Dynamics of cardiac stem cells in myocardial repair/regeneration and regulation of their cell fate by cytokines
Project/Area Number |
20390069
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
|
Research Institution | Osaka University |
Principal Investigator |
FUJIO Yasushi Osaka University, 大学院・薬学研究科, 教授 (20359839)
|
Co-Investigator(Kenkyū-buntansha) |
AZUMA Junichi 大阪大学, 大学院・薬学研究科, 教授 (30144463)
MAEDA Makiko 兵庫医療大学, 薬学部, 講師 (70461168)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
Keywords | 組織幹細胞 / サイトカイン / 心筋リモデリング / 細胞運命 / 心臓 / 心筋組織幹細胞 / 血管内皮 / IL-6 / STAT3 / Pim-1 / 心筋細胞 |
Research Abstract |
So far, cardiac regenerative activity has been believed to be trivial; however, recent studies have demonstrated that pluripotent stem cells exist in myocardium. In this study, we addressed the molecular mechanisms of cardiac stem cell differentiation and examined the cellular dynamics of the cardiac stem cell-derived endothelial cells in infarct myocardium. And we found that IL-6 family cytokines induce endothelial differentiation from cardiac stem cells through STAT3/Pim-1 pathway both in vitro and in vivo.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident stem cells both in vitro and in vivo.2011
Author(s)
Iwakura T., Mohri T., Hamatani T., Obana M., Yamashita T., Maeda M., Katakami N., Kaneto H., Komuro I., Azuma J., Nakayama H., Fujio Y.
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Journal Title
J.Mol.Cell.Cardiol. In press
Related Report
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[Journal Article] SHP2 negatively regulates skeletal alpha-actin gene expression downstream of gp130 signaling in cardiomyocytes.2010
Author(s)
Nakaoka Y., Shioyama W., Kunimoto S., Fujio Y., Higuchi K., Nishida K., Arita, Y., Kuroda T., Hirota H., Yamauchi-Takihara K., Hirano T., Komuro I., Mochizuki N.
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Journal Title
J.Mol.Cell.Cardiol. 49
Pages: 157-164
Related Report
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[Journal Article] Therapeutic activation of STAT3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction.2010
Author(s)
Obana M., Maeda M., Takeda K., Hayama A., Mohri T., Yamashita T., Nakaoka Y., Komuro I., Takeda K., Matsumiya G., Azuma J., Fujio Y.
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Journal Title
Circulation. 121
Pages: 684-691
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[Journal Article] Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38 MAP kinase in cardiac myocytes.2008
Author(s)
Yamamoto, Y., Hoshino, Y., Ito, T., Nariai, T., Mohri, T., Obana M., Hayata, N., Uozumi, Y., Maeda M., Fujio Y., Azuma, J.
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Journal Title
Cardiovasc.Res. 79
Pages: 89-96
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