Role of EMT and growth factor cascade in development and cancer.
| Project/Area Number |
20390096
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
YAMADA Gen Kumamoto University, 発生医学研究所, 教授 (80174712)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 上皮間葉転換 / EMT / 細胞増殖因子 / 癌 / 発生 / Wnt / 遺伝子 / 発生・分化 / 泌尿生殖系 / 外生殖器 / ヘッジホッグ / Bmp(骨形成因子) / Wntシグナル / 間葉 / 平滑筋 / 細胞系譜 / ノギン(noggin) |
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| Research Abstract |
We investigated the role of growth factor cascade and EMT (Epithelia Msenchyme Transition) during development and early oncogenic processes. During this research period, we published more than Development2、Endocrinology4、Molecular Endcrinology1、COGD1 papers. During skin development, we found abnormal Wnt/β catein signaling leads to skin hyperplasia. The phenotype can be studied more in relation to BCC. In such pathological condition, integration of Bmp-hedgehog signal transduction was also incorporated. During cloaca development, we investigated the role of growth factor signals and we found abnormal hedgehog and Wnt/β catein signal altered cloacal epithelial development. During the course of MD and female reproductive tract development, we investigated the role of Wnt/β catein cascade. We also found abnormal gain-of-function of Wnt/b catein signal leads to uterine gland (UG) hyperplasia and found such dysregulation in human endometorial hyperplasia samples. Thus, our project suggested a link of development and pathogenesis in terms of growth factor cascade.
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Report
(4 results)
Research Products
(91 results)
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[Journal Article] Abnormal urethra formation in mouse models of Split-hand/split-foot malformation type 1 and type 4. Eur.2008
Author(s)
Suzuki K., Haraguchi, R., Ogata, T., Barbieri, O., Alegria, O., Vieux-Rochas, M., Nakagata, N., Ito, M., Mills,A., Kurita, T., Levi, G., Yamada G.
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Journal Title
J.Hum. Genet. 16
Pages: 36-44
Related Report
Peer Reviewed
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[Presentation] Reproductive organ formation.2010
Author(s)
Gen Yamada
Organizer
Developmental Mechanism and Disease-joint meeting of Dev.Dyn.and SIBCB
Place of Presentation
Shanghai Institute for Biological Sciences Shanghai, China
Year and Date
2010-06-18
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[Presentation] Workshop 6 : Reproduction & gametology2008
Author(s)
世話人/座長金井克晃、山田源(各シンポジスト:Neil A. Bhowmick、Shigeaki Kato、Toshiaki Nose、Yuko Katoh-Fukui、Yoshiakira Kanai)
Organizer
41^<st> Annual Meeting for the Japanese Society of Developmental Biologists (Jointly sponsored by the International Society of Developmental Biologists)
Place of Presentation
Tokushima Arts Foundation for Culture, Tokushima
Year and Date
2008-05-30
Related Report
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