Influences of genetic and environmental factors on schizophrenia
| Project/Area Number |
20390073
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Meijo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MAMIYA Takayoshi 名城大学, 薬学部, 助教 (70340297)
NIWA Minae , 日本学術振興会・特別研究員 (60469046)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Taku 名古屋大学, 医学部附属病院, 准教授 (10377426)
MOURI Akihiro 名古屋大学, グローバルCOE, 特任助教 (20597851)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Keywords | 統合失調症 / 行動学 / 遺伝子 / ストレス / 神経化学 |
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| Research Abstract |
Genetic susceptibility factors for adult psychiatric illnesses such as DISC1 influence adult high brain functions. Here we report the potential to generate an animal model via in utero gene transfer to address how nonlethal deficits in early development may affect postnatal brain maturation and high brain functions in adulthood, which are impaired in various psychiatric illnesses such as schizophrenia. We show that transient knockdown of DISC1 in the pre- and perinatal stages, specifically in the prefrontal cortex, leads to selective abnormalities in postnatal mesocortical dopaminergic maturation and behavioral abnormalities after puberty.
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Report
(4 results)
Research Products
(150 results)
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[Journal Article]2010
Author(s)
野田幸裕, 毛利彰宏, 鍋島俊隆
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Journal Title
実践行動薬理学(第I編基礎編:行動薬理研究における実験技術 10. 統合失調症動物モデルとその評価法)(金芳堂)
Pages: 79-93
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[Journal Article]2010
Author(s)
永井拓, 鍋島俊隆, 山田清文
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Journal Title
実践行動薬理学(第II編応用編:行動薬理研究の現在、第4章報酬機構関連、3. 依存性薬物による精神障害の分子機序)(金芳堂)
Pages: 272-281
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[Presentation] 覚せい剤により誘発される精神障害に対するガランタミンの効果2009
Author(s)
毛利彰宏, 野田幸裕, 王大勇, 安藤雄, 脇由香里, 古関竹直, 間宮隆吉, 鍋島俊隆
Organizer
第44回日本アルコール・薬物医学会総会・第21回日本アルコール精神医学会・第12回ニコチン・薬物依存研究フォーラム平成21年度合同学術集会
Place of Presentation
横浜
Year and Date
2009-09-08
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