| Project/Area Number |
20390071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YABE Chihiro Kyoto Prefectural University of Medicine, 医学研究科, 教授 (70150571)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAYAMA Aki 筑波技術大学, 保健科学部, 特任教授 (20323298)
IWATA Kazumi 京都府立医科大学, 大学院・医学研究科, 講師 (60305571)
KATSUYAMA Masato 京都府立医科大学, 大学院・医学研究科, 准教授 (60315934)
松野 邦晴 京都府立医科大学, 大学院・医学研究科, 助教 (50420708)
KAKEHI Tomoko 京都府立医科大学, 大学院・医学研究科, プロジェクト研究員 (20433279)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Keywords | 糖尿病 / 循環器・高血圧 / シグナル伝達 / 薬理学 |
|---|
| Research Abstract |
Induction of hyperglycemia with streptozotocin up-regulated the expression of NOX1, a novel isoform of superoxide-generating NADPH oxidase in the kidney. NOX1 derived ROS were shown to increase oxidative stress and to activate p38 MAPK, thereby stimulating renal redox-sensitive signaling under diabetic conditions.
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