| Project/Area Number |
20390080
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
KATAOKA Tohru Kobe University, 大学院・医学研究科, 教授 (40144472)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATOH Takaya 神戸大学, 大学院・医学研究科, 准教授 (20251655)
SHIMA FUMI 神戸大学, 大学院・医学研究科, 講師 (60335445)
EDAMATSU Hironori 神戸大学, 大学院・医学研究科, 助教 (70335438)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HIRASHIMA Masanori 神戸大学, 大学院・医学研究科, 准教授 (40383757)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
|---|
| Keywords | 低分子量G蛋白質 / Rap1 / グアニンヌクレオチド交換因子 / ノックアウトマウス / 血管形成 / 神経細胞移動 / 帯状異所性灰白質症 / 精子形成異常 / 雄性不妊 / 癩癇 / Rapl / 癲癇 |
|---|
| Research Abstract |
RA-GEF-1, RA-GEF-2, and phospholipase Cε? (PLCε) are specific activators (guanine nucleotide exchange factors) for Rap1, which mediate cross-talks between different species of small G proteins. We have elucidated crucial functions of RA-GEF-1 in fetal blood vessel formation and neuronal migration, of RA-GEF-2 in sperm formation, and of PLCε in inflammation and carcinogenesis through generation and phenotypic characterization of whole body and conditional knockout mice of the respective genes.
|
