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Visualizing the dynamics of senescence response in vivo

Research Project

Project/Area Number 20390094
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionJapanese Foundation For Cancer Research

Principal Investigator

HARA Eiji  Japanese Foundation For Cancer Research, 癌研究所がん生物部, 部長 (80263268)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords癌 / 老化 / イメージング / シグナル伝達 / ストレス
Research Abstract

Cellular senescence has long been considered as an important mechanism controlling tumor suppression and aging. However because cellular senescence had been studied mainly in vitro, it was unclear whether cellular senescence indeed occurs in vivo. To circumvent this problem, here we developed a system to visualize the dynamics of senescence response in vivo, especially in the context of living animal. This approach, in comjunction with the knockout mice studies, unveils biological roles of cellular senescence in vivo.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 2008 Other

All Journal Article (12 results) (of which Peer Reviewed: 7 results) Presentation (15 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interferes with epidermal growth factor receptor (EGFR) signaling.2011

    • Author(s)
      Kitajima S., Miki T., Takegami Y., Kido Y., Noda M., Hara E., Shamma A., Takahashi C.
    • Journal Title

      Oncogene 30

      Pages: 737-750

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interferes with epidermal growth factor receptor (EGFR) signaling2011

    • Author(s)
      Shunsuke Kitajima
    • Journal Title

      Oncogene

      Volume: 30 Pages: 737-750

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic cooperation between p16^<INK4a> and p21^<Waf1/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010

    • Author(s)
      Takeuchi S., Takahashi A., Motoi N., Yoshimoto S., Tajima T., Yamakoshi K., Hirao A., Yanagi S., Fukami K., Ishikawa Y., Sone S., Hara E., Ohtani N.
    • Journal Title

      Cancer Res. 70

      Pages: 9381-9390

    • Related Report
      2010 Final Research Report
  • [Journal Article] Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator seil.2010

    • Author(s)
      Fernandez-Marcos P.J., Pantoja C., Gonzalez-Rodriguez A., Martin N., Flores J.M., Valverde A.M., Hara E., Serrano M.
    • Journal Title

      PLoS One. 18

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intrinsic cooperation between p16^<INK4a> and p21<Waf1/Cip1> in the onset of cellular senescence and tumor suppression in vivo2010

    • Author(s)
      Shinji Takeuchi
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 9381-9990

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking cell cycle regulator Sei12010

    • Author(s)
      Pablo J.Fernandez-Marcos
    • Journal Title

      PLOS one 5-1 e8744

      Pages: 1-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time in vivo imaging of p16^<Ink4a> expression : a new approach to study senescence stress signaling in living animals2010

    • Author(s)
      Naoko Ohtani
    • Journal Title

      Cell Division 5:1

      Pages: 1-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time in vivo imaging of p16^<Ink4a> reveals cross-talk with p53.2009

    • Author(s)
      Yamakoshi K., Takahashi A., Hirota F., Nakayama R., Ishimaru N., Kubo Y., Mann D.J., Ohmura M., Hirao A., Saya H., Arase S., Hayashi Y., Nakao K., Matsumoto M., Ohtani N., Hara E.
    • Journal Title

      J. Cell Biol. 186

      Pages: 393-407

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.2009

    • Author(s)
      Inomata K., Aoto T., Binh N.T., Okamoto N., Tanimura S., Wakayama T., Iseki S., Hara E., Masunaga T., Shimizu H., Nishimura E.K.
    • Journal Title

      Cell 137

      Pages: 1088-1099

    • Related Report
      2010 Final Research Report
  • [Journal Article] Real-time in vivo imaging of p16^<Ink4a> reveals cross talk with p532009

    • Author(s)
      Kimi Yamakoshi
    • Journal Title

      The Journal of Cell Biology 186

      Pages: 393-407

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular senescence : Its role in tumor suppression and aging2009

    • Author(s)
      Naoko Ohtani
    • Journal Title

      Cancer Science 100

      Pages: 792-797

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation2009

    • Author(s)
      Ken Inomata
    • Journal Title

      Cell (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cellular senescence : its role in tumor suppression and aging2010

    • Author(s)
      Eiji Hara
    • Organizer
      Asian aging core for longevity research
    • Place of Presentation
      Jeju, South Korea
    • Year and Date
      2010-08-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛍光・発光融合プローブを用いたOct4遺伝子イメージングシステムの開発2010

    • Author(s)
      田島丈子、杉田千鶴、近江谷克祐、中尾和貴、柳茂、深見希代子、原英二、大谷直子
    • Organizer
      日本分子生物学会・日本生化学会合同年会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Backup tumor suppressor role for p16^<INK4a> in the event of p53 inactivation2010

    • Author(s)
      Takahashi A., Yamakoshi K., Ohtani N., Hara E
    • Organizer
      日本分子生物学会・日本生化学会合同年会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] DNA damage dependent degradation of histone methyltransferase in cellular senescence.2010

    • Author(s)
      Takahashi A., Yamakoshi K., Imai Y., Ohtani N., Hara E
    • Organizer
      Cold Spring Harbor Laboratory Meeting : Molecular Genetics of Aging
    • Place of Presentation
      New York, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Intrinsic cooperation between p16^<INK4a> and p21^<Waf1/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010

    • Author(s)
      Takeuchi S., Takahashi A., Motoi N., Yoshimoto S., Tajima T., Yamakoshi K., Ishikawa Y., Sone S., Hara E., Ohtani N.
    • Organizer
      Cold Spring Harbor Laboratory Meeting : Molecular Genetics of Aging
    • Place of Presentation
      New York, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞老化において発癌を促進する因子の探索2010

    • Author(s)
      今井良紀、高橋暁子、八尾良司、大谷直子、広田亨、田原栄俊、井出利憲、野田哲生、原英二
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Cellular senescence: its role in tumor suppression and aging2010

    • Author(s)
      原英二
    • Organizer
      Asian aging core for longevity research
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞老化の分子メカニズムとその役割2010

    • Author(s)
      原英二
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Real-time in vivo imaging of p16^<Ink4a> reveals cross-talk with p53.2010

    • Author(s)
      原英二
    • Organizer
      IMCB symposium on cell cycle regulation and tumorigenesis.
    • Place of Presentation
      Singapore, Singapore
    • Related Report
      2010 Final Research Report
  • [Presentation] Visualizing the dynamics of Oncogenic stress response in living mice2009

    • Author(s)
      Naoko Ohtani
    • Organizer
      American Association for cancer Research Conference on Mouse Models of Cancer
    • Place of Presentation
      米国サンフランンシスコ
    • Year and Date
      2009-01-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Real-time in vivo imaging of p16^<Ink4a> expression unveils a cross-talk between p53 and p16^<Ink4a>2009

    • Author(s)
      Yamakoshi K., Takahashi A., Ohtani N., Hara E
    • Organizer
      The Salk Institute Meeting /Mechanisms & Models of Cancer
    • Place of Presentation
      La Jolla, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Visualizing the dynamics of oncogenic stress response in living mice.2009

    • Author(s)
      Ohtani N., Yamakoshi K., Takahashi A., Hara E
    • Organizer
      AACR Conference on Mouse model of Cancer
    • Place of Presentation
      San Francisco, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Real-time in vivo imaging of p16^<Ink4a> unveils a cross talk between p53 and p16^<Ink4a>2009

    • Author(s)
      Eiji Hara
    • Organizer
      IMCB Symposium on Cell Cycle Regulation & Tumorigenesis
    • Place of Presentation
      シンガポール シンガポール市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Real-time imaging of p16^<INK4a> expression visualizes the dynamics of senescence signaling in living mice2008

    • Author(s)
      Eiji Hara
    • Organizer
      日本分子生物学会・日本生化学会合同大会
    • Place of Presentation
      神戸市ポートアイランド
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Real-time imaging of p16^<INK4a> expression visualizes the dynamics of senescence signalling in living animals.2008

    • Author(s)
      Yamakoshi K., Takahashi A., Ohtani N., Hara E
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Book] がん分子標的治療研究マニュアル(鶴尾隆/曽根三郎編)(細胞周期アッセイ法)2009

    • Author(s)
      高橋暁子、原英二
    • Publisher
      金芳堂
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.jfcr.or.jp/tci/canbio/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.jfcr.or.jp/tci/canbio/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.jfcr.orjp/tci/canbio/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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