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Influences of genetic and environmental factors on schizophrenia

Research Project

Project/Area Number 20390073
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionMeijo University

Principal Investigator

NABESHIMA Toshitaka  Meijo University, 薬学部, 教授 (70076751)

Co-Investigator(Kenkyū-buntansha) MAMIYA Takayoshi  名城大学, 薬学部, 助教 (70340297)
NIWA Minae  , 日本学術振興会・特別研究員 (60469046)
Co-Investigator(Renkei-kenkyūsha) NAGAI Taku  名古屋大学, 医学部附属病院, 准教授 (10377426)
MOURI Akihiro  名古屋大学, グローバルCOE, 特任助教 (20597851)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Keywords統合失調症 / 行動学 / 遺伝子 / ストレス / 神経化学
Research Abstract

Genetic susceptibility factors for adult psychiatric illnesses such as DISC1 influence adult high brain functions. Here we report the potential to generate an animal model via in utero gene transfer to address how nonlethal deficits in early development may affect postnatal brain maturation and high brain functions in adulthood, which are impaired in various psychiatric illnesses such as schizophrenia. We show that transient knockdown of DISC1 in the pre- and perinatal stages, specifically in the prefrontal cortex, leads to selective abnormalities in postnatal mesocortical dopaminergic maturation and behavioral abnormalities after puberty.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (150 results)

All 2011 2010 2009 2008 Other

All Journal Article (52 results) (of which Peer Reviewed: 48 results) Presentation (80 results) Book (4 results) Remarks (8 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 1 results)

  • [Journal Article] Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders.2011

    • Author(s)
      Niwa M, Matsumoto Y, Mouri A, Ozaki N, Nabeshima T.
    • Journal Title

      Int J Neuropsychopharmacol. 14(4)

      Pages: 459-477

    • NAID

      10030656981

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to PCP produces behavioral deficits accompanied by the overexpression of GLAST in the prefrontal cortex of postpubertal mice.2011

    • Author(s)
      Lu L, et al.
    • Journal Title

      Behav Brain Res.

      Volume: 220 Pages: 132-139

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders.2011

    • Author(s)
      Niwa M, et al.
    • Journal Title

      Int J Neuropsychopharmacol.

      Volume: 14 Pages: 459-477

    • NAID

      10030656981

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice : possible involvement of abrain-specific transcription factor Npas4.2010

    • Author(s)
      Yun J, Nagai T, Nabeshima T., et al
    • Journal Title

      J Neurochem. 114(6)

      Pages: 1840-1851

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.2010

    • Author(s)
      Niwa M, Nabeshima T.
    • Journal Title

      Neuron. 65(4)

      Pages: 480-489

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.2010

    • Author(s)
      Ikeda M, Mouri A, Nabeshima T., et al
    • Journal Title

      Biol Psychiatry. 207(2)

      Pages: 235-243

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to phencyclidine produces abnormal behaviour and NMDA receptor expression in postpubertal mice.2010

    • Author(s)
      Lu L, Mamiya T, Toriumi K, Mouri A, Nagai T, Nabeshima T.
    • Journal Title

      Int J Neuropsychopharmacol. 13(7)

      Pages: 877-889

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to phencyclidine produces abnormal behavior and NMDA receptor expression in postpubertal mice.2010

    • Author(s)
      Lu L, et al.
    • Journal Title

      Int J Neuropsychopharmacol.

      Volume: 13 Pages: 877-889

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase.2010

    • Author(s)
      Alkam T, et al.
    • Journal Title

      Behav Brain Res.

      Volume: 210 Pages: 184-190

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine : involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems.2010

    • Author(s)
      Noda Y, et al.
    • Journal Title

      Int J Neuropsychopharmacol.

      Volume: 13 Pages: 1343-1354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme : implications for specialized acetyl coenzyme A metabolism in the CNS.2010

    • Author(s)
      Ariyannur PS, et al.
    • Journal Title

      Brain Res.

      Volume: 1335 Pages: 1-13

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice : possible involvement of a brain-specific transcription factor Npas4.2010

    • Author(s)
      Yun J, et al.
    • Journal Title

      J Neurochem.

      Volume: 114 Pages: 1840-1851

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal formation of PCP-treated mice.2010

    • Author(s)
      Iritani S, et al.
    • Journal Title

      Neurosci Res.

      Volume: 68 Pages: 125-30

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice : involvements of 5-HT1A receptor.2010

    • Author(s)
      Shin EJ, et al.
    • Journal Title

      J Pharmacol Sci.

      Volume: 113 Pages: 404-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of piccolo C2A domain induces depression-like behavior in mice.2010

    • Author(s)
      Furukawa-Hibi Y, et al.
    • Journal Title

      Neuroreport

      Volume: 21 Pages: 1177-81

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential role of NMDA receptor channel ε4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine.2010

    • Author(s)
      Hagino Y, et al.
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of object-based attention in mice.2010

    • Author(s)
      Alkam T, et al.
    • Journal Title

      Behav Brain Res.

      Volume: 220 Pages: 185-193

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bi-directional effect of cholecystokinin receptor-2 overexpression on stress-triggered fear memory and anxiety in the mouse.2010

    • Author(s)
      Chen Q, et al.
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia : integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.2010

    • Author(s)
      Ikeda M, et al.
    • Journal Title

      Biol Psychiatry

      Volume: 207 Pages: 235-243

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined effect of neonatal immune activation and mutant DISCI on phenotypic changes in adulthood2010

    • Author(s)
      Ibi D, et.al.
    • Journal Title

      Behav.Brain Res. 206

      Pages: 32-37

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment2010

    • Author(s)
      Lu P, et.al.
    • Journal Title

      Behav Brain Res 207

      Pages: 387-393

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia : Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches2010

    • Author(s)
      Ikeda M, et.al.
    • Journal Title

      Biol.Psychiatry. 67

      Pages: 263-269

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Cyclophilin D in Learning and Memory2010

    • Author(s)
      Mouri A, et.al.
    • Journal Title

      Hippocampus 20

      Pages: 293-304

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region2010

    • Author(s)
      Ibi D, et.al.
    • Journal Title

      Neurochem Int. 56

      Pages: 77-83

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nociceptin and its metabolite attenuate U0126-induced memory impairment through anociceptin opioid peptide(NOP)receptor-independent mechanism2010

    • Author(s)
      Miwa M, et.al.
    • Journal Title

      Neurobiol.Learn.Mem. 93

      Pages: 396-405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knockdown of DISC 1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits2010

    • Author(s)
      Niwa M, et.al.
    • Journal Title

      Neuron 65

      Pages: 480-489

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      野田幸裕, 毛利彰宏, 鍋島俊隆
    • Journal Title

      実践行動薬理学(第I編基礎編:行動薬理研究における実験技術 10. 統合失調症動物モデルとその評価法)(金芳堂)

      Pages: 79-93

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      永井拓, 鍋島俊隆, 山田清文
    • Journal Title

      実践行動薬理学(第II編応用編:行動薬理研究の現在、第4章報酬機構関連、3. 依存性薬物による精神障害の分子機序)(金芳堂)

      Pages: 272-281

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests.2009

    • Author(s)
      Tomida S, Mamiya T, Nabeshima T, Ebihara S.
    • Journal Title

      Nature Genetics. 41

      Pages: 688-695

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine and 5-HT1A receptors.2009

    • Author(s)
      Nagai T, Nabeshima T.
    • Journal Title

      Psychopharmacology. 202

      Pages: 315-328

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating : involvement of pallidotegmental neurons.2009

    • Author(s)
      Mizoguchi H, Nagai T, Nabeshima T., et al
    • Journal Title

      Psychopharmacology. 207

      Pages: 235-243

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The long-lasting effects of cross-fostering on the emotional behavior in ICR mice.2009

    • Author(s)
      Lu L, Mamiya T, Lu P, Niwa M, Mouri A, Nagai T, Nabeshima T.
    • Journal Title

      Behav Brain Res. 198

      Pages: 172-178

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice2009

    • Author(s)
      Kurata K, et.al.
    • Journal Title

      Am.J.Physiol.Renal.Physiol. 297

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice2009

    • Author(s)
      Lu P, et.al.
    • Journal Title

      Br.J.Pharmacol. 157

      Pages: 1270-1277

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Usp46, encoding a ubiquitin specific peptides, as a quantitative trait gene regulating mouse immobile behavior in the tail suspension test and the forced swimming test2009

    • Author(s)
      Tomida S, et.al.
    • Journal Title

      Nat.Genet. 43

      Pages: 648-653

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fustin flavonoid attenuates β-amyloid(1-42)-induced learning impairment2009

    • Author(s)
      Jin CH, et.al.
    • Journal Title

      J.Neurosci.Res. 87

      Pages: 3658-3670

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of microsomal epoxide hydrolase in methamphetamine-induced drug dependence in mice2009

    • Author(s)
      Shin EJ, et.al.
    • Journal Title

      J.Neurosci.Res. 87

      Pages: 3679-3686

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating : involvement of pallidotegmental neurons2009

    • Author(s)
      Mizoguchi H, et.al.
    • Journal Title

      Psychopharmacology 207

      Pages: 235-243

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloprotease-9 inhibition improves amyloid β-mediated cognitive impairment and neurotoxicity in mice2009

    • Author(s)
      Mizoguchi H, et.al.
    • Journal Title

      J.Pharmacol.Exp.Ther. 331

      Pages: 14-22

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors.2009

    • Author(s)
      Nagai T, et al.
    • Journal Title

      Psychopharmacology(Berl) 202

      Pages: 315-328

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The long-lasting effects of cross-fostering on the emotional behavior in ICR mice.2009

    • Author(s)
      Lu L, et al.
    • Journal Title

      Behav Brain Res 198

      Pages: 172-178

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells.2008

    • Author(s)
      Niwa M, Nabeshima T.
    • Journal Title

      J Neurochem. 107(6)

      Pages: 1697-1708

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Involvement of pallidotegmental neurons in methamphetamine-and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen.2008

    • Author(s)
      Arai S, Nagai T, Nabeshima T, Yamada K.
    • Journal Title

      Neuropsychopharmacology. 33(13)

      Pages: 3164-3175

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization.2008

    • Author(s)
      Cen X, Nabeshima T.
    • Journal Title

      Mol Psychiatry. 13(4)

    • NAID

      10027807733

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Social isolation Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice.2008

    • Author(s)
      Ibi D, Nagai T, Nabeshima T, Yamada K.
    • Journal Title

      J Neurochem. 105(3)

      Pages: 921-932

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens.2008

    • Author(s)
      Fukakusa A, Nagai T, Nabeshima T., et al
    • Journal Title

      J Neurochem. 105

      Pages: 436-444

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【統合失調症の病態進行・難治化と動物モデル】難治性統合失調症の動物モデルと治療薬開発2008

    • Author(s)
      古関竹直, 他
    • Journal Title

      脳と精神の医学 19

      Pages: 31-40

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 統合失調症の薬物療法と精神科専門薬剤師の役割(特集精神科薬物療法と専門薬剤師の役割)2008

    • Author(s)
      亀井浩行, 鍋島俊隆
    • Journal Title

      医薬ジャーナル 44

      Pages: 81-86

    • NAID

      40015794634

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice.2008

    • Author(s)
      Ibi D, et al.
    • Journal Title

      J Neurochem 105

      Pages: 921-932

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase

    • Author(s)
      Alkam T, et.al.
    • Journal Title

      Behav.Brain Res. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine : involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems

    • Author(s)
      Noda Y, et.al.
    • Journal Title

      Int.J.Neuropsychipharmacol (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal exposure to phencyclidine produces abnormal behaviour and NMDA receptor expression in postpubertal mice

    • Author(s)
      Lu L, et.al.
    • Journal Title

      Int.J.Neuropsychopharmacol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新生児期のPolyI:C投与はフェンシクリジン投与によるグルタミン酸作動性神経伝達を障害し、異常行動を増悪させる2011

    • Author(s)
      毛利彰宏, ら
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 幼若期における社会敗北ストレスは脳内モノアミン量変化を伴う社会性行動の障害を惹起する2011

    • Author(s)
      安藤雄, ら
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経発達期の免疫応答誘発性脳機能障害におけるIFITM3の役割2011

    • Author(s)
      衣斐大祐, ら
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Polyl : C誘発性神経発達障害におけるInterferon-induced transmembrane protein 3の役割2010

    • Author(s)
      永井拓, ら
    • Organizer
      第118回日本薬理学会近畿部会
    • Place of Presentation
      大阪
    • Year and Date
      2010-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 新生仔期polyI : C処置によって誘発される不安様行動および学習記憶障害2010

    • Author(s)
      永井拓, ら
    • Organizer
      第20回日本医療薬学会年会
    • Place of Presentation
      千葉
    • Year and Date
      2010-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 精神疾患と脆弱遺伝子DISC12010

    • Author(s)
      鍋島俊隆
    • Organizer
      第20回日本医療薬学会年会
    • Place of Presentation
      千葉
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Impairment of postnatal dopaminergic maturation and adult behavior in disc1 knockdown mice by utero gene transfer.2010

    • Author(s)
      鍋島俊隆, et al
    • Organizer
      The International Symposium of Pharmacology-The 3rd Mainland, Taiwan and Hong Kong Symposium of Pharmacology
    • Place of Presentation
      瀋陽
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Impairment of postnatal dopaminergic maturation and adult behavior in disc1 knockdown mice by utero gene transfer.2010

    • Author(s)
      Nabeshima T, et al
    • Organizer
      The International Symposium of Pharmacology-The 3rd Mainland, Taiwan and Hong Kong Symposium of Pharmacology
    • Place of Presentation
      瀋陽、中国
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新生期のPoly : C投与は若年期フェンサイクリジン投与による情動・認知機能の障害を増強する2010

    • Author(s)
      野田幸裕, ら
    • Organizer
      第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 周産期の免疫異常が神経精神発達におよぼす影響2010

    • Author(s)
      永井拓, ら
    • Organizer
      第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 新生仔期の免疫異常は若年期における精神異常発現薬による情動・認知機能の障害を増強する2010

    • Author(s)
      毛利彰宏, ら
    • Organizer
      名古屋大学医学研究科・生理学研究所合同シンポジウム
    • Place of Presentation
      岡崎
    • Year and Date
      2010-08-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Knockdown of DISC1 by in utero gene transfer impaired postnatal dopaminergic maturation in the frontal cortex and adult behaviors.2010

    • Author(s)
      鍋島俊隆, et al
    • Organizer
      World Pharma 2010 16th World Congress of Basic and Clinical Pharmacology
    • Place of Presentation
      Copenhagen, Germany
    • Year and Date
      2010-07-20
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新生仔期polyI : C処置によって誘発される不安様行動および学習記憶障害に対するニコチンの効果。2010

    • Author(s)
      山田清文, ら
    • Organizer
      第117回日本薬理学会近畿部会
    • Place of Presentation
      徳島
    • Year and Date
      2010-07-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of antipychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal PolyI : C treatment.2010

    • Author(s)
      Ibi D, et al.
    • Organizer
      International Behavioral Neuroscience Society
    • Place of Presentation
      Sardinia, Italy
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] A dipeptide, Leu-Ile, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of ERK in the hippocampus.2010

    • Author(s)
      Nitta A, et al
    • Organizer
      CINP2010 World Congress
    • Place of Presentation
      香港
    • Year and Date
      2010-06-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic -maturation in the frontal cortex and leads to adult behavioral deficits.2010

    • Author(s)
      鍋島俊隆, et al
    • Organizer
      CINP2010 World Congress
    • Place of Presentation
      香港
    • Year and Date
      2010-06-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits2010

    • Author(s)
      Nabeshima T, et al
    • Organizer
      CINP2010 World Congress
    • Place of Presentation
      香港
    • Year and Date
      2010-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発達期大脳皮質におけるDISC1の役割:ドパミン作動性神経系異常に伴う成熟期行動変化について2010

    • Author(s)
      丹羽美苗, ら
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 生後発達期の母子分離・隔離飼育に対する脆弱性が成熟後の行動障害の原因となる2010

    • Author(s)
      丹羽美苗, ら
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 神経発達過程における慢性社会ストレス負荷が社会性行動に及ぼす影響2010

    • Author(s)
      安藤雄, ら
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 妊娠期ニコチン暴露は出生マウスの感情及び認識行動を障害する2010

    • Author(s)
      Tursun Alkam, ら
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規蛋白質 Shati をノックアウトしたマウスの行動解析2010

    • Author(s)
      日比(古川)陽子, 新田淳美, 鍋島俊隆, 山田清文
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウスのメタンフェタミン探索行動に対するガランタミンの効果2010

    • Author(s)
      古関竹直, 毛利彰宏, 間宮隆吉, 鍋島俊隆
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胎生期に受けた心理的ストレスによる成熟期以降の行動障害2010

    • Author(s)
      間宮隆吉, ら
    • Organizer
      第83回日本薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Pre-/Peri-natal nicotine exposure at different time-windows defferentally affected cognition and emotion in offspring of C57BL/6J mice.2010

    • Author(s)
      Trusun Alkam, et al
    • Organizer
      The 56th NIBB Conference "Neocortical Organization
    • Place of Presentation
      岡崎
    • Year and Date
      2010-03-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 新生仔期の免疫異常は、若年期における精神異常発現薬による情動・認知機能の障害を増強する2010

    • Author(s)
      肥田裕丈, ら
    • Organizer
      名城大学学術フロンティア推進事業第2回若手シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2010-01-30
    • Related Report
      2010 Final Research Report
  • [Presentation] A Novel Molecule "Shati" which inhibits the development of Mehtamphetamine-induced Dependence2009

    • Author(s)
      鍋島俊隆
    • Organizer
      Mini-Symposium on Methamphetamine Addiction
    • Place of Presentation
      台湾
    • Year and Date
      2009-12-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胎生期におけるNMDA受容体拮抗薬の投与は神経産生を障害し、長期間持続する行動異常を惹起する2009

    • Author(s)
      鳥海和也, ら
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 統合失調症グルタミン酸仮説に基づくモデル動物の開発と創薬2009

    • Author(s)
      鍋島俊隆
    • Organizer
      第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Neonatal polyI : C treatment in mice induces schizophrenia-like behavioral and neurochemical abnormalities in adulthood.2009

    • Author(s)
      永井拓, et al
    • Organizer
      The 39th annual meeting of the Society for Neuroscience (2009)
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2009-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Synergistic influence of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood.2009

    • Author(s)
      衣斐大祐, et al
    • Organizer
      The 39th annual meeting of the Society for Neuroscience(2009)
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Enriched environment in childhood prevents abnormal behaviors induced by phencyclidine in adulthood.2009

    • Author(s)
      Takenao Koseki, et al
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] ピッコロによるドパミントランスポーター内在化抑制とマウス行動変化2009

    • Author(s)
      新田淳美, 山田清文, 鍋島俊隆
    • Organizer
      第32回日本神経科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 覚せい剤誘発感覚情報処理機能障害に対するニコチンの有効性2009

    • Author(s)
      溝口博之, 衣斐大祐, 亀井浩之, 鍋島俊隆, H-C Kim, 田熊一敞, 山田清文
    • Organizer
      第32回日本神経科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prenatal exposure to phencyclidine produces abnormal behavior and NMDA receptor function in the postpubertal mice.2009

    • Author(s)
      陸玲玲, et al
    • Organizer
      第6回名古屋南京瀋陽学術シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] The involvement of glutamatergic neurotransmission in the isolated dominant-negative Disrupted-in-Schizophrenia-1 transgenic mice.2009

    • Author(s)
      Yurie Matsumoto, et al
    • Organizer
      第6回名古屋南京瀋陽学術シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Prenatal psychological stress produces anxiety-like behavior in offspring.2009

    • Author(s)
      Ping Lu, et al
    • Organizer
      第6回名古屋南京瀋陽学術シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Shati-over-expressed mice shows similar symptoms to the autism2009

    • Author(s)
      Wenting Liu, 新田淳美, 日比(古川)陽子, 鍋島俊隆, 山田清文
    • Organizer
      The 6th Nagoya-Nanjing-Shenyang Symposium on Pharmaceutical and Life Science
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of galantamine on methamphetamine-seeking behavior in mice induced by drug-associated environmental stimuli2009

    • Author(s)
      古関竹直, 毛利彰宏, 間宮隆吉, 鍋島俊隆
    • Organizer
      The 6th Nagoya-Nanjing-Shenyang Symposium on Pharmaceutical and Life Science
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 覚せい剤により誘発される精神障害に対するガランタミンの効果2009

    • Author(s)
      毛利彰宏, 野田幸裕, 王大勇, 安藤雄, 脇由香里, 古関竹直, 間宮隆吉, 鍋島俊隆
    • Organizer
      第44回日本アルコール・薬物医学会総会・第21回日本アルコール精神医学会・第12回ニコチン・薬物依存研究フォーラム平成21年度合同学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-09-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニコチンの報酬効果における組織プラスミノーゲン活性化因子の関与2009

    • Author(s)
      永井拓, 鍋島俊隆, 山田清文
    • Organizer
      第44回日本アルコール・薬物医学会総会・第21回日本アルコール精神医学会・第12回ニコチン・薬物依存研究フォーラム平成21年度合同学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-09-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of a quantitative trait gene underlying "behavioral despair" using CS mice with abnormal circadian rhythms.2009

    • Author(s)
      Ebihara Shizufumi, et al
    • Organizer
      XI Congress of the European Biological Rhythms Society
    • Place of Presentation
      Strasbourgフランス
    • Year and Date
      2009-08-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Roles of a novel molecule 'shati' in the development of methamphetamine-induced dependence2009

    • Author(s)
      Toshitaka Nabeshima, Minae Niwa, Xiaobo Cen, Hiroyuki Mizoguchi, Yasutomo Itoh, Kiyoyuki Kitaichi, Taku Nagai, Norio Ozaki, Yukihiro Noda, Atsumi Nitta
    • Organizer
      The Second Annual International Drug Abuse Research Society/International Society for Neurochemistry Satellite Meeting
    • Place of Presentation
      韓国
    • Year and Date
      2009-08-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Knockdown of disrupted-in -schizophrenia-1 in the developing cerebral cortex leads to dopaminergic disturbance and behavioral deficits after puberty.2009

    • Author(s)
      鍋島俊隆, et al
    • Organizer
      International Symposium on Brain and Mind Sciences Pathogenesis Study of Schizophrenia : Genes, neurobiology and Clinical Service
    • Place of Presentation
      台湾
    • Year and Date
      2009-08-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Usp46, encoding a ubiquitin specific peptidase, is a quantitative trait gene underlying "behavioral despair" in mice : using CS mice with abnormal circadian rhythms.2009

    • Author(s)
      Ebihara Shizufumi, et al
    • Organizer
      International Symposium on Biological Rhythm, Aug.1-4
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Abnormal behavior and NMDA receptor in the postpubertal mice after prenatal exposure to phencyclidine2009

    • Author(s)
      陸玲玲, ら
    • Organizer
      第115回日本薬理学会近畿部会
    • Place of Presentation
      金沢
    • Year and Date
      2009-06-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 隔離飼育ストレス負荷Disrupted-in-Schizophrenia-1変異遺伝子過剰発現マウスは新規統合失調症および気分障害病態モデルマウスとして有用である。2009

    • Author(s)
      丹羽美苗, ら
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保
    • Year and Date
      2009-06-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 発達期大脳皮質におけるDisrupted-in-Schizophrenia-1の役割:ドパミン作動性神経系および精神疾患への関与2009

    • Author(s)
      丹羽美苗, ら
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 胎生期におけるフェンサイクリジンの投与は神経発達障害を惹起し、長期持続する行動障害をもたらす2009

    • Author(s)
      鳥海和也, ら
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 新生児期polyI : C投与がドミナントネガティブ型DISC1トランスジェニックマウスの情動・認知機能に及ぼす影響。2009

    • Author(s)
      衣斐大祐, ら
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 統合失調症モデル動物を用いたプロテオーム解析2009

    • Author(s)
      永井拓、鍋島俊隆
    • Organizer
      名城大学学術フロンティア事業 第1回若手シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 胎生期におけるNMDA受容体拮抗薬フェンサイクリジンの効果2009

    • Author(s)
      鳥海和也, ら
    • Organizer
      名城大学学術フロンティア事業第1回若手シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-02
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Perinatal immune activation in mice leads an impairment of emotional behaviors with altered hippocampal glutamatergic neurotransmission in adolescence.2009

    • Author(s)
      Jinghua Yu, et al
    • Organizer
      名城大学学術フロンティア事業第1回若手シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-02
    • Related Report
      2010 Final Research Report
  • [Presentation] マウスの発達過程における慢性社会敗北ストレス負荷による社会性行動への影響2009

    • Author(s)
      脇由香里, ら
    • Organizer
      名城大学学術フロンティア事業第1回若手シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 飼育環境の変化を用いた季節性感情障害へのアプローチ2009

    • Author(s)
      毛利彰宏, ら
    • Organizer
      名城大学学術フロンティア事業第1回若手シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 統合失調症モデル動物を用いたプロテォーム解析2009

    • Author(s)
      永井拓, 鍋島俊隆
    • Organizer
      名城大学学術フロンティア事業第1回若手シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 隔離飼育ストレス負荷Disrupted-in-Schizophrenia 1変異遺伝子過剰発現マウスの統合失調症および気分障害病態モデルマウスとしての有用性2009

    • Author(s)
      丹羽美苗 Hanna Jaaro-Peled, 尾崎紀夫, 澤 明, 鍋島俊隆
    • Organizer
      名城大学学術フロンティア事業第1回若手シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Knockdown of Disrupted-in-schizophrenia-1in the developing cerebral cortex leads to dopaminergic disturbance and behavioral deficits after puberty.2008

    • Author(s)
      鍋島俊隆, et al
    • Organizer
      The 19th Korea-Japan Joint Seminar on Pharmacology
    • Place of Presentation
      韓国釜山
    • Year and Date
      2008-11-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Knockdown of disrupted-in-schizophrenia-1 in the developing cerebral cortex leads to dopaminergic disturbance and behavioral deficits after puberty2008

    • Author(s)
      Nabeshima T, Niwa M, Kamiya A, Murai R, Kubo K, Lu L, JAARO-PELED H, Nakajima K, Noda Y, Sawa A.
    • Organizer
      The 19th Korea-Japan Joint Seminar on Pharmacology
    • Place of Presentation
      Pusan
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Anti-ADHD drugs attenuate abnormal behaviors induced by PCP2008

    • Author(s)
      Narusawa S, Mouri A, Toriumi K, Koseki T, Aoyama Y, Ikawa N, Mamiya T, Nabeshima T
    • Organizer
      The 19th Korea-Japan Joint Seminar on Pharmacology
    • Place of Presentation
      Pusan
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prenatal phencyclidine-treated mice showed abnormal behavior in adult2008

    • Author(s)
      Toriumi K, Mouri A, Narusawa S, Aoyama Y, Ikawa N, LU L, Nabeshima T.
    • Organizer
      The 19th Korea-Japan Joint Seminar on Pharmacology
    • Place of Presentation
      Pusan
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Phencyclidine-induced abnormal behaviors in adulthood is prevented by enriched environment breeding2008

    • Author(s)
      Koseki T, Mouri A, Mamiy T, Aoyama Y, Furukawa H Nabeshima T.
    • Organizer
      The 19th Korea-Japan Joint Seminar on Pharmacology
    • Place of Presentation
      Pusan
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 明暗リズムおよび気温を変化させた飼育環境がマウスの情動・認知機能に及ぼす影響2008

    • Author(s)
      井川夏実, ら
    • Organizer
      第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 精神疾患モデルは如何にあるべきか : 基礎と臨床の対話 統合失調症モデル作成のため、基礎研究者が臨床医に望むこと2008

    • Author(s)
      野田幸裕, 毛利彰宏, 鍋島俊隆
    • Organizer
      第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] PCP連続投与マウスに認められる行動障害に対する酪酸ナトリウムの効果2008

    • Author(s)
      青山雄紀 毛利彰宏, 井川夏実, 古関竹直, 間宮隆吉, 鍋島俊隆
    • Organizer
      第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] クロザピンのPCP連続投与による認知障害に対する緩解効果にはドパミンD4およびセロトニンS2受容体拮抗作用が関与する2008

    • Author(s)
      毛利彰宏, 野田幸裕, 古川宏小林和人, 鍋島俊隆
    • Organizer
      第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Disturbance of disrupted-in-schizophrenia-1in the cerebral cortex impairs neurodevelopment via in utero gene transfer.2008

    • Author(s)
      鍋島俊隆, et al
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Prenatal psychological stress causes anxiety and depression -like behavior and serotonin depletion in the prefrontal cortex.2008

    • Author(s)
      Ping Lu, et al
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Long-lasting effects of prenatal exposure to NMDA receptor antagonist, phencyclidine on behavior and drug-induced sensitivities in mice.2008

    • Author(s)
      陸玲玲, et al
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Efficacy of metylphenidate and atomoxetine in PCP-treated animal.2008

    • Author(s)
      Shiho Narusawa, et al
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Prenatal treatment with phencyclidine induced the behavioral deficits in mice.2008

    • Author(s)
      鳥海和也, et al
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Disturbance of disrupted-in-schizophrenia-l in the cerebral cortex impairs neurodevelopment via in utero gene transfer2008

    • Author(s)
      Nabeshima T, Niwa M. Murai R. Noda Y, Kamiya A. Kubo K, Lu L, JAARO-PELE Det H, Nakajima K, Sawa A.
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular mechanism of cognitive deficits in schizophrenic animal Model and efficacy of antipsychotics2008

    • Author(s)
      Noda Y, Mouri A, Murai R, Niwa M, Furukawa H, Nabeshima T.
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Long lasting effects of prenatal exposure to NMDA receptor antagonist, phencyclidine on behavior and drug-induced sensitivities in mice2008

    • Author(s)
      Lu L, Mamiya T, Mouri A, Lu P, Hiramatsu M, Zou LB Nabeshima T.
    • Organizer
      International Symposiumon Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Efficacy of methylphenidate and atomoxetine in PCP-treated animal2008

    • Author(s)
      Narusawa S, Mouri A, Toriumi K, Koseki T, Aoyama Y, Ikawa N, Mamiya T, Nabeshima T
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Prenatal treatment with phencyclidine induced the behavioral deficits in mice2008

    • Author(s)
      Toriumi K, Mouri A, Narusawa S, Aoyama Y, Ikawa N, LU L, Nabeshima T.
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Involvement of dopamine D4 receptor in the effects of clozapine on cognitive dysfunction in phencyclidine-treated mice2008

    • Author(s)
      Mouri A, Noda Y, Noda A, Nabeshima A.
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Enriched environment in childhood prevents abnormal behaviors by phencyclidine in adulthood2008

    • Author(s)
      Koseki T, Mouri A, Mamiy T, Aoyama Y, Furukawa H Nabeshima T.
    • Organizer
      International Symposium on Brain Development and Neuropsychiatric Disorders
    • Place of Presentation
      名古屋
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 統合失調症モデルマウスに認められる情動障害におけるグルタミン酸トランスポーターの関与について2008

    • Author(s)
      毛利彰宏, ら
    • Organizer
      第3回トランスポーター研究会年会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-07
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 周産期における免疫異常は思春期マウスにおける情動および認知機能を障害する2008

    • Author(s)
      永井拓, ら
    • Organizer
      第2回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Book] 実験薬理学シリーズ第1巻(第1編行動薬理研究における実験技術10統合失調症動物モデルとその評価法)(日本薬理学会編集)2010

    • Author(s)
      野田幸裕、毛利彰宏、鍋島俊隆
    • Publisher
      金芳堂、東京
    • Related Report
      2010 Final Research Report
  • [Book] 実践行動薬理学(第I編 基礎編:行動薬理研究における実験技術 10.統合失調症動物モデルとその評価法)2010

    • Author(s)
      野田幸裕、毛利彰宏、鍋島俊隆
    • Publisher
      金芳堂
    • Related Report
      2010 Annual Research Report
  • [Book] 実践行動薬理学(第□編 応用編:行動薬理研究の現在、第4章報酬機構関連、3.依存性薬物による精神障害の分子機序)2010

    • Author(s)
      永井拓、鍋島俊隆、山田清文
    • Publisher
      金芳堂
    • Related Report
      2010 Annual Research Report
  • [Book] 「老化・老化病研究のための動物実験ガイドブック」(老年病態モデル編/マウスを用いた学習記憶試験法)(日本基礎老化学会編)2008

    • Author(s)
      鍋島俊隆、間宮隆吉(分担執筆)
    • Publisher
      アドスリー、東京
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://www-yaku.meijo-u.ac.jp/Research/Laboratory/chem_pharm/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www-yaku.meijo-u.ac.jp/frontier_meijo/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www-yaku.meijo-u.ac.jp/Research/Laboratory/chem_pharm/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www-yaku.meijo-u.ac.jp/frontier_meijo/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www-yaku.meijo-u.ac.jp/Research/Laboratory/chem_pharm/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www-yaku.meijo-u.ac.jp/frontier_meijo/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www-yaku.meijo-u.ac.jp/Research/Laboratory/chem_pharm/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www-yaku.meijo-u.ac.jp/frontier_meijo/index.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規ステロイド誘導体及びその製造方法、並びにその新規ステロイド誘導体を含有する医薬2010

    • Inventor(s)
      小鹿一、間宮隆吉、鍋島俊隆
    • Industrial Property Rights Holder
      国立大学法人名古屋大学、学校法人名城大学
    • Filing Date
      2010-02-22
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 新規ステロイド誘導体及びその製造方法、並びにその新規ステロイド誘導体を含有する医薬2010

    • Inventor(s)
      小鹿一, 間宮隆吉, 鍋島俊隆
    • Industrial Property Rights Holder
      名古屋大学、名城大学
    • Filing Date
      2010-02-22
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗うつ・抗不安剤2009

    • Inventor(s)
      新田淳美, 日比陽子、鍋島俊隆、森下幸治、池田武史
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Filing Date
      2009-01-23
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 脳内酸化抑制剤およびその使用2008

    • Inventor(s)
      新田淳美、鍋島俊隆
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Acquisition Date
      2008-05-02
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 脳内酸化抑制剤およびその使用2008

    • Inventor(s)
      新田淳美, 鍋島俊隆
    • Industrial Property Rights Holder
      国立大学法人名古屋大学, 協和発酵バイオ株式会社
    • Filing Date
      2008-05-02
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] セロトニントランスポーターのユビキチン化を指標とするうつ病診断キットの作製

    • Inventor(s)
      毛利彰宏、鍋島俊隆
    • Industrial Property Rights Holder
      学校法人名城大学
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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