Molecular mechanism of elastic fiber assembly.
| Project/Area Number |
20390086
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
NAKAMURA Tomoyuki Kansai Medical University, 医学部, 教授 (20362527)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
|---|
| Keywords | 細胞外マトリックス / 弾性線維 / ミクロフィブリル / 遺伝子改変マウス |
|---|
| Research Abstract |
Elastic fiber is abundant in elastic tissues such as arteries, lungs and skin, and provides elasticity to these tissues. Aging-associated elastic fiber degeneration or fragmentation causes arteriosclerosis, emphysema and loose skin. It is important to uncover the molecular mechanism of elastogenesis for the future elastic fiber regeneration therapy. We previously reported that a secreted protein Fibulin-5 is essential for elastic fiber assembly. In this study, we studied the role for Fibulin-4, a member of the same protein family, in elastogenesis. Smooth muscle-specific knockout of the mouse Fbln4 gene resulted in degenerated elastic laminae in aortae and aneurysm. We also found that Fibulin-4 directly interacts with lysyl oxidase and tropoelastin, thereby tethering the enzyme to its substrate.
|
Report
(4 results)
Research Products
(65 results)
-
-
-
-
-
[Journal Article] MicroRNA-33 encoded by an intron of Srebp2 regulates HDL in vivo.2010
Author(s)
Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, Kinoshita M, Kuwabara Y, Marusawa H, Iwanaga Y, Hasegawa K, Yokode M, Kimura T, Kita T
-
Journal Title
Proc Natl Acad Sci USA 107
Pages: 17321-6
Related Report
Peer Reviewed
-
[Journal Article] Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes : comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.2010
Author(s)
Lu J, Gong D, Choong SY, Xu H, Chan YK, Chen X, Fitzpatrick S, Glyn-Jones S, Zhang S, Nakamura T, Ruggiero K, Obolonkin V, Poppitt SD, Phillips AR, Cooper GJ
-
Journal Title
Diabetologia 53
Pages: 1217-26
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase.2009
Author(s)
Horiguchi M, Inoue T, Ohbayashi T, Hirai M, Noda K, Marmorstein LY, Yabe D, Takagi K, Akama TO, Kita T, Kimura T, Nakamura T
-
Journal Title
Proc Natl Acad Sci USA 106
Pages: 19029-34
Related Report
Peer Reviewed
-
[Journal Article] Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid.2009
Author(s)
Ikeda M, Naitoh M, Kubota H, Ishiko T, Yoshikawa K, Yamawaki S, Kurokawa M, Utani A, Nakamura T, Nagata K, Suzuki S
-
Journal Title
Biochem Biophys Res Commun 390
Pages: 1221-8
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] The role of FIBULINs in elastogenesis.2009
Author(s)
Horiguchi M., Inoue T., Ohbayashi T., Hirai M., Noda K., Marmorstein L.Y., Akama T.O., Kita T., Kimura T., Nakamura T.
Organizer
Poster at Gordon Research Conference on Elastin and Elastic Fiber
Place of Presentation
Biddeford, U.S.A.
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
