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Systems biological analysis of dynamic regulation of stem cells and development by growth factors

Research Project

Project/Area Number 20390075
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

GOTOH Noriko  The University of Tokyo, 医科学研究所, 特任准教授 (10251448)

Co-Investigator(Kenkyū-buntansha) MIYANO Satoru  東京大学, 医科学研究所, 教授 (50128104)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords細胞・組織 / シグナル伝達 / マイクロアレイ / 発生・分化 / システム生物学
Research Abstract

We aimed to clarify molecular mechanisms how growth factors regulate self-renewing activity of tissue type specific stem cells by using novel bioinfomatics. As a result, we identified Hes1 as a key molecular target of self-renewal of neural stem cells and FRS2alpha-Shp2-Tbx2 pathway as a key pathway for development of cardiac progenitor cells. Moreover, we identified NFkB as a key molecular target for self-renewing mammalian stem cells as well as breast cancer stem cells.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (82 results)

All 2011 2010 2009 2008 Other

All Journal Article (63 results) (of which Peer Reviewed: 38 results) Presentation (10 results) Book (2 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 3 results)

  • [Journal Article] Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors.2011

    • Author(s)
      Gotoh, N.
    • Journal Title

      Int.J.Clin.Exp.Pathol. 4

      Pages: 403-409

    • Related Report
      2010 Final Research Report
  • [Journal Article] A genetic study of the effects of reduced Frszafpna gene dosage is exostoses development and cartilage abnormalities observed in Ext2 heterozygous mutant mice2011

    • Author(s)
      後藤典子
    • Journal Title

      Journal of Osaka Medical Center & Research Institute for Maternal & Child Health

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS22011

    • Author(s)
      後藤典子
    • Journal Title

      Encyclopedia of Signaling Molecules

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer.2010

    • Author(s)
      Oyama, M., Nagashima, T., Suzuki, T., Kozuka-Hata, H., Yumoto, N., Shiraishi, Y., Ikeda, K., Kuroki, Y., Gotoh, N., Ishida, T., Inoue, S., Kitano, H., Okada-Hatakeyama, M.
    • Journal Title

      J.Biol.Chem. 286

      Pages: 818-829

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling.2010

    • Author(s)
      Tasaki, S., Nagasaki, M., Kozuka-Hata, H., Semba, K., Gotoh, N., Hattori, S., Inoue, J., Yamamoto, T., Miyano, S., Sugano, S., Oyama, M.
    • Journal Title

      PLoS ONE 5(11)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Inflammatory signaling pathways in self-renewing breast cancer stem cells.2010

    • Author(s)
      Hinohara, K., Gotoh, N.
    • Journal Title

      Curr.Opin.Pharmacol. 10

      Pages: 650-654

    • Related Report
      2010 Final Research Report
  • [Journal Article] Collocation-based sparse estimation for constructing dynamic gene networks.2010

    • Author(s)
      Shimamura, T., Imoto, S., Nagasaki, M., Yamauchi, M., Yamaguchi, R., Fujita, A., Tamada, Y., Gotoh, N., Miyano, S.
    • Journal Title

      Genome Inform. 24

      Pages: 164-178

    • Related Report
      2010 Final Research Report
  • [Journal Article] FGF-FRS2α-Erk axis controls a self-renewal target Hes1 and growth of neural stem/progenitor cells.2010

    • Author(s)
      Sato, T., Shimazaki, T., Naka, H, Fukami, S., Okano, H., Lax, I., Schlessinger, J., Gotoh, N.
    • Journal Title

      Stem Cells. 28

      Pages: 1661-1672

    • Related Report
      2010 Final Research Report
  • [Journal Article] A state space representation of VAR models with sparse learning for dynamic gene networks.2010

    • Author(s)
      Kojima, K., Yamaguchi, R., Imoto, S., Yamauchi, M., Nagasaki, M., Yoshida, R., Shimamura, T, Ueno, K., Higuchi, T.,, Gotoh, N., Miyano, S.
    • Journal Title

      Genome Inform. 22

      Pages: 56-68

    • Related Report
      2010 Final Research Report
  • [Journal Article] FRS2β, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding.2010

    • Author(s)
      Iejima, D., Minegichi, Y., Takenaka, K., Siswanto, A., Watanabe, M., Huang, L., Watanabe, T., Tanaka, F., Kuroda, M., Gotoh, N.
    • Journal Title

      Oncogene 29

      Pages: 3087-3099

    • Related Report
      2010 Final Research Report
  • [Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells.2010

    • Author(s)
      Murohashi, M., Hinohara, K., Kuroda, M., Isagawa, T., Tsuji, S., Kobayashi, S., Umezawa, K., Tojo, A., Aburatani, H., Gotoh, N.
    • Journal Title

      British J.Cancer 102

      Pages: 206-212

    • Related Report
      2010 Final Research Report
  • [Journal Article] An FGF4-FRS2α-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos.2010

    • Author(s)
      Murohashi, M., Nakamura, T., Tanaka, S., Ichise, T., Yoshida, N., Yamamoto, T., Shibuya, M., Schlessinger, J., Gotoh, N.
    • Journal Title

      Stem Cells 28

      Pages: 113-121

    • Related Report
      2010 Final Research Report
  • [Journal Article] Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer2010

    • Author(s)
      後藤典子
    • Journal Title

      J.Biol.Chem

      Volume: 286 Pages: 818-829

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling2010

    • Author(s)
      後藤典子
    • Journal Title

      PLoS ONE

      Volume: 5(11)(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible signaling pathways in cancer stem cells in breast cancer2010

    • Author(s)
      後藤典子
    • Journal Title

      Cancer Stem Cells

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory signaling pathways in self-renewing breast cancer stem cells2010

    • Author(s)
      後藤典子
    • Journal Title

      Curr.Opin.Pharmacol

      Volume: 10 Pages: 650-654

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collocation-based sparse estimation for constructing dynamic gene networks2010

    • Author(s)
      後藤典子
    • Journal Title

      Genome Inform

      Volume: 24 Pages: 164-178

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGF-FRS2 α-Erk axis controls a self-renewal target Hes I and growth of neural stem/progenitor cells2010

    • Author(s)
      後藤典子
    • Journal Title

      Stem Cells

      Volume: 28 Pages: 1661-1672

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A state space representation of VAR models with sparse learning for dynamic gene networks2010

    • Author(s)
      後藤典子
    • Journal Title

      Genome Inform

      Volume: 22 Pages: 56-68

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2 β, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding2010

    • Author(s)
      後藤典子
    • Journal Title

      Oncogene

      Volume: 29 Pages: 3087-3099

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells2010

    • Author(s)
      後藤典子
    • Journal Title

      British J.Cancer

      Volume: 102 Pages: 206-212

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An FGF4-FRS21-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos2010

    • Author(s)
      後藤典子
    • Journal Title

      Stem Cells

      Volume: 28 Pages: 113-121

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gain-of-function of mutated c-Cbl tumor suppressor in myeloid neoplasms with 11q uniparental disomy.2009

    • Author(s)
      Sanada, M., Suzuki, T., Shih, L.-Y., Otsu, M., Kato, M., Yamazaki, S., Tamura, A., Honda, H., Sakata-Yanagimoto, M., Kumano, K., Oda, H., Yamagata, T., Takita, J., Gotoh, N., Nakazaki, K., Kawamata, N., Onodera, M., Nobuyoshi, M., Hayashi, Y., Harada, H., Kurokawa, M., Chiba, S., Mori, H., Ozawa, K., Omine, M., Hirai, H., Nakauchi, H., Koeffler, P., Ogawa, S.
    • Journal Title

      Nature 460

      Pages: 904-909

    • Related Report
      2010 Final Research Report
  • [Journal Article] FRS2βdocking/scaffolding adaptor protein.2009

    • Author(s)
      Iejima, D., Gotoh, N.
    • Journal Title

      Current research in cancer, Research Media, India 3

      Pages: 99-107

    • Related Report
      2010 Final Research Report
  • [Journal Article] FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus.2009

    • Author(s)
      Kameda, Y., Ito, M., Nishimaki, T., Gotoh, N.
    • Journal Title

      Dev.Dyn. 238

      Pages: 503-513

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular mechanisms determining efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates.2009

    • Author(s)
      Yamauchi, M., Gotoh, N.
    • Journal Title

      Biomark.Med. 3

      Pages: 139-151

    • Related Report
      2010 Final Research Report
  • [Journal Article] Frs2beta.2009

    • Author(s)
      Minegishi, Y., Gotoh, N.
    • Journal Title

      Nature Molecule Pages

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prominent expression of FRS2β protein in neural cells and its association with intracellular vesicles.2009

    • Author(s)
      Minegishi, Y., Iwanari, H., Mochizuki, Y., Horii, T., Hoshino, T., Kodama, T., Hamakubo, T., Gotoh, N.
    • Journal Title

      FEBS lett. 583

      Pages: 807-814

    • Related Report
      2010 Final Research Report
  • [Journal Article] The FRS2 family of docking/scaffold adaptor proteins as therapeutic targets of cancer treatment.2009

    • Author(s)
      Sato T., Gotoh, N.
    • Journal Title

      Expert Opinion on Therapeutic Targets 13

      Pages: 689-700

    • Related Report
      2010 Final Research Report
  • [Journal Article] Frs2alpha.2009

    • Author(s)
      Sato, T., Gotoh, N.
    • Journal Title

      Nature Molecule Pages

    • Related Report
      2010 Final Research Report
  • [Journal Article] Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells.2009

    • Author(s)
      Gotoh, N.
    • Journal Title

      Current Stem Cell Research & Therapy 4

      Pages: 9-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Feedback inhibitors of epidermal growth factor receptor signaling pathways.2009

    • Author(s)
      Gotoh, N.
    • Journal Title

      Int.J.Biochem.Cell Biol. 41

      Pages: 511-515

    • Related Report
      2010 Final Research Report
  • [Journal Article] Gain-of-function of mutated c-Cb1 tumor suppressor in myeloid neoplasms with 11q uniparental disomy2009

    • Author(s)
      後藤典子
    • Journal Title

      Nature

      Volume: 460 Pages: 904-909

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2β docking/scaffolding adaptor protein.2009

    • Author(s)
      後藤典子
    • Journal Title

      Current research in cancer

      Volume: 3 Pages: 99-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus2009

    • Author(s)
      後藤典子
    • Journal Title

      Dev.Dyn

      Volume: 238 Pages: 503-513

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms determining efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates2009

    • Author(s)
      後藤典子
    • Journal Title

      Biomark.Med

      Volume: 3 Pages: 139-151

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frs2beta2009

    • Author(s)
      後藤典子
    • Journal Title

      Nature Molecule Pages

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prominent expression of FRS2□ protein in neural cells and its association with int2009

    • Author(s)
      後藤典子
    • Journal Title

      FEBS lett

      Volume: 583 Pages: 807-814

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The FRS2 family of docking/scaffold adaptor proteins as therapeutic targets of cancer treatment2009

    • Author(s)
      後藤典子
    • Journal Title

      Expert Opinion on Therapeutic Targets

      Volume: 13 Pages: 689-700

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frs2alpha2009

    • Author(s)
      後藤典子
    • Journal Title

      Nature Molecule Pages

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells2009

    • Author(s)
      後藤典子
    • Journal Title

      Current Stem Cell Research & Therapy

      Volume: 4 Pages: 9-15

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feedback inhibitors of epidermal growth factor receptor signaling pathways2009

    • Author(s)
      後藤典子
    • Journal Title

      Int.J.Biochem.Cell Biol

      Volume: 41 Pages: 511-515

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2β, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding2009

    • Author(s)
      後藤典子
    • Journal Title

      Oncogene (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An FGF4-FRS2α-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos2009

    • Author(s)
      後藤典子
    • Journal Title

      Stem Cells (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A state space representation of VAR models with sparse learning for dynamic gene networks2009

    • Author(s)
      後藤典子
    • Journal Title

      Genome Infomatics 22

      Pages: 56-58

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells2009

    • Author(s)
      後藤典子
    • Journal Title

      British J.Cancer 102

      Pages: 206-212

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gain-of-function of mutated c-Cbl tumor suppressor in myeloid neoplasms with 11q uniparental disomy2009

    • Author(s)
      後藤典子
    • Journal Title

      Nature 460

      Pages: 904-909

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2β docking/scaffolding adaptor protein2009

    • Author(s)
      後藤典子
    • Journal Title

      Current Research in Cancer 3

      Pages: 99-107

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2α is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus2009

    • Author(s)
      後藤典子
    • Journal Title

      Dev.Dyn 238

      Pages: 503-513

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms determining efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates2009

    • Author(s)
      後藤典子
    • Journal Title

      Biomarkers in Medicine 3

      Pages: 139-151

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prominent expression of FRS2β protein in neural cells and its association with intrace Ilular vesicles2009

    • Author(s)
      後藤典子
    • Journal Title

      FEBS lett. 583

      Pages: 807-814

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The FRS2 family of docking/scaffold adaptor proteins as therapeutic targets of cancer treatment2009

    • Author(s)
      後藤典子
    • Journal Title

      Expert Opinion on Therapeutic Targets 13

      Pages: 689-700

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of sternness by fibroblast growth factor signaling in stem cells and cancer stem cells2009

    • Author(s)
      後藤典子
    • Journal Title

      Current Stem Cell Research & Therapy 4

      Pages: 9-15

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feedback inhibitors of epidermal growth factor receptor signaling pathways2009

    • Author(s)
      後藤典子
    • Journal Title

      Int.J.Biochem.Cell Biol 41

      Pages: 511-515

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting differences in gene regulatory systems by state space models.2008

    • Author(s)
      Yamaguchi, R., Imoto, S., Yamauchi, M., Nagasaki, M., Yoshida, R., Shimamura, T., Hatanaka, Y., Ueno, K., Higuchi, T., Gotoh, N., Miyano, S.
    • Journal Title

      Genome Infomatics 21

      Pages: 101-113

    • NAID

      130003997534

    • Related Report
      2010 Final Research Report
  • [Journal Article] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.2008

    • Author(s)
      Gotoh, N.
    • Journal Title

      Cancer Sci. 99

      Pages: 1319-1325

    • Related Report
      2010 Final Research Report
  • [Journal Article] FRS2α^<2F/2F> mutant mice lack the carotid body and exhibit sympathetic ganglia and carotid sinus nerve abnormalities.2008

    • Author(s)
      Kameda, Y., Ito, M., Nishimaki T., Gotoh, N.
    • Journal Title

      Dev.Biol. 314

      Pages: 236-247

    • Related Report
      2010 Final Research Report
  • [Journal Article] Membrane-linked docking protein.Encyclopedia of Cancer2008

    • Author(s)
      Gotoh, N., Tsuchida, N.
    • Journal Title

      2^<nd> Edition, Springer, Heidelberg, Germany

      Pages: 1819-1823

    • Related Report
      2010 Final Research Report
  • [Journal Article] Predicting differences in gene regulatory systems by state space models2008

    • Author(s)
      後藤典子
    • Journal Title

      Genome Infomatics 21

      Pages: 101-113

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins2008

    • Author(s)
      後藤典子
    • Journal Title

      Cancer Sci 99

      Pages: 1319-1319

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2α^<2F/2F> mutant mice lack the carotid body and exhibit sympathetic ganglia and carotid sinus nerve abnormalities2008

    • Author(s)
      後藤典子
    • Journal Title

      Dev.Biol 314

      Pages: 236-247

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-linked docking protein2008

    • Author(s)
      後藤典子
    • Journal Title

      Encyclopedia of Cancer, 2^<nd> Edition

      Pages: 1819-1823

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genetic study of the effects of reduced Frs2alpha gene dosage in exostoses development and cartilage abnormalities observed in Ext2 heterozygous mutant mice.

    • Author(s)
      Nasirujjaman K., Kimura-Yoshida, C., Gotoh, N., Hiramatsu, R., Matsuo I.
    • Journal Title

      Journal of Osaka Medical Center & Research Institute for Maternal & Child Health. in press

    • Related Report
      2010 Final Research Report
  • [Presentation] システム生物学とゲノム研究による癌の予防、診断、治療戦略2010

    • Author(s)
      後藤典子
    • Organizer
      第33回日本分子生物学年会 第83回日本生化学会大会合同会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規バイオインフォマティクス手法を用いた癌幹細胞内シグナル伝達経路の解明"創薬薬理フォーラム2010

    • Author(s)
      後藤典子
    • Organizer
      第18回シンポジウム
    • Place of Presentation
      東京 招待講演
    • Related Report
      2010 Final Research Report
  • [Presentation] 腫瘍抑制候補アダプタータンパクFRS2betaはCIN85/CD2APと結合しErbB2シグナルを減弱化する2010

    • Author(s)
      峯岸ゆり子、服部成介、後藤典子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪 口演
    • Related Report
      2010 Final Research Report
  • [Presentation] A key role of NF-kB pathway in breast cancer stem cells for tumorigenesis.2009

    • Author(s)
      後藤典子
    • Organizer
      14^<th> World Congress on Advances in Oncology and 12^<th> International Symposium on Molecular Medicine
    • Place of Presentation
      Loutraki, Greece 招待講演
    • Related Report
      2010 Final Research Report
  • [Presentation] Biology Division, National Cancer Center Research Institute, Tokyo, Japan2009

    • Author(s)
      峯岸ゆり子、服部成介、後藤典子
    • Organizer
      Exploration of new biomarkers and molecular targets of lung carcinoma by systems biology approach 68^<th> Annual Meeting of the Japanese Cancer Association 第68回日本癌学会学術総会
    • Place of Presentation
      横浜 招待講演
    • Related Report
      2010 Final Research Report
  • [Presentation] Growth factor signaling systems idenfiy critical genes for survival prediction in lung adenocarcinoma2009

    • Author(s)
      後藤典子
    • Organizer
      The 16^<th> East Asia Joint conference on Biomedical Research
    • Place of Presentation
      京都 招待講演
    • Related Report
      2010 Final Research Report
  • [Presentation] Growth factor signaling systems identify critical genes for survival prediction in lung adenocarcinoma2009

    • Author(s)
      後藤典子
    • Organizer
      The 16th East Asia Joint conference on Biomedical Research
    • Place of Presentation
      京都大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] Exploration of new biomarkers and molecular targets of lung carcinoma by systems biology approach2009

    • Author(s)
      後藤典子
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜・パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] Growth factor signaling systems identify critical genes for survival prediction in lung a denocarcinoma2009

    • Author(s)
      後藤典子
    • Organizer
      The 16^<th> East Asia Joint conference on Biomedical Research
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Exploration of new biomarkers and molecular targets of lung carcinoma by systems biology approach2009

    • Author(s)
      後藤典子
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Book] Encyclopedia of Signaling Molecules.Springer(FRS2.), Germany.

    • Author(s)
      Gotoh, N.
    • Publisher
      Heidelberg
    • Related Report
      2010 Final Research Report
  • [Book] Cancer Stem Cells(Possible signaling pathways in cancer stem cells in breast cancer.)(Nikolic, A.(Ed.))Austria.

    • Author(s)
      Gotoh, N.
    • Publisher
      ITECH, Vienna
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 癌の予後を予測するためのバイオマーカー2009

    • Inventor(s)
      後藤典子、山内麻衣、宮野悟、井元清哉、山口類、横田淳、河野隆志
    • Filing Date
      2009-12-04
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 固形癌の再発予測のための試験方法及び再発予防剤2009

    • Inventor(s)
      後藤典子、室橋道子、油谷浩幸、砂河孝行、黒田雅彦
    • Industrial Property Number
      2009-023933
    • Filing Date
      2009-02-04
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 癌の予後を予測するためのバイオマーカー2009

    • Inventor(s)
      後藤典子
    • Filing Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 癌の予後を予測するためのバイオマーカー2009

    • Inventor(s)
      後藤典子
    • Industrial Property Rights Holder
      東京大学TLO
    • Filing Date
      2009-12-04
    • Related Report
      2008 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 癌の予後を予測するためのバイオマーカー2008

    • Inventor(s)
      後藤典子、山内麻衣、宮野悟、井元清哉、山口類、横田淳、河野隆志
    • Industrial Property Number
      2008-311481
    • Filing Date
      2008-12-05
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 固形癌の再発予測のための試験方法及び再発予防剤2008

    • Inventor(s)
      後藤典子
    • Industrial Property Rights Holder
      東京大学TLO
    • Industrial Property Number
      2009-023933
    • Filing Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌の予後を予測するためのバイオマーカー2008

    • Inventor(s)
      後藤典子
    • Industrial Property Rights Holder
      東京大学TLO
    • Industrial Property Number
      2008-311481
    • Filing Date
      2008-12-05
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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