Study on roles of a novel NADPH oxidase isoform in the development of lifestyle related diseases

• Project/Area Number: 20390071
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: YABE Chihiro Kyoto Prefectural University of Medicine, 医学研究科, 教授 (70150571)
• Co-Investigator(Kenkyū-buntansha): HIRAYAMA Aki 筑波技術大学, 保健科学部, 特任教授 (20323298) ; IWATA Kazumi 京都府立医科大学, 大学院・医学研究科, 講師 (60305571) ; KATSUYAMA Masato 京都府立医科大学, 大学院・医学研究科, 准教授 (60315934) ; 松野 邦晴 京都府立医科大学, 大学院・医学研究科, 助教 (50420708) ; KAKEHI Tomoko 京都府立医科大学, 大学院・医学研究科, プロジェクト研究員 (20433279)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2008: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
• Keywords: 糖尿病 / 循環器・高血圧 / シグナル伝達 / 薬理学

Research Abstract

Induction of hyperglycemia with streptozotocin up-regulated the expression of NOX1, a novel isoform of superoxide-generating NADPH oxidase in the kidney. NOX1 derived ROS were shown to increase oxidative stress and to activate p38 MAPK, thereby stimulating renal redox-sensitive signaling under diabetic conditions.

Research Products

• [Journal Article] NADPH oxidase isoforms and anti-hypertensive effects of atorvastatin demonstrated in two animal models. (2009)
  • Author(s): Cui W, Matsuno K, Iwata K, Ibi M, Katsuyama M, Kakehi T, Sasaki M, Ikami K, Zhu K, Yabe-Nishimura C.
  • Journal Title: J Pharmacol Sci 111 Pages: 260-268
  • NAID: 10026154161
• [Journal Article] NOX enzymes and diabetic complications. (2008)
  • Author(s): Kakehi T, Yabe-Nishimura C.
  • Journal Title: Semin Immunopathol 30 Pages: 301-314
• [Journal Article] The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme : Possible involvement of the ERK1/2-JunB pathway. (2008)
  • Author(s): Cevik MO, Katsuyama M, Kanda S, Kaneko T, Iwata K, Ibi M, Matsuno K, Kakehi T, Cui W, Sasaki M, Yabe-Nishimura C.
  • Journal Title: Biochem Biophys Res Commun 374 Pages: 351-355
• [Journal Article] NOX enzymes and diabetic complications (2008)
  • Author(s): Kakehi T
  • Journal Title: Semin Imraunopathol 30 Pages: 301-314
  • Peer Reviewed
• [Presentation] Renal redox-sensitive signaling in type 1 diabetes is suppressed in Nox1-deficient mice. (2011)
  • Author(s): Zhu K, Matsumoto M, Iwata K, Yabe-Nishimura C.
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-17
• [Presentation] Renal redox-sensitive signaling in type 1 diabetes is suppressed in Nox 1-deficient mice (2011)
  • Author(s): Zhu Kai, Matsumoto M, Iwata K, Yabe-Nishimura C
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-17
• [Presentation] 糖尿病性腎症モデルにおける活性酸素産生酵素NOX1の発現と酸化的ストレス (2009)
  • Author(s): 筧朋子、岩田和実、Taye Ashraf、松野邦晴、矢部千尋
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-22
• [Presentation] 活性酸素産生酵素NADPHオキシダーゼの関わる疾患と病態 (2009)
  • Author(s): 矢部千尋、松野邦晴、衣斐督和、岩田和実
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-16
• [Presentation] 腎臓における活性酸素産生酵素Nox1/NADPH oxidaseの発現の解析 (2008)
  • Author(s): 筧朋子、松野邦晴、岩田和実、Taye Ashraf、矢部千尋
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-14
• [Presentation] 腎臓における活性酸素産生酵素Nox1の発現と腎症モデルを用いた解析 (2008)
  • Author(s): 筧朋子、岩田和実、Taye Ashraf、松野邦晴、矢部千尋
  • Organizer: 第23回日本糖尿病合併症学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-03
• [Presentation] 糖尿病性腎症モデルにおける活性酸素産生酵素Nox1の解析 (2008)
  • Author(s): 筧朋子、岩田和実、Taye Ashraf、松野邦晴、矢部千尋
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22
• [Presentation] 糖尿病性腎症モデルにおける活性酸素産生酵素Nox1の解析 (2008)
  • Author(s): 筧 朋子
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-22