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Elucidation of the significance of the nitric oxide synthase system in vivo by the use of mice lacking all nitric oxide synthases

Research Project

Project/Area Number 20390074
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

TSUTSUI Masato  University of Occupational and Environmental Health, Japan, 大学院・医学研究科, 教授 (70309962)

Co-Investigator(Kenkyū-buntansha) SASAGURI Yasuyuki  産業医科大学, 医学部, 教授 (60140646)
UETA Youichi  産業医科大学, 医学部, 教授 (10232745)
YANAGIHARA Nobuyuki  産業医科大学, 医学部, 教授 (80140896)
Co-Investigator(Renkei-kenkyūsha) SHIMOKAWA Hiroaki  東北大学, 大学院・医学系研究科, 教授 (00235681)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords一酸化窒素合成酵素 / ノックアウトマウス / 心筋梗塞 / 一酸化窒素 / 動脈硬化 / 高脂血症 / 脂質代謝 / 心不全 / 腎臓病 / メタボリック症候群 / 心肥大 / 老化
Research Abstract

In order to examine the role of the nitric oxide synthase (NOS) system in vivo, we generated mice in which all three NOS genes are completely disrupted. In this study, we have clarified that this knockout mouse manifests spontaneous myocardial infarction, abnormality of bone metabolism, hyperlipidemia, diastolic heart failure, and accelerated renal lesion formation. These results suggest that the whole NOS system plays an important role in maintaining homeostasis in the cardiovascular, metabolic, and bone systems.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (89 results)

All 2011 2010 2009 2008 Other

All Journal Article (56 results) (of which Peer Reviewed: 31 results) Presentation (30 results) Remarks (3 results)

  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.
    • Journal Title

      Cell Metabolism 13

      Pages: 294-307

    • Related Report
      2010 Final Research Report
  • [Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein e knockout mice independently of serum cholesterol level.2011

    • Author(s)
      Wang KY, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, Ding Y, Tsutsui M, Kato S, Watanabe T, Ohtsu H, Hirano K, Kohno K, Sasaguri Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 31

      Pages: 800-807

    • Related Report
      2010 Final Research Report
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.2011

    • Author(s)
      Kubota T, et al
    • Journal Title

      Cell Metabolism

      Volume: 13 Pages: 294-307

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein e knockout mice independently of serum cholesterol level.2011

    • Author(s)
      Wang KY, et al
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31 Pages: 800-807

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiological relevance of NO signaling in cardiovascular system : novel insight form mice lacking all NO synthases.2010

    • Author(s)
      Tsutsui M, Shimokawa H, Otsuji Y, Yanagihara N.
    • Journal Title

      Pharmacology & Therapeutics 128(Review)

      Pages: 499-508

    • Related Report
      2010 Final Research Report
  • [Journal Article] Nitric oxide synthases in the pathogenesis of cardiovascular disease-Lessons form genetically modified mice-2010

    • Author(s)
      Shimokawa H, Tsutsui M.
    • Journal Title

      Pflugers Arch 459(Review)

      Pages: 959-967

    • Related Report
      2010 Final Research Report
  • [Journal Article] Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo.2010

    • Author(s)
      Morisada N, Nomura M, Nishii H, Furuno Y, Sakanashi M, Sabanai K, Toyohira Y, Ueno S, Watanabe S, Tamura M, Matsumoto T, Tanimoto A, Sasaguri Y, Shimokawa H, Kusuhara K, Yanagihara N, Shirahata A, Tsutsui M.
    • Journal Title

      J Pharmacol Sci. 114

      Pages: 379-389

    • NAID

      10029890896

    • Related Report
      2010 Final Research Report
  • [Journal Article] Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases.2010

    • Author(s)
      Shibata K, Yatera Y, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Yamazaki F, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M.
    • Journal Title

      Circ J. 74

      Pages: 2681-2692

    • NAID

      10027424618

    • Related Report
      2010 Final Research Report
  • [Journal Article] Upregulation of norepinephrine transporter function by prolonged exposure to nicotine in cultured bovine adrenal medullary cells.2010

    • Author(s)
      Itoh H, Toyohira Y, Ueno S, Tsutsui M, Takahashi K, Yanagihara N.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 382

      Pages: 235-243

    • Related Report
      2010 Final Research Report
  • [Journal Article] Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells.2010

    • Author(s)
      Zhang H, Toyohira Y, Ueno S, Shinohara Y, Itoh H, Furuno Y, Yamakuni T, Tsutsui M, Takahashi K, Yanagihara N.
    • Journal Title

      J Neurochem. 114

      Pages: 1030-1038

    • Related Report
      2010 Final Research Report
  • [Journal Article] Severe dyslipidemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet.2010

    • Author(s)
      Yatera Y, Shibata K, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Toyohira Y, Wang KY, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M.
    • Journal Title

      Cardiovasc Res. 87

      Pages: 675-682

    • Related Report
      2010 Final Research Report
  • [Journal Article] Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats.2010

    • Author(s)
      Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J, Sakanashi M, Tsutsui M, Sakanashi M.
    • Journal Title

      Eur J Pharmacol. 631

      Pages: 28-35

    • Related Report
      2010 Final Research Report
  • [Journal Article] Stimulatory effects of the soy phytoestrogen genistein on noradrenalin transporter and serotonin transporter activity.2010

    • Author(s)
      Toyohira Y, Ueno S, Tsutsui M, Ito H, Sakai N, Saito N, Takahashi K, Yanagihara N.
    • Journal Title

      Mol Nutr Food Res 54

      Pages: 516-524

    • Related Report
      2010 Final Research Report
  • [Journal Article] Inducible nitric oxide synthase downmodulates contact hypersensitivity by suppressing dendritic cell migration and survival.2010

    • Author(s)
      Sugita K, Kabashima K, Yoshiki R, Ikenouchi-Sugita A, Tsutsui M, Nakamura J, Yanagihara N, Tokura Y.
    • Journal Title

      J Invest Dermatol. 130

      Pages: 464-471

    • Related Report
      2010 Final Research Report
  • [Journal Article] Pathophysiological relevance of NO signaling in cardiovascular system : novel insight form mice lacking all NO synthases.2010

    • Author(s)
      Tsutsui M, et al
    • Journal Title

      Pharmacology & Therapeutic s

      Volume: 128 Pages: 499-508

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe dyslipidemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet.2010

    • Author(s)
      Yatera Y, et al
    • Journal Title

      Cardiovasc Res

      Volume: 87 Pages: 675-682

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells.2010

    • Author(s)
      Zhang H, et al
    • Journal Title

      J Nertrochem

      Volume: 114 Pages: 1030-1038

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide synthases in the pathogenesis of cardiovascular disease-Lessons form genetically modified mice-2010

    • Author(s)
      Shimokawa H, et al
    • Journal Title

      Pflusers Arch

      Volume: 459 Pages: 959-967

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo.2010

    • Author(s)
      Morisada N, et al
    • Journal Title

      J Pharmacol Sci

      Volume: 114 Pages: 379-389

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases.2010

    • Author(s)
      Shibata K, at al
    • Journal Title

      Circ J

      Volume: 74 Pages: 2681-2692

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of norepinephrine transporter function by prolonged exposure to nicotine in cultured bovine adrenal medullary cells.2010

    • Author(s)
      Itoh H, et al
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol

      Volume: 382 Pages: 235-243

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats.2010

    • Author(s)
      Noguchi K, et al
    • Journal Title

      Eur J Pharmacol

      Volume: 631 Pages: 28-35

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulatory effects of the soy phytoestrogen genis tein on noradrenalin transporter and serotonin transporter actiuity.2010

    • Author(s)
      Toyohira Y, et al
    • Journal Title

      Mol Nutr Food Res

      Volume: 54 Pages: 516-524

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inducible nitric oxide synthase downmodulates contact hypersensitivity by suppressing dendritic cell migration and survival.2010

    • Author(s)
      Sugita K, et al
    • Journal Title

      J Invest Dermatol

      Volume: 130 Pages: 464-471

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inducible nitric oxide synthase downmodulates contact hypersensitivity by suppressing dendritic cell migration and survival2010

    • Author(s)
      Sugita K
    • Journal Title

      J Invest Dermatol 130

      Pages: 464-471

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats2010

    • Author(s)
      Noguchi K
    • Journal Title

      Eur J Pharmacol 631

      Pages: 28-35

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulatory effects of the soy phytoestrogen genistein on noradrenalin transporter and serotonin transporter activity2010

    • Author(s)
      Toyohira Y
    • Journal Title

      Mol Nutr Food Res. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide synthases in the pathogenesis of cardiovascular disease -Lessons form genetically modified mice-2010

    • Author(s)
      Shimokawa H
    • Journal Title

      Pflugers Arch -Eur J Physiol (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe dyslipidemia, atherosclerosis, and sudden cardiac death in mice lacking all NO syntheses fed a high-fat diet2010

    • Author(s)
      Yatera Y
    • Journal Title

      Cardiovasc Res. (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide synthases and cardiovascular diseases-Insights form genetically modified mice-2009

    • Author(s)
      Tsutsui M, Shimokawa H, Otsuji Y, Ueta Y, Sasaguri Y, Yanagihara N.
    • Journal Title

      Circ J 73(Review)

      Pages: 986-993

    • Related Report
      2010 Final Research Report
  • [Journal Article] Opposite effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex.2009

    • Author(s)
      Ikenouchi-Sugita A, Toyohira Y, Yoshimura R, Ueno S, Tsutsui M, Nakamura J, Yanagihara N.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 380

      Pages: 479-486

    • Related Report
      2010 Final Research Report
  • [Journal Article] Nitric oxide synthases and cardiovascular diseases -Insights form genetically modified mice-2009

    • Author(s)
      Tsutsui M
    • Journal Title

      Circ J. 73

      Pages: 986-993

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opposite effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brainderived neurotrophic factor in mouse brain cortex2009

    • Author(s)
      Ikenouchi-Sugita A
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol 380

      Pages: 479-486

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide synthases and cardiovascular diseases-Insights form genetically modified mice2009

    • Author(s)
      Tsutsui M.
    • Journal Title

      Circ J (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous myocardial infarction and nitric oxide synthase2009

    • Author(s)
      Tsutsui M.
    • Journal Title

      Trends Cardiovasc Med (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous myocardial infarction and nitric oxide synthase.2008

    • Author(s)
      Tsutsui M, Nakata S, Shimokawa H, Otsuji Y, Yanagihara N.
    • Journal Title

      Trends Cardiovasc Med 18(Review)

      Pages: 275-279

    • Related Report
      2010 Final Research Report
  • [Journal Article] Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.2008

    • Author(s)
      Ulrich M, Petre A, Youhnovski N, Promm F, Schirle M, Schumm M, Pero R, Doyle A, Checkel J, Kita H, Thiyagarajan N, Ravi Acharya K, Schmid-Grendelmeier P, Simon HU, Schwarz H, Tsutsui M, Shimokawa H, Bellon G, Lee JJ, Przybylski M, Doering G.
    • Journal Title

      J Biol Chem. 283(42)

      Pages: 28629-28640

    • Related Report
      2010 Final Research Report
  • [Journal Article] Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na^+ and Ca^<2+> influx in bovine adrenal medullary cells.2008

    • Author(s)
      Matsuda T, Toyohira Y, Ueno S, Tsutsui M, Yanagihara N.
    • Journal Title

      J Pharmacol Exp Ther. 327

      Pages: 1-7

    • Related Report
      2010 Final Research Report
  • [Journal Article] Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice.2008

    • Author(s)
      Takaki A, Morikawa K, Tsutsui M, Murayama Y, Tekes E, Yamagishi H, Yanagihara N, Shimokawa H.
    • Journal Title

      J Exp Med. 205

      Pages: 2053-2063

    • Related Report
      2010 Final Research Report
  • [Journal Article] Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms.2008

    • Author(s)
      Nakata S, Tsutsui M, Shimokawa H, Suda O, Morishita T, Shibata K, Yatera Y, Sabanai K, Tanimoto A, Nagasaki M, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y, Yanagihara N.
    • Journal Title

      Circulation. 117

      Pages: 2211-2223

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genetic disruption of all nitric oxide synthase isoforms enhances bone mineral density and bone turnover in mice in vivo : Involvement of the renin-angiotensin system.2008

    • Author(s)
      Sabanai K, Tsutsui M, Sakai A, Hirasawa H, Tanaka S, Nakamura E, Tanimoto A, Sasaguri Y, Ito M, Shimokawa H, Nakamura T, Yanagihara N.
    • Journal Title

      J Bone Miner Res. 23(5)

      Pages: 633-643

    • Related Report
      2010 Final Research Report
  • [Journal Article] Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats.2008

    • Author(s)
      Kamezaki F, Tasaki H, Yamashita K, Tsutsui M, Koide S, Nakata S, Tanimoto A, Okazaki M, Sasaguri Y, Adachi T, Otsuji Y.
    • Journal Title

      Am J Respir Crit Care Med. 177

      Pages: 219-226

    • Related Report
      2010 Final Research Report
  • [Journal Article] Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells.2008

    • Author(s)
      Tanimoto A, Murata Y, Wang KY, Tsutsui M, Kohno K, Sasaguri Y.
    • Journal Title

      J Biol Chem. 283(8)

      Pages: 4643-4651

    • Related Report
      2010 Final Research Report
  • [Journal Article] Matrix metalloproteinase 12 is factor that accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks fibrous plaques in transgenic rabbits.2008

    • Author(s)
      Yamada S, Wang KY, Tanimoto A, Fan Shimajiri S, Kitajima S, Tsutsui Watanabe T, Yasumoto K, Sasaguri Y.
    • Journal Title

      Am J Pathol. 172

      Pages: 1419-1429

    • Related Report
      2010 Final Research Report
  • [Journal Article] Direct inhibition N-methyl-D-aspartate (NMDA) receptor function by antiglaucomatous beta-antagonists.2008

    • Author(s)
      Nagata T, Ueno S, Morita H, Kubota Toyohira Y, Tsutsui M, Tawara Yanagihara N.
    • Journal Title

      J Pharmacol Sci. 106

      Pages: 423-434

    • Related Report
      2010 Final Research Report
  • [Journal Article] Copper, zinc superoxide dismutase enhances the mutagenicity in Salmonella typhimurium induced 2-amino-6-methyldipyrido [1, 2-a : 3', 2'-d] imidazole.2008

    • Author(s)
      Nii H, Tsutsui M, Kondo J, Toyohira Ueno S, Yanagihara N.
    • Journal Title

      Mutat Res.(Genet Toxicol Environ Mutagen) 653

      Pages: 14-22

    • Related Report
      2010 Final Research Report
  • [Journal Article] Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms2008

    • Author(s)
      Nakata s.
    • Journal Title

      Circulation 117

      Pages: 2211-2223

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic disruption of all nitric oxide synthase isoforms enhances bone mineral density and bone turnover in mice in vivo : Involvement of the renin-angiotensin system2008

    • Author(s)
      Sabanai K.
    • Journal Title

      J Bone Miner Res 23

      Pages: 633-643

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice2008

    • Author(s)
      Takaki A.
    • Journal Title

      J Exp Med 205

      Pages: 2053-2063

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats2008

    • Author(s)
      Kamezaki F.
    • Journal Title

      Am J Respir Crit Care Med 177

      Pages: 219-226

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase 12 is a factor that accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits2008

    • Author(s)
      Yamada S.
    • Journal Title

      Am J Pathol 172

      Pages: 1419-1429

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Post-translational tyrosine nitration of eosinophil granuletoxins mediated by eosinophil peroxidase2008

    • Author(s)
      Ulrich M.
    • Journal Title

      J Biol Chem 283

      Pages: 28629-28640

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells2008

    • Author(s)
      Tanimoto A.
    • Journal Title

      J Biol Chem 283

      Pages: 4643-4651

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na^+ and Ca^<2+> influx in bovine adrenal medullary cells2008

    • Author(s)
      Matsuda T.
    • Journal Title

      J Pharmacol Exp Ther 327

      Pages: 1-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct inhibition of N-methyl-D-aspartate (NMDA) receptor function by antiglaucomatous beta-antagonists2008

    • Author(s)
      Nagata T.
    • Journal Title

      J Pharmacol Sci 106

      Pages: 423-434

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copper, zinc superoxide dismutase enhances the mutagenicity in Salmonella typhimurium induced by 2-amino-6-methyldipyrido [1, 2-a : 3', 2', -d]imidazole2008

    • Author(s)
      Nii H.
    • Journal Title

      Mutat Res (Genet Toxicol Environ Mutagen) 653

      Pages: 14-22

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生体内におけるNO合成酵素系の意義:NOSs系完全欠損マウスからの教訓2011

    • Author(s)
      筒井正人
    • Organizer
      琉球大学 第三内科 講演会
    • Place of Presentation
      沖縄、琉球大学医学部
    • Year and Date
      2011-02-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] NO合成酵素と循環器病2011

    • Author(s)
      筒井正人
    • Organizer
      OKN Summitシンポジウム
    • Place of Presentation
      大阪、ホテル阪急インターナショナル
    • Year and Date
      2011-02-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Spontaneous Development of Left Ventricular Hypertrophy and D iastolic Dysfunction in Mice Lacking All Nitric Oxide Syntheses2010

    • Author(s)
      Tsutsui M
    • Organizer
      American Heart Association, Scientific Sessions 2010
    • Place of Presentation
      Chicago, MaCormick Place
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Complete Disruption of All Nitric Oxide Synt hase Genes Causes Markedly Accelerated Renal Remodeling in Mice in Vivo.2010

    • Author(s)
      Tsutsui M
    • Organizer
      American Heart Association, Scientific Sessions 2010
    • Place of Presentation
      Chicago, McCormick Place
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Accelerated Vascular Lesion Formation in Mice Lacking All Nitric Oxide Synthases : Contribution of Bone Marrow Cells.2010

    • Author(s)
      Tsutsui M
    • Organizer
      American Heart Association, Scientific Sessions 2010
    • Place of Presentation
      Chicago, MaCormick Place
    • Year and Date
      2010-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] NO合成酵素の意義:遺伝子改変動物から得られた新知見2010

    • Author(s)
      筒井正人
    • Organizer
      福岡大学医学部大学院 研究セミナー
    • Place of Presentation
      福岡、福岡大学医学部
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 私が研修医の時に受けた衝撃:臨床とリサーチマインド2010

    • Author(s)
      筒井正人
    • Organizer
      福岡大学医学部
    • Place of Presentation
      福岡、福岡大学医学部
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 循環器系における3種類のNO合成酵素の意義2010

    • Author(s)
      筒井正人
    • Organizer
      和歌山県立医科大学
    • Place of Presentation
      和歌山、和歌山県立医科大学
    • Year and Date
      2010-10-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] NOと心血管病:NO合成酵素完全欠損マウスから得られた新知見2010

    • Author(s)
      筒井正人
    • Organizer
      久留米大学医学部小児科グランドラウンド
    • Place of Presentation
      久留米、久留米大学医学部
    • Year and Date
      2010-07-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一酸化窒素と心血管病:最新知見2010

    • Author(s)
      筒井正人
    • Organizer
      産業医科大学大学院セミナー
    • Place of Presentation
      北九州、産業医科大学
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] New insight from genetically manipu lated mice lacking all NOSs.2010

    • Author(s)
      Tsutsui M
    • Organizer
      The 6^<th> International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      Kyoto, Kyoto International Conference Center
    • Year and Date
      2010-06-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Significance of nitric oxide synthase system in the maintenance of vascular homeostasis.2010

    • Author(s)
      Tsutsui M
    • Organizer
      The 87^<th> Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Morioka, Morioka Civic Cultural Hall
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lesson from genetically engineered mice lacking all synthases.2010

    • Author(s)
      Tsutsui M.
    • Organizer
      The XXth Congress of the International Society for Heart Research 2010.
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan(Symposium)
    • Year and Date
      2010-05-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Lesson from genetically engineered mice lacking all NO synthases.2010

    • Author(s)
      Tsutsui M
    • Organizer
      The XXth Congress of the International Society for Heart Research 2010
    • Place of Presentation
      Kyoto, Kyoto International Conference Center
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Significance of nitric oxide synthases (NOSs) in the cardiovascular system : lesson from mice all NOSs.2010

    • Author(s)
      Tsutsui M
    • Organizer
      The Korean Society of Cardiology (Japanese Circulation Society-Joint Symposium)
    • Place of Presentation
      Busan, Bexico
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] NOと疾病:新知見2010

    • Author(s)
      筒井正人
    • Organizer
      第85回琉球大学医学部大学院セミナー
    • Place of Presentation
      沖縄、琉球大学医学部
    • Year and Date
      2010-01-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 私が研修医時代に受けた衝撃:臨床とリサーチマインド2009

    • Author(s)
      筒井正人
    • Organizer
      産業医科大学 大学院講義 臨床生理学概論
    • Place of Presentation
      北九州、産業医科大学
    • Year and Date
      2009-12-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 一酸化窒素合成酵素と循環器疾患2009

    • Author(s)
      筒井正人
    • Organizer
      第62回日本薬理学会西南部会
    • Place of Presentation
      松山、リジュール松山
    • Year and Date
      2009-11-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vasculoprotective role of the nitric oxide synthase system against vascular lesion formation in mice in vivo2009

    • Author(s)
      Furuno Y
    • Organizer
      American Society of Nephrology, Renal Week 2009
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Accelerated Renal Lesion Formation in Mice Lacking Entire Nitric Oxide Synthase System2009

    • Author(s)
      Morisada N
    • Organizer
      American Society of Nephrology, Renal Week 2009
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 一酸化窒素合成酵素系の意義に関する新知見2009

    • Author(s)
      筒井正人
    • Organizer
      第144回琉球医学会例会 教授就任講演
    • Place of Presentation
      沖縄、琉球大学医学部
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Critical role of renin-angiotensin-aldosterone axis in the pathogenesis of acute myocardial infarction in mice lacking entire nitric oxide synthase system2009

    • Author(s)
      Nakata S
    • Organizer
      The 10th International Symposium on Mechanisms of Vasodilatation
    • Place of Presentation
      松島、ホテル松島大観荘
    • Year and Date
      2009-06-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of vascular function in mice lacking entirenitric oxide synthase system2009

    • Author(s)
      Suda O
    • Organizer
      The 10th International Symposium on Mechanisms of Vasodilatation
    • Place of Presentation
      松島、ホテル松島大観荘
    • Year and Date
      2009-06-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Vasculoprotective role of nitric oxide synthase system against vascular lesion formation in mice in vivo2009

    • Author(s)
      Furuno Y
    • Organizer
      The 10th International Symposium on Mechanisms of Vasodilatation
    • Place of Presentation
      松島、ホテル松島大観荘
    • Year and Date
      2009-06-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 一酸化窒素合成酵素系の意義に関する新知見2009

    • Author(s)
      筒井正人
    • Organizer
      第9回日本NO学会学術集会 シンポジウム
    • Place of Presentation
      静岡、グランシップ
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Left ventricular hypertrophy and diastolic disfunction in mice lacking all nitric oxide synthase isoforms2009

    • Author(s)
      Shibata K.
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-03-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 心血管病及びうつ病の成因における一酸化窒素欠損合成酵素システムの意義2009

    • Author(s)
      筒井正人
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 一酸化窒素合成酵素系完全欠損マウスに惹起された自然発症心筋梗塞2008

    • Author(s)
      筒井正人
    • Organizer
      第61回日本薬理学会西南部会
    • Place of Presentation
      米子市
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] A new animal model of hypercholesterolemia and atherosclerosis : micedeficient in all nitric oxide synthases2008

    • Author(s)
      Tsutsui M.
    • Organizer
      American Heart Association, Scientific Sessions 2008
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 一酸化窒素と心血管病2008

    • Author(s)
      筒井正人
    • Organizer
      トランスポーターワークショップIN福岡
    • Place of Presentation
      福岡市
    • Year and Date
      2008-11-02
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://w3.u-ryukyu.ac.jp/pharmaco

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://w3.u-ryukyu.ac.jp/pharmaco

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://w3.u-ryukyu.ac.jp/pharmaco/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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