Physiological roles of the regulatory system of orexin-producing neurons

• Project/Area Number: 20390067
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Kanazawa University
• Principal Investigator: SAKURAI Takeshi Kanazawa University, 医学系, 教授 (60251055)
• Co-Investigator(Kenkyū-buntansha): YAMANAKA Akihiro 大学共同利用法人・自然科学研究機構, 生理学研究所・細胞生理研究部門, 准教授 (60323292)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000); Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2008: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
• Keywords: オレキシン / 睡眠 / 覚醒 / GABA / TRH / 遺伝薬理学 / BRS-3b / ニューロテンシン / バソプレッシン / アセチルコリン

Research Abstract

We studied the physiological roles of the regulatory system of orexin-producing neurons. We examined the involvement of GABA_B receptors in the regulation of orexin neurons, by utilizing mice with a conditional deletion of the GABA_<B1> subunit in these neurons. The frequency of spontaneous fast TPSCs mediated by GABA_A receptors was markedly increased to compensate for an increase in orexin receptor-1 mediated excitation of local GABAergic interneurons. Sleep state analysis of the conditional GABA_<B1> knockout mice revealed that these mice displayed a robust fragmentation of the sleep/waking states. These observations suggest that pre- and postsynaptic GABA_B receptors in orexin neurons are essential for the normal regulation of orexin neuronal activity, and regulation of sleep/wakefulness states in vivo. We also revealed the involvement of BRS-3 in the regulation of orexin neuron. We also found that orexin-overexpresisng mice exhibit fragmentation of NREM sleep, suggesting the importance of inhibitory mechanisms of orexin neurons in maintenance of normal sleep.

Research Products

• [Journal Article] Critical role of neuropeptides b/w receptor 1 signaling in social behavior and fear memory. (2011)
  • Author(s): Nagata-Kuroiwa R, et al.
  • Journal Title: PLOS One. Volume: 6(2)
  • Peer Reviewed
• [Journal Article] Decreased intake of sucrose solutions in orexin knockout mice. (2011)
  • Author(s): Matsuo E, et al.
  • Journal Title: J Mol Neurosci. Volume: 43(2) Pages: 217-224
  • Peer Reviewed
• [Journal Article] Differential roles of orexin receptor-1 and -2 in regulation of non-REM and REM sleep (2011)
  • Author(s): Mieda M, et al.
  • Journal Title: J.Neurosci. Volume: (In press)
  • Peer Reviewed
• [Journal Article] Connectomics of Orexin producing Neurons Interface of Systems of Emo Lion, Energy Homeostasis and Arousal (2011)
  • Author(s): Sakurai T, et al.
  • Journal Title: Trend in Pharmacological Sciences Volume: (In press)
  • Peer Reviewed
• [Journal Article] Orexin neurons are indispensable for stress-induced thermogenesis in mice (2010)
  • Author(s): Zhang W, Sunanaga J, Takahashi Y, Mori T, Sakurai T, Kanmura Y, Kuwaki T.
  • Journal Title: J Physiol. 588(Pt21) Pages: 4117-4129
• [Journal Article] The orexin system : roles in sleep/wake regulation. (2010)
  • Author(s): Sakurai T, Mieda M, Tsujino N.
  • Journal Title: Ann N Y Acad Sci. 1200 Pages: 149-161
• [Journal Article] Ectopic Overexpression of Orexin Alters Sleep/Wakefulness States and Muscle Tone Regulation during REM Sleep in Mice. (2010)
  • Author(s): Willie JT, Takahira H, Shibahara M, Hara J, Nomiyama M, Yanagisawa M, Sakurai T.
  • Journal Title: J Mol Neurosci. 43(2) Pages: 155-161
• [Journal Article] Activation of Bombesin Receptor Subtype-3 Influences Activity of Orexin Neurons by Both Direct and Indirect Pathways. (2010)
  • Author(s): Furutani N, Hondo M, Tsujino N, Sakurai T.
  • Journal Title: J Mol Neurosci. 42(1)[Epub ahead of print] Pages: 106-111
• [Journal Article] Orexin neurons are indispensable for stress induced thermogenesis in mice. (2010)
  • Author(s): Zhang W, et al.
  • Journal Title: J Physiol. Volume: 588(Pt 21) Pages: 4117-4229
  • Peer Reviewed
• [Journal Article] Ectopic overexpression of orexin alters sleep/wakefulness states and mu scle tone regulation during REM sleep in mice. (2010)
  • Author(s): Willie JT, et al.
  • Journal Title: J Mol Neurosci. Volume: 43(2) Pages: 155-161
  • Peer Reviewed
• [Journal Article] The orexin system roles in sleep/wake regulation. (2010)
  • Author(s): Sakurai T, et al.
  • Journal Title: Ann N Y Acad Sci. Volume: 1200 Pages: 149-161
  • Peer Reviewed
• [Journal Article] Activation of Bombesin Receptor Subtype-3 influences Activity of Orexin Neurons by both direct and indirect Pathways. (2010)
  • Author(s): Furutani, N., et al.
  • Journal Title: J.Mol.Neurosci. (in press)
  • Peer Reviewed
• [Journal Article] Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states. (2010)
  • Author(s): Hondo, M.
  • Journal Title: Acta Physiol (Oxf) (in press)
  • Peer Reviewed
• [Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. (2009)
  • Author(s): Shiuchi, T., Haque, M.S., Okamoto, S., Inoue, T., Kageyama, H., Lee, S, Toda, C., Suzuki, A., Bachman, E.S., Kim, Y-B., Sakurai, T., Yanagisawa, M., Shioda, S., Imoto, K., Minokoshi, Y.
  • Journal Title: Cell Metab Dec 10(6) Pages: 466-480
• [Journal Article] Attenuated phrenic long-term facilitation in orexin neuron-ablated mice. (2009)
  • Author(s): Toyama S, Sakurai T, Tatsumi K, Kuwaki T.
  • Journal Title: Respir Physiol Neurobiol. 168(3) Pages: 295-302
• [Journal Article] Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis. (2009)
  • Author(s): Zhang W, Zhang N, Sakurai T, Kuwaki T.
  • Journal Title: Brain Res. 25;1262 Pages: 25-37
• [Journal Article] Thyrotropin-Releasing Hormone Increases Behavioral Arousal through Modulation of Hypocretin/Orexin Neurons. (2009)
  • Author(s): Hara, J.Gerashchenko, D, Wisor, J.P.,Sakurai, T., Xie, X., Kilduff, T.S.
  • Journal Title: J.Neurosci. 29(12) Pages: 3705-3714
• [Journal Article] Integrative physiology of orexins and orexin receptors. (2009)
  • Author(s): Mieda M, Sakurai T.
  • Journal Title: CNS Neurol Disord Drug Targets. 8(4) Pages: 281-295
• [Journal Article] Selective loss of GABA_B receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture. (2009)
  • Author(s): Matsuki, T., Nomiyama, M, Takahira, H., Hirashima, N., Kilduff, T.S., Kunita, S., Takahashi, S., Yagami, K., Bettler, B., Yanagisawa, M., Sakurai, T.
  • Journal Title: Proc.Natl.Acad., Sci., USA. 106(11) Pages: 4456-4464
• [Journal Article] IGFBP3 colocalizes with and regulates hypocretin (orexin). (2009)
  • Author(s): Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E.
  • Journal Title: PLoS ONE. 4(1)
• [Journal Article] Enhanced Orexin Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity. (2009)
  • Author(s): Funato, H., Tsai, A., Willie, J.T., Kisanuki, Y., Williams, S.C., Sakurai, T., Yanagisawa, M.
  • Journal Title: Cell Metab. 7;9(1) Pages: 64-76
• [Journal Article] Orexin/Hypocretin : a neuropeptide at the interface of sleep, energy homeostasis, and reward system. (2009)
  • Author(s): Tsujino N, Sakurai T.
  • Journal Title: Pharmacol Rev. 61(2) Pages: 162-176
• [Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. (2009)
  • Author(s): Shiuchi, T., et al.
  • Journal Title: Cell Metab 10 Pages: 466-480
  • Peer Reviewed
• [Journal Article] Thyrotropin-Releasing Hormone Increases Behavioral Arousal through Modulation of Hypocretin/Orexin Neurons. (2009)
  • Author(s): Hara, J., et al.
  • Journal Title: J. Neurosci. 29 Pages: 3705-3714
  • Peer Reviewed
• [Journal Article] Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor GPR109B. (2009)
  • Author(s): Irukayama, Y., et al.
  • Journal Title: Proc. Natl. Acad., Sci., USA. 106 Pages: 3930-3934
  • Peer Reviewed
• [Journal Article] Selective loss of GABA_B receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture. (2009)
  • Author(s): Matsuki, T., et al.
  • Journal Title: Proc. Natl. Acad., Sci., USA. 106 Pages: 4459-4464
  • Peer Reviewed
• [Journal Article] IGFBP3 colocalizes with and regulates hypocretin (orexin). (2009)
  • Author(s): Honda M., et al.
  • Journal Title: PLoS ONE. 4
  • Peer Reviewed
• [Journal Article] Enhanced Orexin Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity. (2009)
  • Author(s): Funato, H., et al.
  • Journal Title: Cell Metab. 9 Pages: 64-76
  • Peer Reviewed
• [Journal Article] Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice. (2008)
  • Author(s): Liu M, Thankachan S, Kaur S, Begum S, Blanco-Centurion C, Sakurai T, Yanagisawa M, Neve R, Shiromani PJ.
  • Journal Title: Eur J Neurosci. 28(7) Pages: 1382-1393
• [Journal Article] Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. (2008)
  • Author(s): Mishima K, Fujiki N, Yoshida Y, Sakurai T, Honda M, Mignot E, Nishino S.
  • Journal Title: Sleep 31(8) Pages: 1119-1126
• [Journal Article] Identification of a population of sleep-active cerebral cortex neurons. (2008)
  • Author(s): Gerashchenko, D., Wisor, J.P., Burns, D., Reh, R.K., Shiromani, P.J., Sakurai, T., delaIglesia, H.O., Kilduff, T.S.
  • Journal Title: Proc.Natl.Acad., Sci., USA. 105 Pages: 10227-10232
• [Journal Article] Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. (2008)
  • Author(s): Xie X, Wisor JP, Hara J, Crowder TL, Lewinter R, Khroyan TV, Yamanaka A, Diano S, Horvath TL, Sakurai T, Toll L, Kilduff TS.
  • Journal Title: J Clin Invest. 118(7) Pages: 2471-2481
  • NAID: 120001130328
• [Journal Article] Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice. (2008)
  • Author(s): Kaur S, Thankachan S, Begum S, Blanco-Centurion C, Sakurai T, Yanagisawa M, Shiromani PJ.
  • Journal Title: Brain Res. 1205 Pages: 47-54
• [Journal Article] Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse. (2008)
  • Author(s): Murashima-Suginami, A., Takahashi, K., Sakata, T., Tsukamoto, H., Sugai, M., Yanagita, M., Shimizu, A., Sakurai, T., Slavkin, H.C., Bessho, K.
  • Journal Title: Biochem Biophys Res Commun 369(4) Pages: 1012-1016
• [Journal Article] Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice. (2008)
  • Author(s): Tsuneki H, Murata S, Anzawa Y, Soeda Y, Tokai E, Wada T, Kimura I, Yanagisawa M, Sakurai T, Sasaoka T.
  • Journal Title: Diabetologia. 51(4) Pages: 657-667
• [Journal Article] New developments in sleep research : molecular genetics, gene expression, and systems neurobiology. (2008)
  • Author(s): Kilduff TS., et al.
  • Journal Title: J Neurosci. 28 Pages: 11814-11818
  • Peer Reviewed
• [Journal Article] Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice. (2008)
  • Author(s): Liu M., et al.
  • Journal Title: Eur J Neurosci. 31 Pages: 1119-1126
  • Peer Reviewed
• [Journal Article] Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities. (2008)
  • Author(s): Aikawas., et al.
  • Journal Title: Regul Pept. 151 Pages: 147-152
  • Peer Reviewed
• [Journal Article] Identification of a population of sleep-active cerebral cortex neurons. (2008)
  • Author(s): Gerashchenko, D., et al.
  • Journal Title: Proc. Natl. Acad., Sci., USA. 105 Pages: 10227-10232
  • Peer Reviewed
• [Journal Article] Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. (2008)
  • Author(s): Xie X., et al.
  • Journal Title: J Clin Invest 118 Pages: 2471-2481
  • Peer Reviewed
• [Journal Article] Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice. (2008)
  • Author(s): Kaur S., et al.
  • Journal Title: Brain Res. 1205 Pages: 47-54
  • Peer Reviewed
• [Journal Article] Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse. (2008)
  • Author(s): Murashima-Suginami, A., et al
  • Journal Title: Biochem Biophys Res Commun 369 Pages: 1012-1016
  • Peer Reviewed
• [Journal Article] Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice. (2008)
  • Author(s): Tsuneki H., et al.
  • Journal Title: Diabetologia. 51 Pages: 657-667
  • Peer Reviewed
• [Presentation] QRFP欠損マウスにみられた低体重と摂食量減少及び不安様行動と諺様行動 (2011)
  • Author(s): 岡本紀太郎、原淳子、高雄啓三、宮川剛、酒井寿郎、柳沢正史、桜井武
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2011-03-29
• [Presentation] グリシンによるオレキシン作動性ニューロンの抑制 (2011)
  • Author(s): 本堂茉莉、古谷直生、山崎美和子、渡辺雅彦、桜井武
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2011-03-28
• [Presentation] 薬理遺伝学的なオレキシン神経の活動制御による睡眠1覚醒状態の変化 (2011)
  • Author(s): 佐々木功、鈴木美佳、三枝理博、桜井武
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2011-03-28
• [Presentation] オレキシン神経と視索前野GABA神経の組織的および機能的連関について (2011)
  • Author(s): 辻野なつ子、齋藤夕貴、本堂茉莉、三枝理博、桜井武
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2011-03-28
• [Presentation] オレキシン1受容体、2受容体の活性化はノンレム、レム睡眠に対し異なる効果を及ぼす (2011)
  • Author(s): 長谷川恵美、三枝理博、木佐貫泰、柳沢正史、桜井武
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2011-03-28
• [Presentation] SCN以外の前脳腹側部のおけるBMAL1の発現が自発活動の詳細な概日パターンを形成する (2011)
  • Author(s): 三枝理博、長谷川恵美、ケサリスニコレッタ、田中光一、桜井武
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2011-03-28
• [Presentation] NPB/NPw receptor1の社:会行動と恐怖記憶における役割 (2011)
  • Author(s): 黒岩ルビー、古谷直生、原淳子、阿部友美、本池俊行、三枝理博、柳川右千夫、桑木共之、柳沢正史、桜井竹
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2011-03-28
• [Presentation] Orexin neurons at interface of energy homeostasis, emotion, and sleep/wakefulness states. (2010)
  • Author(s): Sakurai, T.
  • Organizer: 5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
  • Place of Presentation: 京都国際会議場、京都 招待講演
  • Year and Date: 2010-12-04
• [Presentation] オレキシンによる睡眠覚醒の制御機構 (2010)
  • Author(s): 桜井武
  • Organizer: 金沢大学薬学シンポジウム2010～生物時計の謎に挑む～
  • Place of Presentation: 金沢大学、石川
  • Year and Date: 2010-12-02
• [Presentation] オレキシンによる睡眠覚醒の制御機構 (2010)
  • Author(s): 桜井武
  • Organizer: 金沢大学薬学シンポジウム2010～生物時計の謎に挑む
  • Place of Presentation: 金沢大学、石川 招待講演
  • Year and Date: 2010-12-02
• [Presentation] オレキシンニューロンのコネクトミクス:各種モデルマウスによる解析 (2010)
  • Author(s): 桜井武
  • Organizer: 第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会シンポジウム7
  • Place of Presentation: 仙台国際センター、宮城
  • Year and Date: 2010-09-16
• [Presentation] オレキシンニューロンのコネクトミクス:各種モデルマウスによる解析 (2010)
  • Author(s): 桜井武
  • Organizer: 第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 仙台国際センター、宮城 招待講演
  • Year and Date: 2010-09-16
• [Presentation] 睡眠・覚醒状態の制御機構におけるオレキシンによる睡眠・覚醒の制御機構およびエネルギー恒常性への関与特別講演 (2010)
  • Author(s): 桜井武
  • Organizer: 第8回メタボリックシンドロームカンファレンス
  • Place of Presentation: 芝蘭会館、京都
  • Year and Date: 2010-07-17
• [Presentation] (特別講演)睡眠・覚醒状態の制御機構におけるオレキシンによる睡眠・覚醒の制御機構およびエネルギー恒常性への関与 (2010)
  • Author(s): 桜井武
  • Organizer: 第8回メタボリックシンドロームカンファレンス
  • Place of Presentation: 京都大学医学部芝蘭会館、京都 招待講演
  • Year and Date: 2010-07-17
• [Presentation] 睡眠・覚醒状態の制御機構におけるオレキシン産生ニューロンの役割 (2010)
  • Author(s): 桜井武
  • Organizer: 第35回日本睡眠学会定期学術集会
  • Place of Presentation: 名古屋国際会議場、愛知 招待講演
  • Year and Date: 2010-07-01
• [Presentation] オレキシン神経欠損マウスにおけるノルアドレナリン神経活動の解析 (2010)
  • Author(s): 辻野なつ子、常松友美、山中章弘、小山純正、桜井武
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡市民文化ホール、岩手
  • Year and Date: 2010-05-19
• [Presentation] 睡眠覚醒状態の維持機構におけるオレキシンニューロンの役割 (2010)
  • Author(s): 桜井武
  • Organizer: 第87回日本生理学会大会シンポジウム7
  • Place of Presentation: 盛岡市民文化ホール、岩手 招待講演
  • Year and Date: 2010-05-19
• [Presentation] 扁桃体におけるNPBWR1の役割 (2010)
  • Author(s): 桜井武
  • Organizer: 第7回GPCR研究会
  • Place of Presentation: 未来館ホール、東京 招待講演
  • Year and Date: 2010-05-07
• [Presentation] Orexin as a waking substance. (2010)
  • Author(s): Sakurai, T.
  • Organizer: Turkish-Japanese Sleep Forum 2010
  • Place of Presentation: Crown Plaza, Izmir, Turky 招待講演
  • Year and Date: 2010-05-03
• [Presentation] Roles of orexins in regulation of energy homeostasis (2010)
  • Author(s): Sakurai, T
  • Organizer: Symposium of the 14^<th> International Congress on Endocrinology
  • Place of Presentation: 京都国際会議場、京都
  • Year and Date: 2010-03-29
• [Presentation] Orexin neurons at interface of energy homeostasis, emotion, and sleep/wakefulness states. (2010)
  • Author(s): 桜井武
  • Organizer: 5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium.
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan.
• [Presentation] 睡眠・覚醒状態の制御機構におけるオレキシン産生ニューロンの役割 (2010)
  • Author(s): 桜井武
  • Organizer: 第35回日本睡眠学会定期学術集会
  • Place of Presentation: 名古屋国際会議場、愛知
• [Presentation] 睡眠覚醒状態の維持機構におけるオレキシンニューロンの役割 (2010)
  • Author(s): 桜井武
  • Organizer: 第87回日本生理学会大会シンポジウム7
  • Place of Presentation: 盛岡市民文化ホール(マリオス)、いわて県民情報センター(アイーナ)、盛岡
• [Presentation] 扁桃体におけるNPBWR1の役割 (2010)
  • Author(s): 桜井武
  • Organizer: 第7回GPCR研究会
  • Place of Presentation: 未来館ホール、東京
• [Presentation] Orexin as a waking substance. (2010)
  • Author(s): 桜井武
  • Organizer: Turkish-Japanese Sleep Forum 2010
  • Place of Presentation: Crown Plaza, Izmir, Turky
• [Presentation] Roles of orexins in regulation of energy homeostasis. (2010)
  • Author(s): 桜井武
  • Organizer: Symposium of the 1^<4th> International Congress on Endocrinology
  • Place of Presentation: Kyoto International Conference Center, Kyoto
• [Presentation] 新規神経ペプチドと睡眠・覚醒・情動 (2009)
  • Author(s): 桜井武
  • Organizer: 第56回中部日本生理学会教育講演
  • Place of Presentation: 石川県立音楽堂、石川
  • Year and Date: 2009-12-04
• [Presentation] A decade of research on orexin. (2009)
  • Author(s): 桜井武
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2009-07-29
• [Presentation] A decade of research on orexin. The 36^<th> Congress of the International Union of Physiological Sciences (2009)
  • Author(s): Sakurai, T
  • Organizer: The 36^<th> Congress of the International Union of Physiological Sciences
  • Place of Presentation: 京都国際会議場、京都
  • Year and Date: 2009-07-29
• [Presentation] オレキシン産生神経による睡眠・覚醒の安定化機構 (2009)
  • Author(s): 桜井武
  • Organizer: 第56回日本実験動物学会総会シンポジウム3
  • Place of Presentation: 大宮ソニックシティ、大宮
  • Year and Date: 2009-05-15
• [Presentation] オレキシンによる睡眠・覚醒の安定化機構と行動制御 (2009)
  • Author(s): 桜井武
  • Organizer: 北陸実験動物研究会
  • Place of Presentation: 金沢大学、石川
  • Year and Date: 2009-04-18
• [Presentation] 睡眠・覚醒と情動における新規神経ペプチドの役割 (2009)
  • Author(s): 桜井武
  • Organizer: 第7回北海道大学脳科学研究教育センターシンポジウム「脳の個性を科学する:遺伝子と環境がつくる脳の力」
  • Place of Presentation: (金)北海道大学、北海道
  • Year and Date: 2009-02-08
• [Presentation] Orexin : a neuropeptide at the interface of emotion, metabolism and sleep/wake states. (2009)
  • Author(s): 桜井武
  • Organizer: Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptide
  • Place of Presentation: Iwasaki Hotel, Yakushima, Kagoshima
• [Presentation] 新規神経ペプチドと覚醒・情動 (2009)
  • Author(s): 桜井武
  • Organizer: 第27回内分泌代謝学サマーセミナー
  • Place of Presentation: 三国観光ホテル、福井
• [Presentation] Orexin : a neuropeptide at the interface of emotion, metabolism and sleep/wake states (2009)
  • Author(s): Sakurai, T
  • Organizer: Satellite Symposium of the 9^<th> International Symposium on VIP, PACAP and Related Peptide
  • Place of Presentation: 屋久島いわさきホテル、鹿児島
• [Presentation] Acute and Chronic Regulation of Sleep-Wakefulness States by Orexin/Hypocretin Neurons. (2008)
  • Author(s): Sakurai, T
  • Organizer: SfN meeting
  • Place of Presentation: ワシントンD. C. (米国)
  • Year and Date: 2008-11-14
• [Presentation] The Neural Circuit of Orexin : Mechanisms for Maintaining Sleep and Wakefulness. (2008)
  • Author(s): Sakurai, T
  • Organizer: 2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] Roles of orexin/hypocretin system in the regulation of sleep-waking cycle. (2008)
  • Author(s): Sakurai, T
  • Organizer: Acta Physiologica International Symposium.
  • Place of Presentation: オウル(フィンランド)
  • Year and Date: 2008-08-13
• [Presentation] Acute and Chronic Regulation of Sleep-Wakefulness States by Orexin/ Hypocretin (2008)
  • Author(s): Sakurai, T
  • Organizer: 22^<nd> APSS annual meeting
  • Place of Presentation: ボルチモア(米国)
  • Year and Date: 2008-06-10
• [Presentation] Orexin (Hypocretin)gene transfer improves narcoleptic symptoms in or exin null mice. (2008)
  • Author(s): Liu, M., et al.
  • Organizer: 22^<nd> APSS annual meeting
  • Place of Presentation: ボルチモア(米国)
  • Year and Date: 2008-06-10
• [Presentation] Entrainment of Temperature and Activity Rhythms to Restricted Feeding in Orexin Knock Out Mice (2008)
  • Author(s): Kaur S., et al.
  • Organizer: 22^<nd> APSS annual meeting
  • Place of Presentation: ボルチモア(米国)
  • Year and Date: 2008-06-07
• [Presentation] Acute and Chronic Regulation of Sleep-Wakefulness States by Orexin/Hypocretin Neurons. (2008)
  • Author(s): 桜井武
  • Organizer: SfN meeting, Walter E.
  • Place of Presentation: Washington Convention CenterWashington D.C., USA
• [Presentation] The Neural Circuit of Orexin : Mechanisms for Maintaining Sleep and Wakefulness. (2008)
  • Author(s): 桜井武
  • Organizer: 2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
  • Place of Presentation: Toyama International Conference Center, Toyama, Japan.
• [Presentation] Roles of orexin/hypocretin system in the regulation of sleep-waking cycle. (2008)
  • Author(s): 桜井武
  • Organizer: Acta Physiologica International Symposium.
  • Place of Presentation: Kastelli Research Centre.University of Oulu, Oulu, Finland
• [Presentation] Acute and Chronic Regulation of Sleep-Wakefulness States by Orexin/Hypocretin Symposium S02 at Sleep 2008 (2008)
  • Author(s): 桜井武
  • Organizer: 22^<nd> APSS annual meeting
  • Place of Presentation: Baltimore Convention Center, Baltimore, MD, USA
• [Book] なぜ目覚めるのか(睡眠の科学-なぜ眠るのか)(ISBN-10: 4062577054、ISBN-13:978-4062577052) (2010)
  • Author(s): 櫻井武
  • Total Pages: 248
  • Publisher: 講談社ブルーバックス
• [Book] 睡眠の科学-なぜ眠るのかなぜ目覚めるのか (2010)
  • Author(s): 櫻井武
  • Total Pages: 248
  • Publisher: 講談社ブルーバックス
• [Book] Orphan G protein-coupled receptors and novel neuropeptides. Orexins and Orexin Receptors : From Molecules to Integrative Physiology. (2008)
  • Author(s): Matsuki T, Sakurai T
  • Total Pages: 256
  • Publisher: Springer
• [Book] The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion. (2008)
  • Author(s): Hondo M., Ishii, M., Sakurai T
  • Total Pages: 256
  • Publisher: Springer
• [Book] 脳と栄養ハンドブック (2008)
  • Author(s): 桜井武
  • Total Pages: 330
  • Publisher: サイエンスフォーラム社
• [Book] 時間生物学辞典 (2008)
  • Author(s): 桜井武
  • Total Pages: 340
  • Publisher: 朝倉書店
• [Book] 臨床睡眠学 (2008)
  • Author(s): 桜井武
  • Total Pages: 470
  • Publisher: 日本臨床社
• [Remarks] ホームページ等
  • URL: http://web.kanazawa-u.ac.jp/~med05/
• [Remarks]
  • URL: http://web.kanazawa-u.ac.jp/~med05/