| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
We investigated the role of growth factor cascade and EMT (Epithelia Msenchyme Transition) during development and early oncogenic processes. During this research period, we published more than Development2、Endocrinology4、Molecular Endcrinology1、COGD1 papers. During skin development, we found abnormal Wnt/β catein signaling leads to skin hyperplasia. The phenotype can be studied more in relation to BCC. In such pathological condition, integration of Bmp-hedgehog signal transduction was also incorporated. During cloaca development, we investigated the role of growth factor signals and we found abnormal hedgehog and Wnt/β catein signal altered cloacal epithelial development. During the course of MD and female reproductive tract development, we investigated the role of Wnt/β catein cascade. We also found abnormal gain-of-function of Wnt/b catein signal leads to uterine gland (UG) hyperplasia and found such dysregulation in human endometorial hyperplasia samples. Thus, our project suggested a link of development and pathogenesis in terms of growth factor cascade.
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