Research on tissue regeneration regulated by Met/HGF receptor ON-OFF regulation

• Project/Area Number: 20390077
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kanazawa University
• Principal Investigator: MATSUMOTO Kunio Kanazawa University, がん研究所, 教授 (90201780)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Takahiro 金沢大学, がん研究所, 助教 (70414018) ; SAKAI Katsuya 金沢大学, がん研究所, 助教 (10523318)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: 細胞増殖因子 / HGF / 組織再生 / 受容体 / 再生医学 / Met / シグナル伝達 / チロシンキナーゼ / ノックアウトマウス / 肝再生 / 形態形成

Research Abstract

HGF-Met pathway participates in tissue regeneration. We found that phosphorylation of Ser985 in the Met receptor regulated dynamics and translocalization of Met, thereby regulating HGF-dependent Met activation. Ser985 phosphorylation was regulated upon liver injury, in a reciprocal manner to Met activation. Phosphorylation and dephosphorylation of Met-Ser985 regulated by tissue injury and intactness may play a role to suppress over-regeneration.

Research Products

• [Journal Article] HGF-Antagonists : Structure, Activities, and Anti-cancer Approach. (2011)
  • Author(s): Sakai K, Nakamura T, Kinoshita T, Nakamura T, Matsumoto K.
  • Journal Title: Current Signal Transduction Therapy 6 Pages: 191-199
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor twenty years on : much more than a growth factor. (2011)
  • Author(s): Nakamura T, Sakai K, Nakamura T, Matsumoto K.
  • Journal Title: J.Gastroenterol. Hepatol. 26 Pages: 188-202
  • NAID: 120003141437
  • Peer Reviewed
• [Journal Article] Induction of donor-specific tolerance using superagonistic CD28 antibody in rat renal allografts: Regulatory T-cell expansion before engraftment may be important. (2011)
  • Author(s): Azuma H, Isaka Y, Nomi H, Inamoto T, Li XK, Hounig T, Takabatake Y, Ichimaru N,Ibuki N, Matsumoto K, Ubai T, Katsuoka Y, Takahara S.
  • Journal Title: Transplantation 90(12) Pages: 1328-1335
  • Peer Reviewed
• [Journal Article] Recombinant human HGF, but not rat HGF, elicits glomerular injury and albuminuria in normal rats via an immune complex-dependent mechanism. (2011)
  • Author(s): Mizuno S, Ikebuchi F, Fukuta K, Kato T, Matsumoto K, Adachi K, Nakamura T.
  • Journal Title: Clin Exp Pharmacol Physiol. 38 Pages: 192-201
  • Peer Reviewed
• [Journal Article] Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer. (2011)
  • Author(s): Donev IS, Wang W, Yamada T, Li Q, Takeuchi S, Matsumoto K, Yamori T, Nishioka Y, Sone S, Yano S.
  • Journal Title: Clin Cancer Res. 17(8) Pages: 2260-2269
  • Peer Reviewed
• [Journal Article] Cellular injury of cardiomyocytes during hepatocyte growth factor gene transfection with ultrasound-triggered bubble liposome destruction. (2011)
  • Author(s): Komamura, K., Tatsumi, R., Tsujita-Kuroda, Y., Onoe, T., Matsumoto, K., Nakamura, T., Miyazaki, J., Horio, T., Sugimachi, M.
  • Journal Title: J.Drug Delivery 2011 Pages: 1-8
  • NAID: 120004898438
  • Peer Reviewed
• [Journal Article] Cellular injury of cardiomyocytes during hepatocyte growth factor gene transfection with ultrasound-triggered bubble liposome destruction. (2011)
  • Author(s): Komamura K, Tatsumi R, Tsujita-Kuroda Y, Onoe T, Matsumoto K, Nakamura T, Miyazaki J, Horio T, Sugimachi M.
  • Journal Title: J Drug Delivery Volume: 2011 Pages: 1-8
  • NAID: 120004898438
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor twenty years on: much more than a growth factor. (2011)
  • Author(s): Nakamura T, Sakai K, Nakamura T, Matsumoto K.
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 188-202
  • NAID: 120003141437
  • Peer Reviewed
• [Journal Article] Induction of donor-specific tolerance using superagonistic CD28 antibody in rat renal allografts : Regulatory T-cell expansion before engraftment may be important. (2011)
  • Author(s): Azuma H, Isaka Y, Nomi H, Inamoto T, Li XK, Hounig T, Takabatake Y, Ichimaru N, Ibuki N, Matsumoto K, Ubai T, Katsuoka Y, Takahara S.
  • Journal Title: Transplantation Volume: 90 Pages: 1328-1335
  • Peer Reviewed
• [Journal Article] Recombinant human HGF, but not rat HGF; elicits glomerular injury and albuminuria in normal rats via an immune complex-dependent mechanism. (2011)
  • Author(s): Mizuno S, Ikebuchi F, Fukuta K, Kato T, Matsumoto K, Adachi K, Nakamura T.
  • Journal Title: Clin Exp Pharmacol Physiol Volume: 38 Pages: 192-201
  • Peer Reviewed
• [Journal Article] Transient PI3K inhibition induces apoptosis and overcomes IIGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer. (2011)
  • Author(s): Donev IS, Wang W, Yamada T, Li Q, Takeuchi S, Matsumoto K, Yamori T, Nishioka Y, Sone S, Yano S.
  • Journal Title: Clin Cancer Res Volume: 17 Pages: 2260-2269
  • Peer Reviewed
• [Journal Article] HGF-antagonists : structure, activities, and anti-cancer approach. (2011)
  • Author(s): Sakai K, Nakamura T, Kinoshita T, Nakamura T, Matsumoto, K.
  • Journal Title: Current Signal Transduction Therapy Volume: (in press)
  • Peer Reviewed
• [Journal Article] Anti-cancer approach with NK4 : Bivalent action and mechanisms. (2010)
  • Author(s): Nakamura T, Sakai K, Nakamura T, Matsumoto K.
  • Journal Title: Anti-Cancer Agent Med. Chem. 10(1) Pages: 36-46
  • Peer Reviewed
• [Journal Article] Facilitated tendon-bone healing by local delivery of recombinant hepatocyte growth factor in rabbits. (2010)
  • Author(s): Nakase J, Kitaoka K, Matsumoto K, Tomita K.
  • Journal Title: Arthroscopy 26 Pages: 84-90
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor reduces susceptibility to an irreversible epigdermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer. (2010)
  • Author(s): Yamada T, Matsumoto K, Wang W, Li Q, Nishioka Y, Sekido Y, Sone S, Yano S.
  • Journal Title: Clin.Cancer Res. 16 Pages: 174-183
  • Peer Reviewed
• [Journal Article] p27 Nuclear localization and growth arrest caused by perlecan knockdown in human endothelial cells. (2010)
  • Author(s): Sakai K, Oka K, Matsumoto K, Nakamura T.
  • Journal Title: Biochem.Biophys.Res.Commun. 392 Pages: 403-408
  • Peer Reviewed
• [Journal Article] hTERT-promotrt-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells. (2010)
  • Author(s): Onimaru M, Ohuchida K, Mizumoto K, Nagai E, Cui L, Toma H, Takayama K, Matsumoto K, Hashizume M, Tanaka M.
  • Journal Title: Cancer Sci. 101 Pages: 735-742
  • Peer Reviewed
• [Journal Article] Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma. (2010)
  • Author(s): Suzuki Y, Sakai K, Ueki J, Xu Q, Nakamura T, Shimada H, Nakamura T, Matsumoto K.
  • Journal Title: Int.J.Cancer 127 Pages: 1948-1957
  • Peer Reviewed
• [Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells. (2010)
  • Author(s): Onimaru M, Ohuchida K, Egami T, Mizumoto K, Nagai E, Cui L, Toma H, Matsumoto K, Hashizume M, Tanaka M.
  • Journal Title: Cancer Gene Ther. 17 Pages: 541-549
  • Peer Reviewed
• [Journal Article] Facilitated tendon-bone healing by local delivery of recombinant hepatocyte growth factor in rabbits. (2010)
  • Author(s): Nakase J, Kitaoka K, Matsumoto K, Tomita K.
  • Journal Title: Arthroscopy Volume: 26 Pages: 84-90
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibition in EGFR-T790M mutant lung cancer. (2010)
  • Author(s): Yamada T, Matsumoto K., Wang W, Li Q, Nishioka Y, Sekido Y, Sone S, Yann S
  • Journal Title: Clin Cancer Res. Volume: 16 Pages: 174-183
  • Peer Reviewed
• [Journal Article] p27 Nuclear localization and growth arrest caused by perlecan knockdown in human endothelial cells. (2010)
  • Author(s): Sakai K Oka K, Matsumoto K, Nakamura T.
  • Journal Title: Biochcm.Biophys.Res.Commun. Volume: 3 Pages: 403-408
  • Peer Reviewed
• [Journal Article] hTERT-promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-detective adenovirus vectors in pancreatic cancer cells. (2010)
  • Author(s): Onimaru M, Ohuchida K, Mizumoto K, Nagai E, Cui L, Toma I-{, Takayama K, Matsumoto K, Hashizume M, Tanaka M.
  • Journal Title: Cancer Sci. Volume: 101 Pages: 735-742
  • Peer Reviewed
• [Journal Article] Anti-cancer approach with NK4 : Bivalent action and mechanisms. (2010)
  • Author(s): Nakamura T, Sakai K, Nakamura T,Matsumoto K.
  • Journal Title: Anti-cancer Agent Med.Chem. Volume: 10 Pages: 36-46
  • Peer Reviewed
• [Journal Article] Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma. (2010)
  • Author(s): Suzuki Y, Sakai K, Ueki J, Xu Q, Nakamura T, Shimada H, Nakamura T, Matsumoto K.
  • Journal Title: Int.J.Cancer Volume: 127 Pages: 1948-1957
  • Peer Reviewed
• [Journal Article] Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells. (2010)
  • Author(s): Onimaru M, Ohuchida K. Egami T, Mizumoto K, Nagai E, Cui L. Toma H, Matsumoto K, Hashizume M, Tanaka M.
  • Journal Title: Cancer Gene Ther Volume: 17 Pages: 541-549
  • Peer Reviewed
• [Journal Article] Facilitated tendon-bone healing by local delivery of recombinant hepatocyte growth factor in rabbits (2010)
  • Author(s): Nakase J, Matsumoto K, et al.
  • Journal Title: Arthroscopy 26 Pages: 84-90
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibition in EGFR-T790M mutant lung cancer (2010)
  • Author(s): Yamada T, Matsumoto K, et al.
  • Journal Title: Clin Cancer Res. 16 Pages: 174-183
  • Peer Reviewed
• [Journal Article] p27 Nuclear localization and growth arrest caused by perlecan knockdown in human endothelial cells (2010)
  • Author(s): Sakai K, Matsumoto K, et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 3 Pages: 403-408
  • Peer Reviewed
• [Journal Article] hTERT-promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells (2010)
  • Author(s): Onimaru M, Matsumoto K, et al.
  • Journal Title: Cancer Sci. 101 Pages: 735-742
  • NAID: 10026589785
  • Peer Reviewed
• [Journal Article] Anti-cancer approach with NK4 : Bivalent action and mechanisms (2010)
  • Author(s): Nakamura T, Matsumoto K, et al.
  • Journal Title: Anti-cancer Agent Med. Chem. 10 Pages: 36-46
  • Peer Reviewed
• [Journal Article] Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma. (2010)
  • Author(s): Suzuki Y, Matsumoto K, et al.
  • Journal Title: Int.J.Cancer (印刷中)
  • Peer Reviewed
• [Journal Article] Angioinhibitory Action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association. (2009)
  • Author(s): Sakai K, Nakamura T, Matsumoto K, Nakamura T.
  • Journal Title: J.Biol.Chem. 284 Pages: 22491-22499
  • Peer Reviewed
• [Journal Article] Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice. (2009)
  • Author(s): Kanai M, Funakoshi H, Takahashi H, Hayakawa T, Mizuno S, Matsumoto K, Nakamura T.
  • Journal Title: Mol.Brain 2 Pages: 8-8
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor prevents multiple organ injuries in endotoxemic mice through a heme oxygenase-1-dependent mechanism. (2009)
  • Author(s): Kamimoto M, Mizuno S, Matsumoto K, Nakamura T.
  • Journal Title: Biochem.Biophys.Res.Commun. 380 Pages: 333-337
  • Peer Reviewed
• [Journal Article] Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models. (2009)
  • Author(s): Kishi Y, Kuba K, Nakamura T, Wen J, Suzuki Y, Mizuno S, Nukiwa T, Matsumoto K, Nakamura T.
  • Journal Title: Cancer Sci. 100 Pages: 1351-1358
  • NAID: 10027192650
  • Peer Reviewed
• [Journal Article] Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS. (2009)
  • Author(s): Kadoyama K, Funakoshi H, Ohya-Shimada W, Nakamura T, Matsumoto K, Matsuyama S, Nakamura T.
  • Journal Title: Neurosci.Res. 65 Pages: 194-200
  • Peer Reviewed
• [Journal Article] Different reactivities of enzyme-linked immunosorbent assays for hepatocyte growth factor. (2009)
  • Author(s): Fukuta K, Adachi E, Matsumoto K, Nakamura, T.
  • Journal Title: Clinica Chimica Acta 402 Pages: 42-46
  • Peer Reviewed
• [Journal Article] Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes. (2009)
  • Author(s): Liu KX, Kato Y, Matsumoto K, Nakamura T, Kaku T, Sugiyama Y.
  • Journal Title: Pharm. Res. 26 Pages: 1012-1021
  • NAID: 120001063570
  • Peer Reviewed
• [Journal Article] Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer. (2009)
  • Author(s): Egami T, Ohuchida K, Miyoshi K, Mizumoto K, Onimaru M, Toma H, Sato N, Matsumoto K, Tanaka M.
  • Journal Title: Cancer Sci. 100 Pages: 722-729
  • NAID: 10025144686
  • Peer Reviewed
• [Journal Article] NK4, an HGF ntagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells. (2009)
  • Author(s): Kubota T, Fujiwara H, Matsumura A, Taiyoh H, Ichikawa I, Okamoto K, Matsumoto M, Nakamura T, Otsuji E.
  • Journal Title: Clin.Exp.Metastasis 26 Pages: 447-456
  • Peer Reviewed
• [Journal Article] Up-regulation of integrin-b3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy. (2009)
  • Author(s): Egami T, Ohuchida K, Yasui T, Mizumoto K, Onimaru M, Toma H, Sato N, Matsumoto K, Tanaka M.
  • Journal Title: Cancer Sci. 100 Pages: 1902-1907
  • Peer Reviewed
• [Journal Article] Gene transfer of NK4, an angiogenesis inhibitor, induces CT26 tumor regression via tumor-specific T-lymphocyte activation. (2009)
  • Author(s): Kubota T, Taiyoh H, Matsumura A, Murayama Y, Ichikawa D, Okamoto O, Fujiwara H, Ikoma H, Nakanishi N, Kikuchi S, Ochiai T, Sakakura C, Kokuba Y, Suzuki Y,Matsumoto K, Nakamura T, Otsuji E.
  • Journal Title: Int.J.Cancer. 125 Pages: 2879-2886
  • Peer Reviewed
• [Journal Article] Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. (2009)
  • Author(s): Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Ooshio T, Nakada M, Sawamoto K, Matsumoto K, Oshima M, Asano M, Saya H, Okano H,Suda T, Hamada J, Hirao A.
  • Journal Title: Proc.Natl Acad.Sci.USA 106(40) Pages: 17163-17168
  • Peer Reviewed
• [Journal Article] Crosstalk to stromal fibroblasts induces resistance of lung cancer to EGFR tyrosine kinase inhibitors. (2009)
  • Author(s): Wang W, Li Q, Matsumoto K, Kayano Y, Matsumoto I, Oda M, Watanabe G, Nishioka Y, Sone S, Yano S.
  • Journal Title: Clin.Cancer Res. 15(21) Pages: 6630-6638
  • Peer Reviewed
• [Journal Article] Angioinhibitory action of NK4 involves impaired extracellular assembly of fibronectin mediated by perlecan-NK4 association (2009)
  • Author(s): Sakai K, Matsumoto K, et al.
  • Journal Title: J.Biol.Chem. 284 Pages: 22491-22499
  • Peer Reviewed
• [Journal Article] Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice (2009)
  • Author(s): Kanai M, Matsumoto K, et al.
  • Journal Title: Molecular Brain 2 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. (2009)
  • Author(s): Tamase A, Matsumoto K, et al.
  • Journal Title: Proc Natl.Acad.Sci.USA 106 Pages: 17163-17168
  • Peer Reviewed
• [Journal Article] Crosstalk to stromal fibroblasts induces resistance of lung cancer to EGFR tyrosine kinase inhibitors. (2009)
  • Author(s): Wang W Li, Matsumoto K, et al.
  • Journal Title: Clin Cancer Res. 15 Pages: 6630-6638
  • Peer Reviewed
• [Journal Article] Different reactivities of enzyme-linked immunosorbent assays for hepatocyte growth factor (2009)
  • Author(s): Fukuta K, Matsumoto K, et al.
  • Journal Title: Clinica Chimica Acta 402 Pages: 42-46
  • Peer Reviewed
• [Journal Article] Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes (2009)
  • Author(s): Liu KX, Matsumoto K, et al.
  • Journal Title: Pharm.Res. 26 Pages: 1012-1021
  • NAID: 120001063570
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor prevents multiple organ injuries in endotoxemic mice through a heme oxygenase-1-dependent mechanism (2009)
  • Author(s): Kamimoto M, Matsumoto K, et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 380 Pages: 333-337
  • Peer Reviewed
• [Journal Article] Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer (2009)
  • Author(s): Egami T, Matsumoto K, et al.
  • Journal Title: Cancer Sci. 100 Pages: 722-729
  • NAID: 10025144686
  • Peer Reviewed
• [Journal Article] Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models (2009)
  • Author(s): Kishi Y, Matsumoto K, et al.
  • Journal Title: Cancer Sci. 100 Pages: 1351-1358
  • NAID: 10027192650
  • Peer Reviewed
• [Journal Article] NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells (2009)
  • Author(s): Kubota T, Matsumoto K, et al.
  • Journal Title: Clin.Exp.Metastasis 26 Pages: 447-456
  • Peer Reviewed
• [Journal Article] Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of transgenic mouse model of ALS (2009)
  • Author(s): Kadoyama K, Matsumoto K, et al.
  • Journal Title: Neurosci.Res. 65 Pages: 194-200
  • Peer Reviewed
• [Journal Article] Up-regulation of integrin-β3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy (2009)
  • Author(s): Egami T, Matsumoto K, et al.
  • Journal Title: Cancer Sci. 100 Pages: 1902-1907
  • NAID: 10027195795
  • Peer Reviewed
• [Journal Article] Gene transfer of NK4, an angiogenesis inhibitor, induces CT26 tumor regression via tumor-specific T-lymphocyte activation (2009)
  • Author(s): Kubota K, Matsumoto K, et al.
  • Journal Title: Int.J.Cancer 125 Pages: 2879-2886
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 中村隆弘, 極本邦夫, 他
  • Journal Title: がん分子標的治療Vol. 7 No. 2(メディカルレビュー社) Pages: 92-101
• [Journal Article] (2009)
  • Author(s): 福田一弘, 松本邦夫, 他
  • Journal Title: 「バイオ医薬開発技術とシーズ」(山本重夫監修)(シーエムシー出版) Pages: 66-78
• [Journal Article] (2009)
  • Author(s): 中村隆弘, 松本邦夫
  • Journal Title: 炎症・再生医学事典(朝倉書店) Pages: 518-521
• [Journal Article] (2009)
  • Author(s): 鈴木芳典, 松本邦夫
  • Journal Title: Surgery Frontier vol. 16(メディカルレビュー社) Pages: 466-470
• [Journal Article] Different reactivities of enzyme-linked immunosorbent assays for hepatocyte growth factor. (2009)
  • Author(s): Fukuta K, Matsumoto K, et al.
  • Journal Title: Clinica Chimica Acta 402 Pages: 42-46
  • Peer Reviewed
• [Journal Article] Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes. (2009)
  • Author(s): Liu KX, Matsumoto K, et al.
  • Journal Title: Pharm. Res. 26 Pages: 1012-1021
  • NAID: 120001063570
  • Peer Reviewed
• [Journal Article] Hepatocyle growth factor prevents multiple organ injuries in endotoxemic mice through a he me oxygenase-1-dependentmechanism. (2009)
  • Author(s): Kamimoto M, Matsumolo K, et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 380 Pages: 333-337
  • Peer Reviewed
• [Journal Article] HGF anlagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells. (2009)
  • Author(s): Kubola T, Matsumolo K, et al.
  • Journal Title: Clin. Exp. Metastasis (In press)
  • Peer Reviewed
• [Journal Article] Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models. (2009)
  • Author(s): Kishi Y, Matsumolo K, el al.
  • Journal Title: Cancer Sci. (In press)
  • Peer Reviewed
• [Journal Article] Tryptophan 2, 3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice. (2009)
  • Author(s): Kanai M, Matsumoto K, et al.
  • Journal Title: Mol. Brain (In press)
  • Peer Reviewed
• [Journal Article] HGF研究の進展と制癌剤開発 (2009)
  • Author(s): 中村隆弘, 松本邦夫
  • Journal Title: がん分子標的治療(メディカルレビュー社) 7 Pages: 92-101
• [Journal Article] NK4 gene therapy targeting HGF-Met and angiogenesis. (2008)
  • Author(s): Matsumoto K, Nakamura T.
  • Journal Title: Front Biosci. 13 Pages: 1943-1951
  • Peer Reviewed
• [Journal Article] The functions and possible significance of Kremen as the gatekeeper of Wnt signaling in development and pathology. (2008)
  • Author(s): Nakamura T, Nakamura T, Matsumoto K.
  • Journal Title: J.Cell.Mol.Med. 12
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor as a renotrophic and anti-fibrotic regulator in chronic renal disease. (2008)
  • Author(s): Mizuno S, Matsumoto K, Nakamura T.
  • Journal Title: Front.Biosci. 13 Pages: 7072-7086
  • Peer Reviewed
• [Journal Article] Hepatocyte Growth Factor and Met in Tumor Biology and Therapeutic Approach with NK4. (2008)
  • Author(s): Matsumoto K, Nakamura T, Sakai K, Nakamura T.
  • Journal Title: Proteomics 8 Pages: 3360-3370
  • NAID: 120001130499
  • Peer Reviewed
• [Journal Article] Generation of engineered recombinant hepatocyte growth factor cleaved and activated by Genenase I. (2008)
  • Author(s): Hayata D, Fukuta K, Matsumoto K, Adachi E, Hanada K, Adachi K, Nakamura T.
  • Journal Title: J Biotechnol. 133 Pages: 478-485
  • NAID: 120000811714
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with EGF Receptor activating mutations. (2008)
  • Author(s): Yano S, Wang W, Li Q, Matsumoto K, Sakurama H, Nakamura T, Ogino H, Kakiuchi S, Hanibuchi M, Nishioka Y, Uehara H, Mitsudomi T, Yatabe Y, Nakamura T, Sone S.
  • Journal Title: Cancer Res. 68 Pages: 9479-9487
  • Peer Reviewed
• [Journal Article] Regulation of cell migration and cytokine production by HGF-like protein (HLP)/macrophage stimulating protein (MSP) in primary microglia. (2008)
  • Author(s): Suzuki Y, Funakoshi H, Machide M, Matsumoto K, Nakamura T.
  • Journal Title: Biomed.Res. 29 Pages: 77-84
  • NAID: 130004724052
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor improves synaptic localization of the NMDA receptor and intracellular signaling after excitotoxic injury in cultured hippocampal neurons. (2008)
  • Author(s): Akita H, Takagi N, Ishihara N, Takagi K, Murotomi K, Funakoshi H, Matsumoto K, Nakamura T, Takeo S.
  • Journal Title: Exp Neurol. 210(1) Pages: 83-94
  • Peer Reviewed
• [Journal Article] Growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice. (2008)
  • Author(s): Ito W, Tanimoto M, Ono K, Mizuno S, Yoshida A, Koga H, Fuchimoto Y, Kondo N, Tanimoto Y, Kiura K, Matsumoto K, Kataoka M, Nakamura T, Gelfand E, Kanehiro A.
  • Journal Title: Int.Arch.Allergy Immunol. 145 Pages: 324-339
  • Peer Reviewed
• [Journal Article] Reduction of fibrosis in a rat model of non-alcoholic steatohepatitis cirrhosis by human HGF gene transfection using electroporation. (2008)
  • Author(s): Kiyama S, Yamada T, Iwata H, Sekino T, Matsuo H, Yoshida N, Miyahara T, Umeda Y, Matsuno Y, Kimura M, Matsumoto K, Nakamura T, Takemura H.
  • Journal Title: J.Gastroenterol.Hepatol. 23
  • Peer Reviewed
• [Journal Article] Radiation enhances adenoviral gene therapy in pancreatic cancer via activation of cytomegalovirus promoter and increased adenovirus uptake. (2008)
  • Author(s): Egami T, Ohuchida K, Mizumoto K, Onimaru M, Toma H, Nishio S, Nagai E, Matsumoto K, Nakamura T, Tanaka M.
  • Journal Title: Clin.CancerRes. 14 Pages: 1859-1867
  • Peer Reviewed
• [Journal Article] Generation of engineered recombinant hepalocyte growth factor cleaved and activated by Generase I. (2008)
  • Author(s): Hayata D, Matsumoto K, et al.
  • Journal Title: J. Biotechnol. 133 Pages: 478-485
  • Peer Reviewed
• [Journal Article] The functions and possible significance of Kremen as the gatekeeper of Wnt signaling in development and palhology. (2008)
  • Author(s): Nakamura T, Malsumolo K, et al.
  • Journal Title: J. Cell. Mol. Med. 12 Pages: 391-408
  • Peer Reviewed
• [Journal Article] NK4 gene therapy targeting HGF-Met and angiogenesis. (2008)
  • Author(s): Matsumolo K, et al.
  • Journal Title: Front Biosci. 13 Pages: 1943-1951
  • Peer Reviewed
• [Journal Article] Hepalocyle growth factor as a renolrophic and anti-fibrolic regulator in chronic renal disease (2008)
  • Author(s): Mizuno S, Matsumolo K, et al.
  • Journal Title: Front. Biosci. 13 Pages: 7072-7086
  • Peer Reviewed
• [Journal Article] Hepatocyte Growth Factor and Mel in Tumor Biology and Therapeutic Approach with NK4. (2008)
  • Author(s): Matsumoto K, et al.
  • Journal Title: Proteomics 8 Pages: 3360-3370
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor improves synaptic localizalion of the NMDA receptor and inlracellular signaling after excitoloxic injury in cultured hippocampal neurons. (2008)
  • Author(s): Akita H, Matsumolo K, el al.
  • Journal Title: Exp Neurol. 210 Pages: 83-94
  • Peer Reviewed
• [Journal Article] Growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice. (2008)
  • Author(s): Ito W, Matsumoto K, et al.
  • Journal Title: Int. Arch. Allergy Immunol. 145 Pages: 324-339
  • Peer Reviewed
• [Journal Article] Regulation of cell migration and cytokine production by HGF-like protein (HLP)/macrophage stimulating protein (MSP)in primary microglia. (2008)
  • Author(s): Suzuki Y, Matsumoto K, et al.
  • Journal Title: Biomed. Res. 29 Pages: 77-84
  • NAID: 130004724052
  • Peer Reviewed
• [Journal Article] Reduction of fibrosis in a rat model of non-alcoholic steatohepatitis cirrhosis by human HGF gene transfection using electroporation. (2008)
  • Author(s): Kiyama S, Matsumoto K, et al.
  • Journal Title: J. Gastroenterol. Hepatol. 23
  • Peer Reviewed
• [Journal Article] Radiation enhances adenoviral gene therapy in pancreatic cancer via activation of cytomegalovirus promoter and increased adenovirus uptake. (2008)
  • Author(s): Egami T, Matsumoto K, et al.
  • Journal Title: Clin. Cancer Res. 14 Pages: 1859-1867
  • Peer Reviewed
• [Journal Article] Hepatocyte growth factor induces gefltinib resistance of lung adenocarcinoma with EGF Receptor activating mutations. (2008)
  • Author(s): Yano S, Matsumoto K, et al.
  • Journal Title: Cancer Res. 68 Pages: 6479-6487
  • Peer Reviewed
• [Presentation] Functional analysis of the Kremen in Lewis lung carcinoma cells throughWnt/b-catenin signaling pathway. (2010)
  • Author(s): Xu Q, Fujikawa M, Nakamura T, Matsumoto K
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] Perlecanによるp27の発現ならびに細胞内細胞内局在の制御を介した血管内皮細胞の増殖制御. (2010)
  • Author(s): 酒井克也、松本邦夫, (他3 名)
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] Pcrlecanによるp27の発現ならびに細胞内細胞内局在の制御を介した血管内皮細胞の増殖制御 (2010)
  • Author(s): 酒井克也、岡清正、中村隆弘、松本邦夫、中村敏一
  • Organizer: 第33回日本分子生物学会年会・日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] Functional analysis of the Kremen in Lewis lung carcinoma cells throughWnt/β-catenin cionalino nathwav (2010)
  • Author(s): Quing Xu, Masataka Fujikawa, Takahiro Nakamura, Kunio Matsumoto.
  • Organizer: 第33回日本分子生物学会年会・日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] 肝細胞におけるMet/HGF受容体Ser985リン酸化と受容体活性化の制御 (2010)
  • Author(s): 中山瑞穂、中村敏一, (他4名)
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-08
• [Presentation] 肝細胞におけるMet/HGF受容体Ser985リン酸化と受容体活性化の制御 (2010)
  • Author(s): 中山瑞穂、山下敦子、中村隆弘、徐慶、中村敏一、松本邦夫
  • Organizer: 第33回同本分子生物学会年会・日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-08
• [Presentation] EGFR変異肺がんのチロシンキナーゼ阻害剤耐性と治療戦略 (2010)
  • Author(s): 矢野聖二、松本邦夫, (他7名)
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-23
• [Presentation] Perlecanによるp27の発現ならびに細胞内細胞内局在の制御を介した血管内皮細胞の増殖制御 (2010)
  • Author(s): 酒井克也、松本邦夫, (他3名)
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] 野生型EGFR肺癌における肝細胞増殖因子(HGF)の抗EGFR抗体Cetuximab耐性誘導機構. (2010)
  • Author(s): 山田忠明、松本邦夫、矢野聖二, (他4名)
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] NK4による腫瘍皮下移植片中のVEGF発現抑制効果は、HGFを介する腫瘍-間質相互作用を阻害することで発揮される (2010)
  • Author(s): 松村篤、松本邦夫、大辻英吾, (他10名)
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] 野生型EGFR肺癌における肝細胞増殖因子(HGF)の抗EGFR抗体Cetuximab耐性誘導機構 (2010)
  • Author(s): 山田忠明、竹内伸司、ドネブイワンシュテレブ、西岡安彦、曽根三郎、松本邦夫、矢野聖二
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] ヒト悪性中皮腫細胞のコラーゲンゲル内浸潤性増殖におけるHGF-Met系の役割とNK4による阻害 (2009)
  • Author(s): 鈴木芳典、松本邦夫, (他3 名)
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2009-10-24
• [Presentation] NK4による血管新生阻害作用の解析-プロテオグリカン結合を介したフィブロネクチン構築阻害. (2009)
  • Author(s): 酒井克也、松本邦夫, (他3名)
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2009-10-24
• [Presentation] ヒト悪性中皮腫細胞のコラーゲンゲル内浸潤性増殖におけるHGF-Met系の役割とNK4による阻害 (2009)
  • Author(s): 鈴木芳典, 松本邦夫, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-10-24
• [Presentation] NK4による血管新生阻害作用の解析・プロテオグリカン結合を介したフィブロネクチン構築阻害 (2009)
  • Author(s): 酒井克也, 松本邦夫, 他
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場 (兵庫県)
  • Year and Date: 2009-10-24
• [Presentation] HGF-Met系を介したヒト悪性中皮腫細胞の遊走制御とMet細胞外領域遺伝子変異 (2009)
  • Author(s): 酒井克也、松本邦夫, (他3名)
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] NK4によるプロテオグリカン結合を介したフィブロネクチン構築阻害 (2009)
  • Author(s): 酒井克也、松本邦夫, (他3名)
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] CT26細胞に対するNK4遺伝子導入による5-FUのアポトーシス増強作用の検討. (2009)
  • Author(s): 大場宏明、松本邦夫、大辻英吾, (他10名)
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] 血管新生阻害剤、NK4遺伝子導入によるCT26腫瘍拒絶と腫瘍特異的免疫誘導のメカニズムの検討. (2009)
  • Author(s): 窪田健、松本邦夫、大辻英吾, (他10名)
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] HGF/c-Metシグナルを介したVEGF発現調節のメカニズムの検討. (2009)
  • Author(s): 松村篤、松本邦夫、大辻英吾, (他10名)
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] HGF-Met系を介したヒト悪性中皮腫細胞の遊走制御とMet細胞外領域遺伝子変異 (2009)
  • Author(s): 鈴木芳典, 松本邦夫, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] NK4によるプロテオグリカン結合を介したフィブロネクチン構築阻害 (2009)
  • Author(s): 酒井克也, 松本邦夫, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] CT26細胞に対するNK4遺伝子導入による5-FUのアポトーシス増強作用の検討 (2009)
  • Author(s): 大場宏明, 松本邦夫, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] 血管新生阻害剤、NK4遺伝子導入によるCT26腫瘍拒絶と腫瘍特異的免疫誘導のメカニズムの検討 (2009)
  • Author(s): 窪田健, 松本邦夫, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] HGF/c-Metシグナルを介したVEGF発現調節のメカニズムの検討 (2009)
  • Author(s): 松村篤, 松本邦夫, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2009-10-03
• [Presentation] HGF-Met系を介した組織再生の制御と創薬 (2009)
  • Author(s): 松本邦夫
  • Organizer: 第24回岡山Vascular Biology研究会
  • Place of Presentation: 岡山大学(岡山県)
  • Year and Date: 2009-03-18
• [Presentation] 濃度勾配因子としてのHGF を介した形態形成・細胞増殖・遊走の制御 (2008)
  • Author(s): 松本邦夫, (他4名)
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2008-12-12
• [Presentation] GenenaseIによってプロセッシング・活性化される組換えHGFの調製. (2008)
  • Author(s): 早田大真、松本邦夫, (他5名)
  • Organizer: 第31回に本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2008-12-12
• [Presentation] Genenase Iによってプロセッシング・活性イヒされる組換えHGFの調製. (2008)
  • Author(s): 早田大真, 松本邦夫, 他
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] 濃度勾配因子としてのHGFを介した形態形成・細胞増殖・遊走の制御 (2008)
  • Author(s): 松本邦夫, 他
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] マトリックスメタロプロテアーゼに依存したヒト悪性中皮腫のコラーゲンマトリックス内浸潤. (2008)
  • Author(s): 酒井克也、松本邦夫, (他3名)
  • Organizer: 第31回に本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2008-12-10
• [Presentation] ヒト悪性中皮腫の浸潤性増殖におけるHGF-Met系の意義とNK4による阻止. (2008)
  • Author(s): 鈴木芳典、松本邦夫, (他2名)
  • Organizer: 第31回に本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2008-12-09
• [Presentation] ヒト悪性中皮腫の浸潤性増殖におけるHGF-Met系の意義とNK4による阻止. (2008)
  • Author(s): 鈴木芳典, 松本邦夫, 他
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] MMPに依存したヒト悪性中皮腫のコラーゲンマトリックス内浸潤. (2008)
  • Author(s): 酒井克也, 松本邦夫, 他
  • Organizer: 第31回日本分子生物学余年会・第81回日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] NK4遺伝子導入CT26腫瘍における血管新生阻害とCD8+T細胞誘導のメカニズムの検討. (2008)
  • Author(s): 窪田健、松本邦夫、大辻英吾, (他9名)
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2008-10-29
• [Presentation] ヒト悪性中皮腫に対する浸潤性増殖ならびに血管新生害を介したNK4の制癌作用. (2008)
  • Author(s): 鈴木芳典、松本邦夫, (他2名)
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2008-10-29
• [Presentation] NK4遺伝子導入CT26腫瘍における血管新生阻害とCD8+T細胞誘導のメカニズムの検討 (2008)
  • Author(s): 窪田健, 松本邦夫, 他
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] ヒト悪性中皮腫に対する浸潤性増殖ならびに血管新生阻害を介したNK4の制癌作用. (2008)
  • Author(s): 鈴木芳典, 松本邦夫, 他
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] マトリックスメタロプロテアーゼに依存したヒト悪性中皮腫のコラーゲンマトリックス内浸潤. (2008)
  • Author(s): 酒井克也、松本邦夫, (他3名)
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2008-10-28
• [Presentation] "Significance of HGF-Met in cancer malignancy and therapeutic approach with NK4" International Session 6 : Chemokine, Cytokine and Cancer (2008)
  • Author(s): 松本邦夫
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2008-10-28
• [Presentation] Significance of HGF-Met in cancer malignancy and therapeutic approach with NK4 (2008)
  • Author(s): 松本邦夫
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] マトリツクスメタロプロテアーゼに依存したヒト悪性中皮腫のコラーゲン内浸潤. (2008)
  • Author(s): 酒井克也, 松本邦夫, 他
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Inhibition of tumor metastasis and angiogenesis by NK4, bifunctional inhibitor of HGF-Met and angiogenesis (2008)
  • Author(s): Kunio Matsumoto
  • Organizer: EHRLICH II World Conference on Magic Bullets
  • Place of Presentation: (Niirnberg, Germany)
  • Year and Date: 2008-10-04
• [Presentation] Inhibition of tumor metastasis and angiogenesis by NK4, bifunctional inhibitor of HGF-Met and angiogenesis (2008)
  • Author(s): 松本邦夫
  • Organizer: EHRLICH II World Conference on Magic Bullets.
  • Place of Presentation: Meistersingerhalle Nurnberg(Germany)
• [Book] In"Cancer Treatment"(Significance, mechanisms, and progress of anticancer drugs targeting HGF-Met) (2011)
  • Author(s): Sakai K, Nakamura T, Suzuki Y, Matsumoto K
  • Publisher: InTech Open Access Publisher, in press
• [Book] 遺伝子医学MOOK別冊「ますます重要になる細胞周辺環境の科学技術」 (2010)
  • Author(s): 中山瑞穂, 松本邦夫
  • Publisher: メディカルドウ(印刷中)
• [Book] バイオ医薬開発技術とシーズ(山本重夫監修・(株))(新規がん分子標的薬-NK4(HGF アンタゴニスト/血管新生阻害分子)の開発-) (2009)
  • Author(s): 福田一弘、松本邦夫、中村敏一
  • Publisher: シーエムシー出版
• [Book] 炎症・再生医学事典(松島剛治・西脇徹編)(HGF) (2009)
  • Author(s): 中村隆弘、松本邦夫
  • Publisher: 朝倉書店
• [Book] 遺伝子医学MOOK別冊「ますます重要になる細胞周辺環境の科学技術」(田畑泰彦編)(細胞増殖因子) (2009)
  • Author(s): 中山瑞穂、松本邦夫
  • Publisher: メディカルドウ
• [Book] がん分子標的治療(HGF研究の進展と制癌剤開) (2009)
  • Author(s): 中村隆弘、櫻間晴子、中村敏一、松本邦夫
  • Publisher: メディカルレビュー社
• [Book] Surgery Frontier(癌の発生,浸潤,転移における腫瘍関連線維芽細胞(cacer-associated fibroblast)の役割) (2009)
  • Author(s): 鈴木芳典、松本邦夫
• [Book] “新規がん分子標的薬- NK4(HGFアンタゴニスト/血管新生阻害分子)の開発"、「バイオ医薬開発技術とシース」 (2009)
  • Author(s): 福田一弘, 松本邦夫, 他(分担分)
  • Total Pages: 13
  • Publisher: シーェムシー出版
• [Book] “HGF"、「炎症・再生医学事典」 (2009)
  • Author(s): 中村隆弘, 松本邦夫
  • Publisher: 朝倉書店(印刷中)
• [Book] “細胞増殖因子"、「ますます重要になる細胞周辺環境の科学技術」 (2009)
  • Author(s): 中山瑞穂, 松本邦夫
  • Publisher: 朝倉書店(印刷中)
• [Book] がんはなぜできるのか(シリーズ新・がん医学入門(2))(谷口直之・杉山治夫・松浦成昭編)(細胞増殖・細胞死の制御異常) (2008)
  • Author(s): 松本邦夫、鈴木芳典
  • Publisher: 中山書店
• [Book] 分子細胞生物学辞典(第2版)(東京化学同人)(肝細胞増殖因子) (2008)
  • Author(s): 松本邦夫
• [Book] “細胞増殖・細胞死の制御異常"、「がん医学人門」 (2008)
  • Author(s): 松本邦夫, 他(分担分)
  • Total Pages: 17
  • Publisher: 中山言店
• [Book] “肝細胞増殖因子"、「分子細胞生物学辞典(第2版)」 (2008)
  • Author(s): 松本邦夫, 他(分担分)
  • Total Pages: 1
  • Publisher: 東京化学同人
• [Remarks]
  • URL: http://www.kanazawa-u.ac.jp/~ganken/shuyoudoutaiseigyo/index.html
• [Patent(Industrial Property Rights)] 分子標的薬に対する感受性が低下している癌の治療薬および分子標的薬に対する感受性を増強する医薬組成物 (2009)
  • Inventor(s): 矢野聖二、松本邦夫
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 2009-078621
  • Filing Date: 2009-03-27
• [Patent(Industrial Property Rights)] 「分子標的薬に対する感受性が低下している癌の治療薬および分子標的薬に対する感受性を増強する医薬組成物」 (2009)
  • Inventor(s): 矢野聖二松本邦夫
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Industrial Property Number: 2009-078621
  • Filing Date: 2009-03-27
• [Patent(Industrial Property Rights)] 骨延長促進剤 (2008)
  • Inventor(s): 冨田勝郎、土屋弘行、松原秀憲、花田敬吾、松本邦夫
  • Filing Date: 2008-07-18
• [Patent(Industrial Property Rights)] 腱骨移行部組織または靭帯骨移行部組織の再生促進剤 (2008)
  • Inventor(s): 冨田勝郎、土屋弘行、松原秀憲、花田敬吾、松本邦夫
  • Filing Date: 2008-10-10
• [Patent(Industrial Property Rights)] 「骨延長促進剤」 (2008)
  • Inventor(s): 富田勝郎土屋弘行松原秀憲花田敬吾松本邦夫
  • Industrial Property Rights Holder: クリングルフアーマ株式会社
  • Filing Date: 2008-07-18
• [Patent(Industrial Property Rights)] 「腱骨移行部組織または靭帯骨移行部組織の再生促進剤」 (2008)
  • Inventor(s): 富田勝郎北岡克彦中瀬順介花田敬吾松本邦夫
  • Industrial Property Rights Holder: クリングルフアーマ株式会社
  • Filing Date: 2008-10-10