Roles of semaphorins in organogenesis during development

• Project/Area Number: 20390079
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Osaka University
• Principal Investigator: TOYOFUKU Toshihiko Osaka University, 微生物病研究所, 准教授 (60322179)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 発生医学 / セマフォリン / 網膜発生 / プレキシン / 心臓神経提細胞

Research Abstract

We investigated the role of semaphorins in the cardiac outflow tract formation and retinal photoreceptor survival during development. Class 6 semaphorins, Sema6A and 6B, navigated the cardiac neural crest cells from dorsal-ventral direction, while class 4 semaphorin, Sema4A, regulated the endosormal sorting of anti-apoptotic prosaposin and retinoid-binding proteins in the retinal pigment cells in retina to support homeostasis of photoreceptor.

Research Products

• [Journal Article] Structural basis for semaphorin signaling through the plexin receptor (2010)
  • Author(s): Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J.
  • Journal Title: Nature. 467 Pages: 1123-1127
  • Peer Reviewed
• [Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. (2010)
  • Author(s): Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A.
  • Journal Title: Nature Immunology. 11 Pages: 594-600
  • Peer Reviewed
• [Journal Article] Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements. (2010)
  • Author(s): Takegahara N, Kang S, Nojima S, Takamatsu H, Okuno T, Kikutani H, Toyofuku T, Kumanogoh A.
  • Journal Title: FASEB J. 24 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II (2010)
  • Author(s): Takamatsu, et al.
  • Journal Title: Nature immunology Volume: 11 Pages: 594-600
  • Peer Reviewed
• [Journal Article] Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangement (2010)
  • Author(s): Takegahara, et al.
  • Journal Title: FASEB J Volume: 24 Pages: 4782-4792
  • Peer Reviewed
• [Journal Article] Structural basis for semaphorin signaling through the plexin receptor (2010)
  • Author(s): Nogi, et al.
  • Journal Title: Nature Volume: 467 Pages: 1123-1127
  • Peer Reviewed
• [Journal Article] Sema4D-Plexin-B1 interactions in the CNS for pathogenesis of experimental autoimmune encephalomyelitis (2010)
  • Author(s): Okuno, et al.
  • Journal Title: J.Immunol. 184 Pages: 1499-1506
  • Peer Reviewed
• [Journal Article] Repulsive and attractive semaphorins cooperate to direct the long-range navigation of cardiac neural crest cells Dev. (2008)
  • Author(s): Toyofuku T, Yamamoto M, Yoshida J, Sugimoto T, Makino N, Takamatsu H, Takegahara N, Suto F, Hori M, Fujisawa H, Kumanogoh A, Kikutani H
  • Journal Title: Biol. 321 Pages: 251-262
  • Peer Reviewed
• [Journal Article] Repulsive and attractive semaphorins cooperate to direct the long-rangenavigation of cardiac neural crest cells (2008)
  • Author(s): Toyofuku, T., et al.
  • Journal Title: Developmental Biology 321 Pages: 251-262
  • Peer Reviewed
• [Journal Article] Involvement of Sema4A in the progression of experimental autoimmunemyocarditis (2008)
  • Author(s): Makino, N., et al.
  • Journal Title: FEBS Letters 582 Pages: 3935-3940
  • Peer Reviewed
• [Presentation] 反発性及び誘引性セマフォリンによる心臓神経提細胞の遊走制御機構 (2009)
  • Author(s): 豊福利彦
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-02
• [Book] 実験医学:心血管ネットワーク形成のダイナミクス心臓発生におけるガイダンス分子の役割 (2009)
  • Author(s): 豊福利彦
  • Total Pages: 129
  • Publisher: 羊土社