口睦男, 椛秀人
  • Organizer: Beijing International Meeting on Research in Taste and Smell
  • Place of Presentation: Beijing, China
• [Presentation] Functional expression of V1R vomeronasal receptors using an adenoviral Cre/loxP system. (2009)
  • Author(s): Namba T, Muramoto K, Moriya-Ito K, Ichikawa M, Kaba H
  • Organizer: Beijing International Meeting on Research in Taste and Smell
  • Place of Presentation: Beijing, China
• [Presentation] Mate recognition memory and maternally inherited peptides that convey strain identity (2009)
  • Author(s): Kaba H, Matsunami H
  • Organizer: The 7th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YR Umami Forum 2009)
  • Place of Presentation: Fukuoka
• [Presentation] Aversive olfactory learning is facilitated by HDAC inhibition in the olfactory bulb (2009)
  • Author(s): 王宇杰, 奥谷文乃, 椛秀人
  • Organizer: The 7th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YR Umami Forum 2009)
  • Place of Presentation: Fukuoka
• [Presentation] マウスの系統認識 (2009)
  • Author(s): 椛秀人
  • Organizer: 日本解剖学会第64回中国・四国支部学術集会
  • Place of Presentation: 南国
• [Presentation] 嗅球内トリコスタチンA注入は記憶の学習成立を促進する (2009)
  • Author(s): 王宇杰, 奥谷文乃, 難波利治, 椛秀人
  • Organizer: 日本味と匂学会第43回大会
  • Place of Presentation: 旭川
• [Presentation] 代謝型グルタミン酸受容体II型によるマウス副嗅球僧帽細胞-顆粒細胞間相反性シナプス電流に対する抑制機構 (2009)
  • Author(s): 谷口睦男, 椛秀人
  • Organizer: 日本味と匂学会第43回大会
  • Place of Presentation: 旭川
• [Presentation] アデノウイルスベクターを用いた鋤鼻受容体の発現とフェロモン応答の再構成 (2009)
  • Author(s): 難波利治, 村本和世, 守屋敬子, 市川眞澄, 椛秀人
  • Organizer: 日本味と匂学会第43回大会
  • Place of Presentation: 旭川
• [Presentation] Intrabulbar infusion of HDAC inhibitors modulates olfactory learning in young rats (2009)
  • Author(s): 奥谷文乃, 王宇杰, 椛秀人
  • Organizer: International Union of Physiological Sciences, Teaching Workshop
  • Place of Presentation: Kobe
• [Presentation] Oxytocin-induced synaptic plasticity in the olfactory bulb is required for the induction of maternal behaviour (2009)
  • Author(s): Kaba H, Huang G-Z, Zhang J-J, Yu G-Z, Okutani F
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] HDAC inhibition facilitates aversive olfactory learning in young rats (2009)
  • Author(s): 奥谷文乃, 椛秀人
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] Suppression of reciprocal synaptic currents by group II meabotropic glutamate receptors in the mouse accessory olfactory bulb (2009)
  • Author(s): 谷口睦男, 椛秀人
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] Muscarinic receptor activation potentiates transmission from granule cells to mitral cells in the mouse accessory olfactory bulb (2009)
  • Author(s): Takahashi Y, Kaba H
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] Establishment of an in vitro forced expression system for vomeronasal receptors using a cre-loxp strategy (2009)
  • Author(s): Namba T, Muramoto K, Moriya-Ito K, Ichikawa M, Kaba H
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto
• [Presentation] Neurophysiology and neuropharmacology of pheromone action in mice. (2009)
  • Author(s): Kaba H, Matsunami H
  • Organizer: 1^<st> International Symposium on Ecological Volatiles
  • Place of Presentation: 東京
• [Presentation] 代謝型グルタミン酸受容体II型によるマウス副嗅球僧帽細胞-顆粒細胞間相反性シナプス電流の調節 (2008)
  • Author(s): 谷口睦男, 椛秀人
  • Organizer: 第60回日本生理学会中四国地方会
  • Place of Presentation: 松山
  • Year and Date: 2008-11-15
• [Presentation] アデノウイルスベクターを用いた鋤鼻受容体のin vitro発現・フェロモン応答評価系の確立 (2008)
  • Author(s): 難波利治, 村本和世, 椛秀人
  • Organizer: 第60回日本生理学会中四国地方会
  • Place of Presentation: 松山
  • Year and Date: 2008-11-15
• [Presentation] The neural basis of social recognition (2008)
  • Author(s): Kaba, H.
  • Organizer: Japan/China symposium 2008
  • Place of Presentation: 筑波大学
  • Year and Date: 2008-10-24
• [Book] 調理学 (2011)
  • Author(s): 椛秀人
  • Total Pages: 224
  • Publisher: 化学同人
• [Book] Springer-Verlag (2009)
  • Author(s): Kaba H, 他
  • Publisher: Encyclopedia of Neuroscience
• [Book] Encyclopedia of Neuroscience, Vol.3 (2009)
  • Author(s): Kaba, H.
  • Total Pages: 4399
  • Publisher: Springer-Verlag
• [Book] Encyclopedia of Neuroscience (2009)
  • Author(s): Kaba, H.
  • Publisher: Springer-Verlag(in press)
• [Book] エッセンシャル神経科学 (2008)
  • Author(s): 椛秀人, 他
  • Publisher: 丸善出版
• [Remarks] ホームページ等
  • URL: http://www.kochi-ms.ac.jp/~ff_phsl1/index.htm
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/~ff_phsll/index.htm
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/~ff_phsl1/index.htm
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/~ff_phsl1/index.htm